Gene 92207.m00089 (T.vaginalis)
92207.m00089
Species: T.vaginalis
Alias: 92207.m00089, TvagK0847
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 92207.m00089.AA | Protein | None | 806 | None | Fasta, JSON |
| 92207.m00089.kin_dom | Protein Kinase Domain | None | 308 | None | Fasta, JSON |
Protein domains of 92207.m00089.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3K_C2 | 92207.m00089.AA | PI3K_C2 | 131-254 | 16 | 1.9e-14 | 54.28 | Pfam | 1-168 (168) | Show / Hide |
Range on Protein: 131-254 Range on HMM: 1-168/168 Sequence Identity: 16% (28 aa) SARAYIIRAAIY--HGSNELGAPTMTKPSLGGT-----SVSWNEVLILT-TQIQLIPRSARVAITLYNYEKIGTKE---------GAVATINIPVFNF-D . .......| || . |. |. .... .. ...||| .... |.. .||.|| ||.... .| ... |.| |.. . PYMDFYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEK GWVNSGVNFCSM-WNGKDTDPMLTT---------------------CQCEDEDATR---IL-FEIPQY . ..| .| | .|...|| .| ..| .. | .. . ... CMLRCGMHKLHMTWPSKPPCPMFPTHTPWKVPRHWRDEMNRLEKLLKKHEWGQMQRNPRCDWLDFLTF |
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| PI3K_C2 | 92207.m00089.AA | PI3K_C2 | 97-209 | 20 | 3.8e-07 | 31.0 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 97-209 Range on HMM: 1-133/133 Sequence Identity: 20% (27 aa) VKPCFAQIGGFPHL----LSKEYFSIIINGCFNIPKELSARAYIIRAAIYHG-SNELGAPTMTKP----SLGGTS-----VSWNEVLIL-TTQIQLIPRS ||.| .. . .| ....| |.. .. | | .......||| . ...| |.. .... . ||| |.. |.. .||. VKICSLWCCNRPFVFLPHEITIYCIHDIMLNWSQDYESSCVDLYVECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTFFPIQYCDLPRM ARVAITLYNYE--KIGTKEGA---VATINIPVF || .||.. . ... ... |.. | | ARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF |
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| PI3Ka | 92207.m00089.AA | PI3Ka | 294-460 | 34 | 1.1e-47 | 165.62 | Pfam | 21-211 (211) | Show / Hide |
Range on Protein: 294-460 Range on HMM: 21-211/211 Sequence Identity: 34% (65 aa) DPLKKLSCEDKNLIYKHRHDLY-DMTSMLP------LVLS-SIDYTIPTQVNEVSILLQR--WDRLSPKEALTLLDSEFAD--YRVRTYAVEILES-FSD ||| .|. |.|.||.|.||... || |. .. . ..||... |... |. ..| .|| |||..|.| || |||..||| .|| DPLSQLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSD DEIMLYMLQLVQALKNE----MYDYSPLCRFLFRRGLNEPKFLGHKLFWQLMSEA------HISHI-RRRFSSFVVNFLYGSGIYREELIT ||. .|.|||||||| | .. |.| |||..|.. . .|| .|| . || |.... ||.. .... | ....|.. DELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK |
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| PI3Ka | 92207.m00089.AA | PI3Ka | 276-460 | 29 | 1.1e-43 | 152.33 | SMART | 1-232 (232) | Show / Hide |
Range on Protein: 276-460 Range on HMM: 1-232/232 Sequence Identity: 29% (68 aa) RISTQQ--RISIENLKKRVF--DPLKKLSCEDKNLIYKHRHDLY-DMTSMLP-----LVLSSIDYTIPTQVNEVSILLQRW--DRLSPKEALTLLDSEFA . .... . .... .|...|. |.|.||.|.||.. . || .|.... . ...|... |...| . ..| .|| |||..|. DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP D---YRVRTYAVEILESFSDDEIMLYMLQLVQALKNE--------------------------MYDYSPLCRFLFRRGLNEPKFLGHKLFWQLMSEA--- | || |||..||..||||. .| |||||||| | | |||||||..| | | .|| ..|.| || DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDH ---HISHIRRRFSSFVVNFLYGS-GIYREELIT | .|. .|| . ...|. | . ..|. CQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK |
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| PI3Kc | 92207.m00089.AA | PI3Kc | 544-805 | 28 | 6.7e-80 | 272.66 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 544-805
Range on HMM: 1-336/336
Sequence Identity: 28% (95 aa)
RVLFKVGDDLRQDQLTLQVMSVMEHLWRQA----GMDFHMRCYGVLPTGFNQGFIEVVPNAITEQALQ--------------------------------
.|.||.|||||||....|. ..| ..|.. ..|.||| |...||| . |.||.|||. | .|
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
-----------------------QEKGTFAGVWNVSLFSDYLCKVNTTEQ-NQMLARENFMYSSAGYAVATCVLGIADRHPGNIMLQ-SDGHFLHIDFGH
. . ... .. . |.. . .... . ||.|| .| ||| ..| .||| |||..|||| .|| .||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
FLGNFKTKLGYQ---RENAPYHFSPACVNVLG--DVNGEMFKKYRQLCGDALNVLRKNSNLLVTLLILMLGTGI-PELQQA-EDIRYMTDMLFLN-KTDS
..|....|.|.. || .| . . |.| | ... ..|...|..| |....||.|||...|. .|....| |... .||.| . ..|. ..|
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EAKIEFDR-----LTDLSIDSKRTKLNNLFHNIAVS
|| |.. | |..|. |.....|||.|
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | 92207.m00089.AA | PI3_PI4_kinase | 542-756 | 23 | 6.3e-55 | 193.59 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 542-756 Range on HMM: 1-300/300 Sequence Identity: 23% (70 aa) PIRVLFKVGDDLR--QDQLTLQVM-----------------------SVMEHLWRQAGMDFH----MRCYGVLPTGFNQGFIEVVPNAITEQALQQEKGT ....||.||||| ||....| ..| .|.. |.|. |. | ..||| . |.||.|||. | . .. .... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV FAG-VWNV----------------------------------SLFSDYLCKVNTTE-QNQMLARENFMYSSAGYAVATCVLGIADRHPGNIML---QSDG . .. . ... | |... . ||.|| .| ||..|.. .||..|||..|||. ..| KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG HFLHIDFGHFLGNFKTKLGYQRENAPYHFSP------ACVNVLGD----VNGEMFKKYRQLCGDALNVLRKNSNLLVTLL-------ILMLGTGIPELQQ | ||||||.....|.| . .| |... . |...|. . ... ..|..| .|...||...||...|| .|. .|.|.. HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | 92207.m00089.AA | FRAP | 640-681 | 51 | 6e-08 | 25.44 | In-house | 137-179 (251) | Show / Hide |
Range on Protein: 640-681 Range on HMM: 137-179/251 Sequence Identity: 51% (22 aa) RENFMYSSAGYAVATCVLGIADRHPGNIMLQ-SDGHFLHIDFG | |. | | .| .||. |||| ||||| | .||||| RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | 92207.m00089.AA | ATR | 620-746 | 18 | 2e-06 | 17.79 | In-house | 144-267 (267) | Show / Hide |
Range on Protein: 620-746 Range on HMM: 144-267/267 Sequence Identity: 18% (24 aa) SLFSDYLCKVNTTEQNQMLARENFMYSSAGYAVATCVLGIADRHPGNIMLQS-DGHFLHIDFGHFLGNFKTKLGYQRENAPYHFSPACVNVLGDVNGEMF ..| |. . |. .|||.. | | ... ..|. ||| ||.... | |.|. . .. | |. |. .| . . PIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQF--EVPEIVPFRLTHNMVFGMGPMKTYGL KKYRQLCGDALNVLRKNSNLLVTLLILM .|. | . . ..|.. . .. .. --FRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | 92207.m00089.AA | PIKK | 639-682 | 44 | 1.3e-05 | 16.84 | In-house | 185-229 (290) | Show / Hide |
Range on Protein: 639-682 Range on HMM: 185-229/290 Sequence Identity: 44% (20 aa) ARENFMYSSAGYAVATCVLGIADRHPGNIMLQSD-GHFLHIDFGH .|||. | | .. .||. |||| |||.... | .|||||. RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | 92207.m00089.AA | PIKK | 546-602 | 34 | 0.000998 | 9.88 | In-house | 34-94 (290) | Show / Hide |
Range on Protein: 546-602 Range on HMM: 34-94/290 Sequence Identity: 34% (21 aa) LFKVGDDLRQDQLTLQVMSVMEHLWRQA----GMDFHMRCYGVLPTGFNQGFIEVVPNAIT |.| ..|||||| ..|. ..| . .. ..|.| | | | . . | || |.|. | LCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVT |
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