Gene 82578.m00512 (T.vaginalis)
82578.m00512
Species: T.vaginalis
Alias: TvagK0869, 82578.m00512
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 82578.m00512.AA | Protein | None | 905 | None | Fasta, JSON |
| 82578.m00512.kin_dom | Protein Kinase Domain | None | 225 | None | Fasta, JSON |
Protein domains of 82578.m00512.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 82578.m00512.AA | TKL | 189-277 | 19 | 2.5e-14 | 48.0 | In-house | 241-364 (364) | Show / Hide |
Range on Protein: 189-277 Range on HMM: 241-364/364 Sequence Identity: 19% (24 aa) PPELLSGN--------------FKKITPESDIYAFGILTFRFICKKIVFNQVDVS---------LSFSQNIIQGKRFMIP----------QFSYT--FLR .||.| |. ... .. .|.|.|||. . .. .... . . . . |.... |.| || . ... .. APEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMK EIVENCWVQDPNKRPSMADVYKKL .. . || .||.||||. .. |.| KLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | 82578.m00512.AA | Fer | 234-278 | 31 | 2.4e-11 | 35.03 | In-house | 237-283 (283) | Show / Hide |
Range on Protein: 234-278 Range on HMM: 237-283/283 Sequence Identity: 31% (15 aa) QNIIQ-GKRFMIPQFSYTFLREIVE-NCWVQDPNKRPSMADVYKKLK ..||. |.. .|. .....|.. .||..||..||.|.....||| KWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| S_TKc | 82578.m00512.AA | S_TKc | 25-285 | 16 | 3.7e-11 | -13.23 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-285 Range on HMM: 1-231/231 Sequence Identity: 16% (47 aa) LRMIDVLKE-------KSTNNEFIAITHTKFGIKDSRKKSFFERVNAMACLHHPAVCTLYGYFLPDNAEKKCPTLLFKNAKR--GCLGYYIDKSRLRSTK ...... . | .... |. .. || . ... .. . ||| ...||..| .. . . . | | ||.| . . .. YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR SYLEPPKILKILLGVASALKYLHSQGFVCGDLQPTSIFLNENYEPLLYPI------LSTHNAYRKLNVATFDMATDLISPPELLSGNFKKITP-ESDIYA ... . . ... ...||.|.||.|.. || | |.|.| | |... | | .||.| . .. ..|... FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--------TTFCGTPWYMAPEVL-----GYGKCKCDWWS FGILTFRFICKKIVFNQVDVSLSFSQNIIQGKRFMIPQFSYTFLREIVENCWVQDPNKRPSMADVYK-KLKQDCPIFL .|.. . ..| . | . ..| | .. ....|.. ||.|||. .. . .. | .. CGCILYEMLCGYPPFP----QMQMMFKKIG---------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 82578.m00512.AA | TKL | 51-159 | 17 | 1.8e-10 | 33.9 | In-house | 63-178 (364) | Show / Hide |
Range on Protein: 51-159 Range on HMM: 63-178/364 Sequence Identity: 17% (22 aa) KDSRKKSFFERVNAMACLH--HPAVCTLYG-YFLPDNAE--------KKCPTLLFKNAKRGC-LGYYIDKSRLRSTKSYLEPPKILKILLGVASALKYLH ..... |||.. .| .. || .. ..| . |.. . .. . . ...|. | |.. ....... |..|... ||| PEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLH SQG--------FVCGDLQPTSIFLNENYE |.. . || . |...||.. SMNPKWCTKPPIIHRDLKSKNILVDENWT |
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| Kinase | 82578.m00512.AA | Pkinase | 189-277 | 13 | 5.3e-09 | 32.91 | Pfam | 179-293 (293) | Show / Hide |
Range on Protein: 189-277 Range on HMM: 179-293/293 Sequence Identity: 13% (16 aa) PPELLSGNFKKITPESDIYAFGILTFRFICKKIVFNQV------DVSLSFSQNIIQGKRFMIPQFSY-------------------TFLREIVENCWVQD .||.. ....|..|....|.. . ..|.. | . | . .. .| .|. . .......|. .| APEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD PNKRPSMADVYKK--L |.|||. ... . . PKKRPTAEQILQHPWF |
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| Kinase | 82578.m00512.AA | RIPK | 189-277 | 23 | 1.5e-08 | 25.2 | In-house | 190-290 (290) | Show / Hide |
Range on Protein: 189-277 Range on HMM: 190-290/290 Sequence Identity: 23% (24 aa) PPELLSGNFKKI----TPESDIYAFGILTFRFICKKIVFNQVDVSLSFSQNIIQGKRFMIPQFSYTFLR--------EIVENCWVQDPNKRPSMADVYKK |||.. . || ||..|.| |.|... .| .. . .. . . ||.| .. . . . | . || ||||.||. .. . PPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEW L T |
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| TyrKc | 82578.m00512.AA | TyrKc | 22-277 | 16 | 2.1e-08 | -86.69 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 22-277
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)
LSELRMID----------VLKEKSTNNEFIAITHTKFGIKDSRKKSFFERVNAMACL--HHPAVCTLYGYFLPD-----NAEKKCPTLLFKNAKRGCLGY
.. .... ..| . |. | . .. | . . | | ||| . |||. . . .| . ... .. |.|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM--IVMEYMPHGDLKD
YIDKSRLRSTKSYLEPPKILKILLGVASALKYLHSQGFVCGDLQPTSIFLNENYEPLLYPILSTHNAY---------RKLNVA--------TFDMAT--D
|. |.| . | ... |.. . .|. ||||.... || . ..||. |.. . .... .
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG
LI-------SPPELLSGNFKKITPESDIYAFGILTFRFICKKIVFNQV-----DVSLSFSQNIIQGKRFMIPQF--------SYTFLREIVENCWVQDPN
.|| . |..| |..||...||.. . ... ||.| ..|. . . .| . || ||.
GKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE
KRPSMADVYKKL
.||.........
DRPTFSEIHECF
|
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| Kinase | 82578.m00512.AA | LRRK | 203-279 | 25 | 3.5e-08 | 25.01 | In-house | 262-351 (351) | Show / Hide |
Range on Protein: 203-279 Range on HMM: 262-351/351 Sequence Identity: 25% (23 aa) ESDIYAFGILTFRFICKK-IVFNQVD-V-----SLSFSQNIIQGKRFMIPQF-SYT-----FLREIVENCWVQDPNKRPSMADVYKKLKQ ..|.|.||.. . . . . | . | . ....|| | | ||| . . . . || .||.|||.. .. |.|.| KVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | 82578.m00512.AA | Dicty4-Unclassified | 251-277 | 40 | 6.4e-08 | 23.18 | In-house | 237-263 (263) | Show / Hide |
Range on Protein: 251-277 Range on HMM: 237-263/263 Sequence Identity: 40% (11 aa) FLREIVENCWVQDPNKRPSMADVYKKL |.. . || ||||||.| .. ..| FWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | 82578.m00512.AA | TKL-Unique | 239-277 | 30 | 8.9e-08 | 23.69 | In-house | 252-290 (290) | Show / Hide |
Range on Protein: 239-277 Range on HMM: 252-290/290 Sequence Identity: 30% (12 aa) GKRFMIPQFSYTFLREIVENCWVQDPNKRPSMADVYKKL ..| .||. .|.. . || .|| .||| .....| NYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | 82578.m00512.AA | TK | 250-277 | 25 | 8.5e-07 | 17.99 | In-house | 459-486 (486) | Show / Hide |
Range on Protein: 250-277 Range on HMM: 459-486/486 Sequence Identity: 25% (7 aa) TFLREIVENCWVQDPNKRPSMADVYKKL ... .. || ||..||........| EEYYDLMQQCWHYDPEDRPTFSQLHEQL |
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| Kinase | 82578.m00512.AA | UTK | 254-277 | 29 | 2e-06 | 18.18 | In-house | 273-296 (296) | Show / Hide |
Range on Protein: 254-277 Range on HMM: 273-296/296 Sequence Identity: 29% (7 aa) EIVENCWVQDPNKRPSMADVYKKL ... || .|| .||.. |..... RLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | 82578.m00512.AA | TKL-Unique | 188-211 | 45 | 7e-06 | 16.87 | In-house | 193-216 (290) | Show / Hide |
Range on Protein: 188-211 Range on HMM: 193-216/290 Sequence Identity: 45% (11 aa) SPPELLSGNFKKITPESDIYAFGI ..||.|..||.... ||.|.||| MAPEVLRMNFCQYSEKSDVYSFGI |
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| Kinase | 82578.m00512.AA | Dicty5 | 205-281 | 24 | 2.3e-05 | 14.43 | In-house | 185-260 (260) | Show / Hide |
Range on Protein: 205-281 Range on HMM: 185-260/260 Sequence Identity: 24% (19 aa) DIYAFGILTFRFICKKIVFNQVDVSLSFSQNIIQGKRFMIPQFSYTFLREIVENCWVQDPNKRPSMADVYKKLKQDC |.|.||| . . .| . . . . . | | || | ... ||.| | .||| . | ... DVYSFGIVLWEMFTRKEPYDNI-NNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII |
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| Kinase | 82578.m00512.AA | TK-Unique | 232-277 | 23 | 6e-05 | 13.13 | In-house | 248-294 (294) | Show / Hide |
Range on Protein: 232-277 Range on HMM: 248-294/294 Sequence Identity: 23% (11 aa) FSQNIIQGKRFMIPQFS-YTFLREIVENCWVQDPNKRPSMADVYKKL . ..| .|.| |. . . .... ..|| .| .||| ... ..| IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | 82578.m00512.AA | TK | 108-147 | 10 | 6.6e-05 | 11.55 | In-house | 147-266 (486) | Show / Hide |
Range on Protein: 108-147 Range on HMM: 147-266/486 Sequence Identity: 10% (13 aa) KSRLRSTKSY---------------------------------------------------------------------------LEPPKILKILLGVAS .. ||. . . | .. | . . .|. RDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIAC ALKYLHSQ------GFVCGDL .. ||||. .|| .|| GMEYLHSKNCEFIQNFVHRDL |
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| Kinase | 82578.m00512.AA | Pkinase_Tyr | 232-277 | 23 | 0.00064 | 13.9 | Pfam | 224-270 (270) | Show / Hide |
Range on Protein: 232-277 Range on HMM: 224-270/270 Sequence Identity: 23% (11 aa) FSQNI-IQGKRFMIPQFSYTFLREIVENCWVQDPNKRPSMADVYKKL . . | .| | .|. . .. || .||..||...... .| VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | 82578.m00512.AA | Dicty5 | 121-159 | 23 | 0.000985 | 8.72 | In-house | 104-142 (260) | Show / Hide |
Range on Protein: 121-159 Range on HMM: 104-142/260 Sequence Identity: 23% (9 aa) PKILKILLGVASALKYLHSQGFVCGDLQPTSIFLNENYE . .| . ...| ....||| . . || . ..||.. FQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWK |
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| Kinase | 82578.m00512.AA | TK | 189-212 | 32 | 0.001728 | 6.71 | In-house | 353-383 (486) | Show / Hide |
Range on Protein: 189-212 Range on HMM: 353-383/486 Sequence Identity: 32% (10 aa) PPELLSGN-------FKKITPESDIYAFGIL .|| | .. ..| |..||...||.| APECLNDRVFSEAEKYGKFTTKSDVWSFGVL |
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| Kinase | 82578.m00512.AA | UTK | 130-148 | 52 | 0.003278 | 6.84 | In-house | 127-145 (296) | Show / Hide |
Range on Protein: 130-148 Range on HMM: 127-145/296 Sequence Identity: 52% (10 aa) VASALKYLHSQGFVCGDLQ .|... ||||.||| .||. IARGMQYLHSCGFVHRDLA |
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| Kinase | 82578.m00512.AA | TK-Unique | 115-147 | 22 | 0.003705 | 6.88 | In-house | 125-159 (294) | Show / Hide |
Range on Protein: 115-147 Range on HMM: 125-159/294 Sequence Identity: 22% (8 aa) KSYLEPPKILKILLGVASALKYLHS--QGFVCGDL .... | . .. ..|....||.| ...| .|| TEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDL |
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| Kinase | 82578.m00512.AA | LRRK | 123-140 | 50 | 0.006736 | 6.07 | In-house | 166-183 (351) | Show / Hide |
Range on Protein: 123-140 Range on HMM: 166-183/351 Sequence Identity: 50% (9 aa) ILKILLGVASALKYLHSQ .||| | .|....||||. KLKIALQIAKGMEYLHSH |
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| Kinase | 82578.m00512.AA | TK-Unique | 189-212 | 36 | 0.015275 | 4.73 | In-house | 204-228 (294) | Show / Hide |
Range on Protein: 189-212 Range on HMM: 204-228/294 Sequence Identity: 36% (9 aa) PPELLSGNFKKI-TPESDIYAFGIL .|| |. . . |..||...||.| APESLKCYHGMYHTTKSDVWSFGVL |
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| Kinase | 82578.m00512.AA | Fer | 201-212 | 33 | 0.018362 | 4.33 | In-house | 196-207 (283) | Show / Hide |
Range on Protein: 201-212 Range on HMM: 196-207/283 Sequence Identity: 33% (4 aa) TPESDIYAFGIL .|..|...||.. SPKTDVWSFGVM |
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| Kinase | 82578.m00512.AA | TKL-Unique | 122-158 | 18 | 0.018908 | 4.67 | In-house | 111-154 (290) | Show / Hide |
Range on Protein: 122-158 Range on HMM: 111-154/290 Sequence Identity: 18% (8 aa) KILKILLGVASALKYLHSQG--FVCGDLQPTSIFLNEN-----Y ...|. . .|... |||. . .|| .... ...| . QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEW |
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| Kinase | 82578.m00512.AA | Pkinase_Tyr | 108-143 | 23 | 0.025164 | 8.5 | Pfam | 95-133 (270) | Show / Hide |
Range on Protein: 108-143 Range on HMM: 95-133/270 Sequence Identity: 23% (9 aa) KSRLRST---KSYLEPPKILKILLGVASALKYLHSQGFV .. ||. | | .. .|.. . .|... ||.|.... LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCI |
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| Kinase | 82578.m00512.AA | Pkinase | 118-143 | 17 | 0.025741 | 9.27 | Pfam | 103-130 (293) | Show / Hide |
Range on Protein: 118-143 Range on HMM: 103-130/293 Sequence Identity: 17% (5 aa) L--EPPKILKILLGVASALKYLHSQGFV . .. . .... ....|.|.||.|.. FYFSEWECKFYMYQILRGLEYCHSMGII |
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| Kinase | 82578.m00512.AA | Fer | 108-141 | 22 | 0.037227 | 3.27 | In-house | 97-131 (283) | Show / Hide |
Range on Protein: 108-141 Range on HMM: 97-131/283 Sequence Identity: 22% (8 aa) KSRLRSTKS-YLEPPKILKILLGVASALKYLHSQG .|.|. .|. . .........|. ..||||.. DSYLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKN |
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| Kinase | 82578.m00512.AA | Dicty4-Unclassified | 123-147 | 28 | 0.069301 | 2.2 | In-house | 111-135 (263) | Show / Hide |
Range on Protein: 123-147 Range on HMM: 111-135/263 Sequence Identity: 28% (7 aa) ILKILLGVASALKYLHSQGFVCGDL |.|. . .| . .||. |. |. IIKYAFDIAQGMQHLHTRNFIHRDI |
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| Ank | 82578.m00512.AA | Ank | 733-754 | 40 | 0.044874 | 11.74 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 733-754 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) FEKTALHSACENGCLEVLAVLI |.|| ||..|..||. |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | 82578.m00512.AA | Ank | 767-800 | 38 | 8.3e-08 | 32.41 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 767-800 Range on HMM: 1-33/33 Sequence Identity: 38% (13 aa) FGQTPLHIAIEHGRNDCAKKLIRSQNIDLNSKDD |.||||.|...|. ...| |. .. |.| .|| DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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| Ank | 82578.m00512.AA | Ank | 801-834 | 38 | 4.9e-05 | 22.43 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 801-834 Range on HMM: 1-33/33 Sequence Identity: 38% (13 aa) DGFSPLFYAINQKNIETVDLLLNDERCDINLQSN |||.|| .|. ..| | .||. .|.|.| . DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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| Ank | 82578.m00512.AA | Ank | 835-868 | 26 | 0.000708 | 18.24 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 835-868 Range on HMM: 1-33/33 Sequence Identity: 26% (9 aa) KGYTALHWSAKHGNDEITIKLLSRKDINTEIADN |.|.||. ...|. |. ||. . . . |. DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD |
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