Gene 95912.m00243 (T.vaginalis)
95912.m00243
Species: T.vaginalis
Alias: TvagK0122, 95912.m00243
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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95912.m00243.AA | Protein | None | 404 | None | Fasta, JSON |
95912.m00243.kin_dom | Protein Kinase Domain | None | 247 | None | Fasta, JSON |
Protein domains of 95912.m00243.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 95912.m00243.AA | AGC | 41-261 | 20 | 3.3e-64 | 163.92 | In-house | 45-395 (395) | Show / Hide |
Range on Protein: 41-261 Range on HMM: 45-395/395 Sequence Identity: 20% (73 aa) VCLKIDEKRKAETE----------NEFRMMKLLN----------HPLTCQ-FYGEFKSGDN--VGAVLEFIE---------GS-TILDFIN---KNGVIK |..| .. ... || .| ......| || .. . |.. |. . |.|... | . . |.|. VIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFD ENYARYLFAE-------LVSIIQHLHCELGMIHQD-LKCENIIIDTHNNLHLIDFGFAHLDSDNL----------------------------------- |. ||. .|| .|. ...|| ..| || | || ||| .| . ...| |||.. .. EERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQ ---------------PLSYSGFG--TPGYIPPEVIKGNRYTFSSDIFS--IGVLLYSMLVGRLPFSGTNSA----------EIFHHTV------TDPVNY . .. | || |..||.. |... |. | |.|.| ||.|. ||.| | |.|. ...| . RNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKF P----------ETISDDVIDLLDSLLDKDPIKRPN----------ISQILLHNWL | . .|.. ||. || ||| ||. ...| | | PFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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S_TKc | 95912.m00243.AA | S_TKc | 15-261 | 26 | 8.8e-63 | 215.81 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-261 Range on HMM: 1-231/231 Sequence Identity: 26% (70 aa) IVVLGKIARGGYASIWNAYCVEMKTHVCLKIDEKRKAETENEFRMMKLLNHPLTCQFYGEFKSGDNVGAVLEFIEG--STILDFINKNGV------IKEN .| || .|.... . .. .. . .| .|| ...| ...| .|| ...|. | . |.. |.|...| . .|.| |.| . | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE- YARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNLHLIDFGFAHLDSDNLPLSYSGFGTPGYIPPEVIKGNRYTF-SSDIFSIGVLLYSMLVGRL ||........ ....| | || ||| ||| .|. .. ..|||.| . .. ||| |..|||. |.. ..|. |.|..|| ||.|. HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP PFSGTNSAEIFHHTVTDPVNYPETISDDVIDLLDSLLDKDPIKRPNISQILL-------HNWL ||. . ...|.. . |....|... .|.||| ||| . ..| | |. PFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 95912.m00243.AA | CAMK | 20-261 | 19 | 1.7e-59 | 190.04 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 20-261 Range on HMM: 1-425/425 Sequence Identity: 19% (82 aa) KIARGGYASIWNAYCVEMK------------THVCLKI--------------------------------DEKRKAETENEFRMMKL-------LNHPLT .. ||... .. . . ..| || ..| ... ..| ..||. |.|| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI CQFYGEFK------------SGDN--------VGAVL---EFIEGS----TILDFINKN---------------GVIKENYARYLFAELVSIIQHLHCEL ...| . . .. . |. |...| ..|.| .. | ..| ||..| ..| ....| IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN GMIHQDLKCENIIIDTH-----------------NNLHLIDFGFA--HLDSDNLP---------------------LSYSGFGTPGYIP-PEVIKGNR-- .| |||.||| .|.. ||. .|||||| ...|. . . .|||.|.. |||..|.. -IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC ------------YTFSSDIFSIGVLLYSMLVGRLPFSGT-------------NSAEIFHHTVTDPVN-YPET---------------ISDD--------V |....|. |.||.|| ||.|..|| | | |.|. . . .|. |||. . NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC IDLLDSLLDKDPIKRPNISQILLHNWL .||. ..| .|| ||..|.|.| | |. KDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | 95912.m00243.AA | Ciliate-E2 | 15-261 | 19 | 7.8e-57 | 193.62 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 15-261 Range on HMM: 1-365/365 Sequence Identity: 19% (73 aa) IVVLGKIARGGYASIWNAYC------------------------VEMKTHVCLKIDEKRKAETENEFRMMK----------------LLNHPLTCQFYGE . .. || .|...|.. . | .| . .. . ....| ..|. .|||| ...| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FK--SGDNVGAVLEFIEGSTILDFINKN-----------GVIKENYARYLFAELVS---------------IIQHLHCELGMIHQDLKCENIIIDTHNNL |. . .|. |.|...| . .|.|..| . ..|. ..|....... ...|| . || |.| |||.. . FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I HLIDFGFA-HLDSD---------NLPLSYSG----------------------FGTPGYIPPEVIK---------GNRYTFSSDIFSIGVLLYSMLVGRL .||||.. .| | . . . . ||||| .||... ...|....||.|.||.|| || |.. KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PFSGTNSAEIFHHTVTD-PVNYP------------------ETISDDVIDLLDS----LLDKDPIKRPN-ISQILLHNWL || . ....| . .|....||. .|.||| ||.. ..||| | |. PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Pkinase | 95912.m00243.AA | Pkinase | 15-261 | 26 | 1.1e-56 | 199.47 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 15-261 Range on HMM: 1-293/293 Sequence Identity: 26% (79 aa) IVVLGKIARGGYASIWNAYCVEMKTHVCLKIDEKRKAETEN--------EFRMMKLLNHPLTCQFYGEFKSGDNVGAVLEFIEGS----TILDFIN--KN .....|| .|.... . .. . |..|| .||... . | ..|| |||| ...|. | ..|.. |.|. || |.| .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GVI--KENYARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNL----HLIDFGFAHLD-SDNLPLSYSGFGTPGYIPPEVIK-GNRYTFSSDIFS |.. |. .. . .... ....| | || ||| ||| || .... ...|||.| . | . .. |||.|..||||. |. |. ..|..| GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS IGVLLYSMLVGRLPFSGT------NSAEIFHHTVTDPVNYPETIS---------------------DDVIDLLDSLLDKDPIKRPNISQILLHNWL .|..|| || ||.||.| . ... . |. ... . .. .|.....|.||| |||.. ||| | |. CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 95912.m00243.AA | Ciliate-E2-Unclassified | 15-261 | 20 | 1.7e-51 | 176.9 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 15-261 Range on HMM: 1-352/352 Sequence Identity: 20% (71 aa) IVVLGKIARGGYASIWNAYCVE------MKTHVCLKIDEKRKAET----------ENEFR-------------MMKLLNHPLTCQFYGEFKSGDNVGAVL .. .| .||..... ... . ||. .|. ... .. .|. .. ..||. .. .|.. .|. |. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM EFIEGSTILDFINKNGV-----------------IKENYAR-----YLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHN---NLHLIDFGFA-HLDSD |..|| . ...|.|.. . |. |. ..||.... ...|| ... || |.|.|||..| . .. .||||.. ..... EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN NL--------------PLSYSGFGTPGYI----PPEVIKGNRYT----FSSDIFSIGVLLYSMLVGRLPFSGTNSAE---------------IFHHTV-T | .... |||.|. .|||..|. | ...||.| ||.|| || |..||...|. . ... NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ DPVNYPE--------TISDDVIDLLD----SLLDKDPIKRPNISQILLHNWL ....|. ..|. ..|.. ..|.|.| ||....||| | |. KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 95912.m00243.AA | CAMKL | 47-261 | 28 | 8.2e-51 | 160.31 | In-house | 54-297 (297) | Show / Hide |
Range on Protein: 47-261 Range on HMM: 54-297/297 Sequence Identity: 28% (71 aa) EKRKAETENEFRMMKLLN---HPLTCQFYGEFKSGDN------VGAVLEFIEGST--ILDFINKN----GVIKENYARYLFAELVSIIQHLHCELGMIHQ |... . | . ||.|| || ...| . .. . |.| ..| .|.| |. | ..|. || .| .|| ....| .| ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHR DLKCENIIIDTHN--NLHLIDFGFA--HLD--SDNLPLSYSGFGTPGYIPPEVIKG--NRYT-FSSDIFSIGVLLYSMLVGRLPFSGT--------NSAE |.| ||| .| .. |. .|||||. . . . . |.| | .||...| .| . || |.||.|| |..|.||| . | . DIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-Y IFHHTVTDPVNYP--ETISDDVIDLLDSLLDKDPIKRPNISQILLHNWL .. . .. ..| .| |..||. ..| ..| |||.| ||. | |. LYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 95912.m00243.AA | RSK | 44-261 | 27 | 2.2e-44 | 153.76 | In-house | 36-278 (278) | Show / Hide |
Range on Protein: 44-261 Range on HMM: 36-278/278 Sequence Identity: 27% (67 aa) KIDEKRK--AETENEFRMMKLLN-HPLTCQFYGEFKSGDNVGAVLEFIEGSTILDFINKNGV---IKENYARYLFAELVSIIQHLHCELGMIHQDLKCEN ||. . | . | | . ... . || .. . |. .. . ..|...| .. . | . . |. |.. .||.|. ..||| ..| || ||| || KIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLH-QQGIIHRDLKPEN IIIDT---HNNLHLIDFGFAHL-DSDNLPLSYSGFGTPGYIPPEVIK---GNR-YTFSSDIFSIGVLLYSMLVGRLPFSG---TNSAEIFHHTVTDP--V |. | . . |.||||. . . |. . .. .| |..||..| ... .. . |..| |||.| ||.|..|| | |..||. . . ILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSL NYP--ETISDDVIDLLDSLLDKDPIKRPN-----ISQILLHNWL . | ...|.. ||. .| .|| ||.. ...|. | |. TMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | 95912.m00243.AA | Ciliate-E2b | 55-261 | 26 | 5.8e-43 | 128.47 | In-house | 49-272 (272) | Show / Hide |
Range on Protein: 55-261 Range on HMM: 49-272/272 Sequence Identity: 26% (60 aa) NEFRMMKLLNHPLTCQFYGEFKSGDNVGAVLEFIEGSTILDFINKNG--VIKENYARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNLHLIDFG .| .. .||| .|. ||. ... ..||. | ..| | | . .. .. .|... ... || ... |. |.| |||..| . |||.| QEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLH-NQNIIYRDIKPENIMVDHKGYMKLIDMG FA-HLDSDNLPL--SYSGFGTPGYIPPEVIK-----GNRYTFSSDIFSIGVLLYSMLVGRLPFS--GTNSAEIFHHTVTD--PVNYPETISDDVI--DLL | |... | . .. ||| | ||.|. | ||...||.|.|. || ...|..|. . || . ....| ..| . .| TAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLM DSLLDKDPIKRP--NISQILLHNWL ...| | | |. .|. .| | LQCLQKMPEVRLGGSYSWLKSHPWF |
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Kinase | 95912.m00243.AA | MARK | 84-261 | 31 | 3.5e-41 | 132.48 | In-house | 80-262 (262) | Show / Hide |
Range on Protein: 84-261 Range on HMM: 80-262/262 Sequence Identity: 31% (59 aa) VLEFIEGSTILDFINKN--GVIKENYARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHN--NLHLIDFGFAHLD-SDNLPLSYSGF-GTPGYIPPE ..| ..| .|.| . | ..|. || .| .|| .. .| .| |.|.||| || .. | .|||||. .... . | ||| | .|| IMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKN-IVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK---LNTFCGTPPYMAPE VIKGNRYT-FSSDIFSIGVLLYSMLVGRLPFSGTN--SAEIFHHTVTDPVNYPETISDDVIDLLDSLLDKDPIKRPNISQILLHNWL .... .|. . || | ||.|| |..|..|| |.. |.. .. .| .|.. .|. .|| .| .|| |..|. | |. IFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | 95912.m00243.AA | MELK | 16-261 | 29 | 2.8e-38 | 128.25 | In-house | 2-254 (254) | Show / Hide |
Range on Protein: 16-261 Range on HMM: 2-254/254 Sequence Identity: 29% (76 aa) VVLGKIARGGYASIWNAYCVEMKTHVCLKIDEKRK-----AETENEFRMMKLLNHPLTCQFYGEFKSGDNVGAVLEFIEGSTILDFINKNGVIKENYARY | .| ||.| . | . .| .|| .|.. . | .| | | ||.| | . |.|. | ..|.| .. ..|. .| EVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRH LFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNLHLIDFGFAHLDSDNLPLS--YSGFGTPGYIPPEVIKGNRYTFS-SDIFSIGVLLYSMLVGRLPF .| ..|| | ..| . | |.||| ||...| . .| |||||. . | | | ||.|.| .| | |..|.|.||| ...| ||| FFRQIVSAIAYVHSQ-GYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPF SGTNSAEIFHHTVTDPVNYPETISDDVIDLLDSLLDKDPIKRPNISQILLHNWL | ... . . |. .| ..|| .| || || . ..| |.|. DDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
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Kinase | 95912.m00243.AA | Delta | 64-261 | 31 | 7.9e-38 | 131.99 | In-house | 58-259 (259) | Show / Hide |
Range on Protein: 64-261 Range on HMM: 58-259/259 Sequence Identity: 31% (64 aa) NHPLTCQFYGEFKSGDNVGAVLEFIEGSTILDFINKNGVIKENYARYLFAELVSIIQHLHCELGMIHQDLKCENIIIDTHNNLHLIDFGFAHLDSDNLPL .|| |... |.. ... |.|.. | .. | . . .|. ||. .|... .| || . |.| ||| .|...| ... ||| . . EHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEKRARFYACEIICGLQFLHKK-GIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKK SYSGFGTPGYIPPEVIKGNRYTFSSDIFSIGVLLYSMLVGRLPFSGTNSAEIFHHTVTDPVNYPETISDDVIDLLDSLLDKDPIKRPNI-----SQILLH . . ||| || ||.|||..|..| | .| |||.| ||.| ||.| . |.|. . | || .|. . |.| |...|| || . .| | ASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPFHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQH NWL . CFF |
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Kinase | 95912.m00243.AA | TyrKc | 15-261 | 18 | 2.6e-10 | -56.02 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 15-261 Range on HMM: 1-280/280 Sequence Identity: 18% (55 aa) IVVLGKIARGGYASIWNAYCVEMKTHV---CLKIDEKRKAETENEFRMMKLL--NHPLTCQFYGEFKSG-------DNVGAVLEFIEGSTILDFINKNGV |. . |. .| . .. . . | .|| | ... .| |.|. | .|| ..|| .. . . |.|. .. .|.. |.. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP IKENYARYLFAELVSII-------QHLHCELGMIHQDLKCENIIIDTHNNLHLIDFGFAHLDSDN-----LPLSYSG-F--GTPG-----YIPPEVIKGN ..|.|. ..|| . || || . |. .. . ||| . | |. |. . .||.|. . K------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG RYTFSSDIFSIGVLLYSML-VGRLPFSG-----TNSAEIFHHTVTDPVNYPETI---------SDDVIDLLDSLLDKDPIKRPNISQILLHNWL ..|. ||..| ||... .. | | .| . .|.... . . .|.. .. . . || .||. |.| | . KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |