Gene 92247.m00068 (T.vaginalis)
92247.m00068
Species: T.vaginalis
Alias: TvagK0953, 92247.m00068
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 92247.m00068.AA | Protein | None | 956 | None | Fasta, JSON |
| 92247.m00068.kin_dom | Protein Kinase Domain | None | 229 | None | Fasta, JSON |
Protein domains of 92247.m00068.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 92247.m00068.AA | TKL | 239-279 | 24 | 2e-07 | 22.79 | In-house | 326-364 (364) | Show / Hide |
Range on Protein: 239-279 Range on HMM: 326-364/364 Sequence Identity: 24% (10 aa) VYSRLMYNEKNFLKRLKNLYKECTSLDPSQRPKSPQVEKML .. . |..........|.| ..| . ||..|| .. | | HH-K-MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| S_TKc | 92247.m00068.AA | S_TKc | 19-286 | 15 | 2.7e-07 | -69.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 19-286 Range on HMM: 1-231/231 Sequence Identity: 15% (45 aa) HKLRRYIIRGTHGNYFIAKDYEIKTDV-SKEVKKFLNVFFGGKTIDKDWTRKYPVTRINRVNIAEELKESFIIEFNVCAALKHTALNPVLDYVIDTRDNE .. | | .|. | . ... . . | |..| |... | ... .| . .|. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD----- KAGLFIV---YKN---SVRDYFDNYISNSVESAVNDIIMIKILLGVISALSYLHSNGIVAGDLRPGTIFLNSRMEPLLINYNLPQLYPCPLIPYEVKKSE |..| . ...|| ... .. . . ... ...|| |.||.||. || | |.|.. . .. | .. . . -DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPW YSAPELADEYKITE-KSDVFSFGVLLSKVYS--------RLMYNEKNFLKRLKNLYKECTSLDPSQRPKSPQVEK--MLFEINQQL | |||. . . |.|. |.|..| .. .|.. . .|.. . | ||..|| .. . .. . . . YMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 92247.m00068.AA | PLK2 | 154-186 | 39 | 5.4e-07 | 18.27 | In-house | 109-141 (257) | Show / Hide |
Range on Protein: 154-186 Range on HMM: 109-141/257 Sequence Identity: 39% (13 aa) LLGVISALSYLHSNGIVAGDLRPGTIFLNSRME .....| | |||. .|. || .| |.| || MRQIVSGLRYLHQQCIIHRDLKLGNFFINDNME |
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| Kinase | 92247.m00068.AA | Ciliate-A5 | 157-181 | 48 | 1e-06 | 18.94 | In-house | 108-132 (275) | Show / Hide |
Range on Protein: 157-181 Range on HMM: 108-132/275 Sequence Identity: 48% (12 aa) VISALSYLHSNGIVAGDLRPGTIFL .||...||..|.|. ||.|| .|.| LISVCMYLQQNNICHGDIRPQNICL |
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| Kinase | 92247.m00068.AA | SCY1 | 202-281 | 19 | 1e-06 | 19.09 | In-house | 216-337 (337) | Show / Hide |
Range on Protein: 202-281 Range on HMM: 216-337/337 Sequence Identity: 19% (24 aa) LIPYEVKKSEYSAPELADE-------------YKITEKSDVFSFGVLLSKVYSRLM---YNEKNF----------------------LKRLKNL----YK ..|.. .....||| . | | | .||.||.|.| .||.... . .| |.|... |. YPPPCQPNPDWLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWWDHIPKELQEHLGHCYC ECTSLDPSQRPKSPQVEKMLFE . . || .||. | . .. HLLHQDPTCRPDPQQFLQHCYF |
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| Kinase | 92247.m00068.AA | NZAK | 211-241 | 41 | 2e-06 | 16.72 | In-house | 237-267 (329) | Show / Hide |
Range on Protein: 211-241 Range on HMM: 237-267/329 Sequence Identity: 41% (13 aa) EYSAPELADEYKITEKSDVFSFGVLLSKVYS .| ||| ..|.|||||.|||.. .. . HYMAPENKNNHRINEKSDVWSFGCTVWQMFG |
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| Kinase | 92247.m00068.AA | TAK1 | 252-278 | 29 | 3e-06 | 17.14 | In-house | 258-284 (284) | Show / Hide |
Range on Protein: 252-278 Range on HMM: 258-284/284 Sequence Identity: 29% (8 aa) KRLKNLYKECTSLDPSQRPKSPQVEKM ||.....| | . .|..|| . ..| KRIEQFMKCCWDDNPEKRPSMQECVKY |
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| Kinase | 92247.m00068.AA | Pkinase_Tyr | 214-236 | 60 | 6e-06 | 20.66 | Pfam | 182-204 (270) | Show / Hide |
Range on Protein: 214-236 Range on HMM: 182-204/270 Sequence Identity: 60% (14 aa) APELADEYKITEKSDVFSFGVLL ||| ..| |.|||| |||||. APECINYGKFTTKSDVWSFGVLM |
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| Kinase | 92247.m00068.AA | MLK | 252-279 | 35 | 1.4e-05 | 15.5 | In-house | 264-291 (291) | Show / Hide |
Range on Protein: 252-279 Range on HMM: 264-291/291 Sequence Identity: 35% (10 aa) KRLKNLYKECTSLDPSQRPKSPQVEKML ...|.|.|.| . ||..||.. |. . | EHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | 92247.m00068.AA | TKL-ciliate1 | 212-236 | 33 | 1.6e-05 | 14.9 | In-house | 180-209 (279) | Show / Hide |
Range on Protein: 212-236 Range on HMM: 180-209/279 Sequence Identity: 33% (10 aa) YSAPELAD-----EYKITEKSDVFSFGVLL . ||| | | |.|| |....|... WMAPEQMDPHIFPNYPINEKIDIYAYGIVM |
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| Kinase | 92247.m00068.AA | TKL | 212-236 | 26 | 1.8e-05 | 15.65 | In-house | 239-279 (364) | Show / Hide |
Range on Protein: 212-236 Range on HMM: 239-279/364 Sequence Identity: 26% (11 aa) YSAPELAD----------------EYKITEKSDVFSFGVLL . |||. . ... .||.||.|||..| WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL |
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| Kinase | 92247.m00068.AA | TK | 214-236 | 43 | 2e-05 | 13.3 | In-house | 353-384 (486) | Show / Hide |
Range on Protein: 214-236 Range on HMM: 353-384/486 Sequence Identity: 43% (14 aa) APELAD---------EYKITEKSDVFSFGVLL ||| . . | |.||||.|||||. APECLNDRVFSEAEKYGKFTTKSDVWSFGVLM |
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| Kinase | 92247.m00068.AA | RAF | 252-279 | 42 | 0.000145 | 11.57 | In-house | 248-275 (275) | Show / Hide |
Range on Protein: 252-279 Range on HMM: 248-275/275 Sequence Identity: 42% (12 aa) KRLKNLYKECTSLDPSQRPKSPQVEKML | .|.|. || | .| || .|. ||. KEMKELLMECWSYQPEERPSFQQIMKMI |
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| Kinase | 92247.m00068.AA | MLK | 214-236 | 46 | 0.000239 | 11.14 | In-house | 201-226 (291) | Show / Hide |
Range on Protein: 214-236 Range on HMM: 201-226/291 Sequence Identity: 46% (12 aa) APEL---ADEYKITEKSDVFSFGVLL ||| . . | .||.||.|.||.| APEVIQQFRCEKYSEKCDVWSWGVVL |
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| Kinase | 92247.m00068.AA | NZAK | 151-192 | 26 | 0.000354 | 9.37 | In-house | 108-149 (329) | Show / Hide |
Range on Protein: 151-192 Range on HMM: 108-149/329 Sequence Identity: 26% (11 aa) IKILLGVISALSYLHSNGIVAGDLRPGTIFLNSRMEPLLINY ||... . .|||| .|. |... . |. . . .||.. IKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLKLIDF |
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| Kinase | 92247.m00068.AA | TKL | 150-186 | 20 | 0.002811 | 7.67 | In-house | 134-178 (364) | Show / Hide |
Range on Protein: 150-186 Range on HMM: 134-178/364 Sequence Identity: 20% (9 aa) MIKILLGVISALSYLHSNG--------IVAGDLRPGTIFLNSRME .... |.. ....||||.. |. || . |.... .. RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT |
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| Kinase | 92247.m00068.AA | TK | 257-279 | 34 | 0.00315 | 5.82 | In-house | 464-486 (486) | Show / Hide |
Range on Protein: 257-279 Range on HMM: 464-486/486 Sequence Identity: 34% (8 aa) LYKECTSLDPSQRPKSPQVEKML | ..| ..||..|| |. ..| LMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | 92247.m00068.AA | RAF | 151-183 | 33 | 0.004001 | 6.57 | In-house | 103-135 (275) | Show / Hide |
Range on Protein: 151-183 Range on HMM: 103-135/275 Sequence Identity: 33% (11 aa) IKILLGVISALSYLHSNGIVAGDLRPGTIFLNS |.| .. . .|||. .|. .||. ||| . IQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHN |
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| Kinase | 92247.m00068.AA | TAK1 | 224-236 | 30 | 0.015375 | 4.28 | In-house | 203-215 (284) | Show / Hide |
Range on Protein: 224-236 Range on HMM: 203-215/284 Sequence Identity: 30% (4 aa) TEKSDVFSFGVLL ..|.|..|.|. . NMKCDIYSWGIIM |
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| Kinase | 92247.m00068.AA | TKL-ciliate1 | 254-279 | 26 | 0.024073 | 3.83 | In-house | 254-279 (279) | Show / Hide |
Range on Protein: 254-279 Range on HMM: 254-279/279 Sequence Identity: 26% (7 aa) LKNLYKECTSLDPSQRPKSPQVEKML . || . | . .| .||.. .. | FHNLMMRCWCQNPNKRPNFNEIIQIL |
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| Kinase | 92247.m00068.AA | RAF | 214-236 | 22 | 0.064009 | 2.39 | In-house | 173-207 (275) | Show / Hide |
Range on Protein: 214-236 Range on HMM: 173-207/275 Sequence Identity: 22% (8 aa) APELADEYKI------------TEKSDVFSFGVLL |||.. . .. ...|||..||. . APEVIRMMRPDWDEYQCDCNPFSFQSDVYAFGTVW |
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| Kinase | 92247.m00068.AA | NZAK | 254-278 | 37 | 0.071707 | 1.49 | In-house | 303-329 (329) | Show / Hide |
Range on Protein: 254-278 Range on HMM: 303-329/329 Sequence Identity: 37% (10 aa) LKNLYKECTSLDPSQRPK--SPQVEKM .|.. . | || .||| | .||. MKDFITQCWDIDPKKRPKDFSHMIEKL |
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| Ank | 92247.m00068.AA | Ank | 694-727 | 23 | 0.385807 | 8.37 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 694-727 Range on HMM: 1-33/33 Sequence Identity: 23% (8 aa) FGKTLFHAAVENGDYLFLRLLLSISNIKPFKRDS | | | |...|.. ...||. . . .| DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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| Ank | 92247.m00068.AA | Ank | 728-740 | 38 | 10.069502 | 3.26 | Pfam | 1-13 (33) | Show / Hide |
Range on Protein: 728-740 Range on HMM: 1-13/33 Sequence Identity: 38% (5 aa) WGRNSLHWAAIYG |. ||.|...| DGFTPLHLACRCG |
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| Ank | 92247.m00068.AA | Ank | 858-891 | 41 | 6.2e-08 | 32.87 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 858-891 Range on HMM: 1-33/33 Sequence Identity: 41% (14 aa) YGMTPLHYAAENGGLNVMKVLFSKIGLDPNLKDE .|.||||.|...|...|.| | . | |.|..| DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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| Ank | 92247.m00068.AA | Ank | 892-925 | 23 | 7.2e-05 | 21.82 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 892-925 Range on HMM: 1-33/33 Sequence Identity: 23% (8 aa) KGRTPLHICAKNDDADCFTFLLKSGKVKPEIEDN |.||||. ........ ..||. . . |. DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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