Gene 90246.m00080 (T.vaginalis)
90246.m00080
Species: T.vaginalis
Alias: 90246.m00080, TvagK0929
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 90246.m00080.AA | Protein | None | 214 | None | Fasta, JSON |
| 90246.m00080.kin_dom | Protein Kinase Domain | None | 183 | None | Fasta, JSON |
Protein domains of 90246.m00080.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 90246.m00080.AA | MARK | 1-183 | 37 | 1.8e-64 | 209.67 | In-house | 81-262 (262) | Show / Hide |
Range on Protein: 1-183 Range on HMM: 81-262/262 Sequence Identity: 37% (70 aa) MEYSDSGNLEQLVQAN--GGIDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSANG--SAKLSDFGLCKHQPENSYLTTTCGTFVYVPPEILEEQ ||| .|.| . ..| | . |.|| .|.|| ||..| |.....||| . |||. .|| .|..|||.. . |... |.| ||| | .|||.. . MEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKK MYDGLKADIWSAGICLYAMTCNHLPWTVDDSIPPEKV--WEETQNQICSGEIQYDDKQCELLRDLLSQMLQVNPEFRPDADEILAHPWL ||| |.|||| |. ||.|.| ..|. .. .| . .| .|. .. .. .|.|....|.|||| ||...||. |||. PYDGPKVDIWSLGVVLYFMVCGYFPFD-------GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 90246.m00080.AA | CAMKL | 1-183 | 36 | 1.1e-63 | 202.08 | In-house | 100-297 (297) | Show / Hide |
Range on Protein: 1-183 Range on HMM: 100-297/297 Sequence Identity: 36% (72 aa) MEYSDSGN--LEQLVQANGG----IDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSANGS--AKLSDFGLC---K-H-QPENSYLTTTCGTFVY ||| ..|. | . ....|. ..|.|| ||.||.||..|.|..|..||| . |||.. ||. .|..|||.. . . ... |.| ||. | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY VPPEILEE--QMYDGLKADIWSAGICLYAMTCNHLPWTVDDSI--PPEKVWEETQNQICSGEIQYDDKQCELLRDLLSQMLQVNPEFRPDADEILAHPWL .|||.. . ||| |.||||.|. |||| | .||. |. . . .. ..| . .. .|||...||||||| || ...|. |||. MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 90246.m00080.AA | CAMK | 1-183 | 22 | 6.9e-63 | 201.19 | In-house | 136-425 (425) | Show / Hide |
Range on Protein: 1-183 Range on HMM: 136-425/425 Sequence Identity: 22% (67 aa) M---EYSDSG----NLEQLVQANGG---------------IDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSAN-----------------GSA | || . | | . ....|. ..|.|| ||.|| ||. |.|.....||| . |||.. | . MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI KLSDFGLCKHQPE------------------------NSYLTTTCGTFVYVP-PEILEE-------------QMYDGLKADIWSAGICLYAMTCNHLPWT |..|||. .. .. . ..| ||| |.. ||.|. . |.| |.|.||.|. ||.| | ..|. KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY VD------DSIPPEKVW-----EETQNQICSGEIQYDDKQCEL------------------------LRDLLSQMLQVNPEFRPDADEILAHPWL | . . | | .|. .|..|. ...... .||...||||.|| |. ....|.|||. GDCDNEICE-D--E--WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 90246.m00080.AA | Ciliate-E2 | 1-183 | 23 | 9.6e-53 | 179.38 | In-house | 113-365 (365) | Show / Hide |
Range on Protein: 1-183
Range on HMM: 113-365/365
Sequence Identity: 23% (64 aa)
MEYSDSGNLEQLVQ------------ANGGIDESEAVLYFKQIMS---------------AISYIHERG-VAHRDVTLKNILVSANGSAKLSDFGLCKHQ
||| . |.|... . . . ..| |. ..||| . |. |.|... . ||| . |||. |..||||.| .
MEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKY
PENSY--------------------------------LTTTCGTFVYVPPEILEEQMYDG--------LKADIWSAGICLYAMTCNHLPWTVDDSIPPEK
.... |.||| |..||||. . ||. |.||||.|..|| | .. .|.
DDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------
VWEETQNQICSGEIQYD-----------------DKQCELL-RDLLSQ----MLQVNPEFRPD-ADEILAHPWL
|.||. ..|... |.... ||... |||..|| |.. ...|| |||.
-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 90246.m00080.AA | Ciliate-E2-Unclassified | 1-183 | 25 | 1.5e-49 | 170.0 | In-house | 100-352 (352) | Show / Hide |
Range on Protein: 1-183 Range on HMM: 100-352/352 Sequence Identity: 25% (65 aa) MEYSDSGNLEQLVQANGG-----------------IDESEAV-----LYFKQIMSAISYIHERG-VAHRDVTLKNILVSANG---SAKLSDFGLCKHQPE ||| . |.|.| . ... ..| .|. ||.|| ....|.|. . . ||| .. |||.. || |..|||..|.. . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ N----------------SYLTTTCGTFVYV----PPEILEEQMYDG---LKADIWSAGICLYAMTCNHLPWTVDDSIPPEKVWE---------ETQNQIC | ..|.||| | .||.|..| ||. |.|||| |..||.| . .| ... ... . . ...|. NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK SGEIQYDD-----------KQC-ELLRDLLSQMLQVNPEFRPDADEILAHPWL ..||.. ... ....|||..||..||. |.....|| |||. QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 90246.m00080.AA | Pkinase | 1-183 | 28 | 1.7e-48 | 172.21 | Pfam | 79-293 (293) | Show / Hide |
Range on Protein: 1-183 Range on HMM: 79-293/293 Sequence Identity: 28% (62 aa) MEYSDSG----NLEQLVQ--ANGGI--DESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSANGSA----KLSDFGLCKH--QPENSYLTTTCGTFV ||| . | | ... ..|.. .| |. |..|| ... |.|..|. |||. . |||.. || |..||||.|. || .|| ||| MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW YVPPEILEEQMYDGLKADIWSAGICLYAMTCNHLPWTVD----DSIPPEKVWEETQNQICSGEIQYDDKQC-----------------ELLRDLLSQMLQ |..||.. .. |.| |.|.||.|. || | | ..|. . . . . .. ... . . ...... | ..|... .|. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC VNPEFRPDADEILAHPWL ..|. || |..|| |||. KDPKKRPTAEQILQHPWF |
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| Kinase | 90246.m00080.AA | ULK | 1-183 | 26 | 2.1e-47 | 163.53 | In-house | 99-329 (329) | Show / Hide |
Range on Protein: 1-183 Range on HMM: 99-329/329 Sequence Identity: 26% (61 aa) MEYSDSGNLEQLVQANGG----------IDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSAN------------GSAKLSDFGLCKH-QPE--- ||| . |.|||. . |.. . |.||. .||||... ..|.... ||| . |||.. . | .|..|||..|| . . MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME -NSYLTTT-----CGTFVYVPPEILE----EQMYDGLKADIWSAGICLYAMTCNHLPWTVDDSIPPE-KVWEETQNQ-------ICSGEIQ-----YDDK . ..|.. ||| | |.||. .. |. |.|||| |. .| | . |. . . .. |. |.. .| .|.. QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ QCELLRDLLSQMLQVNPEFRPDADEILAHPWL . ..||...|||.... | . .|...|||. ISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 90246.m00080.AA | ULK | 1-183 | 27 | 5e-47 | 162.55 | In-house | 96-324 (324) | Show / Hide |
Range on Protein: 1-183 Range on HMM: 96-324/324 Sequence Identity: 27% (64 aa) MEYSDSGNLEQLVQANGG---------IDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSAN------------GSAKLSDFGLCKH-QPEN--- ||| . |.|||. . |.. . |.||. .||||... ..|.... ||| . |||.. . | .|..|||..|| . .| MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ SYLTTTC------GTFVYVPPEILE----EQMYDGLKADIWSAGICLYAMTCNHLP---WTVDDSIPPEKVWEETQNQ-------ICSGEIQYDDKQ--- ..|.. || | |.||. .. |. |.|||| |. .| | . | | | . .. .. .|. |. ||.... QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQY--LY-IQKLINNGKEQQIYIKNQPIQFPKPPKDP --CELLRDLLSQMLQVNPEFRPDADEILAHPWL . ..||...|||.... | . .||..|||. KISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 90246.m00080.AA | AMPK | 1-121 | 38 | 3.6e-39 | 113.99 | In-house | 79-199 (254) | Show / Hide |
Range on Protein: 1-121 Range on HMM: 79-199/254 Sequence Identity: 38% (47 aa) MEYSDSGNLEQLVQANGGIDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSANGSAKLSDFGLCKHQPENSYLTTTCGTFVYVPPEILEEQMYDG ||| | | . .| ..| || .|.|| |...|.|. ...||| . |.| .| . |. |||| . .. .| | || | ||. . . | | MEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCG LKADIWSAGICLYAMTCNHLP .. |||| |. |||| | || PEVDIWSCGVILYAMLCGYLP |
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| Kinase | 90246.m00080.AA | RSK | 17-183 | 30 | 1.1e-37 | 131.5 | In-house | 99-278 (278) | Show / Hide |
Range on Protein: 17-183 Range on HMM: 99-278/278 Sequence Identity: 30% (56 aa) GGIDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSA---NGSAKLSDFGLCKH-QPE-NSYLTTTCGTFVYVPPEILE---EQM-YDGLKADIWS | ..|.|| |. .| .|....|..|. ||| . ||| .|. ||.|||.|| .. |. . | |.| |..||.| | .| .|.|| GCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD-KACDWWS AGICLYAMTCNHLPWTV-DDSIPPEKVWEETQNQICSGE--IQYD--DKQCELLRDLLSQMLQVNPEFRPD-----ADEILAHPWL |. .| | ..| . .| . .|. ..|..|. . .. . .||...||...|. |. |.||..|||. LGVLMYEMLTGCPPFQGPND-----NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 90246.m00080.AA | TSSK | 1-121 | 35 | 1.9e-35 | 113.78 | In-house | 96-228 (289) | Show / Hide |
Range on Protein: 1-121 Range on HMM: 96-228/289 Sequence Identity: 35% (47 aa) MEYSDSGNLEQLVQAN------GGIDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSANGSAKLSDFGLCKHQPENS------YLTTTCGTFVYV ||| ..| | . .|.. |...|..| . |.|. ||. |.| ..|.|||. . ||| . .. ||.||| . .|... ..| || . |. MEYAEHGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYA PPEILEEQMYDGLKADIWSAGICLYAMTCNHLP .|||| .||. ..|.|| |. ||.| |...| APEILRGIPYDPKWYDVWSMGVILYIMVCGCMP |
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| Kinase | 90246.m00080.AA | S_TKc | 1-183 | 22 | 5.6e-24 | 86.89 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-183
Range on HMM: 1-231/231
Sequence Identity: 22% (60 aa)
M-----------------------------------------------------------------EYSDS--GNLEQLVQANGG------IDESEAVLY
|| | |.| .. . .|. ..| .| |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
FKQIMSAISYIHERGVAHRDVTLKNILVSANGSAKLSDFGLCKHQPENSYLTTTCGTFVYVPPEILEEQMYDGLKADIWSAGICLYAMTCNHLPWTVDDS
..|| .|. |.|..|. |||. |||.. |..||||... || ||| |..||.| |.. |.|.|| |..|| | | |.
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----
IPPEKVWEETQNQICSGEIQYDDKQCELLRDLLSQMLQVNPEFRPDADEILA-------HPWL
... ..|. . ..|.....||..|| || | |.|. |||.
-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 90246.m00080.AA | Pkinase_Tyr | 1-70 | 27 | 9.7e-11 | 36.99 | Pfam | 86-159 (270) | Show / Hide |
Range on Protein: 1-70 Range on HMM: 86-159/270 Sequence Identity: 27% (20 aa) MEYSDSGNLEQLVQA----NGGIDESEAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSANGSAKLSDFGLCK ||| |.| .. .. .. .. . . || .. .| .... |||. .|.||. |. .| .||||.. MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR |
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| Kinase | 90246.m00080.AA | TSSK | 157-183 | 44 | 1e-09 | 28.08 | In-house | 263-289 (289) | Show / Hide |
Range on Protein: 157-183 Range on HMM: 263-289/289 Sequence Identity: 44% (12 aa) RDLLSQMLQVNPEFRPDADEILAHPWL .||...||| .| ||...||..|.|. KDLIRHMLQPHPCNRPHINEICHHCWM |
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| Kinase | 90246.m00080.AA | AMPK | 157-183 | 44 | 1.2e-08 | 21.85 | In-house | 228-254 (254) | Show / Hide |
Range on Protein: 157-183 Range on HMM: 228-254/254 Sequence Identity: 44% (12 aa) RDLLSQMLQVNPEFRPDADEILAHPWL .||...||||.|. | . ..| .|||. KDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | 90246.m00080.AA | TyrKc | 1-183 | 15 | 9.2e-07 | -113.33 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-183
Range on HMM: 1-280/280
Sequence Identity: 15% (43 aa)
M--------------------------------------------EY--------------SDS-------------------GNLEQLVQANGG-IDES
.. ... |.| . ..... . .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK
EAVLYFKQIMSAISYIHERGVAHRDVTLKNILVSANGSAKLSDFGLCKHQPEN-------SYLTTT---CGTFV----YVPPEILEEQMYDGLKADIWSA
. . . || . .|.|.... ||| |.||..|. .| |||||.. . .| ... .| .. .|| . . .. | |.||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF
GICLY-AMTCNHLPWTVDDS--IPPEKVWEETQNQICSGEIQYDD--------KQCELLRDLLSQMLQVNPEFRPDADEILAHPWL
|.|.. .| |. . .... | | .. | .. |. . . .| . .|| || || | .
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ--GYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
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