Gene 83746.m00145 (T.vaginalis)

83746.m00145

Species: T.vaginalis
Alias: TvagK0952, 83746.m00145
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
83746.m00145.AA Protein None 1085 None Fasta, JSON
83746.m00145.kin_dom Protein Kinase Domain None 107 None Fasta, JSON

Protein domain

Protein domains of 83746.m00145.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 83746.m00145.AA S_TKc 6-273 18 5.3e-08 -59.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-273
Range on HMM: 1-231/231
Sequence Identity: 18% (55 aa)

AKPEKKIKRGGNKKTIRVRGKKADYILVTEAEIRKENLKDIKKFLNVYYASIKNDPDPNKKLVATKINRNNVPIEIQQQFITEIEVCKTLNHSGVNKPYD
 .  .|| .|.  |  ..| ||                                     ...|| || .        .... ||...|  .|  . | ||
YEILRKIGKGAFGKVYKCRHKK------------------------------------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYD

YAIDNNLGGLFIIYESPIM--DFLENYITTYTT----SPITDCHMIKILIGIASAVAYLHSNGYVCGDLRLGTVFLKSKLEPVIINYNLPELYPCPIIPY
.  |   . |... |        |  ||  . .    .|..  |  ...  |..|..|.||.| .  ||    ..| .  .  |.   |  ..       
VFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------

ETKKS-----EYSAPELENNYVITP-KSDAYSFGVI----LS------KISQKLNNIKGKFYQTMKQLFEMCTDFDPSKRPSFTLIEK---------ML
   ..     .| |||.      .. |.| .|.|.|    |.       . . ...|.    . .|.. . | ..||.|||.   . .          .
---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 83746.m00145.AA RAF 246-273 42 5.7e-08 23.39 In-house 248-275 (275) Show / Hide 
Range on Protein: 246-273
Range on HMM: 248-275/275
Sequence Identity: 42% (12 aa)

QTMKQLFEMCTDFDPSKRPSFTLIEKML
..|| | ..|  ..| .||||. | ||.
KEMKELLMECWSYQPEERPSFQQIMKMI
TyrKc 83746.m00145.AA TyrKc 43-273 16 3.8e-07 -107.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-273
Range on HMM: 1-280/280
Sequence Identity: 16% (51 aa)

LKDIKK-----FLNVYYASIKNDPDPNKKLVATKINRNNVPIEIQQQFITEIEVCKTL--NHSGVNKPYDYAIDN-----NLGGLFIIYESPIMDF--LE
.. .||     |  || .  |         || |  ...     .. |. |... . |  .|  . . | ....        . |.|. |   |.   | 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME--YMPHGDLK

NYITTYTTSPITDCHMIKILIGIASAVAYLHSNGYVCGDLRLGTVFLKSKLEPVI---------INYNL------PELYP-----CPI--IPYETKKSEY
.|.  .    ..  ..... . ||.  .||||....  ||    . .....  ..           |.        . |      .    .|.       
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI-----RW

SAPELENNYVITPKSDAYSFGVIL------------------SKISQKLNNIKGKFYQTMKQL----------------FEMCTDFDPSKRPSFTLIEKM
 |||  | .. |.||| .|||| .                   . .. ....|  ..    .                  ..| ..||..||.|. | . 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase 83746.m00145.AA TKL 248-273 57 6.9e-07 20.85 In-house 339-364 (364) Show / Hide 
Range on Protein: 248-273
Range on HMM: 339-364/364
Sequence Identity: 57% (15 aa)

MKQLFEMCTDFDPSKRPSFTLIEKML
||.| ..| | ||.|||||. | | |
MKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 83746.m00145.AA KSR 246-273 42 2e-06 18.1 In-house 245-272 (272) Show / Hide 
Range on Protein: 246-273
Range on HMM: 245-272/272
Sequence Identity: 42% (12 aa)

QTMKQLFEMCTDFDPSKRPSFTLIEKML
..|| .  ||  ..|  ||.|. | |||
REMKEILMMCWSYEPQERPTFQDIMKML
Kinase 83746.m00145.AA LISK 250-273 41 3e-06 16.09 In-house 273-296 (296) Show / Hide 
Range on Protein: 250-273
Range on HMM: 273-296/296
Sequence Identity: 41% (10 aa)

QLFEMCTDFDPSKRPSFTLIEKML
.|  .|.. ||..||||. |.. |
DLCFDCCKYDPKNRPSFKEIVQWL
Kinase 83746.m00145.AA Ciliate-E3 83-131 28 8e-06 14.45 In-house 47-95 (202) Show / Hide 
Range on Protein: 83-131
Range on HMM: 47-95/202
Sequence Identity: 28% (14 aa)

QQFITEIEVCKTLNHSGVNKPYDYAIDNNLGGLFIIYESPIMDFLENYI
|  . |.  |. .|.  |.| .|   | ..  .||..|  .   | .||
QKTQQEFQNCQQINSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYI
Kinase 83746.m00145.AA RAF 233-275 25 1.5e-05 13.62 In-house 240-282 (282) Show / Hide 
Range on Protein: 233-275
Range on HMM: 240-282/282
Sequence Identity: 25% (11 aa)

ISQKLNNIKGKFYQTMKQLFEMCTDFDPSKRPSFTLIEKMLVE
... |  .  .  . |..| | |  |.. .||.|  | |..  
LRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase 83746.m00145.AA LRRK 248-275 39 1.7e-05 15.43 In-house 324-351 (351) Show / Hide 
Range on Protein: 248-275
Range on HMM: 324-351/351
Sequence Identity: 39% (11 aa)

MKQLFEMCTDFDPSKRPSFTLIEKMLVE
...| . | . || |||.|. | | | .
YQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 83746.m00145.AA NZAK 205-229 52 3.7e-05 12.71 In-house 237-261 (329) Show / Hide 
Range on Protein: 205-229
Range on HMM: 237-261/329
Sequence Identity: 52% (13 aa)

EYSAPELENNYVITPKSDAYSFGVI
.| |||  ||. |. ||| .|||..
HYMAPENKNNHRINEKSDVWSFGCT
Kinase 83746.m00145.AA Ciliate-E3 206-234 34 4.7e-05 12.04 In-house 174-202 (202) Show / Hide 
Range on Protein: 206-234
Range on HMM: 174-202/202
Sequence Identity: 34% (10 aa)

YSAPELENNYVITPKSDAYSFGVILSKIS
|.|||.  .  |   || || |...  . 
YAAPEQNDQQQISKESDYYSVGAVFCQLC
Kinase 83746.m00145.AA TK 136-168 25 9e-05 11.08 In-house 229-266 (486) Show / Hide 
Range on Protein: 136-168
Range on HMM: 229-266/486
Sequence Identity: 25% (10 aa)

TSPITDCHMIKILIGIASAVAYLHSN------GYVCGDL
....|  ... .   ||.. .||||.      ..| .||
KHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDL
Kinase 83746.m00145.AA TKL-Unique 206-230 40 0.0001 12.8 In-house 192-218 (290) Show / Hide 
Range on Protein: 206-230
Range on HMM: 192-218/290
Sequence Identity: 40% (11 aa)

YSAPELENN--YVITPKSDAYSFGVIL
..|||. ..  . .. ||| ||||..|
WMAPEVLRMNFCQYSEKSDVYSFGIVL
Kinase 83746.m00145.AA TK 250-273 33 0.000105 10.86 In-house 463-486 (486) Show / Hide 
Range on Protein: 250-273
Range on HMM: 463-486/486
Sequence Identity: 33% (8 aa)

QLFEMCTDFDPSKRPSFTLIEKML
.|  .| ..||..||.|. . ..|
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase 83746.m00145.AA TKL-Unique 251-273 47 0.000458 10.44 In-house 268-290 (290) Show / Hide 
Range on Protein: 251-273
Range on HMM: 268-290/290
Sequence Identity: 47% (11 aa)

LFEMCTDFDPSKRPSFTLIEKML
| ..| . |||.||||. | . |
LIQQCWHHDPSQRPSFDEIIHRL
Kinase 83746.m00145.AA TKL 143-183 14 0.000634 10.03 In-house 133-195 (364) Show / Hide 
Range on Protein: 143-183
Range on HMM: 133-195/364
Sequence Identity: 14% (9 aa)

HMIKILIGIASAVAYLHSNG--------YVCGDLRLGTVFLKSKLE--------------PVI
..... ..||....||||..         .  ||    ........              . |
QRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI
Kinase 83746.m00145.AA NZAK 246-273 34 0.001678 7.06 In-house 301-329 (329) Show / Hide 
Range on Protein: 246-273
Range on HMM: 301-329/329
Sequence Identity: 34% (10 aa)

QTMKQLFEMCTDFDPSKR-PSFTLIEKML
..|| . . | | || ||   |  ..  |
DKMKDFITQCWDIDPKKRPKDFSHMIEKL
Kinase 83746.m00145.AA LRRK 145-161 47 0.034822 3.51 In-house 167-183 (351) Show / Hide 
Range on Protein: 145-161
Range on HMM: 167-183/351
Sequence Identity: 47% (8 aa)

IKILIGIASAVAYLHSN
.|| . ||....||||.
LKIALQIAKGMEYLHSH
Kinase 83746.m00145.AA TKL 206-230 24 0.062229 2.76 In-house 239-279 (364) Show / Hide 
Range on Protein: 206-230
Range on HMM: 239-279/364
Sequence Identity: 24% (10 aa)

YSAPEL-----ENN-----------YVITPKSDAYSFGVIL
. |||.     ...           .  ..|.| ||||..|
WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 83746.m00145.AA LISK 145-162 44 0.090342 1.3 In-house 104-121 (296) Show / Hide 
Range on Protein: 145-162
Range on HMM: 104-121/296
Sequence Identity: 44% (8 aa)

IKILIGIASAVAYLHSNG
.||  .||.. .||||..
VKIALDIACGMSYLHSMN
Kinase 83746.m00145.AA RAF 218-230 38 0.097854 1.75 In-house 195-207 (275) Show / Hide 
Range on Protein: 218-230
Range on HMM: 195-207/275
Sequence Identity: 38% (5 aa)

TPKSDAYSFGVIL
...|| |.||...
SFQSDVYAFGTVW
Kinase 83746.m00145.AA LRRK 220-230 72 0.103 1.82 In-house 262-272 (351) Show / Hide 
Range on Protein: 220-230
Range on HMM: 262-272/351
Sequence Identity: 72% (8 aa)

KSDAYSFGVIL
|.| ||||.||
KVDCYSFGMIL
Kinase 83746.m00145.AA RAF 218-230 46 0.152919 0.42 In-house 199-211 (282) Show / Hide 
Range on Protein: 218-230
Range on HMM: 199-211/282
Sequence Identity: 46% (6 aa)

TPKSDAYSFGVIL
...|| ||||...
SFQSDVYSFGIVM
Ank 83746.m00145.AA Ank 857-869 46 18.460985 2.31 Pfam 1-13 (33) Show / Hide 
Range on Protein: 857-869
Range on HMM: 1-13/33
Sequence Identity: 46% (6 aa)

WGQNAIHWACRLG
 |. . |.||| |
DGFTPLHLACRCG
Ank 83746.m00145.AA Ank 823-856 23 35.605967 1.28 Pfam 1-33 (33) Show / Hide 
Range on Protein: 823-856
Range on HMM: 1-33/33
Sequence Identity: 23% (8 aa)

FGETIFQAAVKTGDFLFLRLLLSIPNVKPFATDS
 |.|    |.. |.   ...||.  .  . |.| 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 83746.m00145.AA Ank 986-1019 50 1.1e-08 35.61 Pfam 1-33 (33) Show / Hide 
Range on Protein: 986-1019
Range on HMM: 1-33/33
Sequence Identity: 50% (17 aa)

QGMTALHYAAMNGGATVVKMLTNVFGVDVNVQDR
 |.|.||.|...|.. ||||| .  | |||.||.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 83746.m00145.AA Ank 1020-1044 36 0.000581 18.55 Pfam 1-25 (33) Show / Hide 
Range on Protein: 1020-1044
Range on HMM: 1-25/33
Sequence Identity: 36% (9 aa)

KGRTPLHIAARNNDALCYAIILSCG
 |.||||.|.|.... .    |..|
DGFTPLHLACRCGHTEVVKMLLQHG