Gene 109777.m00002 (T.vaginalis)

109777.m00002

Species: T.vaginalis
Alias: 109777.m00002, TvagK0136
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
109777.m00002.AA Protein None 279 None Fasta, JSON
109777.m00002.kin_dom Protein Kinase Domain None 243 None Fasta, JSON

Protein domain

Protein domains of 109777.m00002.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 109777.m00002.AA S_TKc 34-276 30 1.5e-72 248.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 34-276
Range on HMM: 1-231/231
Sequence Identity: 30% (79 aa)

LEFIKIIGQGGYGVIYEVHSANFNSNFAVKKIPKCFFSQAELDCLMRIDDPRIVRLYQIYRYNDFIYMVLEYCPT---DLYKVFSAGGK------LYEED
 |....||.|..|. | ..  . .  .|.|.|.     . |...|.. . | ||.|| ...  |..|||.|||..   ||...    |.      . | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

IYRYAHDAVLAIKSVHDKNIAHCDIKPANFFIDTYGRVKIGDFGLASFNGSSCSCKMAKGTKLFMAPEVYCKKYTPMKSDIWSLGVTLYFLATQTYPFNA
. .|..  ..|..  |...| |.|.||.| ..|.  ..||.||||| .       .   ||  .|||||   .|.. |.|.||.|..|| ...   ||  
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP-

PDIEKLKQCISIGLFATDKVQNKNLLAVISKCLDRDPEKRPTADEILQ-------MPYF
 ..... . |            . ..  |.|||..|||||||| |.||       .|.|
-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 109777.m00002.AA CAMK 39-276 18 4.3e-61 195.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 39-276
Range on HMM: 1-425/425
Sequence Identity: 18% (77 aa)

IIGQGGYGVIYEVHSANFN------------SNFAVKKIPK---------------------------------CFFSQAELDCLMR-------IDDPRI
..|.|..|. ...   | .              .|.| |.|                                 . . . |......       .| | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLYQIYRY-------------------NDFIYMVL---EYCPT-----DLYKVFSAG---------------GKLYEEDIYRYAHDAVLAIKSVHDKNI
..||..|                     ....|||.   |||.      ||.    .                |.. |..  || .  . |..  |..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHCDIKPANFFIDTY-----------------GRVKIGDFGLA--SFNGSSCS----------------------CKMAKGTKLFMA-PEVYCK------
.|.|.|| |  .|.                  . .|| |||.|   . |...                       .|   ||  .|| |||  .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KYTPMKSDIWSLGVTLYFLATQTYPFNAP-------------DIEKLKQCISIGLF--ATDKVQN----------------------KNLLA
        .| . |.|.||.|| ||.. . ..||...             ....|.. |  | .    ... .                      .    
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

VISKCLDRDPEKRPTADEILQMPYF
 |.|.| .|||||.|....|. | .
LIRKMLQVDPEKRMTIEQCLNHPWM
Pkinase 109777.m00002.AA Pkinase 34-276 28 5.9e-60 210.3 Pfam 1-293 (293) Show / Hide 
Range on Protein: 34-276
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

LEFIKIIGQGGYGVIYEVHSANFNSNFAVKKIPKCFFSQ---------AELDCLMRIDDPRIVRLYQIYRYNDFIYMVLEYCPT-----DLYKVFS--AG
......||.|..|. |. |  . .  .|||.|.|.  .          .|.  . |.. | ||||| .....| ||||.|||.      ||. . |  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKL--YEEDIYRYAHDAVLAIKSVHDKNIAHCDIKPANFFIDTYGRV----KIGDFGLASF--NGSSCSCKMAKGTKLFMAPEVYC-KKYTPMKSDIWSL
|..   |... .|.   . ...  |...| |.|.||.|..||  | .    ||.||||| .  . ..  ..   ||  .|||||    .| . |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVTLYFLATQTYPFNAP----DIEKLKQCISIGLFATDKVQN------------------------KNLLAVISKCLDRDPEKRPTADEILQMPYF
|..|| ...   ||       .    .|.|   . .  . .                         .... .|..||..||.|||||..||| |.|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 109777.m00002.AA CAMKL 34-276 25 1.6e-51 162.65 In-house 1-297 (297) Show / Hide 
Range on Protein: 34-276
Range on HMM: 1-297/297
Sequence Identity: 25% (76 aa)

LEFIKIIGQGGYGVIYEVHSANF-NSNFAVKKIP--KCF---FSQA---------------ELDCLMRID---DPRIVRLYQIYRYNDF------IYMVL
 ...| .|.|..|.    .   . .   |.| |   |.    ....               |  ......    | |..||...   ..      ||.|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCPTD---LYKVFSAG----GKLYEEDIYRYAHDAVLAIKSVHDKNIAHCDIKPANFFIDTYG--RVKIGDFGLASF-----NGSSCSCKMAKGTKLFM
|||.     |.    .     |.. |..  ||    | |..  |...|.| |||| |  .|  |   .|| |||.. .     .|.   .|.  |.  .|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVYCK--K-YTPMKSDIWSLGVTLYFLATQTYPFNAP--------DIEKLKQCISIGLFATDKVQNK-NLLAVISKCLDRDPEKRPTADEILQMPYF
|||.. .  | |   | ||||.||.||.. . ..||...        .| .|.  | .| .  ..      .   |.| | ..||||||...|.. | .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 109777.m00002.AA AGC 72-276 20 1.8e-48 122.32 In-house 68-395 (395) Show / Hide 
Range on Protein: 72-276
Range on HMM: 68-395/395
Sequence Identity: 20% (69 aa)

QAELDCLMRID----------DPRIVR-LYQIYRYNDF--IYMVLEYCP---------TDLYKVFSAGG-----KLYEEDIYRYAHD-------AVLAIK
..| . |....           | ||. |.  .  .|   .|.|.||.|          ..   ..  |     .. || .  ||          |||. 
WEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALE

SVHD-KNIAHCD-IKPANFFIDTYGRVKIGDFGLASFNGSSC---------------------------------------------------SCKMAKG
. |. ..| | | .|| |  .|  | .|. ||||.  . ...                                                    ..   |
YLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCG

--TKLFMAPEVYCKKYTPMKSDIWS--LGVTLYFLATQTYPFNAP----------DIEKLKQCISIGL-FATDKVQN---------------KNLLAVIS
  |  .||||.    |..   |.||  ||. .| . |   ||..           . ... | | .|  | ..||.                ...   |.
PCTPEYMAPEIL---YGKA-CDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIK

KCLDRDPEKRPT----------ADEILQMPYF
|.| .|||||..          |.|| . |.|
KLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 109777.m00002.AA Ciliate-E2 34-276 20 3.5e-48 163.5 In-house 1-365 (365) Show / Hide 
Range on Protein: 34-276
Range on HMM: 1-365/365
Sequence Identity: 20% (77 aa)

LEFIKIIGQGGYGVIYEV-HSANFNSN-----------------FAVKKIPKCFFSQAELDCLMRIDDPR-----------------------IVRLYQI
 .|||.||||..|..|.. .  . .                   ...|.. .  ... ..  ......                         |...|  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YR--YNDFIYMVLEYCPT-DLYK------VFS------AGGKLYEEDIYRY-AHDAV--------------LAIKSVHDKN-IAHCDIKPANFFIDTYGR
.    .. ||.|.|||   ||..       ..      . ... |. | .. .. .               ||... | || | | |||| | ..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKIGDFGLASFNGSS---------CSCKMAKG------------------------TKLFMAPEVYC---------KKYTPMKSDIWSLGVTLYFLATQT
.|| ||||. ..  .         |  .|  .                        |  .||||..          .|.   |.|||||||.||.. .  
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

YPFNAPDIEKLKQCISIGLFA--------------TDKVQNKNLLAVISK----CLDRDPEKRPT-ADEILQMPYF
.||    ... |||     ..                |   ..    |.|    .|..|||||.| ...||. |.|
PPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 109777.m00002.AA Ciliate-E2-Unclassified 35-276 22 2.2e-44 151.83 In-house 2-352 (352) Show / Hide 
Range on Protein: 35-276
Range on HMM: 2-352/352
Sequence Identity: 22% (78 aa)

EFIKIIGQGGYGVIYEVHSANFNSNFAVKKIPKCFFSQA---------------ELDCLM----------------RIDDPRIVRLYQIYRYNDFIYMVL
..||.|||||.|..|..   . .  ....|. | . ...               |. ...                 ...| ||... . .  . ||.|.
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYC------------------PTDLYKVFSAGGKLYEEDIY-----RYAHDAVLAIKSVHDKN-IAHCDIKPANFFIDTYG---RVKIGDFGLASFNG--
|||                    ||..    . .. |. .      .|.   ...... | || | | |||| | ..|  |   ..|| |||......  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------SSCSCKMAKGTKLFM----APEVYCK-KYTPM---KSDIWSLGVTLYFLATQTYPFNAPDIEK----------------LKQCISI
              ... ..   ||  .|    ||||... .|  .   |.||||||| ||.. ...|||.... |.                |.| |  
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

G---LFATDK-----VQNKNLLAVIS----KCLDRDPEKRPTADEILQMPYF
.    .  ..       ...    |.    |.|. .|.||.|...||. |.|
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 109777.m00002.AA STE 34-276 19 1.3e-43 151.18 In-house 1-359 (359) Show / Hide 
Range on Protein: 34-276
Range on HMM: 1-359/359
Sequence Identity: 19% (73 aa)

LEFIKIIGQGGYGVIYEVHSA------NFNSN---------FAVKKIPKCFFS----------------------QAELDCLMRID--DPRIVRLYQIYR
.|.|..||.|..|. |             . .         .|.|.....  .                      . |.. ... .   | ||. |  | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YN-------DFIYMVLEYCP----TDLYK-VFSAGGKLY----------EEDIYRYAHDAVLA-IKSVHDKNIAHCDIKPANFFIDTYGRVKIGDFGLAS
..       | .....||..    .|..| ... |. |           |. | ..... . .  .  |...| | |||||| ..     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

-FNGS----------------SCSCKMAKGTKLFMAPEVYCK------KYTPMKSDIWSLGVTLYFLATQTYPF---NAP--------------------
 .. |                .  ..   ||  .|||||  .      |    |.|||||| |.  .||  .|.   . .                    
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----DIEKLKQCIS-----------IGLFATDKVQNKNLLAVISKCLDRDPEKRPTADEILQ--MPYF
    .. .|.. .|             .    .   ...   |.|||..||.|||||.. |.   | .
IVNGPPPPLPDHLSQNEMISYGGSGT-T--YPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 109777.m00002.AA ULK 34-276 21 5.5e-43 149.14 In-house 1-324 (324) Show / Hide 
Range on Protein: 34-276
Range on HMM: 1-324/324
Sequence Identity: 21% (70 aa)

LEFIKIIGQGGYG-VIYEVH-SANF--NSNFAVKKIPKCFFSQAELD--------CLM-------RID---DPR--IVRLYQIYRYNDF--IYMVLEYCP
 . ....|.| .| . |.     .   |  .|.|.|.|. ... ...         |.        ..    |   ||.|| ...  ..  ||...|||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

T-DLYKVFS---------AGGKLYEEDIYRYAHDAVLAIKSVHDKNIAHCDIKPANFFIDTY------------GRVKIGDFGLASFNGSS----CSCKM
  || .             ...| |. .  . .. . . |  |..|| |.||||.|  |               |..||.|||.| .  .     . |. 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

AK------GTKLFMAPEVYCKK-----YTPMKSDIWSLGVTLYFLATQTYPFNAPDIEKLK---------------QCISIGLFATD--KVQN--KNLLA
..      || |.|||..  ..     |.  |.||||||. .| . .  |||... .....               .     .   .  | ..  ...  
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

VISKCLDRDPEKRPTADEILQMPYF
 |...| .|...| . .||...| |
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 109777.m00002.AA ULK 34-276 21 3e-42 145.29 In-house 1-329 (329) Show / Hide 
Range on Protein: 34-276
Range on HMM: 1-329/329
Sequence Identity: 21% (70 aa)

LEFIKIIGQGGYGVIYEVHSANF----NSNFAVKKIP---KCFFS------------QAELDCLMRIDDPR--------IVRLYQIYRYNDF--IYMVLE
 . ....|.| .|. |.    .     |  .|.|.|.   .  ..            . | . . ....|         ||.|| ...  ..  ||...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCPT-DLYKVFS----------AGGKLYEEDIYRYAHDAVLAIKSVHDKNIAHCDIKPANFFIDTY------------GRVKIGDFGLASFNGSS-----
||.  || .  .           ...| |. .  . .. . . |  |..|| |.||||.|  |.              |..||.|||.| .  ..     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

--CSCK---MAKGTKLFMAPEVYCKK-----YTPMKSDIWSLGVTLYFLATQTYPFNAPDIEKLK-----QCISIG-----------LFAT----DKVQN
  ..|.     .|| |.|||..  ..     |.  |.||||||. .| . .  .||.|. .....     . | ..           |       |..  
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

KNLLAVISKCLDRDPEKRPTADEILQMPYF
...   |...| .|...| . .|....| |
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 109777.m00002.AA PLK1 35-276 27 4.2e-35 112.64 In-house 2-253 (253) Show / Hide 
Range on Protein: 35-276
Range on HMM: 2-253/253
Sequence Identity: 27% (69 aa)

EFIKIIGQGGYGVIYEVHSANFNSNFAVKKIPKCFF--------SQAELDCLMRIDDPRIVRLYQIYRYNDFIYMVLEYCPTD-LYKVFSAGGKLYEEDI
|  . .|.||.   ||.. .. .  ||.| .|| ..           |..    .. . ||.... .  ....|.||| |    |  .    . . | . 
EKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPEC

YRYAHDAVLAIKSVHDKNIAHCDIKPANFFIDTYGRVKIGDFGLASFNGSSCSCKMAK-GTKLFMAPEVYCKKYTPMKSDIWSLGVTLYFLATQTYPFNA
  | .  |.... .|...| | |.|  | |..   .||||||||| .   .   |.   ||  ..||||  ||      ||||.|  .| |     || .
RYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFET

PDIEKLKQCISIGLFATDKVQNKNLLAVISKCLDRDPEKRPTADEILQMPYF
  ..   . |    .   .  ..    .| | || ||..|||....|.. .|
KCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 109777.m00002.AA TKL 40-274 18 6.4e-35 122.34 In-house 1-364 (364) Show / Hide 
Range on Protein: 40-274
Range on HMM: 1-364/364
Sequence Identity: 18% (70 aa)

IGQGGYGVIYEVHSANFN--------SNFAVKKIPKC--------------------------------FFSQAELDCLMRIDDPRIVRLYQIYRYNDF-
||.||.|..|  .  . .           ||||...                                 ||   |. .. |.. | ||... .  .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------IYMVLEYC-PTDLYKVFSAGGKLYEEDIYRYAHDAVLAIKSVHD--------KNIAHCDIKPANFFIDTYGR--------------VK
            ...| |||   .|. ..        . . | |.|. ...   |         ..|.|.|.|..| ..|  ..              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IGDFGLASFNGSSCSCKM--------------------AKGTKLFMAPEVYCKK--YTP--------------MKSDIWSLGVTLYFLATQTYPFN-APD
|.||||. |.  | . ..                      ||. .|||||  ..  ||                |.|..| |. |. ..|   |.   | 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

IEKL---------KQCI--SIGLFATDKVQN-----------KNLLAVISKCLDRDPEKRPTADEILQMP
.. .         ....  .  .   .  ||           . .   . .| | ||||||...|||.  
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 109777.m00002.AA TyrKc 34-274 22 1.5e-11 -35.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 34-274
Range on HMM: 1-280/280
Sequence Identity: 22% (63 aa)

LEFIKIIGQGGYGVIYEVHSANFNSNFAVKKIPKCFFSQA---ELDCLMRI--DDPRIVRLYQIYRYN-------DFIYMVLEYCPT-DLYKVFSAGGK-
....|..| | .|..|. .      . |||.. ..   ..   |.  ....  . | ||||| . .         . ...|.||.|  || .   . .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LYEEDIYRYAHDAVLAIKSVHDKNIAHCDIKPANFFIDTYGRVKIGDFGLASFNGSS------CSCKMAK---GTK--L---FMAPEVYCKK-YTPMKSD
|  .|   .....       |.||. | |.   |  ..  ..|||.||||. . ..        . ...|   |.|  |    ||||.  .. .|. |||
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT-KSD

IWSLGVTLYFLATQTYPFNAP------DIEKLKQCISIGLFATDKVQ---------NKNLLAVISKCLDRDPEKRPTADEILQMP
.|| ||... . |   .          . . . ...  |                  . .  ....| ..|||.|||  || .  
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 109777.m00002.AA AGC 34-49 50 0.00012 6.36 In-house 1-16 (395) Show / Hide 
Range on Protein: 34-49
Range on HMM: 1-16/395
Sequence Identity: 50% (8 aa)

LEFIKIIGQGGYGVIY
 ||.|.||.|..|  |
FEFLKVIGKGSFGKVY