Gene 93242.m00178 (T.vaginalis)
93242.m00178
Species: T.vaginalis
Alias: 93242.m00178, TvagK0228
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 93242.m00178.AA | Protein | None | 224 | None | Fasta, JSON |
| 93242.m00178.kin_dom | Protein Kinase Domain | None | 176 | None | Fasta, JSON |
Protein domains of 93242.m00178.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 93242.m00178.AA | Ciliate-E2-Unclassified | 1-176 | 24 | 1.5e-41 | 141.91 | In-house | 100-352 (352) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 100-352/352 Sequence Identity: 24% (62 aa) MEYCPE-TLQSKIKKE-----------------GRLDPNLAI-----QYAREILIGLSLCHANG-ISHGDIKTSNILIDAYG---RIKICDFGMSDFSDD ||||. .|. ||| ... . |. .|...|| ||. .| .. | | ||| .|||.| | .|||.||| | .... MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ P---------------EGLSQHFRGSFPFM----AIEIIDKKAYDR---FKADIYSFGVTLFYTLTGHYPWKGIHREE----------------IINNIQ . . ....| |. .| | |..... || .|.||.|.|| |.. |.| || .. .|. ...||. NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK NGNTLVNL-------IGIP-ELESVID----RCISLCPENRPTADELLEMPIF ..|. .. ... | . | ... .|..|.|....|. |.| QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Pkinase | 93242.m00178.AA | Pkinase | 1-176 | 28 | 1.8e-41 | 147.73 | Pfam | 79-293 (293) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 79-293/293 Sequence Identity: 28% (61 aa) MEYCPE-----TLQSKIK--KEGRL--DPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAYGRI----KICDFGMSDFS-DDPEGLSQHFRGSFP ||||. | . |. ..|.. ... .. |...|| || ||..|| | |.| .||||| | | |||||| . . . . ..| |. . MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW FMAIEIIDKKAYDRFKADIYSFGVTLFYTLTGHYPWKGI------HREEIINNIQNGNTLVNLIGI---------------------PELESVIDRCISL .|| |.| . |. |.|..|.|..|.. |.|. |..| ..|..| . . . .|. ..|..|. . YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK CPENRPTADELLEMPIF .|. ||||...|. | | DPKKRPTAEQILQHPWF |
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| Kinase | 93242.m00178.AA | CAMKL | 1-176 | 30 | 2.1e-41 | 129.79 | In-house | 100-297 (297) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 100-297/297 Sequence Identity: 30% (61 aa) MEYCPET---LQSKIKKE----GRLDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAYG--RIKICDFGMSDFSDD----PEGLSQHFRGSFPF ||||. |. .|.|. ||.... | .| | |. ... || .|| | ||| |||.| | |||.|||.| . .. |. . | || |. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY MAIEIIDK--KAYDRFKADIYSFGVTLFYTLTGHYPWKGIH---------REEIINNIQNGNTLVNLIGIPELESVIDRCISLCPENRPTADELLEMPIF || ||. . | || .|.|| | ||.|. ..|..|... . ... ..... .. . . .... | . .|| |||...... | . MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 93242.m00178.AA | CAMK | 1-176 | 20 | 5.4e-37 | 116.22 | In-house | 136-425 (425) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 136-425/425 Sequence Identity: 20% (59 aa) M---EYCPET-----LQSKIKKE---------------GRLDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAY-----------------GRI | |||. | ..|.. ||.. | .| | |. .. || ..| | |.| |||.| . | MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI KICDFGMSDFSDDPEG-----------------------LSQHFRGSFPFMA-IEIIDK-------------KAYDRFKADIYSFGVTLFYTLTGHYPWK ||.|||.. . |. |. . . | |. ..|| |.. . | |. .|.|. | || |. |.|..|. KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY GIHREEIIN-------------NIQNGN-T-LVNLIGI----------------------PELESVIDRCISLCPENRPTADELLEMPIF | ...||.. .|..|. . . . .| . | .. ||.|.|... |. | . GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | 93242.m00178.AA | Ciliate-E2 | 1-176 | 20 | 1.6e-34 | 115.92 | In-house | 113-365 (365) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 113-365/365 Sequence Identity: 20% (56 aa) MEYCPE-TLQSKIK------------KEGRLDPNLAIQYAREIL---------------IGLSLCHANG-ISHGDIKTSNILIDAYGRIKICDFGMSDFS |||| .|.. || . .... . .... ..|| .| .| .. | | ||| .|||. |||.|||.| . MEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKY DDPEG-------------------------------LSQHFRGSFPFMAIEIIDKKAYDR--------FKADIYSFGVTLFYTLTGHYPWKGIHREEIIN ||.. . . . |. ..|| ||. .| || .|.||.|.||.|.. |.| .|. .. DDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQ NIQNGNTLVN------------------LIGIPELESVIDR----CISLCPENRPT-ADELLEMPIF .|.... . . .| | . .. ||.|.| ....|. |.| QIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 93242.m00178.AA | MARK | 1-176 | 36 | 9.2e-32 | 101.23 | In-house | 81-262 (262) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 81-262/262 Sequence Identity: 36% (67 aa) MEYCPET-LQSKIKKE--GRLDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAYG--RIKICDFGMSDFSDDPEGLSQHFRGSFPFMAIEIIDK |||.... | . ||. ||| ..| .. | |. ... || ..| | ||| |||||. | |||.|||.| |. . | |. |.|| ||. | MEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFS-ICIPPGQKLNTFCGTPPYMAPEIFLK KAYDRFKADIYSFGVTLFYTLTGHYPWKGIH--REEIINNIQNGNTLVNLIGI-PELESVIDRCISLCPENRPTADELLEMPIF | || .|.||.| || |.. ..|..|..| .|. .|..|. . . .|... | | . . || |||..|... | . KPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH-VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 93242.m00178.AA | STE | 1-176 | 25 | 2.9e-30 | 104.14 | In-house | 116-359 (359) | Show / Hide |
Range on Protein: 1-176
Range on HMM: 116-359/359
Sequence Identity: 25% (63 aa)
MEYCP-ETLQSKIK-KEGRLDP-------------NLAIQYAREILIG-LSLCHANGISHGDIKTSNILIDAYGRIKICDFGMSDFSDD-----------
|||.. .| . || | |...| .. . ..|.|| | |.. | ..| | ||| .|||. .|.|||| . .|
MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNII
----PEG-LSQHFRGSFPFMAIEIIDK------KAYDRFKADIYSFGVTLFYTLTGHYPWKGIHREEIINNIQNG--------------NTLVNLIGI--
. ...| |. .|| |.|.. | ||. |.||.|.| |. .||..|| | . . .|... .. |
DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT-KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLS
-------------------PELESVIDRCISLCPENRPTADELLE--MPIF
||. |..| |..||||..||. | .
QNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | 93242.m00178.AA | ULK | 1-176 | 26 | 1.7e-28 | 96.65 | In-house | 99-329 (329) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 99-329/329 Sequence Identity: 26% (61 aa) MEYCPE-TLQSKIKKEGR----------LDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAY------------GRIKICDFGMSDFSDDP--- ||||. .|.. ||| .. | . |||. . || |. | ..| | ||| .||||. |..||.||| . . |.. MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME EGLSQHFR------GSFPFMAIEIID----KKAYDRFKADIYSFGVTLFYTLTGHYP---WKGIHRE-----EIINN-------IQNGNTLVNLIG---- . . . . |. .|| .|. .| |. .|.||.|.|. ... |.| .| | . ||| |.. .. . | QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ -IPELESVIDRCISLCPENRPTADELLEMPIF ||... | |.. .. | . .||...|.| ISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 93242.m00178.AA | ULK | 1-176 | 27 | 6.5e-27 | 92.57 | In-house | 96-324 (324) | Show / Hide |
Range on Protein: 1-176 Range on HMM: 96-324/324 Sequence Identity: 27% (63 aa) MEYCPE-TLQSKIKKE---------GRLDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDAY------------GRIKICDFGMSDFSDDPE--- ||||. .|.. ||| .|| . |||. . |. |. | ..| | ||| .|||| |..||.||| . . |... MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ GLSQHFR------GSFPFMAIEIID----KKAYDRFKADIYSFGVTLFYTLTGHYP---WKGIHRE----EIINN-------IQNGNTLVNL----IGI- . | . |. .|| .|. .| |. .|.||.|.|. ... |.| || | . . ||| |.| . .. . | QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS PELESVIDRCISLCPENRPTADELLEMPIF ||... | |.. .. | . .|....|.| PECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 93242.m00178.AA | RSK | 11-176 | 27 | 2e-22 | 79.04 | In-house | 91-278 (278) | Show / Hide |
Range on Protein: 11-176 Range on HMM: 91-278/278 Sequence Identity: 27% (52 aa) KIKKEGR---LDPNLAIQYAREILIGLSLCHANGISHGDIKTSNILIDA---YGRIKICDFGMSDF-SDDPEGLSQHFRGSFPFMAIEIID----KKAYD ...||.. .. . | .|..|| .. | || | |.| .||| | |.||..||| . . | ... . |... .|| |.. ....| HLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD RFKADIYSFGVTLFYTLTGHYPWKG---IHREEIINNIQNGN---TLV--NLIGIPELESVIDRCISLCPENRPT-----ADELLEMPIF . .|..|.|| .. |||. | .| .|.||...||.|. |. . . .| . | .. |..|.. |.|... | | K-ACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLS-QEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 93242.m00178.AA | TKL | 1-174 | 19 | 8.8e-22 | 75.21 | In-house | 117-364 (364) | Show / Hide |
Range on Protein: 1-174
Range on HMM: 117-364/364
Sequence Identity: 19% (49 aa)
MEYCPE-TLQSKIKKEGRLDPNLAIQYAREILIGLSLCHANG--------ISHGDIKTSNILIDAYGR--------------IKICDFGMSDFSDDPEG-
||||| .| . . ... .. |..| |.. |... | | |.|..|||.| .. .|||||| | | . ..
MEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM
------------------LSQHFRGSFPFMAIEIIDKKAYDR---------------FKADIYSFGVTLFYTLTGHYPWKGIHRE---------EIINNI
. . .|.. .|| |..... ... |.|.||||. |. ||. |..... . |.. .
NDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMV
QNGNTLVNLI--------------GIPELESVIDRCISLCPENRPTADELLEMP
. . . |.. . . .| . ||.||...|.|.
CDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 93242.m00178.AA | S_TKc | 1-176 | 23 | 2.4e-15 | 48.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-176
Range on HMM: 1-231/231
Sequence Identity: 23% (60 aa)
M-----------------------------------------------------------------EYCPE---TLQSKIKKEGR------LDPNLAIQY
|||. .| . ||| || ... | |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
AREILIGLSLCHANGISHGDIKTSNILIDAYGRIKICDFGMSDFSDDPEGLSQHFRGSFPFMAIEIIDKKAYDRFKADIYSFGVTLFYTLTGHYPWKGIH
...|. .| || .|| | |.| .|||.| .|||||||.. . .| |. .|| |.. |...|.|..|.|..|. |.| |. .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--Q
REEIINNIQNGNTLVNLIGIPELESVIDRCISLCPENRPTADELLE-------MPIF
......| ||. . |..| ||.|||| |.|. .| |
MQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 93242.m00178.AA | TyrKc | 6-174 | 16 | 8.1e-07 | -112.4 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 6-174 Range on HMM: 1-280/280 Sequence Identity: 16% (47 aa) ETLQSKI------------------------------------------------------------------------------------KKEGRLDPN || |. |....| . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK LAIQYAREILIGLSLCHANGISHGDIKTSNILIDAYGRIKICDFGMSDFSDDP-------EGLSQHF--RGS--FPF--MAIEIIDKKAYDRFKADIYSF .... | | . | ... | |. . |.|... ...||.|||.| . .| . .. | .| ||.| |... . .| |..|| DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT-TKSDVWSF GVTLF--YTLTGHYPWKG-----IHREEIINNIQNGNTLVNLIG---------IPELESVIDRCISLCPENRPTADELLEMP ||... .|. | |. | . .|.|.....|. . .|. ... .| ||.||| |. | GVCMWEIFTY-GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 93242.m00178.AA | Pkinase_Tyr | 51-140 | 28 | 8.4e-05 | 16.89 | Pfam | 141-235 (270) | Show / Hide |
Range on Protein: 51-140 Range on HMM: 141-235/270 Sequence Identity: 28% (27 aa) NILIDAYGRIKICDFGMSDFS-DDPEG--LSQHFRGSFPFMAIEIIDKKAYDRFKADIYSFGVTLFYTLT-GHYP-WKGIHREEIINNI-QNGNTL |.|.. . .||||||.. .| . ... . . || | | . . | |..||||... .| | | ..|. ||... | ..|. . NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFT-TKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRM |
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