95937.m00100

Species: T.vaginalis
Alias: TvagK0123, 95937.m00100
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
95937.m00100.AA Protein None 434 None Fasta, JSON
95937.m00100.kin_dom Protein Kinase Domain None 235 None Fasta, JSON

Protein domain

Protein domains of 95937.m00100.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 95937.m00100.AA CAMK 32-261 18 8.6e-56 177.9 In-house 7-419 (425) Show / Hide
Range on Protein: 32-261
Range on HMM: 7-419/425
Sequence Identity: 18% (76 aa)

YSQIHTAYHRIHR------------IPLAVKIISKNRIAD------------------------LPKKERILFNE-TILSPL------LDHPNIIHVEEI
... . ..|.                  |.|||.|... |                         ||... ...|  |.. |      |||||||.  |.
FGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEV

IE------------NNSK--------IFQFM---QFAEKG----DLLHSLQKCPP----------------DQKTCFKYVEQLLAAVERIHSLGIVHRDI
.|            . ||        .. .|    ... |    ||.  ... ..                . . . .|. |.. ||. .||..|||||.
YEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDL

KLENILITSND-----------------VLKLSDFGLASITCDGI-------------------------MKDNCGSYEYSA-PEAISH-----------
|.||||...|.                  .|..|||.| .  .|                          ||. ||. || | || ..            
KPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATD

--AEFDGFKADMWGVGIIIYALFQKRLPFEDV---------------RMGYNYNKPVDFSRIPDP---------------------------LQELCKKL
   . .|.|.||| .|.| |..   ..||..                .  .   .  ... .|..                            . | .|.
EEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKM

LSLDPNERPSADEA
|  ||..|......
LQVDPEKRMTIEQC

Kinase 95937.m00100.AA Pkinase 38-265 26 3.5e-53 187.79 Pfam 18-293 (293) Show / Hide
Range on Protein: 38-265
Range on HMM: 18-293/293
Sequence Identity: 26% (74 aa)

AYHRIHRIPLAVKIISKNRIADLPKKERILFN--ETILSPLLDHPNIIHVEEIIENNSKIFQFMQFAEKG----DLLHSLQ---KCPP--DQKTCFKYVE
..|.  ..  |||||.|    . ..|......  |  .   |.||||.   .. |....|   | ..|.|    || . ..   ...   . ..| .|. 
CHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMY

QLLAAVERIHSLGIVHRDIKLENILITSNDVL----KLSDFGLAS---ITCDGIMKDNCGSYEYSAPEAISHAEFDGFKADMWGVGIIIYALFQKRLPFE
|.| ..| .|| ||.|||.|.||||| .|...    |..|||||    .  .. |.. ||...| ||| | ... .| |.|||..|.|.| .. .|.|| 
QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP

DV----------RMGYNYNKPVDFSRI----------------------PDPLQELCKKLLSLDPNERPSADEARRM--L
.           ..  .  .|..|..                       ........|..| .||..||.|...     .
GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase 95937.m00100.AA CAMKL 38-260 28 1.7e-52 165.73 In-house 18-290 (297) Show / Hide
Range on Protein: 38-260
Range on HMM: 18-290/297
Sequence Identity: 28% (78 aa)

AYHRIH-RIPLAVKIISKNRIADLPKKERI-----------LFNETILSPLLD---HPNIIHVEEIIENNSK------IFQFMQFAEKGD--LLHSLQKC
| |... ..  |.||| |..| . |....            .. |  .  .|.   |||||.  |.||. ..      |. .|  .. |.  |.. ..| 
ATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKH

PPDQ-----KTCFKYVEQLLAAVERIHSLGIVHRDIKLENILITSND--VLKLSDFGLASI-T-C----DGIMKDNCGSYEYSAPEAISH--AEFDGFKA
.        . . .|  |...||. .||.||||||||.||||...|.  ..|..|||.. . . |    .  .|  |||..| ||| ..    ..||.|.
GHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKV

DMWGVGIIIYALFQKRLPFEDV---------------RMGYNYNKPVDFSRIPDPLQELCKKLLSLDPNERPSADE
|.|  |.| ||.   .|||.|                 |.  |. |. ..... ... | .|.|  .|..||....
DIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPI-WYHVS-DCRDLIRKMLQVNPEKRPTIHQ

S_TKc 95937.m00100.AA S_TKc 20-265 25 2.4e-48 167.82 SMART 1-231 (231) Show / Hide
Range on Protein: 20-265
Range on HMM: 1-231/231
Sequence Identity: 25% (66 aa)

YNISSQITNYGLYSQIHTAYHRIHRIPLAVKIISKNRIADLPKKERILFNETILSPLLDHPNIIHVEEIIENNSKIFQFMQFAEK--GDLLHSLQKCPP-
| |  .|   | ... . ..|.      |.|||.     .  ..|. .  .       .||||..  ..... .... .| ...   |||.. ..|... 
YEILRKIGK-GAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

------DQKTCFKYVEQLLAAVERIHSLGIVHRDIKLENILITSNDVLKLSDFGLASITCDGIMKDNCGSYEYSAPEAISHAEFDGFKADMWGVGIIIYA
      .  .. .|. |.. |.| .||.||.|||.| ||||...  ..|..||||| .      .  ||. .| ||| .    ....|.|.| .|.|.| 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LFQKRLPFEDVRMGYNYNKPVDFSRIPDPLQELCKKLLSLDPNERPSADEARR---------ML
..  . ||.   |   ..| .     .... .. .|.|  ||..||.| || .          .
MLCGYPPFP--QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 95937.m00100.AA Ciliate-E2 48-261 21 1.1e-47 161.7 In-house 51-359 (365) Show / Hide
Range on Protein: 48-261
Range on HMM: 51-359/365
Sequence Identity: 21% (69 aa)

AVKIISKNRIADLPKKERILF---------NETILSPLLDHPNIIHVEEIIE--NNSKIFQFMQFAEKGDLLHSLQKC------------PPDQKTCFKY
|.||..|| |  . ....|.          ||  .  .|.|||||   |  .  ....|.  | ... |||.. ....            ... | . ..
AMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYI

VEQLLA---------------AVERIHSLG-IVHRDIKLENILITSNDVLKLSDFGLAS------------ITCDGIMKDN-------------------
 .|.|                |.| .|| . |.|||||.||||.     .|..||||.               |  .|  .                   
MKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMF

---CGSYEYSAPEAISHAEFDG--------FKADMWGVGIIIYALFQKRLPFEDVRMGYN--YNKPVDFS-------------------RIPDPLQELCK
   ||...| ||| ..  . |.        .|.|.| .|.|.| .  ...||      ..   ....||.                    ...  . |.|
NTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIK

K----LLSLDPNERPS-ADEA
|    .|  ||..|.. ....
KFGKRMLQKDPEKRITGWEQI

Kinase 95937.m00100.AA Ciliate-E2-Unclassified 20-261 19 1.7e-45 155.78 In-house 1-346 (352) Show / Hide
Range on Protein: 20-261
Range on HMM: 1-346/352
Sequence Identity: 19% (69 aa)

YNISSQITNYGLYSQIHTAYHRIHRIPLAVKIISKNRIAD----LPKKERILFNETILSPL------------------LDHPNIIHVEEIIENNSKIFQ
|.|  || . | ..... ..|. .    | |...|..| .    . |. .|.......  .                  ..||.|.. ... ..  .|. 
YKIIKQI-GQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

FMQFAEKGDLLHSLQKCPP-------------------DQKTCF----KYVEQLLAAVERIHSLG-IVHRDIKLENILITSND---VLKLSDFGLAS---
 |...| |||.  ..|..                    .|...     .|  |.| . | .|. . |.|||||.||||...|     .|..|||...   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------ITCDGIMKDNCGSYEYS----APEAISHAEFDG---FKADMWGVGIIIYALFQKRLPFEDVR-------------------MGYNY
              |. . .|...||...|     ||| .   . |.   .|.|.|..|.|.|..   ..||.|                     .  | 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

-NKPVDFS---------RIPDPLQELCK----KLLSLDPNERPSADEA
 .|...|.         ....  .....    |.|  .||.|......
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI

Kinase 95937.m00100.AA AMPK 38-220 36 3.9e-39 113.88 In-house 18-202 (254) Show / Hide
Range on Protein: 38-220
Range on HMM: 18-202/254
Sequence Identity: 36% (69 aa)

AYHRIHRIPLAVKIISKNRIADLPKKERILFNETILSPLLDHPNIIHVEEII-ENNSKIFQFMQFAEKGDLLHSLQKCP--PDQKTCFKYVEQLLAAVER
..| . .   |.||. | .|.|.  .|||     ||  |. ||.||   |.| | .. || .| ..  |.|     |    . . .| ..  | ...|| 
GTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILK-LFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREAC-RFFQQIISGVEY

IHSLGIVHRDIKLENILITSNDVLKLSDFGLASITCDG-IMKDNCGSYEYSAPEAISHAEFDGFKADMWGVGIIIYALFQKRLPFED
.| ..||||| |.||.|.  |  .|. ||||  .  ||   |  |||  | ||| ||     | . | |  |.| ||.   .|||.|
CHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDD

Kinase 95937.m00100.AA Ciliate-E2a 48-261 28 4e-37 106.84 In-house 28-269 (275) Show / Hide
Range on Protein: 48-261
Range on HMM: 28-269/275
Sequence Identity: 28% (69 aa)

AVKIISKNRIADLPKKERILFNETILSPLLDHPNIIHVEEIIENNSKIFQFMQFAEKGDLLHSLQKCP-PDQK--TCFKYVEQLL-AAVERIHSLGIVHR
|.|...| ....  |... ..||  ..  |||||||   |. |... ..  | . | |.|.. ...|   ...     ..  |||  ... .|...|.||
AMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHR

DIKLENILIT---SN----DVLKLSDFGLASIT--CDG-IMKDNCGSYEYSAPEAISHAE--FD---GFKADMWGVGIIIYALFQKRLPFED--------
|.|.||||..   .|      .|..|||||      ..  |.  ||.  | ||| .   |  ..   . | ||| .|.|.| |   ..||.         
DLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQ

--VRMGYNYNKPVDFSRIPDPLQELCKKLLSLDPNERPSADEA
   .  ...| |. .. .... . | ||.|  ||..|..| .|
QNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQA

Kinase 95937.m00100.AA GIN4 70-220 32 2.2e-35 110.18 In-house 84-237 (293) Show / Hide
Range on Protein: 70-220
Range on HMM: 84-237/293
Sequence Identity: 32% (50 aa)

ETILSPLLDHPNIIHVEEIIENNSKIFQFMQFAEKGDLLHSL-QKCPPDQKTCFKYVEQLLAAVERIHSLGIVHRDIKLENILITSNDV-LKLSDFGLAS
| ..  |..|||.. . .. |.|....  . .||||.|   | .. |   .   .|  |..  |   |...|.|||.| ||.|. .    .|. |||.| 
EIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAA

ITCDG-IMKDNCGSYEYSAPEAISHAEFDGFKADMWGVGIIIYALFQKRLPFED
.  |. ...  |||  | ||| ..   ..|| .|.|  |.|..||   .|||..
LETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDE

Kinase 95937.m00100.AA TKL 32-265 15 4.3e-34 119.57 In-house 6-364 (364) Show / Hide
Range on Protein: 32-265
Range on HMM: 6-364/364
Sequence Identity: 15% (58 aa)

YSQIHTAYHRIHR--------IPLAVKIISKNR----------------------IADLPKKERILFNETILSPL-LDHPNIIHVEEIIENNSK------
..... ...| ..         . |||.....                       ... ....|  ..| |.. . |.||||..   .  ....      
FGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMH

-------IFQFMQFAEKGDLLHSLQKCPPDQKTCFKYVEQLLAAVERIHSLG--------IVHRDIKLENILITSNDV--------------LKLSDFGL
       ..  |.....|.||| |.         .. . .   ...  || .        |.|||.| .|||. .|                .|..||||
PVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGL

AS-ITCDGIMKDN--------------------CGSYEYSAPEAISHAEFDG---------------FKADMWGVGIIIYALFQKRLPFEDVRM------
.  .. .| |.|.                    ||.. . |||..  ....                 |.|..  ||... ..  ..|..|  .      
SRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQ

-------GYNYN---KPVDF------------SRIPDPLQELCKKLLSLDPNERPSADEARRML
        ....   .|               . .|... .|...  . ||..|||..|    |
DPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 95937.m00100.AA MARK 127-260 33 2.1e-31 100.03 In-house 112-255 (262) Show / Hide
Range on Protein: 127-260
Range on HMM: 112-255/262
Sequence Identity: 33% (48 aa)

QLLAAVERIHSLGIVHRDIKLENILITSND--VLKLSDFGLASITCDGI-MKDNCGSYEYSAPEAISHAEFDGFKADMWGVGIIIYALFQKRLPFEDVRM
|.. ||.  || .|||||||.||||| .|     |..|||.. .   |   .  ||...| ||| ..  . ||.|.|.|  |.. |.. . ..||..  .
QIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQ

GYNYN-------KPVDFSRIPDPLQELCKKLLSLDPNERPSADE
.|.         |.  ...... .. | ..|| ..|.|||...|
DYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEE

Kinase 95937.m00100.AA ULK 48-255 20 5.2e-31 107.31 In-house 32-312 (324) Show / Hide
Range on Protein: 48-255
Range on HMM: 32-312/324
Sequence Identity: 20% (59 aa)

AVKIISKNRIADLPKK-----ERILFN--ETILSPLL--DHPN--IIHVEEIIENN--SKIFQFMQFAEKGDLLHSLQKCPP----------DQKTCFKY
|.|.|.|. . . ...        |..    |.  |    |||  |.   .. |.     |. .| . . ||| . ..|  .           .. . ..
ACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQF

VEQLLAAVERIHSLGIVHRDIKLENILITSND------------VLKLSDFGLASI-TCDG----IMKDNC------GSYEYSAPEAIS----HAEFDGF
  |....   .|. .|.|||||..||||. ..            |||..|||.| .  ...    ...  .      |.  | ||. ..    . ... .
FKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDY

KADMWGVGIIIYALFQKRLP----FEDVR-------------MGYNYNKPVDFS------RIPDPLQELCKKLLSLDPNER
|.|.| .|.|.| .   . |    |.|               . | .|.|..|        | . ...| ...|  |...|
KCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR

Kinase 95937.m00100.AA TyrKc 26-265 20 1.4e-11 -35.68 SMART 1-280 (280) Show / Hide
Range on Protein: 26-265
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

ITNY-----GLYSQIHTAYHRIHRIPLAVKIISKNRIADLPKKERILFNETILSPLL--DHPNIIHVEEIIENN-------SKIFQFMQFAEKGDLLHSL
||       | . ... .  .   |. ||| . ..        .. . .|  .   |  .||||.    ..            ..  | ....|||.. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKCP--PDQKTCFKYVEQLLAAVERIHSLGIVHRDIKLENILITSNDVLKLSDFGLASITCDG--------IMKD----NC---GSYEYSAPEAISHAEF
.|.      |.  ..  |  .  | .|| ...|||.   |.|...| . | |||||.    |.          .     ..     .   |||.| . .|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DGFKADMWGVGIII----------YAL-----FQKRLPFEDVRMGYNYNKPVD-----FSRIPDPLQELCKKLLSLDPNERPSADEARRML
  .| | |  |. .          |          .  .|.|. ||   .| .     | . || . .. |.    ||..||.  | .. .
T-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 95937.m00100.AA Pkinase_Tyr 99-166 35 1.7e-05 19.28 Pfam 86-158 (270) Show / Hide
Range on Protein: 99-166
Range on HMM: 86-158/270
Sequence Identity: 35% (26 aa)

MQFAEKGDLLHSLQKC-----PPDQKTCFKYVEQLLAAVERIHSLGIVHRDIKLENILITSNDVLKLSDFGLA
| ....||||. |.|      |.. |.  ..  |  .. |  .| ...|||.   |.|.|.| | | .|||||
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA

Kinase 95937.m00100.AA MARK 38-109 30 0.006122 5.64 In-house 18-91 (262) Show / Hide
Range on Protein: 38-109
Range on HMM: 18-91/262
Sequence Identity: 30% (23 aa)

AYHRIHRIPLAVKIISKNRIADLPKKERILFNETILSPLLDHPNIIHVEEIIE--NNSK-IFQFMQFAEKGDLLH
| |.  ..  |.||. |... | |.. . .. |  .  .|||||||   ..||  .... |.  |  |..|.|..
ACHKHTGRKVAIKIYEKFKLND-PQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYD