Gene 84943.m00217 (T.vaginalis)

84943.m00217

Species: T.vaginalis
Alias: 84943.m00217, TvagK0622
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: ATM

Sequence

Name Sequence Type Origin Length Description Download
84943.m00217.AA Protein None 2666 None Fasta, JSON
84943.m00217.kin_dom Protein Kinase Domain None 138 None Fasta, JSON

Protein domain

Protein domains of 84943.m00217.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84943.m00217.AA PI3Kc 2333-2649 25 8.9e-61 209.15 SMART 1-336 (336) Show / Hide 
Range on Protein: 2333-2649
Range on HMM: 1-336/336
Sequence Identity: 25% (88 aa)

QILKGRNDDLRQDAVMQQLFQLSSQILEKN----KPDLKIRSYKVVPLNPSAGIIEYVEKSISLGSYLT--------APNGAHFRYKSNLSYDKVYALFQ
...   .||||||. |.|.|.|   |. |.    . ||..| ||..|..|  |.|| |  . .| . .          ... . ...  |      .. |
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-V----PEIQ

NASSNYHKANFNR-----SMEISNEQKREMLINTYIQICKDFKPCMRFFFIEKFSNT-GDWFKARMNYCRQTATNSMVGYVFGIGDRHMNNILIDHLTGD
     |    ..       |.  .. . |.|. .  ..|. ..|... .|.|.| .  .||..|| |..|..|  .||.|..|||||| .||..|  || 
-K-NMY-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGH

VIHIDLGIAFEQGKMLRV-----REIVPFRMTPDIIDGFG----HCGGSGVFRNSCEETLSLLRKYSEYLLTVLDVFLRDPL-HNWNVVLKQKKSDKARG
..|||.| .|..|... .     || |||| |.|.... |      |  | ||  |.... ..||.|. ..... ....||.  .|.    .|. .. | 
CFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--EKDIKYLRQ

LTMPE-TSEPKTAESVIMRCRYKLEGKETGETLSVEGQVAQLISEA
  ... .|. . |. .  . . || ... .. ..   ...... ..
RFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase 84943.m00217.AA ATM 2450-2590 49 5.1e-57 180.55 In-house 108-248 (304) Show / Hide 
Range on Protein: 2450-2590
Range on HMM: 108-248/304
Sequence Identity: 49% (70 aa)

YIQICKDFKPCMRFFFIEKFSNTGDWFKARMNYCRQTATNSMVGYVFGIGDRHMNNILIDHLTGDVIHIDLGIAFEQGKMLRVREIVPFRMTPDIIDGFG
.. .|. |.|  |.| .|||     ||  |. | |  || |.|||. |.||||. ||||     ...|||||.||||||.|   | ||||.| ||.|| |
FMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMG

HCGGSGVFRNSCEETLSLLRKYSEYLLTVLDVFLRDPLHNW
  |  ||||  || |.  .|   | |||. .| | |||  |
ITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDW
Kinase 84943.m00217.AA ATR 2300-2582 32 2.7e-56 190.18 In-house 1-267 (267) Show / Hide 
Range on Protein: 2300-2582
Range on HMM: 1-267/267
Sequence Identity: 32% (93 aa)

TKIAQFEDKMKPLEGITKPVKIKVLGANGRKYHQILKGRNDDLRQDAVMQQLFQLSSQIL----EKNKPDLKIRSYKVVPLNPSAGIIEYVEKSISLGSY
. || |.| .. |  . || || . |..|. |  . | . ||||.|   ..  .| ....    |. .  ...|.| |.|||  ..|||.|.  ..| . 
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPK-DDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPI

LTAPNGAHFRYKSNLSYDKVYALFQNASSNYHKANFNRSMEISNEQK--REMLINTYIQICKDFKPCMRFFFIEKFSNTGDWFKARMNYCRQTATNSMVG
|.        .|    | . | | | .          .| | .. ||  ||.|.  .  | .|       .|  .|    .|. .| |||| .|  .|||
LDK------LWKEKKQYMQFYQLRQCM--------DKKSREEWEKQKVFREFLLPRHPPIFHD-------WFNRRFPDPQQWYSSRENYCRSYAVWCMVG

YVFGIGDRHMNNILIDHLTGDVIHIDLGIAFEQGKMLRVREIVPFRMTPDIIDGFGHCGGSGVFRNSCEETLSLLRKYSEYLLTVLDVF
|. |.|||| .||||| ..|...|.|  . | .|. . | ||||||.|  .. |.|  .  |.||  ||... ..|.  . .. |.| |
YIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase 84943.m00217.AA PI3_PI4_kinase 2330-2592 22 8.8e-55 193.11 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2330-2592
Range on HMM: 1-300/300
Sequence Identity: 22% (72 aa)

KYHQILKGRNDDLR--QDAVMQQLF-----------------------QLSSQILEKNKPDLK----IRSYKVVPLNPSAGIIEYVEKS-----ISLGSY
 |..|.|| .||||  ||. | |..                       .|   .. |.. |..    .. |...|..|  |.|| |. .     | .  |
WYPFIFKG-GDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEI-PRTY

LTAPNGAHFRYKSNLSYDKVYALFQNASSNYHKANFNRSMEISNEQKREMLINTYIQICKDFKPCMRFFFIEKFSNT-GDWFKARMNYCRQTATNSMVGY
..  . .|| .. . .... ..  ..                    . ....  ...|.| .|| .. .|.... .  ..|..|| |..|. |  ..|.|
MVKCKHKHFNKEHKMWMKMWPDWWHLM-------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDY

VFGIGDRHMNNILI--DHLTGDVIHIDLGIAFE--QGKMLRVREIVPFRMTP------DIIDGF------GHCGGSGVFRNSCEETLSLLRKYSEYLLTV
..|.|||| .||..  |. || ..||| |..|.  ..| . ..| |||| |.      ......      .  |  | || .|.... .||.... ....
ILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNL

L-------DVFLRDPLHNWNV
|       . ...|.| .|. 
LKKAVMRGECMVHDGLPMWRS
Kinase 84943.m00217.AA PIKK 2464-2582 44 1.2e-54 187.85 In-house 171-290 (290) Show / Hide 
Range on Protein: 2464-2582
Range on HMM: 171-290/290
Sequence Identity: 44% (53 aa)

FFIEKFSNTGDWFKARMNYCRQTATNSMVGYVFGIGDRHMNNILIDHLTGDVIHIDLGIAFE-QGKMLRVREIVPFRMTPDIIDGFGHCGGSGVFRNSCE
.| .||..  .|. .| ||.|..|. .||||. |.|||| .||.|| .||...|||.| .|| ... |.| |.||||.|...... | .| .||||..||
WFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCE

ETLSLLRKYSEYLLTVLDVF
 .. ..|.  | |.||..||
HVMMCMRQHRETLMTVCEVF
Kinase 84943.m00217.AA FRAP 2475-2592 41 2.4e-29 103.79 In-house 133-251 (251) Show / Hide 
Range on Protein: 2475-2592
Range on HMM: 133-251/251
Sequence Identity: 41% (50 aa)

WFKARMNYCRQTATNSMVGYVFGIGDRHMNNILIDHLTGDVIHIDLGIAFEQGKMLRVR--EIVPFRMTPDIIDGFGHCGGSGVFRNSCEETLSLLRKYS
||  | || |  || ||.||. |.||||  ||... .|| ..||| |  ||   | | .  | .|||.|  ..     ||  | .|| ||  .  .|   
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVA-MRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHK

EYLLTVLDVFLRDPLHNWNV
| .. ||. |  ||| .| .
ESVMAVLEAFVYDPLFYWRL
Kinase 84943.m00217.AA SMG1 2474-2534 54 8.9e-25 78.89 In-house 182-242 (242) Show / Hide 
Range on Protein: 2474-2534
Range on HMM: 182-242/242
Sequence Identity: 54% (33 aa)

DWFKARMNYCRQTATNSMVGYVFGIGDRHMNNILIDHLTGDVIHIDLGIAFEQGKMLRVRE
.|..    | | ||  |||||. |.||||. |.|||  ||.|.|||  | ||.|| |.| |
EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase 84943.m00217.AA PIKK 2301-2393 35 4.9e-24 84.61 In-house 1-96 (290) Show / Hide 
Range on Protein: 2301-2393
Range on HMM: 1-96/290
Sequence Identity: 35% (34 aa)

KIAQFEDKMKPLEGITKPVKIKVLGANGRKYHQILKGRNDDLRQDAVMQQLFQLSSQILEKN----KPDLKIRSYKVVPLNPSAGIIEYVEKSISLG
 |. . .    .   .|| ||  .| .|. |.. .||. .|||||....|||||   .|.|.    |..| ||.|.|.|...  |.|| |... .|.
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGH-EDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLK
Kinase 84943.m00217.AA ATM 2332-2409 44 8.4e-20 59.58 In-house 1-82 (304) Show / Hide 
Range on Protein: 2332-2409
Range on HMM: 1-82/304
Sequence Identity: 44% (37 aa)

HQILKGRNDDLRQDAVMQQLFQLSSQILEKN----KPDLKIRSYKVVPLNPSAGIIEYVEKSISLGS-YLTAPNGAHFRYKSN
 |. ||| ||||||||||| ||.   .| .|    |  | |  ||||||   .|..|.    |  .     . .||| ||. |
RQLVKGR-DDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNEDGAHKRYRPN
Kinase 84943.m00217.AA DNAPK 2493-2592 32 1.2e-19 68.06 In-house 201-301 (301) Show / Hide 
Range on Protein: 2493-2592
Range on HMM: 201-301/301
Sequence Identity: 32% (33 aa)

GYVFGIGDRHMNNILIDHLTGDVIHIDLGIAFE-QGKMLRVREIVPFRMTPDIIDGFGHCGGSGVFRNSCEETLSLLRKYSEYLLTVLDVFLRDPLHNWN
... ||||||.|| ..   .||.| || | .|   .  | | |  |||.|   |      .  |... .    .  .||    |.   ||| .||.  | 
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

V
 
N
Kinase 84943.m00217.AA FATC 2634-2666 60 7.3e-19 63.46 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2634-2666
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

ETLSVEGQVAQLISEATDPSKLAMMYAGWKPYL
| ||||.|| .||.|||||. |..|| || |..
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase 84943.m00217.AA DNAPK 2299-2392 29 6.7e-08 24.63 In-house 1-97 (301) Show / Hide 
Range on Protein: 2299-2392
Range on HMM: 1-97/301
Sequence Identity: 29% (29 aa)

YTKIAQFEDKMKPLEGITKPVKIKVLGANGRKYHQILKGRNDDLRQDAVMQQLFQLSSQILEK----NKPDLKIRSYKVVPLNPSAGIIEYVEKSISL
  .|| |....  .  . .| .| . |   |    . ||   |||||    ||||    |.|        .|. | | ..|.    | || |..   |
HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKG-IEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL
Kinase 84943.m00217.AA FRAP 2330-2388 38 1.3e-07 24.23 In-house 1-62 (251) Show / Hide 
Range on Protein: 2330-2388
Range on HMM: 1-62/251
Sequence Identity: 38% (24 aa)

KYHQILKGRNDDLRQDAVMQQLFQLSSQILEKN----KPDLKIRSYKVVPLNPSAGIIEYVEK
 || .|||. .|.|||    ||| |  ..|. |    | .| |. | ..||   .|.| .|..
EYHFLLKGH-EDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH
Kinase 84943.m00217.AA SMG1 2309-2387 30 0.000547 8.93 In-house 1-82 (242) Show / Hide 
Range on Protein: 2309-2387
Range on HMM: 1-82/242
Sequence Identity: 30% (25 aa)

MKPLEGITKPVKIKVLGANGRKYHQILKGRNDDLRQDAVMQQLF---QLSSQILEKNKPDLKIRSYKVVPLNPSAGIIEYVE
.  |   ||| |.  ||. |. |  . ||  |    . .|| |     .   |  .  |    | | | ||   .|.| .|.
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD