Gene 89650.m00238 (T.vaginalis)
89650.m00238
Species: T.vaginalis
Alias: TvagK0547, 89650.m00238
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 89650.m00238.AA | Protein | None | 231 | None | Fasta, JSON |
| 89650.m00238.kin_dom | Protein Kinase Domain | None | 172 | None | Fasta, JSON |
Protein domains of 89650.m00238.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Pkinase | 89650.m00238.AA | Pkinase | 1-172 | 30 | 5.9e-53 | 187.03 | Pfam | 79-293 (293) | Show / Hide |
Range on Protein: 1-172 Range on HMM: 79-293/293 Sequence Identity: 30% (67 aa) MEYLPNS----DLQTILE--RGVQF--TIYEQVRIFKEIVLGLNYLHKRGISHRDIKPENILFDENYHP----KIIDFGFS----RENCSKLNTYCGTPF |||... || .... |. | . | .....|. ||.|.|..|| |||.||||||.|.|.|. ||.|||.. | | ..|.||||. MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW FVAPEVITSDQYDGTKADLWSLAVTMHIMNTGKFPWRYR------SDVQLIKDMQFGRLEIHNEAK---------------------GLIGLIIGKLLTF ..||||| ..||.|.|.| ||. .....| .|..|.. . .. |.|. ..|. . . . .| ..|.. YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK DPADRPTTDDILNM--F ||..||| ..||. | DPKKRPTAEQILQHPWF |
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| Kinase | 89650.m00238.AA | CAMK | 1-170 | 23 | 1.2e-52 | 167.59 | In-house | 136-421 (425) | Show / Hide |
Range on Protein: 1-170
Range on HMM: 136-421/425
Sequence Identity: 23% (67 aa)
M---EYLPNS----D-LQTILERG--------------VQFTIYEQVRIFKEIVLGLNYLHKRGISHRDIKPENILFDEN-----------------YHP
| || .. | .. | |.| || | |.|. |. ...|.|...| |||.||||||.|.| .
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI
KIIDFGFSRENCS--------------------------KLNTYCGTPFFVA-PEVITS-------------DQYDGTKADLWSLAVTMHIMNTGKFPWR
|||||||... . |..|.|||| ..| |||. . .|.| |.| ||. | . || .|..|..
KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY
YR-------------SDVQLIKDMQFGRLE-IHNEAKG-----------------------LIGLIIGKLLTFDPADRPTTDDILN
.| .| . . |. . .. . .. | |.|. || .|.| ...||
GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
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| Kinase | 89650.m00238.AA | CAMKL | 1-170 | 34 | 4.9e-51 | 161.03 | In-house | 100-293 (297) | Show / Hide |
Range on Protein: 1-170 Range on HMM: 100-293/297 Sequence Identity: 34% (67 aa) MEYLPNSD--LQTIL--ERGVQ--FTIYEQVRIFKEIVLGLNYLHKRGISHRDIKPENILFDENY--HPKIIDFGFSRE---N----CSKLNTYCGTPFF ||| .. . |. . .... .. | |.|. || ..||.|..|| ||||||||||.||| |||||||| . . ||.| ||.| . MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY VAPEVITS--DQYDGTKADLWSLAVTMHIMNTGKFPWRYRSD--------VQLIKDMQFGRLE-IHNEAKGLIGLIIGKLLTFDPADRPTTDDILN |||.. . ..||| |.| ||. |.. | .|..|.. .. . |.|. . |... .| |.|. .| .||| ..|.| MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN |
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| Kinase | 89650.m00238.AA | MARK | 26-170 | 44 | 4.6e-49 | 158.62 | In-house | 108-258 (262) | Show / Hide |
Range on Protein: 26-170 Range on HMM: 108-258/262 Sequence Identity: 44% (67 aa) RIFKEIVLGLNYLHKRGISHRDIKPENILFDENY--HPKIIDFGFSREN--CSKLNTYCGTPFFVAPEVITSDQYDGTKADLWSLAVTMHIMNTGKFPWR |||. || ..||.|...| |||||||||| ||| ||||||||.. .|||| |||| . |||.. . |||.|.| ||| | . .| .|.||.. RIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFD YRS--DVQLIKDMQFGRLEIHNEAKGLIGLIIGKLLTFDPADRPTTDDILN . ...| | .. |. .| . .| .|||..| .||| ..|.. GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMK |
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| Kinase | 89650.m00238.AA | Ciliate-E2 | 1-170 | 27 | 1.2e-43 | 147.67 | In-house | 113-361 (365) | Show / Hide |
Range on Protein: 1-170 Range on HMM: 113-361/365 Sequence Identity: 27% (72 aa) MEYLPNSDLQTILE------------RGVQFTIYEQVRIFKEIVL---------------GLNYLHKRG-ISHRDIKPENILFDENYHPKIIDFGFSR-- |||. ||. ... .||..| .|.|.|. .|.|||... | ||||||||||| .||||||.|. MEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKY --ENCSKL------------------------------NTYCGTPFFVAPEVITSDQYDG--------TKADLWSLAVTMHIMNTGKFPWRYRSDVQLIK .|. .. ||.|||| ..|||.. . .||. .|.|.||| |....| .||.|. | || DDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIK --DMQFG-----------------RLEIHNEAKGLIGLIIGK--LLTFDPADRPT-TDDILN . .| ... .|.| || .| || |.| ..||| QCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK-F-GKRMLQKDPEKRITGWEQILN |
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| Kinase | 89650.m00238.AA | Ciliate-E2-Unclassified | 1-170 | 27 | 1.4e-41 | 142.04 | In-house | 100-348 (352) | Show / Hide |
Range on Protein: 1-170
Range on HMM: 100-348/352
Sequence Identity: 27% (68 aa)
MEYLPNSDLQTILER-----------------GVQFTIYEQV-----RIFKEIVLGLNYLHKRG-ISHRDIKPENILFDENY---HPKIIDFGFSRENCS
|||... ||. ... . .|| .. . ..|..|..||.|||. . | ||||||||||||.| ..||||||.|... .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
K------------------LNTYCGTPFFV----APEVITSDQYDG---TKADLWSLAVTMHIMNTGKFPWRYRSDVQ---------------LIKDMQF
..| |||| . ||||. . .||. |.| ||| | .. | .|..| .... | ... ..
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK
GR-------------LEIHNEAKGLIGLIIGKLLTFDPADRPTTDDILN
. ...||| .| .. |.| .| |.| ..|||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
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| Kinase | 89650.m00238.AA | ULK | 25-174 | 26 | 7e-39 | 133.39 | In-house | 133-329 (329) | Show / Hide |
Range on Protein: 25-174 Range on HMM: 133-329/329 Sequence Identity: 26% (53 aa) VRIFKEIVLGLNYLHKRGISHRDIKPENILFDEN------------YHPKIIDFGFSRE-NCS-----KLNTYC------GTPFFVAPEVITSD----QY . .|| |. |. .|||..| ||||||.||| ... .. || ||||.. ... . |. ||| . ||... . .| IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPY DGTKADLWSLAVTMHIMNTGKFP---WRYRSDV-----QLIKD-------MQFGRLE---------IHNEAKGLIGLIIGKLLTFDPADRPTTDDILNMF . |.|.||| . .. | .|| | | ..... .||.. .. |. | .| | | | ..|..|. || . ....|.. YDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDL----IRRMLQYDEKDRISWEELFNHP AE WF |
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| Kinase | 89650.m00238.AA | ULK | 1-174 | 23 | 2.1e-37 | 130.3 | In-house | 96-324 (324) | Show / Hide |
Range on Protein: 1-174 Range on HMM: 96-324/324 Sequence Identity: 23% (54 aa) MEYLPNSDLQTILERGVQFTIYE----------QVRIFKEIVLGLNYLHKRGISHRDIKPENILFDEN------------YHPKIIDFGFSRE-NC---- ||| . ||...... .. . . .|| |. |. .|||..| ||||||.||| .. .. || ||||.. .. MEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNME -SKLNTYC------GTPFFVAPEVITSD----QYDGTKADLWSLAVTMHIMNTGKFP---WRYRSDV----QLIKD-------MQFGRLEIHN--EAKGL .. |.. ||| . ||... . .|. |.|.||| . .. | .|| | | ..... .||. .. ... . ... . QQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKI ---IGLIIGKLLTFDPADRPTTDDILNMFAE . .| ..|..|. || . ..|.|.. SPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 89650.m00238.AA | RSK | 27-170 | 33 | 6.5e-36 | 125.63 | In-house | 109-274 (278) | Show / Hide |
Range on Protein: 27-170 Range on HMM: 109-274/278 Sequence Identity: 33% (57 aa) IFKEIVLGLNYLHKRGISHRDIKPENILFDE---NYHPKIIDFGFSRE-NCS---KLNTYCGTPFFVAPEVIT---SDQ-YDGTKADLWSLAVTMHIMNT .. |||| . .||..|| |||.||||||.|. . | |..||||... .|. ...|.|.| ..|||... . .| .|.||| | |. | | YMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLT GKFPWRY---RSDVQLIKDMQFGR--LEIH------NEAKGLIGLIIGKLLTFDPADRPT-----TDDILN |. | . . ...| .| |. |.. .||| | | |.|. ||..|.. ...|.. GCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDL----IRKMLHRDPHKRLGCGPQDAEEIKQ |
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| Kinase | 89650.m00238.AA | QIK | 26-171 | 35 | 2.3e-35 | 123.78 | In-house | 122-272 (272) | Show / Hide |
Range on Protein: 26-171 Range on HMM: 122-272/272 Sequence Identity: 35% (54 aa) RIFKEIVLGLNYLHKRGISHRDIKPENILFDENYHPKIIDFGFS--RENCSKLNTYCGTPFFVAPEVITSDQYDGTKADLWSLAVTMHIMNTGKFPWRYR |.|..|... |.|||.| |||.| ||||.|.| ||.||||| .. |.|.||.| . |||. .||| |.| ||. | . .. .|..| RWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGK SDVQLIKDMQFGRLEIHNEAKGLIGLIIGKLLTFDPADRPTTDDILN---M .. .| . . |. | .| . |. ||. | |.. |.. | TLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
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| Kinase | 89650.m00238.AA | MSK | 27-174 | 31 | 4.7e-33 | 109.08 | In-house | 106-277 (277) | Show / Hide |
Range on Protein: 27-174 Range on HMM: 106-277/277 Sequence Identity: 31% (54 aa) IFKEIVLGLNYLHKRGISHRDIKPENILFDEN---YHPKIIDFGFSRENCSK----LNTYCGTPFFVAPEVIT----SDQ-YDGTKADLWSLAVTMHIMN |. |.|. . ..|..|| |||.||||||||.. | |.|||||.|.. . ....|.| . |||... .| || |.||| |.. | IMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYD-EACDWWSLGVILYTML TGKFPWR-YRSDVQ--------LIKDMQFGRLEIH----NEAKGLIGLIIGKLLTFDPADRPTTDDILNMFAE ||. | . .|.| . | .. |. . ... |..||| ||..|....|.. TGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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| Kinase | 89650.m00238.AA | S_TKc | 1-178 | 22 | 1.6e-22 | 82.09 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-178
Range on HMM: 1-231/231
Sequence Identity: 22% (57 aa)
M-----------------------------------------------------------------EYLPN--SDLQTILERGVQ------FTIYEQVRI
||... || ..... |. . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
FKEIVLGLNYLHKRGISHRDIKPENILFDENYHPKIIDFGFSRENCSKLNTYCGTPFFVAPEVITSDQYDGTKADLWSLAVTMHIMNTGKFPWRYRSDVQ
...|...|.|.|..|| |||.||||||.|| | ||.|||..|. .|.||||...||||. .|.. |.| ||. ... .| .|. |.. . .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQM
LIKDMQFGRLEIHNEAKGLIGLIIGKLLTFDPADRPTTDDILN---MFAEHEQI
..| . . .. .| |.|..||..||| ..|. . |. .
MFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 89650.m00238.AA | TyrKc | 1-172 | 19 | 2e-06 | -118.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-172
Range on HMM: 1-280/280
Sequence Identity: 19% (54 aa)
M-----------------------------------------------------------------------------EYLPNSDLQTIL-ERGVQFTIY
|| |. ||. | ... ...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK
EQVRIFKEIVLGLNYLHKRGISHRDIKPENILFDENYHPKIIDFGFSRENCSK------LNTYC-----GTP-----FFVAPEVITSDQYDGTKADLWSL
. . . | | .|||.... |||. |.| .||.. || ||| ||. .. .| |. |||.| . || | ||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF
AVTMH-IMNTGKFPWRY-----RSDVQLIKDMQFG-RLEIHNE--------AKGLIGLIIGKLLTFDPADRPTTDDILNMF
|.| |. |. |. |. ..|.. . | |... . . . |. . .||.|||| .| |
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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