Gene 86188.m00083 (T.vaginalis)

86188.m00083

Species: T.vaginalis
Alias: TvagK0187, 86188.m00083
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
86188.m00083.AA Protein None 226 None Fasta, JSON
86188.m00083.kin_dom Protein Kinase Domain None 174 None Fasta, JSON

Protein domain

Protein domains of 86188.m00083.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 86188.m00083.AA Pkinase 1-174 25 7.9e-40 141.91 Pfam 79-293 (293) Show / Hide 
Range on Protein: 1-174
Range on HMM: 79-293/293
Sequence Identity: 25% (56 aa)

MEFCPS-----DLSELIR---DHDL--SDYQLQKYCCDILKAIKACHDQHIAHNDIKLSNFLIDRYGRL----KCCDFGLSAV--YDSSNQNLNFRGTML
||.|.      ||...|.   .  .  |. ....|.  ||.... ||.. | | |.|..|.|||. | .    | |||||...  | ..  .  | ||  
MEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW

YMAPEIFNRGKYNPLKADIWSIGVTFFIMATHFYPFFAM------EKENFIQIVKTGNYPMHEIKN---------------------LNLRKVIIACLQL
|||||. . |.| . |.|.||.|.....|..   ||         ..   |. .. . .. .. .                       .....|  ||..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

NPDCRPTVDELLGYDFF
.| .||| ...|  ..|
DPKKRPTAEQILQHPWF
Kinase 86188.m00083.AA CAMK 1-174 18 5.2e-37 116.29 In-house 136-425 (425) Show / Hide 
Range on Protein: 1-174
Range on HMM: 136-425/425
Sequence Identity: 18% (55 aa)

M---EFCPS-----DLSELIRDH--------------D--LSDYQLQKYCCDILKAIKACHDQHIAHNDIKLSNFLIDRY-----------------GRL
|   |.|.      || . |..|              .  ..  . ..|   |. |.. ||...|.| |.|. | |.|                   . .
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNI

KCCDFGLSAVYDSSNQNLN------------------------FRGTMLYMA-PEIFNR-------------GKYNPLKADIWSIGVTFFIMATHFYPFF
| .|||.....|....|..                        | ||  ||| ||..|.              .| . |.|.||.||  .|| . ..|| 
KIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY

AM-------------EKENFIQIVKTGNY--PMHEIKNLN----------------------LRKVIIACLQLNPDCRPTVDELLGYDFF
.              . ..  . ...|.|  | ......                        .  |  .|| .|. |.|... |   ..
GDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 86188.m00083.AA Ciliate-E2-Unclassified 1-174 23 2.6e-35 119.92 In-house 100-352 (352) Show / Hide 
Range on Protein: 1-174
Range on HMM: 100-352/352
Sequence Identity: 23% (59 aa)

MEFCPS-DLSELIRD------------------HDLSDYQLQ-----KYCCDILKAIKACHDQH-IAHNDIKLSNFLIDRYG---RLKCCDFGLSAVYDS
||.|.  ||.. |..                  . ....| .     .|.  ||.... .| .. | | |||..| |.|  |   ..| .|||.|  |..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

SNQ----------------NLNFRGTMLYM----APEIFNRGKYNP---LKADIWSIGVTFFIMATHFYPFFAMEKEN----------------FIQIVK
.|.                   | ||  ||    |||.. . .|.     |.|||| || .. | .  |||..  .|                 ..|. |
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

TGNYP--------MHEIKNLNLRKVII----ACLQLNPDCRPTVDELLGYDFF
 .|.          . . . .    |      .|. ||. |.| ...|   .|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 86188.m00083.AA Ciliate-E2 1-174 21 6.1e-32 106.92 In-house 113-365 (365) Show / Hide 
Range on Protein: 1-174
Range on HMM: 113-365/365
Sequence Identity: 21% (60 aa)

MEFCPS-DLSELIRDH--------------------DLSDYQLQ-------KYCCDILKAIKACHDQH-IAHNDIKLSNFLIDRYGRLKCCDFGLSAVYD
||.|   || ..|...                    ... ..||        |.. |..|.. .| .. | | |||..| |.     .| .|||||  ||
MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYD

SSNQ---------NLNFRG------------------------TMLYMAPEIFNRGKY--------NPLKADIWSIGVTFFIMATHFYPFFAMEKENFIQ
 .||         .. | .                        |  ||||||.|..||           |.||||.||....| .  .||          
DDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------

IVKTGNYPMHEIKNLNLR----------------------------KVIIA----CLQLNPDCRPT-VDELLGYDFF
        . .||. ...                              |      .|| .|. |.|  ...|   .|
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 86188.m00083.AA CAMKL 23-174 31 1e-30 95.11 In-house 130-297 (297) Show / Hide 
Range on Protein: 23-174
Range on HMM: 130-297/297
Sequence Identity: 31% (53 aa)

QKYCCDILKAIKACHDQHIAHNDIKLSNFLIDRYG--RLKCCDFGLSAVYDS----SNQNLN-FRGTMLYMAPEIFNR--GKYNPLKADIWSIGVTFFIM
..| . |. |.. ||...|.| |||. | |.|  |   .| .|||.|. |.     ..| |. | |.  |||||||..   .|.  |.||||.||. . |
RRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAM

ATHFYPFFAM--------EKENFIQIVKTGNYPMHEIKNL-NLRKVIIACLQLNPDCRPTVDELLGYDFF
 .  .|| .          . ..  ....| | .   . .  .|  |   || ||. |||.....   ..
VCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 86188.m00083.AA MARK 29-174 33 1.8e-29 93.64 In-house 113-262 (262) Show / Hide 
Range on Protein: 29-174
Range on HMM: 113-262/262
Sequence Identity: 33% (52 aa)

ILKAIKACHDQHIAHNDIKLSNFLIDRYG--RLKCCDFGLSAVYDSSNQNLNFRGTMLYMAPEIFNRGKYNPLKADIWSIGVTFFIMATHFYPFF--AME
|. |.. ||...|.| |||. | |||  |    | .|||.|.   . .    | ||  |||||||.. .|.  |.|||| ||  ..| .  .||    ..
IVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQD

KENFIQIVKTGNYP--MHEIKNL--NLRKVIIACLQLNPDCRPTVDELLGYDFF
 ..  . . .|.|.  .|    .   .|. |   |..||. |||..|..   ..
YKELYKKILRGKYDIPCH----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 86188.m00083.AA STE 1-174 22 1.9e-27 94.04 In-house 116-359 (359) Show / Hide 
Range on Protein: 1-174
Range on HMM: 116-359/359
Sequence Identity: 22% (56 aa)

MEFCP-SDLSELIR-------DHD--------LSDYQLQKYCCDILKA-IKACHDQHIAHNDIKLSNFLIDRYGRLKCCDFGLSA-VYDSSN--------
||...   |...|.       ...        ..  |. ..|..|||.  .  |..|| | ||| .| |.      | ||||... . ||.         
MEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNII

--------QNLNFRGTMLYMAPEIFNRGKYNPL------KADIWSIGVTFFIMATHFYPF---FAM-EKENFIQIVKTGN---------YPMHEIKN---
        ..  | ||  .||||. .... .        |.||||.| |   |||  .|.     |    ....  . ..          |   ...   
DCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLS

-------------------LNLRKVIIACLQLNPDCRPTVDELLG--YDFF
                    ...  |  ||| .|. |||...||     |.
QNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 86188.m00083.AA CAMKK-Unclassified 17-174 24 2.1e-26 82.81 In-house 175-392 (392) Show / Hide 
Range on Protein: 17-174
Range on HMM: 175-392/392
Sequence Identity: 24% (54 aa)

LSDYQLQKYCCDILKAIKACHDQH---------------------IAHNDIKLSNFLIDRYGR-----LKCCDFGLSAVYDSSNQN--LNFRGTMLYMAP
.. ..|.||  ...|... .|..                      | | |||  | |||  ..     .| .|||.|    ...|.   |  ||  .|||
MHEQYLKKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIMEHEQQKKLKNNAGTYCFMAP

EIFNRG--KYNPLK-------------------------ADIWSIGVTFFIMATHFYPFFAMEKE---NFIQIVKTG-NYPM--HEIKNLNLRKVIIACL
| . .   ||...                          ||||| ||||..|..|  ||..   .   .  .| .   | |   |   .  .   |  ..
EFWSKENFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFH-QMICQKEINFPPQYHPHCSHEFKDLIQKMC

QLNPDCRPTVDELLGYDFF
  ||. | |.| .|  ..|
DKNPKKRITIDQMLVHPWF
Kinase 86188.m00083.AA ULK 1-174 24 3.5e-25 86.32 In-house 96-324 (324) Show / Hide 
Range on Protein: 1-174
Range on HMM: 96-324/324
Sequence Identity: 24% (56 aa)

MEFCPS-DLSELIRDH----------DLSDYQLQKYCCDILKAIKACHDQHIAHNDIKLSNFLIDRY------------GRLKCCDFGLSAVYDSSNQNL
||.|.  ||...|  .           ||  . .... .|. . |. |.. | | |||..| ||               |.|| .|||.. . |. |.. 
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

NFR----------GTMLYMAPEIFN----RGKYNPLKADIWSIGVTFFIMATHFYPFFAM-EKEN-----FIQ-------IVKTGNYPMH---EIKN--L
. .          || |||||.|..    . .|.  |.||||.|. |. | .  ||||.. ....      |.       ..|. . .     ....   
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP

NLRKVIIACLQLNPDCRPTVDELLGYDFF
...  |  .|| ... | . .|..   .|
ECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 86188.m00083.AA ULK 1-174 23 2e-24 82.27 In-house 99-329 (329) Show / Hide 
Range on Protein: 1-174
Range on HMM: 99-329/329
Sequence Identity: 23% (55 aa)

MEFCPS-DLSELIRDH-----------DLSDYQLQKYCCDILKAIKACHDQHIAHNDIKLSNFLIDRY------------GRLKCCDFGLSAVYDSS---
||.|.  ||...|  .            ||  . ......|| . |. |.. | | |||..| ||.              |.|| .|||.. . |..   
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

-NQNLNFR------GTMLYMAPEIFN----RGKYNPLKADIWSIGVTFFIMATHFYPFFAM-EKEN---FIQIVKTG------------NYP---MHEIK
 .... .       || |||||.|..    . .|.  |.||||.|. |. | .  .||.|. ....    .. .. .            ..|    . . 
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

NLNLRKVIIACLQLNPDCRPTVDELLGYDFF
  ...  |  .|| ... | . .||.   .|
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 86188.m00083.AA TKL 37-172 18 1e-21 74.99 In-house 149-364 (364) Show / Hide 
Range on Protein: 37-172
Range on HMM: 149-364/364
Sequence Identity: 18% (39 aa)

HDQH--------IAHNDIKLSNFLIDRYGR--------------LKCCDFGLSAVYDSSN--------------------QNLNFRGTMLYMAPEIFNRG
| ..        |.| |.| .| |.|. ..              .| |||||| . . |.                    .. . .||  .||||...  
HSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQ

KYNP---------------LKADIWSIGVTFFIMAT--HFYPFFAME--------KENFIQIVKTGNYPMHE---------IKNLN----LRKVIIACLQ
 ...                |.|..| |. .. ..|  . |  . ..        .| |..... |. |             .. .    ..| .  | .
MNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWD

LNPDCRPTVDELLGYD
 .|. ||. .|.| . 
HDPEKRPSFQEILKRL
Kinase 86188.m00083.AA S_TKc 1-174 19 2.8e-16 61.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-174
Range on HMM: 1-231/231
Sequence Identity: 19% (51 aa)

M-----------------------------------------------------------------EFCPS---DLSELIRDHD-------LSDYQLQKY
                                                                  |.|.    || ..|...        ..  . ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

CCDILKAIKACHDQHIAHNDIKLSNFLIDRYGRLKCCDFGLSAVYDSSNQNLNFRGTMLYMAPEIFNRGKYNPLKADIWSIGVTFFIMATHFYPFFAMEK
.. |..|.. ||...| | |.| .| |.|.  ..| |||||....        | ||  |||||..   .|.. |.|.||.|.....|..   ||   . 
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QM

ENFIQIVKTGNYPMHEIKNLNLRKVIIACLQLNPDCRPTVDELLG-------YDFF
.  .....             ..  |  ||| .|. |||. |.|          .|
QMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 86188.m00083.AA TyrKc 1-174 16 6.1e-07 -110.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-174
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)

M--------------------------------------------EF--------------CPS--------------------DLSELIRDHD--LSDY
                                             ..                .                    || . .|.|   |.  
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

QLQKYCCDILKAIKACHDQHIAHNDIKLSNFLIDRYGRLKCCDFGLSAVYDSS------NQNLNFR---GTM--L---YMAPEIFNRGKYNPLKADIWSI
.| ..| .| .     |.... | |.   | |... .. | .|||||   ..        .    .   |.   |    |||| .| ||... | |.|| 
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-KSDVWSF

GVTFFIMATHFYPFFA------MEKENFIQIVKTGNYPMHEIK---------NLNLRKVIIACLQLNPDCRPTVDELLGYDFF
||. . . |   .         |. .  |. ||.|....                . ...  | . .|..|||  |.  ...|
GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF