Gene 83260.m00086 (T.vaginalis)

83260.m00086

Species: T.vaginalis
Alias: 83260.m00086, TvagK0990
External Links:
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
83260.m00086.AA Protein None 343 None Fasta, JSON
83260.m00086.kin_dom Protein Kinase Domain None 277 None Fasta, JSON

Protein domain

Protein domains of 83260.m00086.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc 83260.m00086.AA S_TKc 32-308 22 5.3e-45 156.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 32-308
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

ITNDSIFSCGQYGKAFILRHRSFENKMCVKLIGFRKENPSHDDIEREFNIQIQFKHPNIVPIVNSLDLPNNGTNKDILGYVCFIMPYYPL--KDLYYYLL
 .   .   | .|| .  ||..   .. .| |         ..|.|| .|  . .||||| .  . .           ......| | .    ||. |. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDLFDYIK

DQPN----HIIQIKEVQCIGKQILEALIYMNGVGYFHNDLKLENVLIKKENGFTVAALCDFGFTQLIRDDKDILYYDNGRGTLLYNAPEKHRGDNKYNY-
...     . .   ..... .||..|| |.   |  | ||| ||.|. .     .  .||||.  ..         .   ||. | |||      .|.. 
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKC

LADNWSFGIILYMMAYGKYPFYDPPDVYKSLQYHILITRSNIQYPDNPDNIDEFNNLKDLLEGLLKLNPNERITLEAARD-------HPFF
 .| ||.|.||| |..|. ||.        . ....                    .||.....|. .|..|.|   |         ||.|
KCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase 83260.m00086.AA Pkinase 41-308 25 2.2e-37 133.27 Pfam 10-293 (293) Show / Hide 
Range on Protein: 41-308
Range on HMM: 10-293/293
Sequence Identity: 25% (77 aa)

GQYGKAFILRHRSFENKMCVKLIGFRKENPSHDDIER---EFNIQIQFKHPNIVPIVNSLDLPNNGTNKDILGYVCFIMPYYPLK----DLYYYLLDQPN
| .|. .. .|.. . . .|| |  |.|... | . |   |  |   ..||||| .  .             ......|.| .      ||. |.  . .
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------KDHIYMVMEYCEGGLYVMDLFDYISTWRH

HII--QIKEVQCIGKQILEALIYMNGVGYFHNDLKLENVLIKKENGFT----VAALCDFGFTQLIRDDKDILYYDNGRGTLLYNAPEKHRGDNKYNYLAD
  .  . .|.... .|||..| |.   |  | |||.||.||. .|| .       .||||.  ...       ..   ||. | ||| .||...| . .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVK--ICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

NWSFGIILYMMAYGKYPFYDP---PDVYKSLQYHILITRSNIQYP-DNPDNIDEF---------------NNLKDLLEGLLKLNPNERITLEAARDHPFF
 ||.|.||| |. |. ||..    .. .  .| . .| .  . .. .....|  |                ..||.....|...|..|.| | .  ||.|
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 83260.m00086.AA Ciliate-E2 111-308 23 3.4e-37 125.22 In-house 108-365 (365) Show / Hide 
Range on Protein: 111-308
Range on HMM: 108-365/365
Sequence Identity: 23% (66 aa)

YVCFIMPYYPLKDLYYYLLDQ---PNHIIQ------IKEVQCIGKQILE---------------ALIYMNGVG-YFHNDLKLENVLIKKENGFTVAALCD
.. ..| |.  .||..|. ..    ||.|.      .||.. | ||||.               || |.   .  .| |.|.||.|.          ..|
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIID

FGFTQLIRDDKD--------ILYYDNG----------------------RGTLLYNAPEKHRGDNK--------YNYLADNWSFGIILYMMAYGKYPFYD
||. . . || .         .| . .                       ||. | ||| ..| .         |.| .| ||.|.|||.| .||.||  
FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--

PPDVYKSLQYHILITRSNIQYPDNPDNIDEFNNLK---------------DLLEG----LLKLNPNERIT-LEAARDHPFF
           . |   .|..| .  . | .. ..               ||.      .|. .|..|||  | . .||.|
----------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 83260.m00086.AA CAMK 66-308 17 3.4e-34 107.05 In-house 59-425 (425) Show / Hide 
Range on Protein: 66-308
Range on HMM: 59-425/425
Sequence Identity: 17% (66 aa)

RKENPSH----------DDIEREFNIQIQ-------FKHPNIVPIVNSLDLPNNGTNKDILG-----------YVCFIM---PYYPLK----DLYYYLLD
.|....|          . ..|| .|  .        .||||. .    . |... | .. .           .....|    | .      ||. |. .
DKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTND-YETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVE

QPN-------------HIIQIKEVQCIGKQILEALIYMNGVGYFHNDLKLENVLIKKENGFT--------------VAALCDFGFTQLIRDDK-------
...             . .. .|.. . .||..|. |.   .  | |||.||.|. . |. .                 ..|||| . .....       
HGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSD

---------------DILYYDNGRGTLLYNA-PEKHRG-------------DNKYNYLADNWSFGIILYMMAYGKYPFYDPP--DVYKSL--------QY
               . ....   ||. | | ||  .|                |.. .| || |.|||.|  |..|||..   . .. .        . 
YKGGEMHNQWTTPTEGQKMKTF-CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-DEWIGMNDYEL

HILITRSNIQYPDNPDN------IDEFNN-------------LKDLLEGLLKLNPNERITLEAARDHPFF
.  |.. . ..|. .         .|. .              |||. ..|. .|..|.|.| . .||..
FEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 83260.m00086.AA ULK 139-308 28 1.7e-31 109.01 In-house 126-324 (324) Show / Hide 
Range on Protein: 139-308
Range on HMM: 126-324/324
Sequence Identity: 28% (57 aa)

KEVQCIGKQILEALIYMNGVGYFHNDLKLENVLIKKENGFT---------VAALCDFGFTQLIRDD----KDILYYD---NGRGTLLYNAPEKHRGD--N
.|.. . |||.... ...  .. | |.|..| ||.. .. |         |. ..|||| . . ..     .. ..      .|| || ||.   |   .
QEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQ

KYNY-L-ADNWSFGIILYMMAYGKYPFYDP-PDVY----KSLQY----HILITRSNIQYPDNPDNIDEF-NNLKDLLEGLLKLNPNERITLEAARDHPFF
|  |   .| ||.|.|.| | ||||||. .  | |    | ..      |.|   .||.|..| ... . ...|||. ..|. ....||. |   .||.|
KPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 83260.m00086.AA CAMKL 66-308 25 2.7e-30 93.77 In-house 51-297 (297) Show / Hide 
Range on Protein: 66-308
Range on HMM: 51-297/297
Sequence Identity: 25% (65 aa)

RKENPSHDD-IEREFNIQIQFK---HPNIVPIVNSLDLPNNGTNKDILGYVCFIMPYYPLKD--LYYYLLDQPNHI--IQIKEVQCIGKQILEALIYMNG
.|   . |. |.|| .|. ...   ||||. .   .. |..  ...  .... .| | .  .  |. |.  ....   .. .| . . .||..|. |.  
QKH--ESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEH--DIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHS

VGYFHNDLKLENVLIKKENGFTVAALCDFGFTQLIRD--DKDILYYDNGRGTLLYNAPEKHRG-DNKYN-YLADNWSFGIILYMMAYGKYPFYDPPDVYK
 |  | |.|.||.|. . .   .. ..||||  ..|.  ...    .   |.. | |||   |   .|. . .| || |.|||.| .|..|| |...  |
HGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K

----SLQYHILITRSNIQYPDNPDNI-DEFNNLKDLLEGLLKLNPNERITLEAARDHPFF
       |  .....   ||. .  . |    ..||. ..|. ||..|.|..  . ||..
QGKDNI-YLYWKIMCG-YYPPIWYHVSD----CRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 83260.m00086.AA Ciliate-E2-Unclassified 111-308 24 4.7e-28 94.41 In-house 95-352 (352) Show / Hide 
Range on Protein: 111-308
Range on HMM: 95-352/352
Sequence Identity: 24% (64 aa)

YVCFIMPYYPLKDLYYYLLDQPN---------------HIIQIKEVQ-----CIGKQILEAL-IYMNGVGYFHNDLKLENVLIKKENGFTVAALCDFGFT
.....| | . .|| .|. ....               .|.. ....      . .|||..|  .    .  | |.|.||.|......     ..|||. 
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

QLIRDD----------KDILYYDNG---RGTLLYN----APEKHRGDNKYN---YLADNWSFGIILYMMAYGKYPFYDPPDVY------------KSLQY
  . ..          ..|.....     ||. |     |||  .| | ..   | .| ||.|.||| | .|.|||||. .                .|.
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

HILITRSNIQYPDNP-----DNIDEFNNLKDLLE----GLLKLNPNERITLEAARDHPFF
.  |   |||.|  |     .....  . ||...     .|| |||.|||.| .  ||.|
YQNIKQKNIQFPKFPWQQIPKHWSP--EAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 83260.m00086.AA ULK 139-308 28 1.1e-27 93.83 In-house 130-329 (329) Show / Hide 
Range on Protein: 139-308
Range on HMM: 130-329/329
Sequence Identity: 28% (58 aa)

KEVQCIGKQILEALIYMNGVGYFHNDLKLENVLIKKENGFT---------VAALCDFGFTQLIRDD---KDILYYDN----GRGTLLYNAPEKHRGD--N
.|.. . ||||... ...  .. | |.|..|.||.. .. |         |. ..|||| . . .|   ......       .|| || ||.   |   .
QEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQ

KYNY-L-ADNWSFGIILYMMAYGKYPFYDP-PDVY-----KSLQYHI----LITRSNIQYPD--NPDNIDEFNNLKDLLEGLLKLNPNERITLEAARDHP
|  |   .| ||.|.|.| | |||.||| .  | |     | ...      .|   ..|.|.  | ..| .  ..|||. ..|. ....||. |   .||
KPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP--ECKDLIRRMLQYDEKDRISWEELFNHP

FF
.|
WF
Kinase 83260.m00086.AA AGC 111-308 18 3.3e-27 66.03 In-house 107-395 (395) Show / Hide 
Range on Protein: 111-308
Range on HMM: 107-395/395
Sequence Identity: 18% (55 aa)

YVCFIMPYYP--------LKD--LYYYLLDQ-PNHIIQIKEVQCIGKQ-------ILEALIYMNG-VGYFHND-LKLENVLIKKENGFTVAALCDFGF-T
|..|.| |.|          .  |...| ..  . .   .... .  .       |. || |.    |. | | ||.||.|. ..       |.|||. .
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLCK

QLIRDD-----------------------------KDILYYDNG------------------RG--TLLYNAPEKHRGDNKYNYLADNWS--FGIILYMM
....|.                             .     .|.                   |  |  | |||       |.. .| ||  .|...| |
EGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEM

AYGKYPFYDPP------------DVYKSLQYHILITRSNIQYP-----DNPDNIDEFNNLKDLLEGLLKLNPNERIT----------LEAARDHPFF
 .|. |||. .            ..... ......   ....|     . |..    ...|||...||. .|..|..           |  ..||.|
LTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 83260.m00086.AA STE 41-308 19 2.1e-19 65.24 In-house 10-359 (359) Show / Hide 
Range on Protein: 41-308
Range on HMM: 10-359/359
Sequence Identity: 19% (69 aa)

GQYGKAFILRHR------SFENK---------MCVKLIGFRKEN----------------PSHDDIEREFNIQIQFK--HPNIVPIVNS-LDLPNNGTNK
| .|. .  ...      .  ..         | .| . ....|                  ...|..| .|  ...  |||||    . ..  .|   .
GAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN---H

DILGYVCFIMPYYP---LKDLYY--YLLDQPNHIIQ-----IKEVQC--IGKQILEA-LIYMNGVGYFHNDLKLENVLIKKENGFTVAALCDFGFTQLIR
.  .... .| | .   | |..   |   .|... .     ..| |   | .|||.. | |    .. | |.|  |.|.        . |||||.   . 
KNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLT

DDKDIL--------------YYDNGRGTLLYNAPEKHRG-----DNKYNYLADNWSFGIILYMMAYGKYPFYDPPDVYKSLQYHILITRSN---------
|. . .                .   ||  . |||  ..     |..|.. .| ||.|. .  || ||.|. | .. .  ..  . .  ..         
DSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVN

IQYPDNPDNIDEF-----------------NNLKDLLEGLLKLNPNERITLEAARD--HPFF
 . |  ||....                   ..|| ..  |. .||.| | .      |||.
GPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 83260.m00086.AA CMGC 283-308 50 2.1e-10 29.48 In-house 488-513 (513) Show / Hide 
Range on Protein: 283-308
Range on HMM: 488-513/513
Sequence Identity: 50% (13 aa)

DLLEGLLKLNPNERITLEAARDHPFF
|||...|...|..||| | | .||.|
DLLKKMLQYDPDKRITAEQALQHPYF
Kinase 83260.m00086.AA CMGC 69-188 16 4e-10 28.5 In-house 48-250 (513) Show / Hide 
Range on Protein: 69-188
Range on HMM: 48-250/513
Sequence Identity: 16% (34 aa)

NPSHDDIE---------------REFNIQIQFK-----------------HPNIVPIVNSLDLPNNGTNKDI--------LGYVCFIMPYYPLKDLYYYL
||  ....               ||  |  ...                 |.||| . ...  .|. .| .         . ...... | . .||| |.
NPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMD-HDLYQYI

LDQP--------------------------NHIIQIKEVQCIGKQILEALI--YMNGVG--YFHNDLKLENVLIKKENGF-----------------TVA
 ...                             . |  .. . .|||..|   |.   .   .| ||| ||.|| ...                    . 
KNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRL

ALCDFGF
 .||||.
KICDFGL
TyrKc 83260.m00086.AA TyrKc 32-308 20 1.2e-09 -66.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 32-308
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

ITNDSIFSCGQYG---KAFILRHRSFENKMCVKLIGFRKENPSHDDIEREFNIQIQF--KHPNIVPIVNSLDLP--NNGTNKDIL---GYVCFIMPYYPL
|| . .  .|..|   |.          .  || .   ||.  . |. || .|  ..  .||||| ..     .  |           . .. .| | |.
ITLGKKLGEGAFGEVYKGTWK------IQVAVKML---KEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------FMYIEPLMIVMEYMPH

KDLYYYLLDQPNHIIQIKEVQCIGKQILEALIYMNGVGYFHNDLKLENVLIKKENGFTVAALCDFGFTQLIRDD-----KDILYYD----NGR--GTLLY
 ||  || .  .. .. |.   .  || .   |    .. | ||   |.|.....   ..  .||| .  | ||      .  |      .|.    .  
GDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

NAPEKHRGDNKYNYLADNWSFGIILY-MMAYGKYPFYD-------PPDVYKSLQYHILITRSNIQYPDNPDNI---DEFNNLKDLLEGLLKLNPNERITL
 |||    ..|..   | ||||. .. .. ||. | ..       . .|.. ..      .    |   |  .        . .. .   . .|..| | 
MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P--MSFVCCPDEMYQIMKQCWHEDPEDRPTF

EAARDHPFF
..   | .|
SEI--HECF
Kinase 83260.m00086.AA CAMKL-Unclassified 206-245 39 3.4e-08 23.88 In-house 172-212 (290) Show / Hide 
Range on Protein: 206-245
Range on HMM: 172-212/290
Sequence Identity: 39% (16 aa)

GTLLYNAPEKHRGDNKY-NYLADNWSFGIILYMMAYGKYPF
|.|.| |||   .  |   |  | |..|..|||.  .  ||
GSLRYMAPEMKNQQVKQIQYSIDIWAMGVMLYMCIVQFFPF
Kinase 83260.m00086.AA CAMKL-Unclassified 140-187 39 1e-06 18.56 In-house 108-155 (290) Show / Hide 
Range on Protein: 140-187
Range on HMM: 108-155/290
Sequence Identity: 39% (19 aa)

EVQCIGKQILEALIYMNGVGYFHNDLKLENVLIKKENGFTVAALCDFG
|.| . .|| .|. |.      | ||||||||. .  .  |    |||
EIQQYFQQIVDAMQYCHKNCIIHRDLKLENVLLRQQDSSPVIKIFDFG
Kinase 83260.m00086.AA CAMKL-Unclassified 280-308 29 3e-06 17.21 In-house 257-290 (290) Show / Hide 
Range on Protein: 280-308
Range on HMM: 257-290/290
Sequence Identity: 29% (10 aa)

NLKD-----LLEGLLKLNPNERITLEAARDHPFF
. ||     |.|  .  ||  |.|.   . ||..
ECKDQRLISLIENIFQVNPKNRFTTHQIMQHPWM