Gene 94243.m00046 (T.vaginalis)

94243.m00046

Species: T.vaginalis
Alias: TvagK0636, 94243.m00046
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
94243.m00046.AA Protein None 2130 None Fasta, JSON
94243.m00046.kin_dom Protein Kinase Domain None 189 None Fasta, JSON

Protein domain

Protein domains of 94243.m00046.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT 94243.m00046.AA FAT 1371-1400 43 0.015616 8.71 Pfam 95-124 (408) Show / Hide 
Range on Protein: 1371-1400
Range on HMM: 95-124/408
Sequence Identity: 43% (13 aa)

YSEAYNSMIYCQVLWELHEIIKTKGKPNSN
|  .|. |  .| | ||.|||. |.. |.|
YNRHYPVMVRVQMLAELEEIIQYKSQCNQN
FAT 94243.m00046.AA FAT 1467-1484 50 0.076464 6.4 Pfam 235-252 (408) Show / Hide 
Range on Protein: 1467-1484
Range on HMM: 235-252/408
Sequence Identity: 50% (9 aa)

HAKMKYLWALGRREEALQ
.| .||.|| |...||.|
YAYLKYMWATGQQQEAFQ
FAT 94243.m00046.AA FAT 1540-1586 28 1e-06 22.63 Pfam 349-408 (408) Show / Hide 
Range on Protein: 1540-1586
Range on HMM: 349-408/408
Sequence Identity: 28% (17 aa)

RWASVNFHLFQLHP------------ENLNYAVEAVRGFVPAIKNSAS-AHFSDVLQLLW
.||  || .||. .            ......| ||..|  .|. | .  .. | | |||
NWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Kinase 94243.m00046.AA PIKK 1798-2068 31 8.9e-80 271.34 In-house 1-290 (290) Show / Hide 
Range on Protein: 1798-2068
Range on HMM: 1-290/290
Sequence Identity: 31% (90 aa)

YISSILPEIDILNSKQHPRRVRFQGNDGIIRPFLLKSNEDLALDQRFMQYMRLVNIFIQQESCLYNNNVCLREYEIVPLSPQVGLIQWVEGSDTISRLIE
.| .. . . .. .|| |..  . | || . |.|.|  ||| .||| ||  .|.|   |...     .  .| | ..|.|.. |||.||....|.  .. 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EYRKVH--SIDPLLEK-----------------HFMELLSVNAVDKLTPMQRYECLSVVGQITSDADLRTIIWLRSPSSQDWLSRHIHLQRSAAVNSVVG
....    . .. .                   .. ..   . ..... ....| . .. | |   ... . |...|....|..|  .  || || ..||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YTIGLGDRHASNIMIDRKTGDMIHIDFGDCFEVNKDRILFPEKIPFRLSRMLVSAFGLAGIDGEFRKTAEKVMSLVRDNANSLASVLELF
| .|||||| .|||||. ||. .|||||.|||. . |  .|||.|||| |..| | |  |..| ||.. |.|| . |.. ..| .|.| |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 94243.m00046.AA FRAP 1830-2068 44 2.2e-77 263.4 In-house 4-241 (251) Show / Hide 
Range on Protein: 1830-2068
Range on HMM: 4-241/251
Sequence Identity: 44% (106 aa)

FLLKSNEDLALDQRFMQYMRLVNIFIQQESCLYNNNVCLREYEIVPLSPQVGLIQWVEGSDTISRLIEEYRKVHSIDPLLEKHFMELLSVNAVDKLTPMQ
||||  ||.  | | ||   |.|  .. .      |  .. | |.||| . ||| ||.  ||.  || .||| . |    |  .|.  ..|  |.|. |.
FLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMD-RMCNDYDHLPLMN

RYECLSVVGQITSDADLRTIIWLRSPSSQDWLSRHIHLQRSAAVNSVVGYTIGLGDRHASNIMIDRKTGDMIHIDFGDCFEVNKDRILFPEKIPFRLSRM
. |    . . |   ||. ..||.||.|  |. |     || |. |..|| .|||||| ||||..| || ..||||||||||   |  ||||||||| ||
KVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRM

LVSAFGLAGIDGEFRKTAEKVMSLVRDNANSLASVLELF
|| |   .||.| .| | | ||  .|.. .|.  ||| |
LVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAF
Kinase 94243.m00046.AA PI3_PI4_kinase 1826-2078 24 2.7e-53 188.17 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1826-2078
Range on HMM: 1-300/300
Sequence Identity: 24% (73 aa)

IIRPFLLKSNEDLA--LDQRFMQYM-----------------------RLVNIFIQQESCLYNNNVCLREYEIVPLSPQVGLIQWVEGSDTISRLIEEYR
.. ||..|...||    |.| ||.                        ||.| . ....|. . | ... | ..|..|. |.|.||. ..|..... .|.
WY-PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYM

KVHSIDPLLEKHFMELLSVNAVDKLTPMQRYECLSVVGQITSDADLRTIIWLRSPSS-QDWLSRHIHLQRSAAVNSVVGYTIGLGDRHASNIMI--DRKT
.  .. ..  .|.|....  . . |. ||. |  . .   |   .|.   |  .|.   .|...  .  || |. .||.| .|.||||..|||.  |..|
VKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTT

GDMIHIDFGDCFE-VNKDRILFPEKIPFRLSR------MLVSAF------GLAGIDGEFRKTAEKVMSLVRDNANSLASVL-------ELFLLESDASML
| ..|||||.||. ..  .  .||..|||. .      ..|.|.      .  | .|.||.. .... ..| ..|.. ..|       |...     .  
GHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWR

E
.
S
Kinase 94243.m00046.AA PI3Kc 1829-2126 23 4.7e-47 163.56 SMART 1-336 (336) Show / Hide 
Range on Protein: 1829-2126
Range on HMM: 1-336/336
Sequence Identity: 23% (80 aa)

PFLLKSNEDLALDQRFMQYMRLVNIFIQQESCLYNNNVCLREYEIVPLSPQVGLIQWVEGSDTISRLIEEYRKVHSIDPLLEKHFM-ELLSV--------
....| ..||  |.| ||  ||.|   |...   . ....| | ..|..|. |.|.||  ..|.  .  .|.|  .... ..  ||   | |        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

---------NAVDKLTPMQRYECLSVVGQITS---DADLRTIIWLRSPSSQ-DWLSRHIHLQRSAAVNSVVGYTIGLGDRHASNIMIDRKTGDMIHIDFG
          . .  ..| . | | . .  |.   . .|.   | ..|..  || ..  .  || |. ..|.|  |.|||| .|||.|.||| ..|||||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DCFEVNKDRILFP----EKIPFRLSRMLVSAFG----LAGIDGEFRKTAEKVMSLVRDNANSLASVLELFLLESD----ASMLEKRMIKRTWDKMSGD-D
..|.  . ...|.    |. |||| ...| . |     .| .|.||....... ..| ..|.. ...|...  .      .|  . .||   ...  |  
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQRFRLDHL

FDDKKSLTP------EEQVSRLINDAVDKYNISHLYTGW
 |.. .         .  .. .    .  |.. |.... 
SDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 94243.m00046.AA ATR 1955-2068 39 1.2e-30 101.31 In-house 155-267 (267) Show / Hide 
Range on Protein: 1955-2068
Range on HMM: 155-267/267
Sequence Identity: 39% (45 aa)

PSSQDWLSRHIHLQRSAAVNSVVGYTIGLGDRHASNIMIDRKTGDMIHIDFGDCFEVNK-DRILFPEKIPFRLSRMLVSAFGLAGIDGEFRKTAEKVMSL
| .|.| | .    || || ..||| |||||||. ||.||. .|...|.|.   |  |. ...  || .|||| . .| ..|  . .| ||.  | .| .
PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIF--NSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMC

VRDNANSLASVLELF
.||. . . ||.. |
MRDHRDDIMSVWDCF
Kinase 94243.m00046.AA ATM 1960-2069 41 7.5e-28 85.75 In-house 133-241 (304) Show / Hide 
Range on Protein: 1960-2069
Range on HMM: 133-241/304
Sequence Identity: 41% (46 aa)

WLSRHIHLQRSAAVNSVVGYTIGLGDRHASNIMIDRKTGDMIHIDFGDCFEVNKDRIL-FPEKIPFRLSRMLVSAFGLAGIDGEFRKTAEKVMSLVRDNA
|  . .   || |  |.||| .||||||  ||.|  .  ...||| |  ||  |  ||  || .|||| | .|   |. |..| ||.  || |  .|   
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGK--ILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ

NSLASVLELFL
  |  . |  |
ETLLTIVEVLL
Kinase 94243.m00046.AA SMG1 1969-2020 55 9.8e-17 51.82 In-house 192-242 (242) Show / Hide 
Range on Protein: 1969-2020
Range on HMM: 192-242/242
Sequence Identity: 55% (29 aa)

RSAAVNSVVGYTIGLGDRHASNIMIDRKTGDMIHIDFGDCFEVNKDRILFPE
|| || |.||| |||||||  |..||  ||...|||.  |||  |  .  ||
RSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGK-KLNVPE
Kinase 94243.m00046.AA SMG1 1806-1888 39 2.8e-16 50.28 In-house 1-83 (242) Show / Hide 
Range on Protein: 1806-1888
Range on HMM: 1-83/242
Sequence Identity: 39% (33 aa)

IDILNSKQHPRRVRFQGNDGIIRPFLLKSNEDLALDQRFMQYMRLVNIFIQQESCLYNNNVCLREYEIVPLSPQVGLIQWVEG
| ||  |  |... | | ||   |.| |  ||| || | ||.. .||                | | . ||    ||||||.|
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDG
Kinase 94243.m00046.AA FATC 2098-2130 45 1.5e-15 52.83 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2098-2130
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

KSLTPEEQVSRLINDAVDKYNISHLYTGWAPLW
..|..|.||.|||..|.| .|....| ||.| |
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 94243.m00046.AA ATR 1797-1887 28 3.6e-11 33.87 In-house 1-91 (267) Show / Hide 
Range on Protein: 1797-1887
Range on HMM: 1-91/267
Sequence Identity: 28% (26 aa)

VYISSILPEIDILNSKQHPRRVRFQGNDGIIRPFLLKSNEDLALDQRFMQYMRLVNIFIQQESCLYNNNVCLREYEIVPLSPQVGLIQWVE
 ||. .   ..|| | |.|... ..| || .   . |  .||  | | |..  |.|   ...         .| | ..||  | ..| ||.
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVN
Kinase 94243.m00046.AA DNAPK 1797-1887 30 2.7e-10 33.51 In-house 2-92 (301) Show / Hide 
Range on Protein: 1797-1887
Range on HMM: 2-92/301
Sequence Identity: 30% (28 aa)

VYISSILPEIDILNSKQHPRRVRFQGNDGIIRPFLLKSNEDLALDQRFMQYMRLVNIFIQQESCLYNNNVCLREYEIVPLSPQVGLIQWVE
| |      . .. |   |.|.   | |    ||. |  ||| .|||  |     |  . . .        || | |.|.    ||| ||.
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVD
Kinase 94243.m00046.AA DNAPK 1978-2028 43 3e-09 29.62 In-house 201-251 (301) Show / Hide 
Range on Protein: 1978-2028
Range on HMM: 201-251/301
Sequence Identity: 43% (22 aa)

GYTIGLGDRHASNIMIDRKTGDMIHIDFGDCFEVNKDRILFPEKIPFRLSR
..  | ||||  | |.   .|| | ||||  |         ||  |||| |
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTR
Kinase 94243.m00046.AA ATM 1831-1888 27 0.006925 4.6 In-house 3-60 (304) Show / Hide 
Range on Protein: 1831-1888
Range on HMM: 3-60/304
Sequence Identity: 27% (16 aa)

LLKSNEDLALDQRFMQYMRLVNIFIQQESCLYNNNVCLREYEIVPLSPQVGLIQWVEG
| |  .||  |    |   . |  .|         . .  | .||||   | . |  |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG