Gene 82140.m00097 (T.vaginalis)

82140.m00097

Species: T.vaginalis
Alias: 82140.m00097, TvagK0617
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
82140.m00097.AA Protein None 2228 None Fasta, JSON
82140.m00097.kin_dom Protein Kinase Domain None 103 None Fasta, JSON

Protein domain

Protein domains of 82140.m00097.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HEAT 82140.m00097.AA HEAT 175-200 19 54.898433 0.35 Pfam 1-26 (31) Show / Hide 
Range on Protein: 175-200
Range on HMM: 1-26/31
Sequence Identity: 19% (5 aa)

HIPEIWNALCSGDPDFRHNAVKVMTR
 .| . ..|.. |.. | .|.. ...
ILPHLLKCLNDPDWEVREAACWCLGQ
HEAT 82140.m00097.AA HEAT 507-523 47 0.582404 7.19 Pfam 5-21 (31) Show / Hide 
Range on Protein: 507-523
Range on HMM: 5-21/31
Sequence Identity: 47% (8 aa)

LVNLLADPSYSVRIAAI
|...| ||...|| ||.
LLKCLNDPDWEVREAAC
HEAT 82140.m00097.AA HEAT 689-720 21 19.745352 1.89 Pfam 1-31 (31) Show / Hide 
Range on Protein: 689-720
Range on HMM: 1-31/31
Sequence Identity: 21% (7 aa)

IVPLFINTFKAKHKDEVYLAAIDSLIDITLAF
|.|.... .. .  .|| .||. .| ..   .
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
HEAT 82140.m00097.AA HEAT 733-764 18 1.194282 6.11 Pfam 1-31 (31) Show / Hide 
Range on Protein: 733-764
Range on HMM: 1-31/31
Sequence Identity: 18% (6 aa)

FLNILMKLLSESTSDKVAISILKLIGTIGPSG
.|..|.|.|. .....|  . .. .|.. .  
ILPHLLKCLN-DPDWEVREAACWCLGQLCEHC
FAT 82140.m00097.AA FAT 1382-1448 18 0.000446 13.88 Pfam 106-201 (408) Show / Hide 
Range on Protein: 1382-1448
Range on HMM: 106-201/408
Sequence Identity: 18% (18 aa)

HQLVELQETLELK--------------KGGAKNVPEIWQNRLVAF-SEESDAWLSLIKTRSLVVS--------------PADHIKTCIKMLSVLRK
..|.||.|  . |               .  | . . |..||        ..| .... |..|.|              |.. ... ||. .. ||
QMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCRK
FAT 82140.m00097.AA FAT 1562-1644 16 1.7e-07 25.34 Pfam 306-403 (408) Show / Hide 
Range on Protein: 1562-1644
Range on HMM: 306-403/408
Sequence Identity: 16% (16 aa)

ATWQYNL---YKANTSSVASLSNILQSFQLSNKLNDKDYR-TWAGMAYATSRALSHSE-----------EKVPEYAVDAISGFLEATKLNTS-FSLEYL
. || .|    . | .   . . |||....  ..... |.  |. .|..  ....| .           ... ...| |...|... .|. .  |....
GMWQWKLYEEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSRQDT
HEAT 82140.m00097.AA HEAT 1679-1709 12 0.005924 14.09 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1679-1709
Range on HMM: 1-31/31
Sequence Identity: 12% (4 aa)

IIPQIVAHLTHKEESIRRIVTSIITKFAADH
|.| .. .|.......|. . . .....  .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Kinase 82140.m00097.AA FRAP 1916-2167 42 9.6e-81 274.56 In-house 1-251 (251) Show / Hide 
Range on Protein: 1916-2167
Range on HMM: 1-251/251
Sequence Identity: 42% (106 aa)

KWKFLLKGNEDLRLDQRIMQFFSLLNSLIKTNRLTSDLGVTIEQYAIIPFAPDAGLVTWVTGADTLLQLVYDFRNERGINPLLEQIVCKEFTEAQYTYLN
 . ||||| ||.| | |.|| | |.| |.. |  |   .  |. |.|||   ..||. ||   |||  |. |.|.   |    |  . ..  .  |  | 
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCN-DYDHLP

NLQRLEICKDIFKISPANELRETIWLRSSSSQAWVAHTRSYTLSTSLMSIAGFVIGLGDRHPSNIMIQRHTGKVVHIDFGDSFDSTVLRKKFPEYVPFRL
 ... || . | .    ..|.  .||.| .|  |      || |   ||.||...|||||||||||.|| |||.||||||| |.    | |||| .||||
LMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRL

TRMIVNALDGESVEGLFRKSCEDILWVLRDNLSPIVAQLEIFVHEPIFSNKT
|||.|||..   .|| .|  || .. |.|..   ..| || ||  |.|  . 
TRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase 82140.m00097.AA PIKK 1887-2157 31 8.6e-79 268.07 In-house 1-290 (290) Show / Hide 
Range on Protein: 1887-2157
Range on HMM: 1-290/290
Sequence Identity: 31% (91 aa)

KIHYIDPTLHVLNTAQHPRSTHLVDETGKKWKFLLKGNEDLRLDQRIMQFFSLLNSLIKTNRLTSDLGVTIEQYAIIPFAPDAGLVTWVTGADTLLQLVY
 |  .|. . |. . | |.   .    ||   .|.|| ||||.|||.||.|.|.| .  ..  ..    .|  |..||  .  ||. ||....||  .  
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DFRN------ERGINP---------LLEQIV-CKEFTEAQ---YTYLNNLQRLEICKDIFKISPANELRETIWLRSSSSQAWVAHTRSYTLSTSLMSIAG
. .       | .. .          | |.   | . ..|   |  ..  ...|.  ..   .|.. ...  |........| . . .|| |. .|...|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

FVIGLGDRHPSNIMIQRHTGKVVHIDFGDSFDSTVLRKKFPEYVPFRLTRMIVNALDGESVEGLFRKSCEDILWVLRDNLSPIVAQLEIF
...|||||||.||||.. ||..||||||..| |   | ..|| |||||||..|||.    |||.||..||... ..|..  .. . .| |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase 82140.m00097.AA PI3_PI4_kinase 1916-2167 20 3.6e-50 177.77 Pfam 1-300 (300) Show / Hide 
Range on Protein: 1916-2167
Range on HMM: 1-300/300
Sequence Identity: 20% (66 aa)

KWKFLLKGNEDLR--LDQRIMQFF-----------------------SLLNSLIKTNRLTSDLGVTIEQYAIIPFAPDAGLVTWVTGADTLLQLVYDFRN
  .|..||..|||   |.|.||..                       .| | . | ....     ..  | .|| .|. |.. ||  ..|. ..   ...
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

ERGINP----------------LLEQIVCKEFTEAQYTYLNNLQRLEICKDIFKISPANELRETIWLRSSSS-QAWVAHTRSYTLSTSLMSIAGFVIGLG
.... .                 |.                 .|..|.     .  | . |..  |  . .   .| .  . ...|   |.......|.|
KCKHKHFNKEHKMWMKMWPDWWHLM----------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNG

DRHPSNIMI--QRHTGKVVHIDFGDSFD-STVLRKKFPEYVPFRLTR------MIVNAL------DGESVEGLFRKSCEDILWVLRDNLSPIVAQL----
|||..|||.   . ||...|||||..|. .   . ..|| ||||.|.      ..|.|.      |  . .|.||..|.... .|| ..  ... |    
DRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAV

---EIFVHEPIFSNKT
   |..|| .... . 
MRGECMVHDGLPMWRS
Kinase 82140.m00097.AA PI3Kc 1918-2211 20 5.6e-47 163.3 SMART 1-336 (336) Show / Hide 
Range on Protein: 1918-2211
Range on HMM: 1-336/336
Sequence Identity: 20% (69 aa)

KFLLKGNEDLRLDQRIMQFFSLLNSLIKTNRLTSDLGVTIEQYAIIPFAPDAGLVTWVTGADTLLQLVYDFRNERGINPLLEQIV---------------
 ...|...||| |.|.||.|.| | . .... .. . ... .|..||  |. |.. ||. ..|| |.   .. .... . ..|..               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

--CKEFTEAQYTYLNNLQRLEICKDIFKISPAN---ELRETIWLRSSSSQ-AWVAHTRSYTLSTSLMSIAGFVIGLGDRHPSNIMIQRHTGKVVHIDFGD
   ... .   .   .. ..| .|....   ..    |..  | .. ..  .|..  . .|.|.  ....... |.||||..|||. . ||...|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

SFDSTVLRKKFP----EYVPFRLTRMIVNALDG----ESVEGLFRKSCEDILWVLRDNLSPIVAQLEIFVHEPI-FSNKTN-SDGGAVQHNILSR-----
 |..  .. .|.    | ||||||...|..  |      ..|.||. |. .. ..| .   |.. .|..|. || .. . .  |   ... .        
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

-VAAKLSG-----LHESPTGHEMKTGEQVDLLISKA
 .| .        |.|.  ..  ..  ... .. ..
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 82140.m00097.AA ATR 2046-2157 36 2.5e-32 107.18 In-house 157-267 (267) Show / Hide 
Range on Protein: 2046-2157
Range on HMM: 157-267/267
Sequence Identity: 36% (41 aa)

SQAWVAHTRSYTLSTSLMSIAGFVIGLGDRHPSNIMIQRHTGKVVHIDFGDSFDS-TVLRKKFPEYVPFRLTRMIVNALDGESVEGLFRKSCEDILWVLR
.| | .    |  |.  ... |..|||||||  ||.|.. .| .||.|.   | |   .  . || ||||||. .|...     .||||. ||.|. ..|
PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQF--EVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMR

DNLSPIVAQLEIF
|.. .|.. .. |
DHRDDIMSVWDCF
Kinase 82140.m00097.AA ATM 2049-2163 39 2.2e-24 74.46 In-house 133-246 (304) Show / Hide 
Range on Protein: 2049-2163
Range on HMM: 133-246/304
Sequence Identity: 39% (45 aa)

WVAHTRSYTLSTSLMSIAGFVIGLGDRHPSNIMIQRHTGKVVHIDFGDSFDSTVLRKKFPEYVPFRLTRMIVNALDGESVEGLFRKSCEDILWVLRDNLS
|      || |    || |...||||||  ||.|      .|||| |  |.   .    || ||||||| ||  .    ||| ||. ||  . |.|    
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

PIVAQLEIFVHEPIF
 ..   |. . .|.|
TLLTIVEVLLYDPLF
Kinase 82140.m00097.AA DNAPK 2065-2167 30 1.2e-16 56.97 In-house 199-301 (301) Show / Hide 
Range on Protein: 2065-2167
Range on HMM: 199-301/301
Sequence Identity: 30% (31 aa)

IAGFVIGLGDRHPSNIMIQRHTGKVVHIDFGDSFDSTVLRKKFPEYVPFRLTRMIVNALDGESVEGLFRKSCEDILWVLRDNLSPIVAQLEIFVHEPIFS
| ... | ||||  | |.   .| .. |||| || |  .    ||  ||||||  .| .    . |... .    .  .|      .   ..|. .| | 
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD

NKT
 | 
WKN
Kinase 82140.m00097.AA SMG1 2031-2094 45 1.7e-15 47.68 In-house 165-228 (242) Show / Hide 
Range on Protein: 2031-2094
Range on HMM: 165-228/242
Sequence Identity: 45% (29 aa)

PANELRETIWLRSSSSQAWVAHTRSYTLSTSLMSIAGFVIGLGDRHPSNIMIQRHTGKVVHIDF
| | |   .|        |   | ||  ||  ||. |..|||||||  |..|   || |||||.
PPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase 82140.m00097.AA FATC 2196-2228 45 1.5e-14 49.68 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2196-2228
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

HEMKTGEQVDLLISKAIDPVLYSRHYIGWCPFW
... . .||| ||. | ||  ....||||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 82140.m00097.AA SMG1 1895-1984 34 4.4e-13 39.55 In-house 1-90 (242) Show / Hide 
Range on Protein: 1895-1984
Range on HMM: 1-90/242
Sequence Identity: 34% (31 aa)

LHVLNTAQHPRSTHLVDETGKKWKFLLKGNEDLRLDQRIMQFFSLLNSLIKTNRLTSDLGVTIEQYAIIPFAPDAGLVTWVTGADTLLQL
. .| |   |.    .   || . .| || ||| || ||||| |. | .  |             |.. |    .||. || ||  |  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGL
Kinase 82140.m00097.AA ATR 1887-1981 27 3.8e-10 30.33 In-house 2-96 (267) Show / Hide 
Range on Protein: 1887-1981
Range on HMM: 2-96/267
Sequence Identity: 27% (26 aa)

KIHYIDPTLHVLNTAQHPRSTHLVDETGKKWKFLLKGNEDLRLDQRIMQFFSLLNSLIKTNRLTSDLGVTIEQYAIIPFAPDAGLVTWVTGADTL
 |  .|  . .| . |.|.   |    || .  . |  .||| | | |.| .|.| . .           .  ||.||   ..... ||    ||
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL
Kinase 82140.m00097.AA ATM 1918-1977 35 1.5e-08 23.03 In-house 1-60 (304) Show / Hide 
Range on Protein: 1918-1977
Range on HMM: 1-60/304
Sequence Identity: 35% (21 aa)

KFLLKGNEDLRLDQRIMQFFSLLNSLIKTNRLTSDLGVTIEQYAIIPFAPDAGLVTWVTG
. | || .||| |  . | | . | |.. |  |    .||  | ..| .  .| . | ||
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG
Kinase 82140.m00097.AA DNAPK 1919-1975 38 1.2e-07 23.68 In-house 35-91 (301) Show / Hide 
Range on Protein: 1919-1975
Range on HMM: 35-91/301
Sequence Identity: 38% (22 aa)

FLLKGNEDLRLDQRIMQFFSLLNSLIKTNRLTSDLGVTIEQYAIIPFAPDAGLVTWV
|. || ||||.|||| | |  .|  .      .        | |||     ||. ||
FCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV