Gene 86141.m00105 (T.vaginalis)
86141.m00105
Species: T.vaginalis
Alias: TvagK0905, 86141.m00105
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 86141.m00105.AA | Protein | None | 269 | None | Fasta, JSON |
| 86141.m00105.kin_dom | Protein Kinase Domain | None | 203 | None | Fasta, JSON |
Protein domains of 86141.m00105.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 86141.m00105.AA | CAMK | 59-261 | 19 | 9.7e-41 | 128.52 | In-house | 82-425 (425) | Show / Hide |
Range on Protein: 59-261
Range on HMM: 82-425/425
Sequence Identity: 19% (67 aa)
IELLSSCF-------HPNIQKYIDCHYEGVF-------------------QYIIL---EYEENT--FYSLFEKNDS------------------LNRREI
||..... |||| | .. . . |... || .. | ||.. . .. ||
IEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREA
FGIFKQIVSALEYLHQNNIVHLDIRPESIFLTDN-----------------NELRLGNFYNAHKIEP------------------------DELITVPYG
.|.||.||..|.|..||||.|. || | |.|| | . . | | |..| ... . . |
RRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG
TLNFAA-PETKTD-------------KPYDGKAADVFACGILLLSMFIRKLAISGS-------------TIEEIEQNFANGQI-FIPSFINE--------
|. ..| || |||.|...|. .||..| | .. |. ...|. .. .|. |.|... .
TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE
---------------DVRSLISSMIDFNPEKRIPIENVKLSQWY
....||..| .||||. || .. .|.
WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 86141.m00105.AA | CAMKL | 59-261 | 25 | 5.7e-35 | 108.92 | In-house | 63-297 (297) | Show / Hide |
Range on Protein: 59-261 Range on HMM: 63-297/297 Sequence Identity: 25% (61 aa) IELLSSCF---HPNIQKYIDCHYEGVF------QYIILEYEENT---FYSLFEKN----DSLNRREIFGIFKQIVSALEYLHQNNIVHLDIRPESIFLTD |..... |||| | .. . . |...|| .. . .|. ... .| .|.|||||..|.|...||| || || | |.. IQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDE NN--ELR-----LGNFYNAHKIEPDELITVPYGTLNFAAPETKTD--KPYDGKAADVFACGILLLSMFIRKLAISGSTI--------EEIEQNFANGQIF |. . ..|.| . . |... . |.....||| . |||||...|. .||..| | .| . |. .. ... . NGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYP -IPSFINEDVRSLISSMIDFNPEKRIPIENVKLSQWY |.... |.|.||..| |||||. |.... |. PIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 86141.m00105.AA | Ciliate-E2 | 25-261 | 17 | 3e-30 | 101.05 | In-house | 16-365 (365) | Show / Hide |
Range on Protein: 25-261
Range on HMM: 16-365/365
Sequence Identity: 17% (64 aa)
YIGECKSTKQ------------------KFSILKINRFFISNS-LLFLNLKVQIE--------------LLSSCFHPNIQKYIDCHY--EGVFQYIILEY
| .. ..... |. | ... .... . ... . .| .|.. |||| |...| . |...||
YKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEY
EEN-TFYSLFEKND-----------SLNRREIFGIFKQIVS---------------ALEYLHQNN-IVHLDIRPESIFLTDNNELRLGNFYNAHKIEPD-
. . ... ..|. ... .|| |.|||.. ||||||..| |.| || || |.. . . | .. |. .|
CQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDN
---------ELITVPY-----------------------GTLNFAAPETKTDKPYDG--------KAADVFACGILLLSMFIRKLAISGSTIEEIEQNFA
.... ||... ||| |.||. ...|....|..| | |. .|.
QNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIK
NGQIFIPSF------------------INEDVRSLISS----MIDFNPEKRIP-IENVKLSQWY
...| .|.. . ... ||. |.. .||||| .| .. .|
QCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
|
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| Kinase | 86141.m00105.AA | Ciliate-E2-Unclassified | 25-261 | 18 | 3e-29 | 98.62 | In-house | 16-352 (352) | Show / Hide |
Range on Protein: 25-261
Range on HMM: 16-352/352
Sequence Identity: 18% (64 aa)
YIGECKSTKQKFSILKINRFFISNSLLFLN----LKVQIELLSS----------------CFHPNIQKYIDCHYEGVF--QYIILEYEENTFYSLFEKN-
| ..|..||.. . .. . | .... .| . ..|. . ||.. .. ..... ||..|| |. . . |.
YKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKR
-----------DSLNRREIF-----------GIFKQIVSALEYLHQNN-IVHLDIRPESIFLTDNN---ELRLGNFYNAHKIE----------------P
.....|.|| .|.||...|||||..| |.| || || |....|. .... | .. |.. .
KKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWK
DELITVPYGTLNFA----APETKTDKPYDG---KAADVFACGILLLSMFIRKLAISGSTIEE----------------IEQNFANGQIFIPSFIN-----
..... ||.|. ||| . ||. ...|....|..| | .. .. . |. ..||. ...|..|.| .
QQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPK
---EDVRSLIS----SMIDFNPEKRIPIENVKLSQWY
. . .|. .|.. ||.||| .| .. .|
HWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 86141.m00105.AA | Pkinase | 59-261 | 20 | 2.2e-28 | 101.46 | Pfam | 51-293 (293) | Show / Hide |
Range on Protein: 59-261
Range on HMM: 51-293/293
Sequence Identity: 20% (51 aa)
IELLSSCFHPNIQKYIDCHYEGVFQYIILEYEENT--FYSLF-----EKNDSL--NRREIFGIFKQIVSALEYLHQNNIVHLDIRPESIFLTDNNEL---
|... .. |||| ...|. ... |...|| |.. .|| ... .. .|. ...||...|||.|...|.| |. || |.. .|...
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDAC
-RLGNFYNAHK--IEPDELITVPYGTLNFAAPETKTDKPYDGKAADVFACGILLLSMFIRKLAISGS----TIEEIEQNFANGQIFIPSFIN--------
... | | . . ... |.. ||....||| . .|.|...|...||..| |. ... .|. . . | ... ...|
VKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISY
----------------EDVRSLISSMIDFNPEKRIPIENVKLSQWY
|. ...|.......|.||. .| .. . |
FFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | 86141.m00105.AA | BRSK | 113-261 | 30 | 3.1e-24 | 79.45 | In-house | 106-254 (254) | Show / Hide |
Range on Protein: 113-261 Range on HMM: 106-254/254 Sequence Identity: 30% (46 aa) FKQIVSALEYLHQNNIVHLDIRPESIFLTDNNELRLGNFYNAHKIEPDELITVPYGTLNFAAPETKTDKPYDGKAADVFACGILLLSMFIRKLAISGSTI |.||.|||.. | || | | .|| | . | . | | | . | .| || |||. ||| ||. | . . .| . FRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNL EEIEQNFANGQIFIPSFINEDVRSLISSMIDFNPEKRIPIENVKLSQWY . .| .| || |. .| ||. .|.||| ..... || RQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY |
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| Kinase | 86141.m00105.AA | GIN4 | 67-262 | 27 | 6.3e-24 | 72.95 | In-house | 93-293 (293) | Show / Hide |
Range on Protein: 67-262 Range on HMM: 93-293/293 Sequence Identity: 27% (55 aa) HPNIQKYIDCHYEGVFQYIILEY-EENTFYSLFEKNDSLNRREIFGIFKQIVSALEYLHQNNIVHLDIRPESIFLTDNNE-LRLGNFYNAHKIEPDELIT |||. . | . |..||| |. . . . | || .|.||. . | | ||.| |..|| . | .. ... | | . .|. HPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAALETDNKLLE VPYGTLNFAAPETKTDKPYDGKAADVFACGILLLSMFIRKLAISGS--TIEEIEQNFANGQIFIPSF--INEDVRSLISSMIDFNPEKRIPIENVKLSQW | .|||| ||.| |.||..||..| . .| | .. |. .|| | . . ||. .. ||||| . .. |. TSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDI-LKHP YT LI |
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| S_TKc | 86141.m00105.AA | S_TKc | 15-261 | 19 | 3e-22 | 81.17 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-261
Range on HMM: 1-231/231
Sequence Identity: 19% (53 aa)
IYPECQIGE-----QYIGECKSTKQKFSILKINRFFISNSLLFLNLKVQIELLSSCFHPNIQKYIDCHYEGVFQYIILEYEEN---TFYSLFEKNDS---
.||. | . |.|.... | .|. ... |..|.. |||| |..|. .. . |...|| .. . ... .|. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL
---LNRREIFGIFKQIVSALEYLHQNNIVHLDIRPESIFLTDNNELRLGNFYNAHKIEPDELITVPYGTLNFAAPETKTDKPYDGKAADVFACGILLLSM
.. .. ...||..||||.|...|.| |. || |.|.. .. .. | | .. | ||... ||| .|.....|. .||..| |
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM
FIRKLAISGSTIEEIEQNFANGQIFIPSFINEDVRSLISSMIDFNPEKRIPIENVKL-------SQWY
. .. . ..... .. ......|. . ...||||. . . .|
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 86141.m00105.AA | QIK | 112-261 | 31 | 4.2e-20 | 73.12 | In-house | 123-272 (272) | Show / Hide |
Range on Protein: 112-261 Range on HMM: 123-272/272 Sequence Identity: 31% (47 aa) IFKQIVSALEYLHQNNIVHLDIRPESIFLTDNNELRLGNFYNAHKIEPDELITVPYGTLNFAAPETKTDKPYDGKAADVFACGILLLSMFIRKLAISGST .|.||.|| .|.|. |||| |. | | | | . . | ....| |. .|||| | ||| .|. |..| .. .| |.| WFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKT IEEIEQNFANGQIFIPSFINEDVRSLISSMIDFNPEKRIPIENVKLSQWY ... | |. || |. .| .|| | .||.|. |.... .| LQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
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| Kinase | 86141.m00105.AA | AMPK | 171-261 | 29 | 2.9e-19 | 53.89 | In-house | 164-254 (254) | Show / Hide |
Range on Protein: 171-261 Range on HMM: 164-254/254 Sequence Identity: 29% (27 aa) NFAAPETKTDKPYDGKAADVFACGILLLSMFIRKLAISGSTIEEIEQNFANGQIFIPSFINEDVRSLISSMIDFNPEKRIPIENVKLSQWY . ||||. . |.| | |. ||. | | ..| . . . .. ||. ||.|.......||..| .|.||| |. .. ..|. CYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | 86141.m00105.AA | MARK | 168-261 | 31 | 3.7e-18 | 56.1 | In-house | 167-262 (262) | Show / Hide |
Range on Protein: 168-261 Range on HMM: 167-262/262 Sequence Identity: 31% (30 aa) GTLNFAAPETKTDKPYDGKAADVFACGILLLSMFIRKLAISGST--IEEIEQNFANGQIFIPSFINEDVRSLISSMIDFNPEKRIPIENVKLSQWY ||. ..||| |||||...|. ..|..| | .. |.| ..|.... .|. ||... . |.||.... .|||.|. ||.. | GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | 86141.m00105.AA | Ciliate-C1 | 112-151 | 42 | 2e-15 | 35.98 | In-house | 134-173 (328) | Show / Hide |
Range on Protein: 112-151 Range on HMM: 134-173/328 Sequence Identity: 42% (17 aa) IFKQIVSALEYLHQNNIVHLDIRPESIFLTDNNELRLGNF .|.| .....|.||||| |.|. || |.| .| | .. | YFHQLINVIQYIHQNNICHRDLKPENILLDENFNLKIADF |
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| Kinase | 86141.m00105.AA | AMPK | 100-146 | 40 | 6.1e-12 | 31.8 | In-house | 93-139 (254) | Show / Hide |
Range on Protein: 100-146 Range on HMM: 93-139/254 Sequence Identity: 40% (19 aa) KNDSLNRREIFGIFKQIVSALEYLHQNNIVHLDIRPESIFLTDNNEL |.. |. || |.||.|..||.|...||| | || . | .|... KHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNI |
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| Kinase | 86141.m00105.AA | MARK | 112-136 | 68 | 1.1e-10 | 31.35 | In-house | 109-133 (262) | Show / Hide |
Range on Protein: 112-136 Range on HMM: 109-133/262 Sequence Identity: 68% (17 aa) IFKQIVSALEYLHQNNIVHLDIRPE ||.|||||..|.|..|||| || || IFRQIVSAVNYCHSKNIVHRDIKPE |
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| Kinase | 86141.m00105.AA | Ciliate-C1 | 229-261 | 36 | 8.3e-08 | 15.77 | In-house | 296-328 (328) | Show / Hide |
Range on Protein: 229-261 Range on HMM: 296-328/328 Sequence Identity: 36% (12 aa) FINEDVRSLISSMIDFNPEKRIPIENVKLSQWY |. .. .|| .| .||.||| .. .| || FFSNEFMDLINQMLAYNPQKRITLQEIKCHPWY |
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| Kinase | 86141.m00105.AA | Ciliate-C1 | 174-201 | 42 | 2.1e-07 | 14.71 | In-house | 228-255 (328) | Show / Hide |
Range on Protein: 174-201 Range on HMM: 228-255/328 Sequence Identity: 42% (12 aa) APETKTDKPYDGKAADVFACGILLLSMF ||| ..|.|.. | ||||. | .|. APELHEKQRYCGSKVDIFACGVILFCMV |
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| TyrKc | 86141.m00105.AA | TyrKc | 10-260 | 14 | 2.2e-05 | -135.66 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 10-260 Range on HMM: 1-280/280 Sequence Identity: 14% (43 aa) PHKKEIYPECQIGEQYIGECKSTKQKFSI------LKINRFFISNSLLFLNLKVQIELLSSC--FHPNIQKYIDCHYEG-------VFQYIILEYEEN-T ..... |.. || | |. | | || . . ...... |||| . . . .. .|..|| .. ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD FYSLFEKNDS-LNRREIFGIFKQIVSALEYLHQNNIVHLDIRPESIFLTDNNELRLGNFYNAHKIEPD-------ELITV-----PY--GTLNFAAPETK . |. |. .. . || . ||||..|..| |. . ...|. . . | . .|. | . ... . |||. LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI TDKPYDGKAADVFACGILL--LSMFIRKLAISG----STIEEIEQNFANG-QIFIPSF--------INEDVRSLISSMIDFNPEKRIPIENVKLSQW .. . . ||.. |... . . . . .|. .. .| .| ... ..... ...||.| ... ... NYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
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