Gene 93576.m00080 (T.vaginalis)
93576.m00080
Species: T.vaginalis
Alias: TvagK0237, 93576.m00080
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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93576.m00080.AA | Protein | None | 263 | None | Fasta, JSON |
93576.m00080.kin_dom | Protein Kinase Domain | None | 206 | None | Fasta, JSON |
Protein domains of 93576.m00080.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 93576.m00080.AA | Pkinase | 14-220 | 25 | 7.4e-56 | 196.69 | Pfam | 45-293 (293) | Show / Hide |
Range on Protein: 14-220 Range on HMM: 45-293/293 Sequence Identity: 25% (65 aa) NKN--EIDCMKEVDNNNIVRLYDYDYYDGSVYLMMEFCPT-----SLDKFIR--KKRVL--TREQLLKYSYGVLKSIKACHRFNVAHLDIKPANFLIDNY . . || ||... |||||||. ......|. ||.|. .| .|. ..... . ... .| | .|. .. ||. .. | |.||.|.|||| HRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN DRI----RVCDFGFSA---IHQDEHLEENCEGSVPFMPPEVILGHPHDPFKADVWAIGVTFFIMSTGKFPWEGD------DRKTLCDNLLKEPPRTELIQ . | ..||||... . .. . | |. ..|.||||.|..... |.|.|..|.....| .|..|. |. | . . .. .. |.. . . GHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPW C---------------------KDYAEVIEKCLAKDPNERPSIDELLELPLF .. ..|..||.|||..||.....|. | | WCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 93576.m00080.AA | CAMK | 15-220 | 19 | 3.1e-43 | 136.7 | In-house | 79-425 (425) | Show / Hide |
Range on Protein: 15-220 Range on HMM: 79-425/425 Sequence Identity: 19% (67 aa) KNEIDCMKE-------VDNNNIVRLYD-----------YDYY---------DGSVYLMM---EFCPTS------LDKFIRK--------------KRVLT ..||..|| .| ||..||. | | | .|. | |.|. .|. ... .. .| RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFT REQLLKYSYGVLKSIKACHRFNVAHLDIKPANFLIDNYD-----------------RIRVCDFGFSAIHQDEH-------------------------LE .. .| .. .. || |..|.|.|| | |.|. . | ..||||... .. . .. EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK ENCEGSVPFMP-PEVILG-------------HPHDPFKADVWAIGVTFFIMSTGKFPWEGD-------------DRKTLCDNLLKEPPR-TELI------ . | |. ..|. |||..| .| ...|.|.|..|| .|| .|..|..|| . . |. . .| . . TFC-GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISC --------------------QCKDYAEVIEKCLAKDPNERPSIDELLELPLF .||| | |.| .||..|..|.. |. | . NYGPEWWDDISDEFHHFVSQECKD---LIRKMLQVDPEKRMTIEQCLNHPWM |
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S_TKc | 93576.m00080.AA | S_TKc | 1-220 | 23 | 4.6e-42 | 146.97 | SMART | 17-231 (231) | Show / Hide |
Range on Protein: 1-220 Range on HMM: 17-231/231 Sequence Identity: 23% (58 aa) MIQHTT----------ENLHLKFNKNEIDCMKEVDNNNIVRLYDYDYYDGSVYLMMEFCPT---SLDKFIRKKRV------LTREQLLKYSYGVLKSIKA .|. . ..||...|. . |||.|||. . ...|. ||.|.. .| ..|.|.. .. . .| | ... .. KCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEY CHRFNVAHLDIKPANFLIDNYDRIRVCDFGFSAIHQDEHLEENCEGSVPFMPPEVILGHPHDPFKADVWAIGVTFFIMSTGKFPWEGDDRKTLCDNLLKE ||. .. | |.||.| |.|. .| .||||.... . |. .|.|||. .....|.|.|..|.....| .|. |.. . ... .... CHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-- PPRTELIQCKDYAEVIEKCLAKDPNERPSIDELLE-------LPLF .. . |.||| |||..||.. |.|. | | --------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 93576.m00080.AA | Ciliate-E2 | 11-220 | 18 | 5.5e-42 | 141.91 | In-house | 60-365 (365) | Show / Hide |
Range on Protein: 11-220 Range on HMM: 60-365/365 Sequence Identity: 18% (61 aa) LKFNKNEIDCMKEVD----------------NNNIVRLYDYDY--YDGSVYLMMEFCPT-SLDKFIR---KKR--------VLTREQLLKYSYGVLK--- ... |.||. |.|.. ..||...|.. . | ..|| ||.| .| ..|. ||| .| .. ..... .|. IEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFK ------------SIKACHRFN-VAHLDIKPANFLIDNYDRIRVCDFGFSAIHQDEHLEEN----CE----------------------------GSVPFM .. .| | . | |||| | |. | ..|||.| . .|.. .. |. |. ..| TKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYM PPEVILG--------HPHDPFKADVWAIGVTFFIMSTGKFPWEGDDRKTLCDNLLKEPPRTELIQCK----------------------DY-------AE .||.. | . . .|.|.|..||....| .||.|. . .... .. APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKD VIEK----CLAKDPNERPS-IDELLELPLF | | .| |||..|.. ....|. | | LIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 93576.m00080.AA | Ciliate-E2-Unclassified | 21-220 | 21 | 4.3e-39 | 133.26 | In-house | 71-352 (352) | Show / Hide |
Range on Protein: 21-220 Range on HMM: 71-352/352 Sequence Identity: 21% (60 aa) MKE----VDNNNIVRLYDYDYYDGSVYLMMEFCP-TSLDKFIRKK-----------------RVLTREQLL-----KYSYGVLKSIKACHRFN-VAHLDI |.. .. .||...... . .|. ||.|. .| ..|.|. . .| .| . .| . .|. .. .|. | . | || MQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDI KPANFLIDNYD---RIRVCDFGFSA-----------------IHQDEHLEENCEGSVPFM----PPEVILGHPHDP---FKADVWAIGVTFFIMSTGKFP || | |.|| .|...|||.| | ..... .| |. .| .|||. |. .| .|.|.|. || .. | .|..| KPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFC-GTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP WEGDDRKT----------------LCDNLLKEPPRTEL-----------IQCKDYAE-VIEKCLAKDPNERPSIDELLELPLF .. ... | .| .. .. ..|| . . |.| |.||.|......|. |.| FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 93576.m00080.AA | STE | 15-220 | 22 | 5.6e-38 | 131.72 | In-house | 76-359 (359) | Show / Hide |
Range on Protein: 15-220 Range on HMM: 76-359/359 Sequence Identity: 22% (66 aa) KNEIDCMKEVD--NNNIVRLYDYDYYDG-------SVYLMMEFCP-TSLDKFIR-KKRVLTR------------EQLL-KYSYGVLKS-IKACHRFNVAH ..||. ||. . |||. |.. ...| .... ||... |||..|. |. .. . |... .. . .|| . |. .. | LKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIH LDIKPANFLIDNYDRIRVCDFGFSAIHQDEHLEE-----------------NCEGSVPFMPPEVILG------HPHDPFKADVWAIGVTFFIMSTGKFPW |||||| |. . ||||.... .|.. . . |. .| ||||.. ...| .|.|.| .| | | ||| || RDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD-TKCDIWSLGCTIIEMATGKPPW -EGDDRKTLCDNLLK---------------EPPRTELIQC-------------------KDYAEVIEKCLAKDPNERPSIDELLE--LPLF .. . . . . . .||. . . .. . |.||| ||||.||. ..||. | . HDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 93576.m00080.AA | CAMKL | 15-220 | 24 | 1.1e-37 | 117.7 | In-house | 46-297 (297) | Show / Hide |
Range on Protein: 15-220 Range on HMM: 46-297/297 Sequence Identity: 24% (63 aa) KN--------------EIDCMKEVD---NNNIVRLYDYDYYDGS------VYLMMEFCPTS---LDKFIRKK----RVLTREQLLKYSYGVLKSIKACHR || || .|| .. ||..||. . . .|| || |. | .|.|. . .. .. .| .. .. ||. KNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHS FNVAHLDIKPANFLIDNYD--RIRVCDFGFSAIHQD-----EHLEENCEGSVPFMPPEVILG--HPHDPFKADVWAIGVTFFIMSTGKFPWEGDD----- ...| |||| | |.|. . | ..|||||..... ... . . || |.|.||...| |.| .|.|.|..||. . | .|..|...|. HGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQG ----RKTLCDNLLKEPPRTELIQCKDYAEVIEKCLAKDPNERPSIDELLELPLF .. . .. . . |. . | | | | ..|..||.|..... | . KDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 93576.m00080.AA | ULK | 15-220 | 24 | 2e-36 | 124.73 | In-house | 58-329 (329) | Show / Hide |
Range on Protein: 15-220 Range on HMM: 58-329/329 Sequence Identity: 24% (67 aa) KNEIDCMKEVD--------NNNIVRLYDYDYYDGS--VYLMMEFCPT-SLDKFIRKKRV----------LTREQLLKYSYGVLKSIKACHRFNVAHLDIK ||||. ||. . . |||.|||. . . . .|..||.|. |...| |.. |. .. ... . | |. | |. | ||| KNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIK PANFLIDNYD------------RIRVCDFGFSAIHQDE----HLEENCE------GSVPFMPPEVILGH----PHDPFKADVWAIGVTFFIMSTGKFP-- |.| ||.| . .. ..||||. ... .. | |. .| |... |. |.. .|.|.| .|. |. | .|| | PQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY -WEGDDRK-TLCDNLLKEPPR------TELIQ----------CKDYAEVIEKCLAKDPNERPSIDELLELPLF | | . . .|.. ||. .. .| .. . | ..| .|...| |..||.. |.| AW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | 93576.m00080.AA | ULK | 15-220 | 22 | 7.9e-36 | 124.63 | In-house | 58-324 (324) | Show / Hide |
Range on Protein: 15-220 Range on HMM: 58-324/324 Sequence Identity: 22% (62 aa) KNEIDCMKEVD------NNNIVRLYDYDYYDGS--VYLMMEFCPT-SLDKFIRKKRV---------LTREQLLKYSYGVLKSIKACHRFNVAHLDIKPAN |||| ||. . . .||.|||. . . . .|..||.|. |...| |.. |. .. ... . . |. | |. | ||||.| KNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQN FLIDNYD------------RIRVCDFGFSAI-H---QDEHLEENCE------GSVPFMPPEVILGH----PHDPFKADVWAIGVTFFIMSTGKFP---WE || | . .. ..||||. . ... . | |. .| |... |. |.. .|.|.| .|. |. | .|| | | ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW- GDDRK---------------TLCDNLLKEP-PRTELIQC-KDYAEVIEKCLAKDPNERPSIDELLELPLF | . . ... .. | |. . ... .. . | ..| .|...| |..|... |.| FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | 93576.m00080.AA | GIN4 | 17-220 | 30 | 1.3e-29 | 91.4 | In-house | 84-293 (293) | Show / Hide |
Range on Protein: 17-220 Range on HMM: 84-293/293 Sequence Identity: 30% (64 aa) EIDCMKEVDNNNIVRLYDYDYYDGSVYLMMEFCPT-SLDKFIRKKRVLTREQLLKYSYGVLKSIKACHRFNVAHLDIKPANFLIDNYDR-IRVCDFGFSA || || .. |..|||| . .||..|. | .. .. | ..| .. . || ||. | |.|| | |.|. . |.. ||| | EIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAA IHQDEHLEENCEGSVPFMPPEVILGHPHDPFKADVWAIGVTFFIMSTGKFPWEGD--DRKTLCDNLLK---EPPRTELIQCKDYAEVIEKCLAKDPNERP .. |..| | || . ||.. | | . | .|||. || | . ||. |.. . ..| | | | . | .. ..|.| | ||. | LETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEI-SREAQDLIRKILVVDPEKRI SIDELLELPLF . ..|. || KTRDILKHPLI |
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Kinase | 93576.m00080.AA | CMGC | 17-157 | 17 | 3.8e-25 | 78.79 | In-house | 71-326 (513) | Show / Hide |
Range on Protein: 17-157 Range on HMM: 71-326/513 Sequence Identity: 17% (46 aa) EIDCMKEV-----------------DNNNIVRLYDYDYYDG-----------------SVYLMMEFCPTSLDKFIRKKR---------VLTREQ------ || ..|.. . ||||.|||. |... ..|| .|.....| ..|.... |. . EIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPH ------LLKYS------YGVLKSIK--ACHRFN--VAHLDIKPANFLIDN--------------------YDRIRVCDFGFS---AIHQDEHLE------ ... | .|...| ||. . . | |.||.| ||.. .|...||||.. .|.|.| . RRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSF -------------ENCEGSVPFMPPEVILGH---------PHDPFKADVWAIGVTFF . . .||..|| | . |.|..| |. KNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFA |
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Kinase | 93576.m00080.AA | TKL | 12-218 | 17 | 5e-25 | 87.07 | In-house | 70-364 (364) | Show / Hide |
Range on Protein: 12-218 Range on HMM: 70-364/364 Sequence Identity: 17% (52 aa) KFNKNEIDCMKEVDNNNIVRLYDYDYYDGS-------------VYLMMEFC-PTS-LDKFIRKKRVLTREQLLKYSYGVLKSIKACHRFN--------VA .| ..|| .|. . |||... |. . .. .. ||.| | |. .. .|... .... . . | | .. FFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPII HLDIKPANFLIDNYDR--------------IRVCDFGFSAIHQDEH--------------------LEENCEGSVPFMPPEVILGHPHDP---------- | |.|..| |.|. . . .||||.| .. . .. |. .|.|||. |.. .. HRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCK -----FKADVWAIGVTFFIMSTGKFPWEGDDR-------------KTLCDNLLKEPPRTELIQ---------C-KDYAEVIEKCLAKDPNERPSIDELLE |.||.. |. .. . |.. |..... . ||. |. |. .. . | ..... ...| . ||..||| .|.|. GFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK LP RL |
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Kinase | 93576.m00080.AA | TyrKc | 11-218 | 18 | 4.4e-11 | -43.54 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 11-218 Range on HMM: 1-280/280 Sequence Identity: 18% (53 aa) LKFNK---------------------------------NEIDCMKEV--DNNNIVRLYDYDYYD-------GSVYLMMEFCPT-SLDKFIRKKRV-LTRE ....| .|. |... .. |||||| . . . ... ||..| .|....||.| |. . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK QLLKYSYGVLKSIKACHRFNVAHLDIKPANFLIDNYDRIRVCDFGFSAIHQDE--------HLEE----NCEGSVPF--MPPEVILGHPHDPFKA----- .||.... . . |. |. | |. | |... .....||| | . |. .. . .| |.||.| .. DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------NYGKFTTK -DVWAIGVTFF-IMSTGKFPWEG-----DDRKTLCDNLLKE--PPRTEL--------IQCKDYAEVIEKCLAKDPNERPSIDELLELP |||. ||. . |.. |. |..| . . . .. . .|. . . | ....| . ||..||. |. |. SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF |
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Pkinase_Tyr | 93576.m00080.AA | Pkinase_Tyr | 3-75 | 26 | 3e-06 | 21.72 | Pfam | 38-120 (270) | Show / Hide |
Range on Protein: 3-75 Range on HMM: 38-120/270 Sequence Identity: 26% (22 aa) QHTTENL--HLKFNKNEIDCMKEV-DNNNIVRLYDYDY-YDGS--VYLMMEFCPT-SLDKFIRK----KRVLTREQLLKYSYGV ..... . .| . |. ||. .. |||||| . ... .|. ||..| .|... || |. || ..||.... . EGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQI |
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Kinase | 93576.m00080.AA | CMGC | 197-220 | 33 | 4.5e-05 | 11.61 | In-house | 490-513 (513) | Show / Hide |
Range on Protein: 197-220 Range on HMM: 490-513/513 Sequence Identity: 33% (8 aa) IEKCLAKDPNERPSIDELLELPLF ..|.| ||..|..... |. | | LKKMLQYDPDKRITAEQALQHPYF |
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Kinase | 93576.m00080.AA | Pkinase_Tyr | 195-216 | 31 | 0.812052 | 3.39 | Pfam | 247-268 (270) | Show / Hide |
Range on Protein: 195-216 Range on HMM: 247-268/270 Sequence Identity: 31% (7 aa) EVIEKCLAKDPNERPSIDELLE ... .| ..||..||. |..| DLMKQCWHYDPEDRPTFSEIHE |