Gene 93204.m00186 (T.vaginalis)

93204.m00186

Species: T.vaginalis
Alias: 93204.m00186, TvagK0872
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag2

Sequence

Name Sequence Type Origin Length Description Download
93204.m00186.AA Protein None 912 None Fasta, JSON
93204.m00186.kin_dom Protein Kinase Domain None 216 None Fasta, JSON

Protein domain

Protein domains of 93204.m00186.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93204.m00186.AA TKL 61-277 12 6.2e-13 42.91 In-house 74-364 (364) Show / Hide 
Range on Protein: 61-277
Range on HMM: 74-364/364
Sequence Identity: 12% (39 aa)

RMIQRMKQIEHPGILPVVGYTFADPE---------THQNPIVIYEYPGGEN-LSAIIDSISLGMKNTTMDFTTIMKLIYGILATITFLHENN--------
. |  |... || |.. .|| .. |          .  ..  ..||  | . |. ..             .  .......|   . .|| .|        
EEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPP

IVHGDIQPSSIFLTDNKE--------------PKIASVGILTQNPNTYQQTH------------DVHTMLMLSA--------EMFSKNIPF---------
|.| |. .. |.. .| .              .||.  |. . . .. ....            . ....|           |.. .....         
IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEF

-----LTIQSDIYALAMLIYRISA---PPQIFKRDEFGGS----FSDYIINNSGLPQNIR--------------AFSFLCDFITQGWEKNPDNRPLLQTI
      . ..|.|. ..... | .   | . .. ..  ..       ... . ||.  |               .   ... ... |. .|..||  |.|
CKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEI

IQPF
.. .
LKRL
Kinase 93204.m00186.AA Ciliate-E1 115-207 21 1.8e-11 33.99 In-house 102-202 (202) Show / Hide 
Range on Protein: 115-207
Range on HMM: 102-202/202
Sequence Identity: 21% (22 aa)

KNTTMDFTTIMKLIYGILATITFLHENNIVHGDIQPSSIFLTDNKEPKIASVGILT--QNPNTYQQTHDVHTMLMLSAEMFS------KNIPFLTIQSDI
..  ..|. .|..|. ..  .  || .|| |.|| |. |  ..... ...  ||    .| ...|.  . .|  . . |         ..    ...|||
NQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDI

Y
|
Y
Kinase 93204.m00186.AA Ciliate-A5 127-179 27 2e-10 32.45 In-house 104-161 (275) Show / Hide 
Range on Protein: 127-179
Range on HMM: 104-161/275
Sequence Identity: 27% (16 aa)

LIYGILATITFLHENNIVHGDIQPSSIFLTDNKEPKIASVG----ILT-QNPNTYQQT
..  ...   .|..|||.|||| |..|.||.. . |.. ..     .. .|.  |.|.
IMDCLISVCMYLQQNNICHGDIRPQNICLTQDGQVKLMDMNESKDFFYQINWSSYKQY
S_TKc 93204.m00186.AA S_TKc 15-278 17 4.1e-10 -28.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-278
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)

YQKLDTISITESRTVYTCMNETTGTIYAMYEYNMIDTSPTGIGKLARMIQRMKQIEHPGILPVVGYTFADPETHQNPIVIYEYPGG--ENLSAIIDSISL
|..|..|      .|| | .  || |.|. . .          .. | || .|.  || |    ..        ..  .. || .|   .|  .|..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

GMKNTTMDFTTIMKLIYGILATITFLHENNIVHGDIQPSSIFLTDNKEPKIA----SVGILTQNPNTYQQTHDVHTMLMLSAEMFSKNIPFLTI-QSDIY
. ..  ..  .. ...| |.  . ..|...|.| |. |. |.|..  . ||.    .  .          |. . |   .. |..       .   .|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-----GYGKCKCDWW

ALAMLIYRISA-------PPQIFKRDEFGGSFSDYIINNSGLPQNIRAFSFLCDFITQGWEKNPDNRPLLQTIIQ--------PFK
..  ..|   .       . ..||.                        . ..||| . ..|.|..||    . |        |. 
SCGCILYEMLCGYPPFPQMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93204.m00186.AA Ciliate-E2-Unclassified 89-168 24 7.2e-09 26.92 In-house 94-193 (352) Show / Hide 
Range on Protein: 89-168
Range on HMM: 94-193/352
Sequence Identity: 24% (24 aa)

QNPIVIYEYPGGENLSAIIDSIS--------LGMKNTT---MDFTTIM-----KLIYGILATITFLHENN-IVHGDIQPSSIFLTDNK---EPKIASVGI
||.. ..||  | .|. .| . .        |.... .    .   .      .... ||  . .||..| |.| ||.|. |....|.   ..||.  ||
QNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGI
Kinase 93204.m00186.AA Ciliate-C3 131-166 50 8.4e-09 27.92 In-house 105-140 (140) Show / Hide 
Range on Protein: 131-166
Range on HMM: 105-140/140
Sequence Identity: 50% (18 aa)

ILATITFLHENNIVHGDIQPSSIFLTDNKEPKIASV
||  | .||| |||||||..| | .  ..| ||   
ILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF
Kinase 93204.m00186.AA CDKL 124-163 36 9.1e-07 19.17 In-house 100-140 (286) Show / Hide 
Range on Protein: 124-163
Range on HMM: 100-140/286
Sequence Identity: 36% (15 aa)

IMKLIYGILATITFLHENNIVHGDIQPSSIFLT-DNKEPKI
..| .. ||  | |.| .|..| || |  |..|  |.. |.
VRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKL
Kinase 93204.m00186.AA TBCK 114-163 32 9.5e-07 20.09 In-house 72-121 (346) Show / Hide 
Range on Protein: 114-163
Range on HMM: 72-121/346
Sequence Identity: 32% (16 aa)

MKNTTMDFTTIMKLIYGILATITFLHENNIVHGDIQPSSIFLTDNKEPKI
.. |  |  .|   .| ||  . ..|  .|||.   |..| |.||.. |.
KRHTPKDCSQILCIYYQILCGLSYMHKHHIVHRFLHPHNIYLDDNGNQKL
Kinase 93204.m00186.AA Ciliate-E4 137-165 44 1e-06 18.93 In-house 122-150 (150) Show / Hide 
Range on Protein: 137-165
Range on HMM: 122-150/150
Sequence Identity: 44% (13 aa)

FLHENNIVHGDIQPSSIFLTDNKEPKIAS
.|   || |||. || ||.... . ||| 
YLQQVNITHGDLKPSNIFFDQYFMVKIAD
Kinase 93204.m00186.AA Ciliate-E2 86-164 20 2e-06 17.98 In-house 104-198 (365) Show / Hide 
Range on Protein: 86-164
Range on HMM: 104-198/365
Sequence Identity: 20% (20 aa)

ETHQNPIVIYEYPGGENLSAIIDSISLGMKNT-----TMDFTTIMKLIYGILA---------------TITFLHENN-IVHGDIQPSSIFLTDNKEPKIA
.. .|   . ||  | .|  .| . ..  ..       ..   | .... ||                 . .||..| |.| || |. |..     .||.
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII
Kinase 93204.m00186.AA NZAK 86-162 27 6e-06 15.42 In-house 72-145 (329) Show / Hide 
Range on Protein: 86-162
Range on HMM: 72-145/329
Sequence Identity: 27% (21 aa)

ETHQNPIVIYEYPGGENLSAIIDSISLGMKNTTMDFTTIMKLIYGILATITFLHENNIVHGDIQPSSIFLTDNKEPK
|   .  .. |.  |.||. ..   .   |   .    | |.|  |  |. .||   |.| ||... . |  ||. |
EDDNYHCIYMEWMEGGNLTQFL---MNDKKQLRFKEHRIIKMIADIAETMSYLHKHHIIHRDIKSNNVILDFNKNLK
TyrKc 93204.m00186.AA TyrKc 23-277 11 3.2e-05 -138.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-277
Range on HMM: 1-280/280
Sequence Identity: 11% (38 aa)

ITESRT--------VYTCMNETTGTIYAMYEYN----MIDTSPTGIGKLARMIQRMKQI--EHPGILPVVGYTFADPETH---QNPIVIYEYPGGENLSA
||  ..        || ..            ..    |.  .   .  . | .. |...  .|| |.  .|.   . .     . . .. ||  . .|  
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

IIDSISLGMKNTTMDFTTIMKLIYGILATITFLHENNIVHGDIQPSSIFLTDNKEPKIASVGILTQNPNTY------QQTHDVHT--MLM-------LSA
 . .             .  .  . | .   .||..|..| |.    . ...|.  ||.  | |. .   .      ... .. .            .. 
YLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG-LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EMFSKN-----------------------IPFL------TIQSDIYALAMLIYRISAPPQ----IFKRDEFGGSFSDYIINNSGLPQNIRAFSFLCDFIT
| . ..                        |           ...... .  ||   ||                       .      .. . . . ..
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------F-----VCCPDEMYQIMK

QGWEKNPDNRPLLQTIIQPF
| |. .|..||  ..|.. |
QCWHEDPEDRPTFSEIHECF
Kinase 93204.m00186.AA NZAK 204-268 28 0.017763 3.56 In-house 253-319 (329) Show / Hide 
Range on Protein: 204-268
Range on HMM: 253-319/329
Sequence Identity: 28% (20 aa)

SDIYALAMLIYRIS--APP-QIFKRDEFGGSFSDYIINNSGLPQNIRAFS-FLCDFITQGWEKNPDNRP
||.. . ...  .   .||  |.   |     || ..|  . ||     .  . ||||| |  .| .||
SDVWSFGCTVWQMFGYNPPNTIYSPKEMASMVSDQKFN--YIPQIPFHVPDKMKDFITQCWDIDPKKRP
Ank 93204.m00186.AA Ank 774-807 38 7.5e-07 28.97 Pfam 1-33 (33) Show / Hide 
Range on Protein: 774-807
Range on HMM: 1-33/33
Sequence Identity: 38% (13 aa)

WGVTPLHIAADNCQIDSIRLLLNTPQVDVNARTD
 | ||||.|. . ... ...||.    ||||..|
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 93204.m00186.AA Ank 740-773 44 8e-06 25.25 Pfam 1-33 (33) Show / Hide 
Range on Protein: 740-773
Range on HMM: 1-33/33
Sequence Identity: 44% (15 aa)

FQRTALHAAAEYGNTDALYMLLDISGIDVNAGDA
  .|.|| |...|.|. . |||.  | |||| | 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 93204.m00186.AA Ank 808-841 35 1.8e-05 23.99 Pfam 1-33 (33) Show / Hide 
Range on Protein: 808-841
Range on HMM: 1-33/33
Sequence Identity: 35% (12 aa)

EGKTPLHIAVETDYDYIVKFFVDVPSVDVNAKTK
.| ||||.|.. ..  .||....    ||||...
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank 93204.m00186.AA Ank 842-865 33 0.00182 16.76 Pfam 1-24 (33) Show / Hide 
Range on Protein: 842-865
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

SNKTPLHIATKKRNVQIVQLLLSR
   ||||.| .. ....|..||..
DGFTPLHLACRCGHTEVVKMLLQH
Ank 93204.m00186.AA Ank 707-739 21 0.209026 9.33 Pfam 1-33 (33) Show / Hide 
Range on Protein: 707-739
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

DGRLPIVVSAITNNISILLDLLKRGILPNETEI
||. |  . .. ...... .||..|  .| .  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 93204.m00186.AA Ank 693-706 28 41.756698 1.03 Pfam 20-33 (33) Show / Hide 
Range on Protein: 693-706
Range on HMM: 20-33/33
Sequence Identity: 28% (4 aa)

LLIQKKYNPNIPDK
.|.|.  ..|. |.
MLLQHGADVNAQDD
Ank 93204.m00186.AA Ank 876-896 19 4.308768 4.59 Pfam 1-21 (33) Show / Hide 
Range on Protein: 876-896
Range on HMM: 1-21/33
Sequence Identity: 19% (4 aa)

KGRTPYMIAVENEDQKLIEIF
 |.|| ..|... . . .. .
DGFTPLHLACRCGHTEVVKML