90729.m00129

Species: T.vaginalis
Alias: 90729.m00129, TvagK0704
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
90729.m00129.AA Protein None 316 None Fasta, JSON
90729.m00129.kin_dom Protein Kinase Domain None 199 None Fasta, JSON

Protein domain

Protein domains of 90729.m00129.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 90729.m00129.AA CAMK 64-260 18 5.8e-46 145.65 In-house 84-421 (425) Show / Hide
Range on Protein: 64-260
Range on HMM: 84-421/425
Sequence Identity: 18% (63 aa)

LLKRTA-------HPNIRSIQDYFID-------------------TNCYFQVM---EYIPKG----SIRRYIDHA---------------GKVSIDDLHS
..|.         |||| .. ... |                   ..... ||   ||.. |     .  ||                  |... .. . 
IMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARR

YTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDF-----------------NRLKLSDIDLASYCVNG-------------------------LCNSFHGSL
|   ...||.|.||. |.| |.|| |...||                  | .|..|  .| ..  |                         ... | |..
YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP

QYIA-PEVINQ-------------IPHDPFKADVWAIGVCLYEMATGVLPWRST-------------SLADLKNELSLGYYTFPSEIPYI----------
 |.| |||.|.             .| ...|.|.|..|| || | .| .|...              .. .|.     | |.||..   .          
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW

--------------IQALIQMCLIPNPNERCNLRDLLA
               . ||. .| ..|..| .. . |.
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN

Kinase 90729.m00129.AA CAMKL 64-259 26 1.8e-44 139.76 In-house 65-292 (297) Show / Hide
Range on Protein: 64-259
Range on HMM: 65-292/297
Sequence Identity: 26% (61 aa)

LLKRTA---HPNIRSIQDYFIDTNC------YFQVMEYIPKGS--IRRYIDHA----GKVSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMID-DF
..|.     |||| .. . . . ..      .. ||||.. |.     ||.      |. . .. . |   .. ||||.||. |.| |||| |...| . 
IMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENG

N-RLKLSDIDLASYCV------NGLCNSFHGSLQYIAPEVINQ--IPHDPFKADVWAIGVCLYEMATGVLPWRSTSLA-------DLKNELSLGYYTFP-
|  .|..|  .. ..       . ... | ||. | |||...    |.| .|.|.|..|| || | .| ||..  ...        |...   | | .| 
NNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPI

-SEIPYIIQALIQMCLIPNPNERCNLRDLL
 ....   . ||.  | .||..| .. ...
WYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

S_TKc 90729.m00129.AA S_TKc 13-262 23 1.5e-43 151.93 SMART 1-231 (231) Show / Hide
Range on Protein: 13-262
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

YSVERVLNNQQYESSYIVSKPDTGKQYCIKAIVLGHVDQAIISSFLEPNSTLLKRTAHPNIRSIQDYFIDTNCYFQVMEYIPK--GSIRRYIDHAGK---
| . |..    . . | . . .||... || |             ..    .||.  ||||  . |.| | .... ||||..   |. ..||.. |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFNRLKLSDIDLASYCVNGLCNSFHGSLQYIAPEVINQIPHDPFKADVWAIGVCLYEMA
    .  .  .|.  ...|..|.||..| | |.||.|...|.  ..|..|  ||        ..| |.. |.||||.   .....|.|.|..|..||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TGVLPWRSTSLADLKNELSLGYYTFPSEIPYIIQALIQMCLIPNPNERCNLRDLLA---------VL
.|  |..   .. . . .           .     .|. ||  .|..|    ..|.          .
CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 90729.m00129.AA Pkinase 64-262 25 9.8e-38 134.51 Pfam 53-293 (293) Show / Hide
Range on Protein: 64-262
Range on HMM: 53-293/293
Sequence Identity: 25% (63 aa)

LLKRTAHPNIRSIQDYFIDTNCYFQVMEYIPKG----SIRRYID--HAGKV--SIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFNRL----K
..||  ||||  . |.| | . .  |||| ..|    .  .||     |..  | ... .|   .|....|.||. | | |.||.|..||. . .    |
IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK

LSDIDLAS---YCVNGLCNSFHGSLQYIAPEVINQIPHDPFKADVWAIGVCLYEMATGVLPWRST-----------SLADLKNELSLGYYTFPS------
..|  ||    |  |. ...| |.. |.|||||.  .... |.|.|..|. ||||..| .|...               ... .|.  ...  |      
ICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFF

----------EIPYIIQALIQMCLIPNPNERCNLRDLLAV--L
          ...   . .|  || ..|..|.. ...|    .
RHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 90729.m00129.AA Ciliate-E2 13-259 17 2.6e-37 125.65 In-house 1-360 (365) Show / Hide
Range on Protein: 13-259
Range on HMM: 1-360/365
Sequence Identity: 17% (65 aa)

YSVERVLNNQQYE-----SSYIVSK------------------PDTGKQYCIKAIV---LGHVDQAIISS--------FLEPNSTLLKRTAHPNIRSIQD
| . ... . ..      . . | |                   ...|.| .| .    . .. | |           ..  .  .|..  ||||  . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

YFI--DTNCYFQVMEYIPKGSIRRYID------------HAGKVSIDDLHSYTSHLLQ---------------AVNYIHSNQ-IAHHDIKPSNLMIDDFN
.|.  |.|... ||||.  |. . ||               .. ..     .. ..||               |..|.||.  | | ||||.|...    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

RLKLSDIDLASYCVNG---------------------------------LCNSFHGSLQYIAPEVINQIP--------HDPFKADVWAIGVCLYEMATGV
 .|..|  |. .. .                                  . |.. |.. | |||..|  .        .  .|.|.|..||.|||| .| 
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

LPWRSTSLADLKNELSLGYYTFPSE------------------IPYIIQALIQM----CLIPNPNERCN-LRDLL
.|.         ..   . . ||..                  ..   . ||.     .|  .|..| .   ..|
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL

Kinase 90729.m00129.AA Ciliate-E2-Unclassified 13-252 19 3.5e-36 123.03 In-house 1-340 (352) Show / Hide
Range on Protein: 13-252
Range on HMM: 1-340/352
Sequence Identity: 19% (68 aa)

YSVERVLNNQQYESSYIVSKPDTGKQY-----CIKAIVLG-----HVDQAIISSFLEPNST--------------LLKRTAHPNIRSIQDYFIDTNCYFQ
| . ........ . | . . ... ||      .|...       ..|  |. . .| |.               .|.   ||.|    ..| |... . 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYIPKGSIRRYIDHAGK---------------VSIDDLHS-------YTSHLLQAVNYIHSNQ-IAHHDIKPSNLMIDDFN---RLKLSDIDLAS---
||||.. |. . || . .|                 ... ..       |. ..||. .|.|... | | ||||.|...|. .   ..|..|  ...   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

YCVN--------------GLCNSFHGSLQYI----APEVINQIPHDP---FKADVWAIGVCLYEMATGVLPWRSTSLAD----------------LKNEL
...|               ....| |...|.    ||||. .  .|    .|.|.|. ||.|||| .| .|  ...  .                |... 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

SLGYYTFPSEIP----YIIQ--------ALIQMCLIPNPNER
  . . ||.. .    ....         |.| .|  |||.|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKR

Kinase 90729.m00129.AA MARK 64-259 29 7.1e-34 108.23 In-house 52-257 (262) Show / Hide
Range on Protein: 64-259
Range on HMM: 52-257/262
Sequence Identity: 29% (60 aa)

LLKRTAHPNIRSIQDYFI--DTNC-YFQVMEYIPKGSIRRYIDHA--GKVSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFN--RLKLSDID
..|.  |||| .  ...   ....  . .|||...|. . ||  .  |. . .. . . . .. |||| ||. |.| |||| |..||. .    |..|  
IMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG

LASYC-VNGLCNSFHGSLQYIAPEVINQIPHDPFKADVWAIGVCLYEMATGVLPWRSTS--LADLKNELSLGYYTFPSEIPYIIQALIQMCLIPNPNERC
..  .  . . |.| |.. | |||.... | | .|.|.|. || || | .| .|.. ..  . .|. .   | |..|. ..  .. |||  | .||.|| 
FSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERP

NLRDLL
 . ...
TIEEIM

Kinase 90729.m00129.AA STE 64-259 20 4.4e-31 107.06 In-house 81-352 (359) Show / Hide
Range on Protein: 64-259
Range on HMM: 81-352/359
Sequence Identity: 20% (57 aa)

LLKRTA--HPNIRSIQDYFIDT-------NCYFQVMEYIPKGSIRRYIDHAGKVSI-------------DDLH-SYTSHLLQA-VNYIHSNQIAHHDIKP
..|.    ||||    .....        .  . .|||.. ||..  |.| ...                ..   ..  .|..  .|.||..| | ||||
IMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKP

SNLMIDDFNRLKLSDIDLASYCVN------------------GLCNSFHGSLQYIAPEVINQ------IPHDPFKADVWAIGVCLYEMATGVLPWRS-TS
.| ..      ||.|  ...  ..                  . .|.| |.  . |||||.|       ..| .|.|.| .| .. |||||  ||   . 
ANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPWHDMHP

L-ADLKNELS--------------LGYYTFPSEIP-------------------YIIQALIQMCLIPNPNERCNLRDLL
. | .    .               .  ..|...                       .  |. ||. .||.| .  .||
MRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLL

Kinase 90729.m00129.AA ULK 64-260 20 3.4e-29 100.76 In-house 63-320 (324) Show / Hide
Range on Protein: 64-260
Range on HMM: 63-320/324
Sequence Identity: 20% (54 aa)

LLKRTA---HPN--IRSIQDYFIDT--NCYFQVMEYIPKGSIRRYIDHAGKVSIDD----------LHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDD
..|      |||  |    |.| ..  | .. .||| . |  . ||   .| .               ..  .....  ..|...| | ||||.|..| .
IMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHN

FN------------RLKLSDIDLASYCVNG-----LCNSFH------GSLQYIAPEVIN----QIPHDPFKADVWAIGVCLYEMATGVLP---WRSTSLA
 .            .||..|  .|  . |.     .| ..       |.  | ||....    |.|.. .|.|.| .|. .||| .|  |   |  ... 
GQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQY

----DLKNE-------LSLGYYTFP---SEIP--YIIQALIQMCLIPNPNERCNLRDLLA
    .|.|               ||   ....    .. ||. .|. ....|..  ....
LYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFN

Kinase 90729.m00129.AA ULK 64-260 20 2.2e-28 96.21 In-house 63-325 (329) Show / Hide
Range on Protein: 64-260
Range on HMM: 63-325/329
Sequence Identity: 20% (54 aa)

LLKRTA--------HPNIRSIQDYFIDT--NCYFQVMEYIPKGSIRRYIDHAGKVSIDD----------LHSYTSHLLQAVNYIHSNQIAHHDIKPSNLM
..|.          ||||    |.| ..  |... .||| . |  . ||   .| . |             ..  ..|..  ..|...| | ||||.| .
IMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL

IDDFN------------RLKLSDIDLASYCVNG-----LCNSFH------GSLQYIAPEVIN----QIPHDPFKADVWAIGVCLYEMATGVLP---WRST
|.. .            .||..|  .|  . |.     .  ..       |.  | ||....    |.|.. .|.|.| .|. .||| .|  |   |  .
IHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FN

SLADLKNELSLGYY--------TFPSE---------IPYIIQALIQMCLIPNPNERCNLRDLLA
.. .....  . ..        ..| .         |   .. ||. .|. ....|..  .|..
DQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFN

Kinase 90729.m00129.AA PLK1 66-264 25 5.3e-27 85.57 In-house 54-253 (253) Show / Hide
Range on Protein: 66-264
Range on HMM: 54-253/253
Sequence Identity: 25% (52 aa)

KRTAHPNIRSIQDYFIDTNCYFQVMEYIPKGSIRRYIDHAGKVSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFNRLKLSDIDLASYCVNG-
.  .|..|  . ..| | .  . |.|   . |.     . . .   .   |.  ..... |.| |.| | |.|  || ..|  ..|. |  ||  | .  
RQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDG

-LCNSFHGSLQYIAPEVINQIPHDPFKADVWAIGVCLYEMATGVLPWRSTSLADLKNELSLGYYTFPSEIPYIIQALIQMCLIPNPNERCNLRDLLAVLQ
       |   ||||||.|.. |  |  |.|.||  .| .  |  |. . .| .    .    |. ||.|    . ||.  | |.|..| . . .|    
ERKKTLCGTPNYIAPEVLNKKGHS-FEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEF

G
 
F

Kinase 90729.m00129.AA TKL 64-262 17 2.5e-26 91.83 In-house 78-364 (364) Show / Hide
Range on Protein: 64-262
Range on HMM: 78-364/364
Sequence Identity: 17% (50 aa)

LLKRTAHPNIRSIQDYFIDTNC-------------YFQVMEYIPKGSIRRYIDHAGKVSIDDLHSYTSHLLQAVNYIHSNQ--------IAHHDIKPSNL
...|. |||| ..  | .. .|             .. ||||.|.|| . |.       .. ...      ...|| ||..        |.| |.|..|.
MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI

MIDDFNR--------------LKLSDIDLASYCVNGLC---------------------NSFHGSLQYIAPEVINQIPHDP---------------FKAD
..|. ..              .|..|  |.    .                        ..  |.... ||||... . ..                |.|
LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD

VWAIGVCLYEMATGVLPWRSTSLADLK------NELSLGYY-----TFP------------SEIPYIIQALIQMCLIPNPNERCNLRDLLAVL
|.. |..|.|..|. .|..     . .       .... ..     . |            . .|  .  |.|.|  ..|..| .  ..|  |
VYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 90729.m00129.AA TyrKc 13-262 17 1.5e-10 -52.27 SMART 1-280 (280) Show / Hide
Range on Protein: 13-262
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

YSVERVLNNQQ----YESSYIVSKPDTGKQYCIKAIVLGHVDQAIISSFLEPNSTLLKR-TAHPNIRSIQDYFIDT-------NCYFQVMEYIPKGSIRR
 . ...| . .    |.  ..        |  .| .  ..     .  |..  . . |    ||||  .  . ..          .. |||| |.|. . 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YI-DHAGKVSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFNRLKLSD----IDLASY---CVNGLCNSFHG--SLQ------YIAPEVINQI
|. .| .|.. .||.|.     .  .|.||... | |.   | .... .. | ||     |. ..    ...   .  .  .          |||.|   
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

PHDPFKA------DVWAIGVCLYEMAT-GVLPWRS-----TSLADLKNELSLGYYTFPSEI---------PYIIQALIQMCLIPNPNERCNLRDLLAVL
    ..       |||. |||..|. | |  |.        | ... . .  ||.  . .          |  .  ....|   .|..|.. ...   .
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 90729.m00129.AA Pkinase_Tyr 190-210 43 0.021521 8.73 Pfam 194-216 (270) Show / Hide
Range on Protein: 190-210
Range on HMM: 194-216/270
Sequence Identity: 43% (10 aa)

KADVWAIGVCLYEMAT-GVLP-W
| |||. ||...|. | |  | .
KSDVWSFGVLMWEIFTYGEQPTY

Kinase 90729.m00129.AA Pkinase_Tyr 237-262 23 0.369047 4.55 Pfam 245-270 (270) Show / Hide
Range on Protein: 237-262
Range on HMM: 245-270/270
Sequence Identity: 23% (6 aa)

IQALIQMCLIPNPNERCNLRDLLAVL
|  |...|  ..|..|   ....  |
IYDLMKQCWHYDPEDRPTFSEIHEQL