Gene 94502.m00072 (T.vaginalis)
94502.m00072
Species: T.vaginalis
Alias: 94502.m00072, TvagK0245
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
94502.m00072.AA | Protein | None | 322 | None | Fasta, JSON |
94502.m00072.kin_dom | Protein Kinase Domain | None | 244 | None | Fasta, JSON |
Protein domains of 94502.m00072.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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S_TKc | 94502.m00072.AA | S_TKc | 14-257 | 25 | 3.7e-70 | 240.29 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 14-257 Range on HMM: 1-231/231 Sequence Identity: 25% (66 aa) IQVLEKIASGGNGEIFIVFSHQYFSQFILKKIRENIFNEAEIECMMRCSDPSIVALYKYYKFGGYIYLLMELCKC---DLEKYIKTTQN------ISEKD ..|.|| .|. |. . . . .. .|.|. . . ||..... | || || .. ...|. ||.| || .||| . ..| . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H TANLIKSLILAVKACHDHNIAHCDIKPSNFLIDNYQRVKIADFGLSSIFGQNKTSNICVGTIYFMAPEVIRRQAHDSLAADIWALGVTIYFIATGKYPFY .. ... ...|.. ||.|.| |.|.||.| |.|. ..||.||||. .. . ..|| ..|||||. .. ..|.|..|...| ..|. ||. ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP SAVPDELIAQIFQGQYSTACIADSKLVQLIAACLSPDPQSRPTVNQLLQ-------MDYI .... .. .. . ..| || ||. |||. ..|| . .. ---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 94502.m00072.AA | CAMK | 52-257 | 20 | 2.8e-60 | 192.61 | In-house | 79-425 (425) | Show / Hide |
Range on Protein: 52-257 Range on HMM: 79-425/425 Sequence Identity: 20% (70 aa) EAEIECMMRCS-------DPSIVALYKYYK------------FGGY--------IYLLM---ELCKC-----DLEKYIKTTQN---------------IS . |||.|.... | |. || .| . . .|. | |.| || ||. . .. RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFT EKDTANLIKSLILAVKACHDHNIAHCDIKPSNFLIDNYQ-----------------RVKIADFGLSSIFGQ------------------------NKTSN |.... ... .. ||. ||.|||.|.|.|| | |.|. .||.|||.. .| . .. . EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK ICVGTIYFMA-PEVIRR-------------QAHDSLAADIWALGVTIYFIATGKYPFYSA-------------VPDELIAQIFQGQYS-TAC-------- ..|| ..|| |||... . .. ..|.|..|| |. .|..|||. . || .| .|.|. TFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCN --------IADS-------KLVQLIAACLSPDPQSRPTVNQLLQMDYI | |. .|| .| .||. |.|. | |. . YGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Pkinase | 94502.m00072.AA | Pkinase | 14-257 | 25 | 2.7e-58 | 204.79 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 14-257 Range on HMM: 1-293/293 Sequence Identity: 25% (76 aa) IQVLEKIASGGNGEIFIVFSHQYFSQFILKKIRENIFNE---------AEIECMMRCSDPSIVALYKYYKFGGYIYLLMELCKC-----DLEKYIK--TT .....|| ||. |. .. . . .. .|.|. .. .||. | |.. | || || .. ...||. ||.| . || ||. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH QNI--SEKDTANLIKSLILAVKACHDHNIAHCDIKPSNFLID-NYQR---VKIADFGLSSI--FGQNKTSNICVGTIYFMAPEVIRRQAHDSLAADIWAL .. ||.. . .. .. ... ||...| |.|.||.|.||| |.. |||.||||. | . .||...||||||| . ... ..|.|.. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GVTIYFIATGKYPFYSA------VPDELIAQIFQGQYSTACIAD---------------------SKLVQLIAACLSPDPQSRPTVNQLLQMDYI |...| ..|. ||... ....|..| ..... . . . . ..| || .||..||| |.|| ... GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 94502.m00072.AA | CAMKL | 41-257 | 23 | 2.3e-53 | 168.58 | In-house | 32-297 (297) | Show / Hide |
Range on Protein: 41-257 Range on HMM: 32-297/297 Sequence Identity: 23% (63 aa) ILK--KIRENIFNEA---------------EIECMMRCS---DPSIVALYKYYKFGGY------IYLLMELCKCD---LEKYIKTTQN----ISEKDTAN |.. ||... .... ||..|.. . | |. || . . ||| ||.| | ||. . ..|... IIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARR LIKSLILAVKACHDHNIAHCDIKPSNFLIDNYQ--RVKIADFGLSSIFG-Q----NKTSNICVGTIYFMAPEVIRR--QAHDSLAADIWALGVTIYFIAT . . .. ||. ||.|.|.| |||| | |.|. . .||.|||.| .. . ... ... |. .||||.. . . .| ..|||..||. |.. . YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVC GKYPFY----------SAVPDELIAQIFQGQYSTACIADSKLVQLIAACLSPDPQSRPTVNQLLQMDYI |..|| ... . ... . . . .|| | ..| |||. |... GYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 94502.m00072.AA | Ciliate-E2-Unclassified | 14-257 | 21 | 1e-48 | 167.08 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 14-257 Range on HMM: 1-352/352 Sequence Identity: 21% (76 aa) IQVLEKIASGGNGEIFIV---------------FSHQYFSQFILKKIRENIFNEAEIECMM----R----------CSDPSIVALYKYYKFG--GYIYLL ....| .||.|... . ...| .. |..|. | .... |..... | . |... ....| | .||. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV MELCK-CDLEKYIKTT-----------------QNISEKDTA-----NLIKSLILAVKACHDHN-IAHCDIKPSNFLIDNYQ---RVKIADFGLSSIFGQ ||.|. ||..||| . ..|. .. .... .... . .| | | | ||||.| |.|| . ..||.|||.|. .| MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ N----------------KTSNICVGTIYFM----APEVIRRQAHDS---LAADIWALGVTIYFIATGKYPFYSAVPDE----------------LIAQIF | . .. ..||...| ||||...| .| ..|||.||| .|.. .|.||||. .. |. .|. NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK QGQYSTACIAD-------SKLV-----QLIAACLSPDPQSRPTVNQLLQMDYI |.... . |. . .|. .| .| .|.| .|.|. .. QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 94502.m00072.AA | Ciliate-E2 | 14-257 | 18 | 8.7e-47 | 158.63 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 14-257 Range on HMM: 1-365/365 Sequence Identity: 18% (72 aa) IQVLEKIASGGNGEIFIV--------------------------FSHQYFSQFILKKIRENIFNEAEIEC---------------MMRCSDPSIVALYKY . ...|| .|. | .. . . ... |.|| .... . .. . . . | |. .| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YK--FGGYIYLLMELCKC-DLEKYIK------------TTQNISEKDTANLIKSLIL---------------AVKACHDHN-IAHCDIKPSNFLIDNYQR .. .||| ||.|. ||..||| ....|| ....| .. |.. .| | | | ||||.| |. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- VKIADFGLSSIFGQNKTSNI--------------------------------CVGTIYFMAPEVIRRQA--------HDSLAADIWALGVTIYFIATGKY .||.||||| .. .. .. ..|| ..||||..... . . ..|||.|||..|. .||. IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PFYSAVPDELIAQIFQGQYSTACI------------------ADSKLVQLIAA----CLSPDPQSRPT-VNQLLQMDYI || . || |.... | . . .|| .| ||. |.| .|.|. .. PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 94502.m00072.AA | MARK | 79-257 | 33 | 2e-41 | 133.28 | In-house | 77-262 (262) | Show / Hide |
Range on Protein: 79-257 Range on HMM: 77-262/262 Sequence Identity: 33% (63 aa) IYLLMELC-KCDLEKYIKTT--QNISEKDTANLIKSLILAVKACHDHNIAHCDIKPSNFLIDNYQ--RVKIADFGLSSIFGQNKTSNICVGTIYFMAPEV ||| ||.. . .| ||| ..|... . . .. ||. ||..||.|.|||| | ||| .||.|||.| .. .. |.. || .||||. IYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEI IRRQAHDSLAADIWALGVTIYFIATGKYPFYSAV--PDELIAQIFQGQYSTACIADSKLVQLIAACLSPDPQSRPTVNQLLQMDYI . .. | ..|||.||| ||. .|..|| . || .| |.|. | .. .|| | ..| |||. .... . FLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | 94502.m00072.AA | STE | 14-257 | 21 | 8.5e-41 | 141.8 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 14-257 Range on HMM: 1-359/359 Sequence Identity: 21% (77 aa) IQVLEKIASGGNGEIFIVFSHQ---------------YFSQFILKKIR----------------------ENIFNEAEIECMMRCS--DPSIVALYKYYK . .||| .|. |. . | . |... | . ||. |..|. | || | .| WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF FGG-------YIYLLMELCKC-DLEKYIK---TTQN-----------ISEKDTANLIKSLILA-VKACHDHNIAHCDIKPSNFLIDNYQRVKIADFGLSS .| .... ||.. |.. || ... ..|. | ..... . . |.|.| | ||||.| |. ||..|||... KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG IFGQN-----------------KTSNICVGTIYFMAPEVIRRQAHDSL------AADIWALGVTIYFIATGKYPFYS-AVPDELIAQIFQ---GQ----- .. .. . .| .||| .||||||... .. .||| || || ||||.|. . . . .| .| QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL ----YSTACIAD----------------------SKLVQLIAACLSPDPQSRPTVNQLLQ--MDYI . | ... . |. || ||. |||..|||. | CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI |
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Kinase | 94502.m00072.AA | CAMK-Unique | 78-257 | 23 | 1.3e-39 | 128.25 | In-house | 109-363 (363) | Show / Hide |
Range on Protein: 78-257 Range on HMM: 109-363/363 Sequence Identity: 23% (59 aa) YIYLLMELCKCD-LEKYIKT--------------------TQNISE--KDTANLIKSLILAVKACHDHNIAHCDIKPSNFLIDNY--------------- |.|..||.| . | ..| . || ||.... .| ||. |. .| | |.|. | .. . YMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWS -QRVKIADFGLSSIFGQNKTSN---ICVGTIYFMAP--------------EVIRRQAHDSLAA---DIWALGVTIYFIATGKYPFYSAVPD--------E ..|..||||. . .|| . . .||...||| ||| .| |. |||.|||. |. ..|. ||.... | | NWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKE LIAQIFQGQY---STACIADS-----KLVQLIAACLSPDPQSRPTVNQLLQMDYI ... | .|.| .. .. . ... |. || .| . ..||. ..| IFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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Kinase | 94502.m00072.AA | CMGC | 14-194 | 16 | 3.5e-36 | 115.73 | In-house | 1-326 (513) | Show / Hide |
Range on Protein: 14-194 Range on HMM: 1-326/513 Sequence Identity: 16% (53 aa) IQVLEKIASGGNGEIFIVFS--------------HQYFSQFILKKIRENIFNE-----------------AEIECMMRCS-----------------DPS ....|| .| |. . . |.. . .|||... .| ||..... . .. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IVALYKYYKFGG-----------------YIYLLMELCKCDLEKYIKTTQ---------NISEKD------------TANLI------KSLILAVK--AC || || .... . ..|| .|.. .|| .||| .| . || ... . .. ..| | IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HDHN--IAHCDIKPSNFLIDNYQRV--------------------KIADFGLSSIFGQN----------------------KTSNICVGTIYFMAPEVIR | |. | |.|.||.| ||.. .. ||.||||. ..... .. | | . |||.. HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL RQ---------AHDSLAADIWALGVTIY . | . . |.|..| .. GWKHYTNHNYSMHYTTPIDMWSVGCIFA |
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Kinase | 94502.m00072.AA | ULK | 66-257 | 26 | 8.6e-36 | 124.49 | In-house | 77-324 (324) | Show / Hide |
Range on Protein: 66-257 Range on HMM: 77-324/324 Sequence Identity: 26% (65 aa) IVALYKYYKFG--GYIYLLMELCKC-DLEKYIKTTQN---------ISEKDTANLIKSLILAVKACHDHNIAHCDIKPSNFLIDNYQ------------R || ||.... .||. ||.| . |||.|||. .. .||. . . .| .. . |. |.||| |.||||.| || | | . IVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGV VKIADFGLSSIFGQN-KTSNIC---V------GTIYFMAPEVIR----RQAHDSLAADIWALGVTIYFIATGKYPFYSAVPDELI--------------- .||||||.. .. | . ..| | || ..|||... .. ... .||| ||. .| . .|||||.| . ... LKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQI -AQIFQGQYSTAC---IADSKLVQLIAACLSPDPQSRPTVNQLLQMDYI . . |. . . ... .|| .| |. | . ..... . YIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | 94502.m00072.AA | NEK | 64-257 | 29 | 9.9e-34 | 116.34 | In-house | 64-286 (286) | Show / Hide |
Range on Protein: 64-257 Range on HMM: 64-286/286 Sequence Identity: 29% (68 aa) PSIVALYKYYKFGG--YIYLLMELCK--CDLEKY---IKTTQ----NISEKDTANLIKSLIL--------AVKACHDH-----NIAHCDIKPSNFLIDNY | ||. | . . ... || | ||.. || . ...|. |. |.| .||. .| | ||||.| ... PNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEE--------QIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKN QR----VKIADFGLSSIFGQNKTSNI---CVGTIYFMAPEVIRRQAHDSLAADIWALGVTIYFIATG--KYPFYSA--VPDELIAQIFQG-QYSTAC-I- . ||| |||.| ...|. .||| |.|.|||.. . .. .|||.||. .| ..| | ||.. .|. .| .| ||. NNDYHNVKIGDFGIS-KVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNK-SDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHR -ADSKLVQLIAACLSPDPQSRPTVNQLLQMDYI ..| .|| .| .||..||..||.|.| .| MYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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Kinase | 94502.m00072.AA | TyrKc | 14-257 | 21 | 3.6e-11 | -41.98 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 14-257 Range on HMM: 1-280/280 Sequence Identity: 21% (64 aa) IQVLEKIASGGNGEIFIVFSHQYFSQFIL---KKIRENIFNEA---EIECMMRC--SDPSIVALYKYYKFG-------GYIYLLMELCKC-DLEKYIKTT |. ..|. .| ||.. | |...|. |. |.. |.. . | ||.|| . . . ....||... || .|.. . ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH QN-ISEKDTANLIKSLILAVKACHDHNIAHCDIKPSNFLIDNYQRVKIADFGLSSIFGQNK------TSNICV-----GT----IYFMAPEVIRRQAHDS .. .. || . |..|. | |. | |... ..|||.|||| | .. .. .. . . | | ||||.| . . RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL-SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT LAADIWALGVTIYFIAT-GKYPFYS-----AVPDELIAQIFQG----QYSTAC-----IADSKLVQLIAACLSPDPQSRPTVNQLLQMDYI . |.|. ||... | | |. | . ..|.|... || | .. .. ... |.. | || .||| ... ... TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | 94502.m00072.AA | CMGC | 226-257 | 34 | 3.4e-05 | 11.99 | In-house | 482-513 (513) | Show / Hide |
Range on Protein: 226-257 Range on HMM: 482-513/513 Sequence Identity: 34% (11 aa) ADSKLVQLIAACLSPDPQSRPTVNQLLQMDYI .|.... |. .| ||. |.|. | ||..|. CDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |