Gene 87875.m00084 (T.vaginalis)
87875.m00084
Species: T.vaginalis
Alias: TvagK0475, 87875.m00084
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
87875.m00084.AA | Protein | None | 361 | None | Fasta, JSON |
87875.m00084.kin_dom | Protein Kinase Domain | None | 257 | None | Fasta, JSON |
Protein domains of 87875.m00084.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 87875.m00084.AA | CK1 | 1-251 | 50 | 1.4e-132 | 446.8 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 1-251 Range on HMM: 1-271/271 Sequence Identity: 50% (137 aa) MKVGERIGGGSYGNIFYAYNTANKKE---LALKIESEKTKRSQIFNEYRALKCLAG------YVGIPKVYFETCY--GNQNAFTMELLGDSLEKLFERCG .||..|| || | |. ..|. ...| | |.|..|.| .|. |.. .| | | .|||..| . |. |. |.||| |||.|| |. YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN RKFSLKTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIGT-GPNSNVIYIIDFGLAKRYINGQTLTHIPYREGRSFTGTTRYGSINDHLDIEQSRRDDM ||||||||||.|||||. ..|.|.|.||||||||.|| .|. | .....|||||||||||. | .||||||....|||.|| ||| || ||||||||| RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM ESLAYTLIYFLKGFLPWHGCKRET--------FQIKLSTSVEELCEG-LPVEFSIFLQDMRKLDFEEEPNYS |||.| |.|||.| ||| | | .| .|.||.||.||.| .|.|| .|. .|.|.|||.|.| ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 87875.m00084.AA | CK1-Unclassified | 1-225 | 50 | 9.90000000001e-130 | 385.04 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 1-225 Range on HMM: 1-244/244 Sequence Identity: 50% (123 aa) MKVGERIGGGSYGNIFYAYNTANKKELALKIESEKTKRSQIFNEYRALKCLAGYV-------GIPKVYFETCY--GNQNAFTMELLGDSLEKLFERCGRK .|.|.|| || |.|. ..|. ...| |.|.|....| .|.. | . .. | . ||||.| |. | |.||| |||.|| |.|| YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK FSLKTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIG-TGPNSNVIYIIDFGLAKRYING-QTLTHIPYREGRSFTGTTRYGSINDHLDIEQSRRDDME ||||||||.|||||. ..|.| |.||||||||.|| .| .| |....|||||||.|||| | .||||||....|||.|| ||| || ||||||||.| FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE SLAYTLIYFLKGFLPWHGCKRETFQ--------IKLSTSVEELC ||.|.||||||| ||| . | .. . .|.||.||.|| SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | 87875.m00084.AA | CK1-D | 1-253 | 49 | 1.1e-105 | 357.38 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 1-253 Range on HMM: 1-261/261 Sequence Identity: 49% (129 aa) MKVGERIGGGSYGNIFYAYNTANKKELALKIESEKTKRSQIFNEYRALKCLAGYVGIPKVYFETCYGNQNAFTMELLGDSLEKLFERCGRKFSLKTVLML ..| .||.||.|.|.. | .. | |.|.|. ||| |. | . | . | .|||.. . |. |. |.||| ||| || |.||||||||||| YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML ADQMIKCVQYIHTKSFIHRDIKPENFTIGTGPNSNVIYIIDFGLAKRYINGQTLTHIPYREGRSFTGTTRYGSINDHLDIEQSRRDDMESLAYTLIYFLK |||||. ..|||...||||||||.|| .| | |..||||||||||| .| |||||| .. ||| || ||| |. ||||||||.||| | |.|| . ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR GFLPWHGCKRET--------FQIKLSTSVEELCEGLPVEFSIFLQDMRKLDFEEEPNYSKY | ||| | | | . |.||....||.|.| ||. .. |.| |.. |.|. GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 87875.m00084.AA | CK1-G | 2-254 | 46 | 5.5e-102 | 345.11 | In-house | 2-266 (266) | Show / Hide |
Range on Protein: 2-254 Range on HMM: 2-266/266 Sequence Identity: 46% (125 aa) KVGERIGGGSYGNIFYAYNTANKKELALKIESEKTKRSQIFNEYRALKCLAGYV-GIPKVYFETCYGNQNAFTMELLGDSLEKLFERCGRKFSLKTVLML .|| .|| |..| .| | | | |.| |.. | |||. | |.| . |||.||. | |. |.||| ||| ||. |.||||.|||.|. RVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMV ADQMIKCVQYIHTKSFIHRDIKPENFTIG--TGPNSNVIYIIDFGLAKRYINGQTLTHIPYREGRSFTGTTRYGSINDHLDIEQSRRDDMESLAYTLIYF | |||. ..|.|... | ||.||.|| || .. .||.|||||.|| || .| |||||| .| ||| || ||| || |||||||||.| .|| AIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMYF LKGFLPWHGCKRETF--------QIKLSTSVEELCEG--LPVEFSIFLQDMRKLDFEEEPNYSKYL | | ||| | | .. . | .| .| ||.. .|..| .|. |.|||.|.| | || LRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYD-YL |
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Kinase | 87875.m00084.AA | CK1-A | 2-254 | 49 | 4.7e-101 | 342.02 | In-house | 2-261 (261) | Show / Hide |
Range on Protein: 2-254 Range on HMM: 2-261/261 Sequence Identity: 49% (128 aa) KVGERIGGGSYGNIFYAYNTANKKELALKIESEKTKRSQIFNEYRALKCLAGYVGIPKVYFETCYGNQNAFTMELLGDSLEKLFERCGRKFSLKTVLMLA .. .|| ||.| |. . |. | .|.|.|.||.| . |. | . . |.| ||||.. . | . |.. |.||| ||| || | |.|..||||||| RLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLA DQMIKCVQYIHTKSFIHRDIKPENFTIGTGPNSNVIYIIDFGLAKRYINGQTLTHIPYREGRSFTGTTRYGSINDHLDIEQSRRDDMESLAYTLIYFLKG |||| . |.|.|.||||||||.|| .|.| | ...|||||||.| .| .|||||| . ||| || ||| || |||||||||||..| ..|| .| DQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRG FLPWHGCKRETFQIK--------LSTSVEELCEGLPVEFSIFLQDMRKLDFEEEPNYSKYL ||| | | | . | .||..|.|| | | ||..... .|.| |||.|.| || KLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDY-MYL |
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Kinase | 87875.m00084.AA | CK1 | 2-253 | 31 | 4.2e-96 | 325.58 | In-house | 2-339 (339) | Show / Hide |
Range on Protein: 2-253 Range on HMM: 2-339/339 Sequence Identity: 31% (107 aa) KVGERIGGGSYG-NIFYA-----YNTANK-----KELALKIESEKTK--RSQIFNEYRALKCLAGY-------------------VGIPKVYFETCYGN- ||.. ||.|..| |. . ... |. .| |.|.|..|.. .| ||. .| | | ...|..| .. KVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDD -QNAFTMELLGDSLEKLFE---RCGRKFSLKTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIGT------GPNSN--------VIYIIDFGLAK-RYI | |.||| .||.|.. |.||||.||.||.|.||.. ..|.| . ||||||||.|| .| | . . ..|.||||.|. .|. YYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKYR NG-----------QTLTHIPYRE---GRSFTG-TTRYGSINDHLDIEQSRRDDMESLAYTLIYFLKGF--LPWHGCKRETF-------QIKL-------- . | |.|.|| ..|.| |.|| ||| || .||.||||..|..|.||..||| |||...|.|. . | DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM STSVEELCEG-----LPVEFSIFLQDMRKLDFEEEPNYSKY ||... ||.. .| || ... |.|.....|.| . STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 87875.m00084.AA | TTBKL | 2-257 | 26 | 4e-53 | 177.72 | In-house | 2-288 (288) | Show / Hide |
Range on Protein: 2-257 Range on HMM: 2-288/288 Sequence Identity: 26% (77 aa) KVGERIGGGSYGNIFYAYNTANKKE-LALKIESEK-TKRSQIF-NEYRALKCLA--GYVGIPKVYFETCYGNQNAFTMELLGDSLEKLFERCGRK--FSL .. . ||.| .| .... .. .||. |.|.|. . . ... | |. |. | .||... ... | . |.|.|..| .| . .| || MIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFSD KTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIGTG----PNSNVIYIIDFGLAKRYI---NGQ-------TLTHIPYRE---GRSFTGTTRYGSINDH |.. .. | .......| . |||||.|| |. .| ... ..|.||||.|..|. ... .... . |. .| ||||| |.| | GTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMH LDIEQSRRDDMESLAYTLIYFLKGFLPWHGCK-RE-TFQIKLSTSVEELCEG------LPVEFSIFLQDMRKLDFEEEPNYSKYLQLF . ||.| ||. |. |..|....| |||.... .. . . |.... | |. . .| || | . | |.. ..|.|.. ...| DRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 87875.m00084.AA | TTBK | 2-253 | 35 | 1.2e-47 | 164.59 | In-house | 2-257 (257) | Show / Hide |
Range on Protein: 2-253 Range on HMM: 2-257/257 Sequence Identity: 35% (92 aa) KVGERIGGGSYGNIFYAYNTANK-KELALKIESEKTKRSQIFNEYRALKCLAGYVGIPKVYFETCYGNQ--NAFTMELLGDSLEKL-FERCGRKFSLKTV || .|||| .| |. | . |. . |.|.|| .... | || | | . . | .| | | |.|.| .| | . .||| | KVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCR--FIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT LMLADQMIKCVQYIHTKSFIHRDIKPENFTIGTGP-NSNVIYIIDFGLAKRYINGQTLTHIPYREGRSFTGTTRYGSINDHLDIEQSRRDDMESLAYTLI | | |... .. || | |||||| || .| | . . .|..||||| .|.|.. | || | || || ||| |. | |.||. || | |. LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPP-REVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLV YFLKGFLPWHGC--KRETFQIKLSTSVEELCEGLPVEFSIFLQDMRKLDFEEEPNYSKY |..| ||| | . ..| | . .| ||..|.. .. |..|. |.| EFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 87875.m00084.AA | Worm6 | 74-253 | 29 | 5.9e-39 | 135.75 | In-house | 82-279 (279) | Show / Hide |
Range on Protein: 74-253 Range on HMM: 82-279/279 Sequence Identity: 29% (59 aa) MELLGDSLEKLFERC-GRKFSLKTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIGT-----GPNSNVIYIIDFGLAK--RYINGQT-LTHIPYR-EGR |.|.| .|. | . . .||||. | | .| |... .. | |||||.|| ||.|| .. ||..|||... .|.| .. | .. | . MTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNEL--RTPRWTAC SFTGTTRYGSINDHLDIEQSRRDDMESLAYTLIYFLKGFLPWHGCKRETFQIKLSTSV---------EELCEGLPV-EFSIFLQDMRKLDFEEEPNYSKY | ||.||.... | .||.|.||.|| | .. ...| |||...|.. .. |. ... .. | ||. .. .......|.| . GFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | 87875.m00084.AA | VRK | 74-209 | 37 | 1.9e-23 | 72.36 | In-house | 108-244 (284) | Show / Hide |
Range on Protein: 74-209 Range on HMM: 108-244/284 Sequence Identity: 37% (52 aa) MELLGDSLEKLFE-RCGRKFSLKTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIGTGPNSNVIYIIDFGLAKRYINGQTLTHIPYREG--RSFTGTTR |. .| .|.|. | .| .|| |||| || .|. .|.| . | ||| .| | | . | .|.||| || .. | .| |. | || MPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNG--KHRQYKEDPRRCHNGTCE YGSINDHLDIEQSRRDDMESLAYTLIYFLKGFLPWHGCK . |. |. ||| | |.|.| ... | |.||| |. FTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCL |
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Kinase | 87875.m00084.AA | Pkinase | 1-223 | 20 | 3.1e-18 | 65.57 | Pfam | 1-237 (293) | Show / Hide |
Range on Protein: 1-223 Range on HMM: 1-237/293 Sequence Identity: 20% (51 aa) MKVGERIGGGSYGNIFYAYNTANKKELALKIESEKTKRSQIF------NEYRALKCLAGYVGIPKVYFETCYGNQNAFTMELLGDSLEKLFERC------ ..|..|| ||.| . ... . |. |.|| . ....|. .| . .| | . .. . .. . ||... |. ... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTW -GRKF--SLKTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIGTGPNSNV---IYIIDFGLAKRYINGQTLTHIPYREGRSFTGTTRYGSINDHL-DIE ...| | ... . . |... ..|.| ...||||.||||. | | .. . |.|||||| . . ... .|.|| .| . .. . . RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQY QSRRDDMESLAYTLIYFLKGFLPWHGC-------KRETFQIKLSTSVEE ... || |. .|...| | .|. |. ... .. .... ... YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHF |
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Kinase | 87875.m00084.AA | S_TKc | 1-358 | 14 | 3.1e-15 | 46.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-358 Range on HMM: 1-231/231 Sequence Identity: 14% (56 aa) MKVGERIGGGSYGNIFYAYNTANKKELALKIESEKTKRSQIFNEYRALKCLAGYVGIPKVYFETCYGNQNAFTMELLGD---SLEKLFERCGRK-----F .... || |..| . .... ... |.|| . .| .| . || . | | | . . ||... .| .. ...||. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SLKTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIGTGPNSNVIYIIDFGLAKRYINGQTLTHIPYREGRSFTGTTRYGS---INDHLDIEQSR-RDDM . .. .. |... ..|.| . .||||.|||| . . .| |.|||||... ..| || | . . .. . |. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------GYGKCKCDW ESLAYTLIYFLKGFLPWHGCKRETFQIKLSTSVEELCEGLPVEFSIFLQDMRKLDFEEEPNYSKYLQLFRSLFLNSGFVYDDVYDWTLLPEEPPRPHFKQ |. .|. .| | |.. ..|.. . WSCGCILYEMLCGYPPFP-QMQMMFKKIG----------------------------------------------------------------------- DVFNSKISNDDSSDSIIKTKQPHREKSAGTSRLSLISLPTQNVLAQSGIFLTKKPPKRLSLETNQT-------LPSL | . . . . |.| | ||.. . | . ------------------------------------SPEAKDFIRK---CLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 87875.m00084.AA | Worm6 | 2-40 | 32 | 4.1e-05 | 14.67 | In-house | 2-44 (279) | Show / Hide |
Range on Protein: 2-40 Range on HMM: 2-44/279 Sequence Identity: 32% (14 aa) KVGERIGGGSYGNIFYAYNTANKK--ELALKIES--EKTKRSQ ||.. || |..| .. . .. .|| . |.| |. |. ||.. KVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQM |
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Kinase | 87875.m00084.AA | TyrKc | 1-224 | 14 | 9.9e-05 | -146.11 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-224 Range on HMM: 1-280/280 Sequence Identity: 14% (45 aa) MKVGERIGGGSYGNIFYAYNTANKKELALKIESEKTKRSQIFNEYRALKCL----------AGYVGIP----------KVYFETC-YGNQNAFTMELLGD . |. .| | .| .. . . . | | | . | . .| | .. | |.. . . .| . .|. . . . .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK SLEKLFERCGRKFSLKTVLMLADQMIKCVQYIHTKSFIHRDIKPENFTIGTGPNSNVIYIIDFGLAKRYING-------QTL-------TH--IPYR--- ...|. | . | . .|.| | .||||. | .| . .. | ||||.. .. .. .. .|.| ------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA ----EGRSFT------------------GTTRYGS-----INDHL---DIEQSRRDDMESL--------AYTLIY-FLKGFLPWHGCKRETFQIKLSTSV . || | . | ... ...| .| . . . .| | .| ||. . PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----H EEL |.. ECF |
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Kinase | 87875.m00084.AA | VRK | 2-26 | 32 | 0.153283 | 1.21 | In-house | 2-26 (284) | Show / Hide |
Range on Protein: 2-26 Range on HMM: 2-26/284 Sequence Identity: 32% (8 aa) KVGERIGGGSYGNIFYAYNTANKKE ..| || | .| |. | . .|.. RLGKPIGQGGFGCIYLASPNTCKPC |