Gene 90729.m00129 (T.vaginalis)
90729.m00129
Species: T.vaginalis
Alias: 90729.m00129, TvagK0704
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
90729.m00129.AA | Protein | None | 316 | None | Fasta, JSON |
90729.m00129.kin_dom | Protein Kinase Domain | None | 199 | None | Fasta, JSON |
Protein domains of 90729.m00129.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 90729.m00129.AA | CAMK | 64-260 | 18 | 5.8e-46 | 145.65 | In-house | 84-421 (425) | Show / Hide |
Range on Protein: 64-260 Range on HMM: 84-421/425 Sequence Identity: 18% (63 aa) LLKRTA-------HPNIRSIQDYFID-------------------TNCYFQVM---EYIPKG----SIRRYIDHA---------------GKVSIDDLHS ..|. |||| .. ... | ..... || ||.. | . || |... .. . IMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARR YTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDF-----------------NRLKLSDIDLASYCVNG-------------------------LCNSFHGSL | ...||.|.||. |.| |.|| |...|| | .|..| .| .. | ... | |.. YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP QYIA-PEVINQ-------------IPHDPFKADVWAIGVCLYEMATGVLPWRST-------------SLADLKNELSLGYYTFPSEIPYI---------- |.| |||.|. .| ...|.|.|..|| || | .| .|... .. .|. | |.||.. . EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW --------------IQALIQMCLIPNPNERCNLRDLLA . ||. .| ..|..| .. . |. DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN |
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Kinase | 90729.m00129.AA | CAMKL | 64-259 | 26 | 1.8e-44 | 139.76 | In-house | 65-292 (297) | Show / Hide |
Range on Protein: 64-259 Range on HMM: 65-292/297 Sequence Identity: 26% (61 aa) LLKRTA---HPNIRSIQDYFIDTNC------YFQVMEYIPKGS--IRRYIDHA----GKVSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMID-DF ..|. |||| .. . . . .. .. ||||.. |. ||. |. . .. . | .. ||||.||. |.| |||| |...| . IMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENG N-RLKLSDIDLASYCV------NGLCNSFHGSLQYIAPEVINQ--IPHDPFKADVWAIGVCLYEMATGVLPWRSTSLA-------DLKNELSLGYYTFP- | .|..| .. .. . ... | ||. | |||... |.| .|.|.|..|| || | .| ||.. ... |... | | .| NNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPI -SEIPYIIQALIQMCLIPNPNERCNLRDLL .... . ||. | .||..| .. ... WYHVS-DCRDLIRKMLQVNPEKRPTIHQIM |
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S_TKc | 90729.m00129.AA | S_TKc | 13-262 | 23 | 1.5e-43 | 151.93 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-262 Range on HMM: 1-231/231 Sequence Identity: 23% (64 aa) YSVERVLNNQQYESSYIVSKPDTGKQYCIKAIVLGHVDQAIISSFLEPNSTLLKRTAHPNIRSIQDYFIDTNCYFQVMEYIPK--GSIRRYIDHAGK--- | . |.. . . | . . .||... || | .. .||. |||| . |.| | .... ||||.. |. ..||.. |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---VSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFNRLKLSDIDLASYCVNGLCNSFHGSLQYIAPEVINQIPHDPFKADVWAIGVCLYEMA . . .|. ...|..|.||..| | |.||.|...|. ..|..| || ..| |.. |.||||. .....|.|.|..|..||||. RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML TGVLPWRSTSLADLKNELSLGYYTFPSEIPYIIQALIQMCLIPNPNERCNLRDLLA---------VL .| |.. .. . . . . .|. || .|..| ..|. . CGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 90729.m00129.AA | Pkinase | 64-262 | 25 | 9.8e-38 | 134.51 | Pfam | 53-293 (293) | Show / Hide |
Range on Protein: 64-262 Range on HMM: 53-293/293 Sequence Identity: 25% (63 aa) LLKRTAHPNIRSIQDYFIDTNCYFQVMEYIPKG----SIRRYID--HAGKV--SIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFNRL----K ..|| |||| . |.| | . . |||| ..| . .|| |.. | ... .| .|....|.||. | | |.||.|..||. . . | IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK LSDIDLAS---YCVNGLCNSFHGSLQYIAPEVINQIPHDPFKADVWAIGVCLYEMATGVLPWRST-----------SLADLKNELSLGYYTFPS------ ..| || | |. ...| |.. |.|||||. .... |.|.|..|. ||||..| .|... ... .|. ... | ICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFF ----------EIPYIIQALIQMCLIPNPNERCNLRDLLAV--L ... . .| || ..|..|.. ...| . RHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 90729.m00129.AA | Ciliate-E2 | 13-259 | 17 | 2.6e-37 | 125.65 | In-house | 1-360 (365) | Show / Hide |
Range on Protein: 13-259 Range on HMM: 1-360/365 Sequence Identity: 17% (65 aa) YSVERVLNNQQYE-----SSYIVSK------------------PDTGKQYCIKAIV---LGHVDQAIISS--------FLEPNSTLLKRTAHPNIRSIQD | . ... . .. . . | | ...|.| .| . . .. | | .. . .|.. |||| . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE YFI--DTNCYFQVMEYIPKGSIRRYID------------HAGKVSIDDLHSYTSHLLQ---------------AVNYIHSNQ-IAHHDIKPSNLMIDDFN .|. |.|... ||||. |. . || .. .. .. ..|| |..|.||. | | ||||.|... CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- RLKLSDIDLASYCVNG---------------------------------LCNSFHGSLQYIAPEVINQIP--------HDPFKADVWAIGVCLYEMATGV .|..| |. .. . . |.. |.. | |||..| . . .|.|.|..||.|||| .| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK LPWRSTSLADLKNELSLGYYTFPSE------------------IPYIIQALIQM----CLIPNPNERCN-LRDLL .|. .. . . ||.. .. . ||. .| .|..| . ..| PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL |
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Kinase | 90729.m00129.AA | Ciliate-E2-Unclassified | 13-252 | 19 | 3.5e-36 | 123.03 | In-house | 1-340 (352) | Show / Hide |
Range on Protein: 13-252 Range on HMM: 1-340/352 Sequence Identity: 19% (68 aa) YSVERVLNNQQYESSYIVSKPDTGKQY-----CIKAIVLG-----HVDQAIISSFLEPNST--------------LLKRTAHPNIRSIQDYFIDTNCYFQ | . ........ . | . . ... || .|... ..| |. . .| |. .|. ||.| ..| |... . YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI VMEYIPKGSIRRYIDHAGK---------------VSIDDLHS-------YTSHLLQAVNYIHSNQ-IAHHDIKPSNLMIDDFN---RLKLSDIDLAS--- ||||.. |. . || . .| ... .. |. ..||. .|.|... | | ||||.|...|. . ..|..| ... VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ YCVN--------------GLCNSFHGSLQYI----APEVINQIPHDP---FKADVWAIGVCLYEMATGVLPWRSTSLAD----------------LKNEL ...| ....| |...|. ||||. . .| .|.|.|. ||.|||| .| .| ... . |... QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI SLGYYTFPSEIP----YIIQ--------ALIQMCLIPNPNER . . ||.. . .... |.| .| |||.| KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKR |
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Kinase | 90729.m00129.AA | MARK | 64-259 | 29 | 7.1e-34 | 108.23 | In-house | 52-257 (262) | Show / Hide |
Range on Protein: 64-259 Range on HMM: 52-257/262 Sequence Identity: 29% (60 aa) LLKRTAHPNIRSIQDYFI--DTNC-YFQVMEYIPKGSIRRYIDHA--GKVSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFN--RLKLSDID ..|. |||| . ... .... . .|||...|. . || . |. . .. . . . .. |||| ||. |.| |||| |..||. . |..| IMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG LASYC-VNGLCNSFHGSLQYIAPEVINQIPHDPFKADVWAIGVCLYEMATGVLPWRSTS--LADLKNELSLGYYTFPSEIPYIIQALIQMCLIPNPNERC .. . . . |.| |.. | |||.... | | .|.|.|. || || | .| .|.. .. . .|. . | |..|. .. .. ||| | .||.|| FSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERP NLRDLL . ... TIEEIM |
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Kinase | 90729.m00129.AA | STE | 64-259 | 20 | 4.4e-31 | 107.06 | In-house | 81-352 (359) | Show / Hide |
Range on Protein: 64-259 Range on HMM: 81-352/359 Sequence Identity: 20% (57 aa) LLKRTA--HPNIRSIQDYFIDT-------NCYFQVMEYIPKGSIRRYIDHAGKVSI-------------DDLH-SYTSHLLQA-VNYIHSNQIAHHDIKP ..|. |||| ..... . . .|||.. ||.. |.| ... .. .. .|.. .|.||..| | |||| IMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKP SNLMIDDFNRLKLSDIDLASYCVN------------------GLCNSFHGSLQYIAPEVINQ------IPHDPFKADVWAIGVCLYEMATGVLPWRS-TS .| .. ||.| ... .. . .|.| |. . |||||.| ..| .|.|.| .| .. ||||| || . ANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPWHDMHP L-ADLKNELS--------------LGYYTFPSEIP-------------------YIIQALIQMCLIPNPNERCNLRDLL . | . . . ..|... . |. ||. .||.| . .|| MRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLL |
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Kinase | 90729.m00129.AA | ULK | 64-260 | 20 | 3.4e-29 | 100.76 | In-house | 63-320 (324) | Show / Hide |
Range on Protein: 64-260 Range on HMM: 63-320/324 Sequence Identity: 20% (54 aa) LLKRTA---HPN--IRSIQDYFIDT--NCYFQVMEYIPKGSIRRYIDHAGKVSIDD----------LHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDD ..| ||| | |.| .. | .. .||| . | . || .| . .. ..... ..|...| | ||||.|..| . IMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHN FN------------RLKLSDIDLASYCVNG-----LCNSFH------GSLQYIAPEVIN----QIPHDPFKADVWAIGVCLYEMATGVLP---WRSTSLA . .||..| .| . |. .| .. |. | ||.... |.|.. .|.|.| .|. .||| .| | | ... GQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQY ----DLKNE-------LSLGYYTFP---SEIP--YIIQALIQMCLIPNPNERCNLRDLLA .|.| || .... .. ||. .|. ....|.. .... LYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFN |
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Kinase | 90729.m00129.AA | ULK | 64-260 | 20 | 2.2e-28 | 96.21 | In-house | 63-325 (329) | Show / Hide |
Range on Protein: 64-260 Range on HMM: 63-325/329 Sequence Identity: 20% (54 aa) LLKRTA--------HPNIRSIQDYFIDT--NCYFQVMEYIPKGSIRRYIDHAGKVSIDD----------LHSYTSHLLQAVNYIHSNQIAHHDIKPSNLM ..|. |||| |.| .. |... .||| . | . || .| . | .. ..|.. ..|...| | ||||.| . IMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL IDDFN------------RLKLSDIDLASYCVNG-----LCNSFH------GSLQYIAPEVIN----QIPHDPFKADVWAIGVCLYEMATGVLP---WRST |.. . .||..| .| . |. . .. |. | ||.... |.|.. .|.|.| .|. .||| .| | | . IHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FN SLADLKNELSLGYY--------TFPSE---------IPYIIQALIQMCLIPNPNERCNLRDLLA .. ..... . .. ..| . | .. ||. .|. ....|.. .|.. DQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFN |
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Kinase | 90729.m00129.AA | PLK1 | 66-264 | 25 | 5.3e-27 | 85.57 | In-house | 54-253 (253) | Show / Hide |
Range on Protein: 66-264 Range on HMM: 54-253/253 Sequence Identity: 25% (52 aa) KRTAHPNIRSIQDYFIDTNCYFQVMEYIPKGSIRRYIDHAGKVSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFNRLKLSDIDLASYCVNG- . .|..| . ..| | . . |.| . |. . . . . |. ..... |.| |.| | |.| || ..| ..|. | || | . RQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDG -LCNSFHGSLQYIAPEVINQIPHDPFKADVWAIGVCLYEMATGVLPWRSTSLADLKNELSLGYYTFPSEIPYIIQALIQMCLIPNPNERCNLRDLLAVLQ | ||||||.|.. | | |.|.|| .| . | |. . .| . . |. ||.| . ||. | |.|..| . . .| ERKKTLCGTPNYIAPEVLNKKGHS-FEVDIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEF G F |
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Kinase | 90729.m00129.AA | TKL | 64-262 | 17 | 2.5e-26 | 91.83 | In-house | 78-364 (364) | Show / Hide |
Range on Protein: 64-262 Range on HMM: 78-364/364 Sequence Identity: 17% (50 aa) LLKRTAHPNIRSIQDYFIDTNC-------------YFQVMEYIPKGSIRRYIDHAGKVSIDDLHSYTSHLLQAVNYIHSNQ--------IAHHDIKPSNL ...|. |||| .. | .. .| .. ||||.|.|| . |. .. ... ...|| ||.. |.| |.|..|. MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI MIDDFNR--------------LKLSDIDLASYCVNGLC---------------------NSFHGSLQYIAPEVINQIPHDP---------------FKAD ..|. .. .|..| |. . .. |.... ||||... . .. |.| LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCD VWAIGVCLYEMATGVLPWRSTSLADLK------NELSLGYY-----TFP------------SEIPYIIQALIQMCLIPNPNERCNLRDLLAVL |.. |..|.|..|. .|.. . . .... .. . | . .| . |.|.| ..|..| . ..| | VYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 90729.m00129.AA | TyrKc | 13-262 | 17 | 1.5e-10 | -52.27 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-262 Range on HMM: 1-280/280 Sequence Identity: 17% (53 aa) YSVERVLNNQQ----YESSYIVSKPDTGKQYCIKAIVLGHVDQAIISSFLEPNSTLLKR-TAHPNIRSIQDYFIDT-------NCYFQVMEYIPKGSIRR . ...| . . |. .. | .| . .. . |.. . . | |||| . . .. .. |||| |.|. . ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD YI-DHAGKVSIDDLHSYTSHLLQAVNYIHSNQIAHHDIKPSNLMIDDFNRLKLSD----IDLASY---CVNGLCNSFHG--SLQ------YIAPEVINQI |. .| .|.. .||.|. . .|.||... | |. | .... .. | || |. .. ... . . . |||.| YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--- PHDPFKA------DVWAIGVCLYEMAT-GVLPWRS-----TSLADLKNELSLGYYTFPSEI---------PYIIQALIQMCLIPNPNERCNLRDLLAVL .. |||. |||..|. | | |. | ... . . ||. . . | . ....| .|..|.. ... . ----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 90729.m00129.AA | Pkinase_Tyr | 190-210 | 43 | 0.021521 | 8.73 | Pfam | 194-216 (270) | Show / Hide |
Range on Protein: 190-210 Range on HMM: 194-216/270 Sequence Identity: 43% (10 aa) KADVWAIGVCLYEMAT-GVLP-W | |||. ||...|. | | | . KSDVWSFGVLMWEIFTYGEQPTY |
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Kinase | 90729.m00129.AA | Pkinase_Tyr | 237-262 | 23 | 0.369047 | 4.55 | Pfam | 245-270 (270) | Show / Hide |
Range on Protein: 237-262 Range on HMM: 245-270/270 Sequence Identity: 23% (6 aa) IQALIQMCLIPNPNERCNLRDLLAVL | |...| ..|..| .... | IYDLMKQCWHYDPEDRPTFSEIHEQL |