Gene 81529.m00379 (T.vaginalis)

81529.m00379

Species: T.vaginalis
Alias: TvagK0825, 81529.m00379
External Links:
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: CAMKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
81529.m00379.AA Protein None 280 None Fasta, JSON
81529.m00379.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of 81529.m00379.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 81529.m00379.AA Ciliate-E2 25-239 17 8.1e-22 71.66 In-house 12-365 (365) Show / Hide 
Range on Protein: 25-239
Range on HMM: 12-365/365
Sequence Identity: 17% (62 aa)

HGKVFLV-EWLKYN----------------------QLFSLKRIERA--HYEQNQINIIR----------------NLYHFNIINVYKTFM--REKYVYL
.|.|...  |.. .                      ... .|...     .  . |.|.|                .| | |||. | .|    ....||
FGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYL

LMDYCPL-DIQRYIEQRGVLSESR--------FAEAAYSMLKSVS------------------LMHSKR-ICHNNIRPSKFLLDKYGRVQISDFCNAAQY
 |.||   | . ||...   . .           |..| | . ..                   .|||  |.| .| |.  |.     . |.|| .. .|
VMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKY

Q-------------------------------------------------ENEESKFE--------HAQSVDSWSLGVTFYYMLTGRL-----IT--DLY
.                                                 |. ..| .        .  ..| |||||..|.||.|..     |   .. 
DDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQIKQCKID

FSEEEAMSKDFSHIK------YPEVSKECIRLISS----CLNNNEKARPS-VDELLSSPLF
|...|  .. .  ..      . ..|.||. ||.     .|. ... |..  ...|  | |
FPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
S_TKc 81529.m00379.AA S_TKc 14-239 23 2.6e-21 78.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 14-239
Range on HMM: 1-231/231
Sequence Identity: 23% (60 aa)

LAFKCVITTTKHGKVFLVEWLKYNQLFSLKRIERAHYEQNQINIIRNLYHFNIINVYKTFMREKYVYLLMDYCPL---DIQRYIEQRGV------LSESR
  .  .|     |||... . | .... .|.|      .. |.| ..  | ||.. | .|   ...|. |.||.    |  .||..||       ..| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

FAEAAYSMLKSVSLMHSKRICHNNIRPSKFLLDKYGRVQISDFCNAAQYQENEESKF------------EHAQ-SVDSWSLGVTFYYMLTGRLITDLYFS
 .  .| ... .  .||..|.|  . |.  |||.  .. |.||  |.|.     . |             .   ..| ||.|...| ||.|.   .    
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP----

EEEAMSKDFSHIKYPEVSKECIRLISSCLNNNEKARPSVDELLS-------SPLF
....| |          |.|.. .|. ||. . . ||.. |.|         | |
QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 81529.m00379.AA Ciliate-E2-Unclassified 25-239 16 9.3e-20 65.22 In-house 12-352 (352) Show / Hide 
Range on Protein: 25-239
Range on HMM: 12-352/352
Sequence Identity: 16% (58 aa)

HGKVFLVEWLKYNQLF-----SLKRIERA-HYEQN---------QINII----------------RNLYHFNIINVYKTFMREKYVYLLMDYCP-LDIQR
.|||....  | . ..       | .... .. .|         ..|..                .|..| .|.. . .|  ....|. |.||. .| . 
FGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQ

YIEQRGV-----------------LSESRFA-----EAAYSMLKSVSLMHSK-RICHNNIRPSKFLLDKYG---RVQISDFCNAA---------------
||..|.                  ..|   .       ..  |.  . .|.|  |.| .| |.  |.|. |   .. |.|| ..                
YIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQK

----------------QYQ------ENEES-KFEHA--QSVDSWSLGVTFYYMLTGRLITDLYF----------------------SEEEAMSKDFSHIK
                .|.      |  .. . .|    ..| ||||| .|.||.|..    ..                       ... . |...  |
MQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYY---PFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPK

YPE------VSKECIRLIS----SCLNNNEKARPSVDELLSSPLF
.|.      .|.|.. .|.    ..|..| . |.. ...|  |.|
FPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 81529.m00379.AA CAMKL 163-239 23 2e-13 39.07 In-house 213-297 (297) Show / Hide 
Range on Protein: 163-239
Range on HMM: 213-297/297
Sequence Identity: 23% (21 aa)

HAQSVDSWSLGVTFYYMLTGRL----------ITDLYFSEEEAMSKDFSHI-KYPEVSKECIRLISSCLNNNEKARPSVDELLSSPLF
... || ||.||. | |..|.|          . | .  ...   ..  .. ....|| .|..||.. |. | . ||....... | .
DGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 81529.m00379.AA CAMK 19-159 16 1.4e-12 36.17 In-house 1-252 (425) Show / Hide 
Range on Protein: 19-159
Range on HMM: 1-252/425
Sequence Identity: 16% (41 aa)

VITTTKHGKVFLVEWLKYN------------QLFSLKRIE------------------------------RAHYEQ---NQINIIRN-------LYHFNI
.. .   |||.|..  . .            | .  | |.                              |.. ..   . |.| ..       | | ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

INVYKTFMR-------------------EKYVYLLM---DYC---PL--DIQRYIEQR---------------GVLSESRFAEAAYSMLKSVSLMHSKRI
|. | ..                     .|..|. |   .||    |  |.  || ..               | ..|.  .     ..  |  .||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

CHNNIRPSKFLLDKY-----------------GRVQISDFCNAAQYQENEES
.|  . |   |||.                  . . |.||  |......|..
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENN
Kinase 81529.m00379.AA CAMK 165-239 18 1.5e-12 36.07 In-house 313-425 (425) Show / Hide 
Range on Protein: 165-239
Range on HMM: 313-425/425
Sequence Identity: 18% (21 aa)

QSVDSWSLGVTFYYMLTG--------------------------RLITDLYFS-EEEAMSK-------DFSH-----IKYPEVSKECIRLISSCLNNNEK
...| ||.||  | ||.|                          . |.   .. ... .|.       .. .     ..  .||.||. ||...|. . .
PKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECKDLIRKMLQVDPE

ARPSVDELLSSPLF
 |..... |. | .
KRMTIEQCLNHPWM
Kinase 81529.m00379.AA Pkinase 26-126 24 2.4e-12 44.75 Pfam 13-131 (293) Show / Hide 
Range on Protein: 26-126
Range on HMM: 13-131/293
Sequence Identity: 24% (29 aa)

GKVFLVEWLKYNQLFSLKRIERAHYEQNQ---------INIIRNLYHFNIINVYKTFMREKYVYLLMDYCPL-----DIQRYIE--QRGVL--SESRFAE
|.|..  . ...... .|.|.. | . ..         | | ..| | ||.  | .|......|. |.||.      |  .||.  ..|..  ||     
GCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKF

AAYSMLKSVSLMHSKRICH
 .| .|. .  .||..|.|
YMYQILRGLEYCHSMGIIH
Kinase 81529.m00379.AA CMGC 42-147 16 9e-12 34.03 In-house 43-248 (513) Show / Hide 
Range on Protein: 42-147
Range on HMM: 43-248/513
Sequence Identity: 16% (34 aa)

LKRIERAHYEQNQ-----------------INIIRNL-----------------YHFNIINVYKTFMREK-----------------YVYLLMDYCPLDI
.|.| ... ...|                 | | ..|                  | ||.. |  |....                 ..|| ..|.. | 
IKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDL

QRYIEQRG---------VLSESR------------FAEAA------YSMLKSVS--LMHSKR--ICHNNIRPSKFLLD--------------------KY
 .||..            |||                         | .|...    .||..  |.|  . |.  |..                    | 
YQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKN

GRVQISDF
||. | ||
GRLKICDF
Kinase 81529.m00379.AA Pkinase 165-239 22 1.2e-11 42.31 Pfam 191-293 (293) Show / Hide 
Range on Protein: 165-239
Range on HMM: 191-293/293
Sequence Identity: 22% (24 aa)

QSVDSWSLGVTFYYMLTGRLITDLYFSEE-------------EAMSKDFSHIKYPEVS-------------------KECIRLISSCLNNNEKARPSVDE
..|| ||.|...|.||.||    . |...             . |.....   . . |                   .||. .|..||. . | ||. ..
PKVDMWSCGCILYEMLCGR----PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLSSPLF
.| .| |
ILQHPWF
Kinase 81529.m00379.AA AGC 163-239 18 2.4e-11 24.08 In-house 280-395 (395) Show / Hide 
Range on Protein: 163-239
Range on HMM: 280-395/395
Sequence Identity: 18% (22 aa)

HAQSVDSWS--LGVTFYYMLTG----------------RLITDLYFSEEEAMSKDFSHIKYP-----------EVSKECIRLISSCLNNNEKARPS----
. ...| ||  ||. .| ||||                |   ... . .. . . .  .|.|           ..|.|.  ||. .|. . . |.     
YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGN

------VDELLSSPLF
      ..|. . | |
DFGDKGAEEIKNHPWF
Kinase 81529.m00379.AA KHS 52-152 27 1.6e-10 31.46 In-house 44-145 (258) Show / Hide 
Range on Protein: 52-152
Range on HMM: 44-145/258
Sequence Identity: 27% (28 aa)

QNQINIIRNLYHFNIINVYKTFMREKYVYLLMDYCPL-DIQRYIEQRGVLSESRFAEAAYSMLKSVSLMHSKRICHNNIRPSKFLLDKYGRVQISDFCNA
|  | ....  | ||.  .  ..|.. ... |.||    .|   .  | |||   |  .   |. .  .||.   |  |.    || ..| |.. ||  .
QQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVS

AQ
||
AQ
Kinase 81529.m00379.AA ULK 170-239 26 1.2e-08 26.44 In-house 240-329 (329) Show / Hide 
Range on Protein: 170-239
Range on HMM: 240-329/329
Sequence Identity: 26% (24 aa)

WSLGVTFYYMLTGRLI--TDLYFSEE-----EAMSKDFSH--------IKYPE------VSKECIRLISSCLNNNEKARPSVDELLSSPLF
||||. ||.||.|.    .  ....      .   . . .        ...|       .|.||. ||. .|  .|| | | .||.. |.|
WSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 81529.m00379.AA STE 166-239 19 2.2e-08 25.85 In-house 248-359 (359) Show / Hide 
Range on Protein: 166-239
Range on HMM: 248-359/359
Sequence Identity: 19% (22 aa)

SVDSWSLGVTFYYMLTGRLI-TDLYFSEEEAMSKDF---------------SHIKYPE--------------------VSKECIRLISSCLNNNEKARPS
..| |||| |   |.||.    |..  .   |  .                 . . |.                    .|.|..  |. ||. . . ||.
KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT

VDELLS--SPLF
...||.   | .
ASQLLKSEHPFI
Kinase 81529.m00379.AA CAMKL 55-103 27 1e-06 17.28 In-house 63-127 (297) Show / Hide 
Range on Protein: 55-103
Range on HMM: 63-127/297
Sequence Identity: 27% (18 aa)

INIIRNLY---HFNIINVYKTFMREKY------VYLLMDYCP---LDIQRYIEQR----GVLSES
|.| . |    | |||  | ..  ...      .|| | ||.   .| . ||...    | ..|.
IQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEH
TyrKc 81529.m00379.AA TyrKc 14-239 14 1.4e-05 -132.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 14-239
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)

LAFKCVITTTKHGKVFLVEWLKYNQLF----SLKRIERAHYE-QNQINIIRNL--YHFNIINVYKTFMRE-------KYVYLLMDYCPL-DIQRYIEQRG
. .. ..     |.|.. .|     .     .||     . .  . ..| ..|   | ||.. |   . .       . ....| |.|. | . |.  ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

V-LSESRFAEAAYSMLKSVSLMHSKRICHNNIRPSKFLLDKYGRVQISDF---CNAAQY-------QENEE-----SK------------FEHA---QSV
  |. . . . ..   .  .  |||.. |  .     |... ..| ||||    .   .       .         .|            . .       
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DSWSLGVTFYYMLT-------G-----RLITDLYFSEEEAMSKDFSHIKYPE-----VSKECIRLISSCLNNNEKARPSVDELLSSPLF
| || ||. . ..|       |        ....   .. .  .  .  | .      ..|  .....| . . . ||.  |.    .|
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 81529.m00379.AA MARK 205-239 37 2.6e-05 13.53 In-house 228-262 (262) Show / Hide 
Range on Protein: 205-239
Range on HMM: 228-262/262
Sequence Identity: 37% (13 aa)

YPEVSKECIRLISSCLNNNEKARPSVDELLSSPLF
.. |||||  ||.. |. | . ||...|... | .
PCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 81529.m00379.AA STE 52-147 21 3e-05 14.63 In-house 76-191 (359) Show / Hide 
Range on Protein: 52-147
Range on HMM: 76-191/359
Sequence Identity: 21% (26 aa)

QNQINIIRNLY--HFNIINVYKTFMRE-------KYVYLLMDYCP-LDIQRYIEQR--------------GVLSESRFAEAAYSMLKS-VSLMHSKRICH
.. |.| ...   | ||.. | ....|        .... | |..   .   |...              ....||  |  ... ||   .. ||..| |
LKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIH

NNIRPSKFLLDKYGRVQISDF
  | |.  ||     | ..||
RDIKPANILL-----VKLCDF
Kinase 81529.m00379.AA MARK 55-103 30 3e-05 13.29 In-house 50-104 (262) Show / Hide 
Range on Protein: 55-103
Range on HMM: 50-104/262
Sequence Identity: 30% (17 aa)

INIIRNLYHFNIINVYKTFM--REKY-VYLLMDYCP-LDIQRYIEQR--GVLSES
|.| . | | |||  ....    |.  .|| |.|..  .   ||...  | |.|.
IEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEE
Kinase 81529.m00379.AA MARK 164-184 47 0.000168 10.82 In-house 184-204 (262) Show / Hide 
Range on Protein: 164-184
Range on HMM: 184-204/262
Sequence Identity: 47% (10 aa)

AQSVDSWSLGVTFYYMLTGRL
.. || |||||  |.|..|..
GPKVDIWSLGVVLYFMVCGYF
Kinase 81529.m00379.AA CMGC 198-239 10 0.000196 9.46 In-house 438-513 (513) Show / Hide 
Range on Protein: 198-239
Range on HMM: 438-513/513
Sequence Identity: 10% (8 aa)

KDFSHIKYP----------------------------------EVSKECIRLISSCLNNNEKARPSVDELLSSPLF
|... .. .                                    ....| |.. .|  . . |..... |. | |
KPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 81529.m00379.AA ULK 52-103 28 0.000299 10.84 In-house 58-120 (329) Show / Hide 
Range on Protein: 52-103
Range on HMM: 58-120/329
Sequence Identity: 28% (18 aa)

QNQINIIRNLY--------HFNIINVYKTFMRE--KYVYLLMDYCPL-DIQRYIEQRGVLSES
.| | |.. |         | ||.  |. |.    ...|. |.||.  | . ||.... |.|.
KNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPED
Kinase 81529.m00379.AA AGC 26-104 14 0.000747 4.26 In-house 13-147 (395) Show / Hide 
Range on Protein: 26-104
Range on HMM: 13-147/395
Sequence Identity: 14% (20 aa)

GKVFLVEWL------KYNQLFSLKRIERAH---------YEQNQ--------------INIIRNLY----------HFNIIN-VYKTFMREKY--VYLLM
|||.||.          .... .| .. .|          |...               ||  ..           | .|..  . .|  ...  .|..|
GKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVM

DYCP-----------LDIQRYIE---QRGVLSESR
.|.|           ..   ..    ..|...|.|
EYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEER
Kinase 81529.m00379.AA KHS 216-239 33 0.016548 4.1 In-house 235-258 (258) Show / Hide 
Range on Protein: 216-239
Range on HMM: 235-258/258
Sequence Identity: 33% (8 aa)

ISSCLNNNEKARPSVDELLSSPLF
.  .|  | | ||. . ||. |..
VKMALTKNPKKRPTAEKLLQHPFV