Gene 85666.m00040 (T.vaginalis)

85666.m00040

Species: T.vaginalis
Alias: TvagK0180, 85666.m00040
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
85666.m00040.AA Protein None 237 None Fasta, JSON
85666.m00040.kin_dom Protein Kinase Domain None 174 None Fasta, JSON

Protein domain

Protein domains of 85666.m00040.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85666.m00040.AA CAMK 1-174 18 7.5e-43 135.45 In-house 136-425 (425) Show / Hide 
Range on Protein: 1-174
Range on HMM: 136-425/425
Sequence Identity: 18% (55 aa)

M---EYCPS-----DLSSMMKQ----------------GELAEPQLCQYCHDILVAIKNCHDNYIAHNDIKPSNFLIDKY-----------------GRL
|   |||.      || .. ..                | . | . ..| . |. |.. ||.. |.| |.|| | |.|.                  . .
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI

KVCDFGISTYHGM------------------------TRTSDLFLGTTLFMA-PEVLEK-------------KEYDPMKSDVWSIGITFYYMATQNYPYN
|..||| ...                           .     | ||  .|| ||||..             |.|.. |.|.||.|.  | | .  .|..
KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY

AD-------------DKEILLKQIQNSRL--LLYNIDNPK----------------------LAKVIKRCLTINPEERATIDELLAMSYF
.|             . . |...|.. .     . ....                           |...|. .||.|.||.. |.   .
GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 85666.m00040.AA CAMKL 1-174 28 3.1e-42 132.47 In-house 100-297 (297) Show / Hide 
Range on Protein: 1-174
Range on HMM: 100-297/297
Sequence Identity: 28% (56 aa)

MEYCPSD---LSSMMK-QGE----LAEPQLCQYCHDILVAIKNCHDNYIAHNDIKPSNFLIDKYG--RLKVCDFGISTYHGM-----TRTSDLFLGTTLF
||||..    |  . . .|.    . |.. ..|   |. |.. ||.. |.| |||| | |.|. |   .|..||| |...        .. . | |.  .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPEVLEK--KEYDPMKSDVWSIGITFYYMATQNYPYNAD-------DKEILLKQIQNSRLLLYNID-NP-KLAKVIKRCLTINPEERATIDELLAMSYF
||||....  |.||  | |.||.|.. | | . ..| ..|       |   .|. ....    ..|   .  .   |.. |. |||.|.||....    .
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Pkinase 85666.m00040.AA Pkinase 1-174 26 2.5e-40 143.7 Pfam 79-293 (293) Show / Hide 
Range on Protein: 1-174
Range on HMM: 79-293/293
Sequence Identity: 26% (57 aa)

MEYCPS-----DLSSMMK---QGEL--AEPQLCQYCHDILVAIKNCHDNYIAHNDIKPSNFLIDKYGRL----KVCDFGISTY--HGMTRTSDLFLGTTL
||||.      ||.....   .| .   | ... |.  || ... ||.. | | |.||.|.|||. | .    |.||||..    .   .  . | ||  
MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

FMAPEVLEKKEYDPMKSDVWSIGITFYYMATQNYPYNAD------DKEILLKQIQNSRLLLYNIDN---------------------PKLAKVIKRCLTI
.|||||. . .|.. |.|.||.|...|.|.. . |.  .      |.  ....|   .|                            . . ..||.||. 
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

NPEERATIDELLAMSYF
.|..| |....|   .|
DPKKRPTAEQILQHPWF
Kinase 85666.m00040.AA Ciliate-E2-Unclassified 1-174 24 6.4e-40 136.17 In-house 100-352 (352) Show / Hide 
Range on Protein: 1-174
Range on HMM: 100-352/352
Sequence Identity: 24% (61 aa)

MEYCPS-DLSSMMKQ------------------GELAEPQLC-----QYCHDILVAIKNCHDNY-IAHNDIKPSNFLIDKYG---RLKVCDFGIST----
||||.  ||. ..|.                   .. | | .     .|.  ||.... .| .  | | ||||.| |.|. |   ..|..|||||     
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----YHGM---------TRTSDLFLGTTLFM----APEVLEKKEYDPM---KSDVWSIGITFYYMATQNYPYNADDKEI----------------LLKQI
    . .             .. | ||  .|    |||||....|| .   |.|.|| |. .|.| ...||... ..|.                |...|
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

QNSRLLLYNIDN--------PKLAKVIK----RCLTINPEERATIDELLAMSYF
..  .   . ..        |. .  |.    ..|  ||..| |....|   .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 85666.m00040.AA ULK 1-174 24 3.9e-39 136.32 In-house 96-324 (324) Show / Hide 
Range on Protein: 1-174
Range on HMM: 96-324/324
Sequence Identity: 24% (56 aa)

MEYCPS-DLSSMMKQ----------GELAEPQLCQYCHDILVAIKNCHDNYIAHNDIKPSNFLIDKY------------GRLKVCDFGISTY--HGMTRT
||||.  ||.. .|.          . | |..  |....|. . |  |.. | | ||||.| || .             |.||..||| .     ..   
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

SDL--FL------GTTLFMAPEVLE----KKEYDPMKSDVWSIGITFYYMATQNYPYNADDKEILLKQ--------------IQNSRLLLY---NIDN--
 ..  ..      || |.|||..|.    .|.|.  |.|.||.|. ||.| .  ||.... .. . ..              |.|  .  .   ....  
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

PKLAKVIKRCLTINPEERATIDELLAMSYF
|..   |.|.|......| ...|....  |
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 85666.m00040.AA ULK 1-174 25 1.7e-38 131.99 In-house 99-329 (329) Show / Hide 
Range on Protein: 1-174
Range on HMM: 99-329/329
Sequence Identity: 25% (58 aa)

MEYCPS-DLSSMMKQ-----------GELAEPQLCQYCHDILVAIKNCHDNYIAHNDIKPSNFLIDKY------------GRLKVCDFGISTY-HGM---
||||.  ||.. .|.           . | |..  |....|| . |  |.. | | ||||.| ||..             |.||..||| .         
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

TRTSDLFL------GTTLFMAPEVLE----KKEYDPMKSDVWSIGITFYYMATQNYPYNADDKEILLKQIQNSRLLL----------YNID---------
 .    ..      || |.|||..|.    .|.|.  |.|.||.|. ||.| .  .|..|  .. . .||... . .           ...         
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

-NPKLAKVIKRCLTINPEERATIDELLAMSYF
  |..   |.|.|......| ...||...  |
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 85666.m00040.AA Ciliate-E2 21-174 21 6e-37 124.36 In-house 153-365 (365) Show / Hide 
Range on Protein: 21-174
Range on HMM: 153-365/365
Sequence Identity: 21% (49 aa)

QLCQ--------YCHDILVAIKNCHDNY-IAHNDIKPSNFLIDKYGRLKVCDFGISTY-----------------------HGMTRTSDL---------F
|..|        |.  |..|.. .| .  | | ||||.| |.     .|..|||.|..                       ..... .|.         .
QILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTI

LGTTLFMAPEVLEKKEYDP--------MKSDVWSIGITFYYMATQNYPYNADDKEILLKQIQNSRLL------------------LYNIDNPKLAKVIKR
.||  .||||.|..|.||          |.|.||.|...|.| . ..|.        ..||..  .                    ..   ..    ||.
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK

----CLTINPEERAT-IDELLAMSYF
    .|  .||.| | ....|   .|
FGKRMLQKDPEKRITGWEQILNHPWF
Kinase 85666.m00040.AA MARK 13-174 34 6.9e-35 111.59 In-house 95-262 (262) Show / Hide 
Range on Protein: 13-174
Range on HMM: 95-262/262
Sequence Identity: 34% (58 aa)

KQ--GELAEPQLCQYCHDILVAIKNCHDNYIAHNDIKPSNFLIDKYG--RLKVCDFGISTYHGMTRTSDLFLGTTLFMAPEVLEKKEYDPMKSDVWSIGI
..  | | |.   .... |. |.. ||.. |.| |||| | |||. |    | .||| |.   . .  . | ||  .||||...||.||  | |.|| |.
AHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV

TFYYMATQNYPYNADD--KEILLKQIQNSRLLLYNIDNPKLAKVIKRCLTINPEERATIDELLAMSYF
  |.| . ..|. .|.   . | |.|.. .   .    ... . |.| ||.|||||.||.|..  . .
VLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 85666.m00040.AA AGC 1-174 18 9.8e-35 85.96 In-house 112-395 (395) Show / Hide 
Range on Protein: 1-174
Range on HMM: 112-395/395
Sequence Identity: 18% (54 aa)

MEYCP----------S-DLSSMM----KQGELAEPQLCQYCHD-------ILVAIKNCHD-NYIAHND-IKPSNFLIDKYGRLKVCDFGISTYHGMTR--
|||.|            .| ...    |.| . |.. . |.         |. |.   |. . | | | .|| | |.|. | .| .||| ..   . .  
MEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEK

-------------------------------------------------TSDLFLG--TTLFMAPEVLEKKEYDPMKSDVWS--IGITFYYMATQNYPYN
                                                 .   | |  |  .||||.|    |..   | ||   |. .| | |   |..
GQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKA-CDWWSFGLGCLMYEMLTGYPPFY

AD----------DKEILLKQIQ------NSRLLLYNIDN----------PKLAKVIKRCLTINPEERAT----------IDELLAMSYF
.|          ... . ..|.      | .. . . ..          | .   ||..|. .||.| .          ..|. .  .|
GDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 85666.m00040.AA STE 1-174 23 8.8e-33 113.13 In-house 116-359 (359) Show / Hide 
Range on Protein: 1-174
Range on HMM: 116-359/359
Sequence Identity: 23% (58 aa)

MEYCP-SDLSSMMK-----QGELA----------EPQLCQYCHDILVA-IKNCHDNYIAHNDIKPSNFLIDKYGRLKVCDFGISTYHG------------
|||..   |....|     ...|           |.|.. .|..|| .  .  |.. | | ||||.| |.      | ||||...               
MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNII

-----MTRTSDLFLGTTLFMAPEVLEK------KEYDPMKSDVWSIGITFYYMATQNYPYNA-DDKEILLKQIQN----------------SRLLLYNID
     |   .. | ||  .|||||...      |.||  |.|.||.|.|   ||| ..|.    . . ..  ..|                .  |  ...
DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLS

N------------------PKLAKVIKRCLTINPEERATIDELLA--MSYF
.                  |..   |..||...|..|.| ..||    . .
QNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 85666.m00040.AA CAMKK 28-174 21 1.1e-29 91.08 In-house 184-396 (396) Show / Hide 
Range on Protein: 28-174
Range on HMM: 184-396/396
Sequence Identity: 21% (46 aa)

DILVAIKNCH-DNY-------------------IAHNDIKPSNFLIDKYG---RLKVCDFGISTYHGMTRTSDLF------------LGTTLFMAPEVLE
|.. ... .| ..                    | | ||||.| |||. |   ..|..|||.|.  . .  ..               ||  |||||...
DCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCS

K-KE--------------YDPMKSDVWSIGITFYYMATQNYPYNADDKEILLK---QIQNSRLLLYN-------------IDNPKLAKVIKRCLTINPEE
| ..              |.  . |.|. |.|.|.. . . |..... . |..   .|.|  .                   .. |  .|||.|  ||..
KENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKNPTK

RATIDELLAMSYF
| ||....    .
RITIPQIKVHPWV
Kinase 85666.m00040.AA S_TKc 1-174 21 1.4e-16 62.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-174
Range on HMM: 1-231/231
Sequence Identity: 21% (56 aa)

M-----------------------------------------------------------------EYCPS---DLSSMMKQGE-------LAEPQLCQY
                                                                  |||.    || ...|.         . | . . |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

CHDILVAIKNCHDNYIAHNDIKPSNFLIDKYGRLKVCDFGISTYHGMTRTSDLFLGTTLFMAPEVLEKKEYDPMKSDVWSIGITFYYMATQNYPYNADDK
.. |. |.. ||.. | | |.||.| |.|.  ..|.||||...        . | ||  .||||||    |.. |.|.||.|...| |..   |.   . 
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QM

EILLKQIQNSRLLLYNIDNPKLAKVIKRCLTINPEERATIDELLA-------MSYF
. ..|.|            | .   |..||. .||.| |. |.|.       . .|
QMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85666.m00040.AA TyrKc 1-174 14 2e-06 -119.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-174
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)

M--------------------------------------------EY--------------CPS--------------------DLSSMMKQGE--LAEP
                                             ..                .                    || .  .  .  |  .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

QLCQYCHDILVAIKNCHDNYIAHNDIKPSNFLIDKYGRLKVCDFGISTYHGMT-----RTSDLF-----LGTTLF----MAPEVLEKKEYDPMKSDVWSI
.|...|..|       |.. . | |.   | |... .. |..||| | ...       ...         | |..    ||||.. .... . |||||| 
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-KSDVWSF

GITFYYMAT--QNYPYN-----ADDKEILLKQIQNSRLLLYNI--------DNPKLAKVIKRCLTINPEERATIDELLAMSYF
|.. . . |  |  ...      ...|.. .  |  |.               ... ...|.|   .||.| |  |.   ..|
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF