Gene 94962.m00228 (T.vaginalis)

94962.m00228

Species: T.vaginalis
Alias: TvagK0503, 94962.m00228
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
94962.m00228.AA Protein None 428 None Fasta, JSON
94962.m00228.kin_dom Protein Kinase Domain None 233 None Fasta, JSON

Protein domain

Protein domains of 94962.m00228.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94962.m00228.AA CK1-Unclassified 13-245 47 1.8e-129 384.25 In-house 1-244 (244) Show / Hide 
Range on Protein: 13-245
Range on HMM: 1-244/244
Sequence Identity: 47% (115 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIKVALKIEPNDVKNSPLEIESKMYGVFTNNN-------YVPKMYFYGSD--SDKNLLAIDLLDKSLEKHLADCKRK
. ..||||.| ||.||.. .. .. .||.|.| ...|.. | .| | .  . |.        ..|||| .| .  .|.| .  |||..|||. .  |.||
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

MSLKTVLMLIDQMITCVQYIHSCDFIHRDIKPENFMTG-CGEFSKRIYIIDFGLCKRYRNQ-YNHQHIPYTEGNSLTGTPRYASINALAGGKQSRRDDME
 |||||||. ||||. ..|.|.. ||||||||.||. |  |  ....||||||| |||.    ...|||| |. .|||| |||||||  |  ||||||.|
FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLE

SLGYVWIYLLKGELPWMDEKSEDVNVKFAKVLKKKQSTKIEDLC
||||| ||.|||.|||.. | ..   |. | . .|.|| .| ||
SLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC
Kinase 94962.m00228.AA CK1 13-271 46 1.1e-125 423.81 In-house 1-271 (271) Show / Hide 
Range on Protein: 13-271
Range on HMM: 1-271/271
Sequence Identity: 46% (127 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIK--VALKIEPNDVKNSPLEIESKMYGVFTN------NNYVPKMYFYGSD--SDKNLLAIDLLDKSLEKHLADCKR
. .|.|||.| ||.||..... .. .  || |.|.|. |.. | .|.| |  . .        ..|.|| .| .  .| | . .||| .|||. .  |.|
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

KMSLKTVLMLIDQMITCVQYIHSCDFIHRDIKPENFMTGC-GEFSKRIYIIDFGLCKRYRNQYNHQHIPYTEGNSLTGTPRYASINALAGGKQSRRDDME
| |||||||. ||||. ..|.|...||||||||.||. |  |  ....||||||| ||||   .|||||| |. .|||| ||||||.  |  ||||||||
KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDME

SLGYVWIYLLKGELPWMDEKSEDVNVKFAKVLKKKQSTKIEDLCKG-LPIEFTRYFEMIKSLQFHQEPEYD
||||| .|.|.|.|||.. | .    |. | . ||.|| .|.|||| .| ||..|.. ...|.| ..| |.
SLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 94962.m00228.AA CK1-D 13-273 48 1.4e-99 337.1 In-house 1-261 (261) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-261/261
Sequence Identity: 48% (126 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIKVALKIEPNDVKNSPLEIESKMYGVFTNNNYVPKMYFYGSDSDKNLLAIDLLDKSLEKHLADCKRKMSLKTVLML
. .| |||.| ||.||  ..      ||.|.|.   |   |.||||.| ..     .|.. ..|.. | |.. .|||  |||     |.|| ||||||||
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

IDQMITCVQYIHSCDFIHRDIKPENFMTGCGEFSKRIYIIDFGLCKRYRNQYNHQHIPYTEGNSLTGTPRYASINALAGGKQSRRDDMESLGYVWIYLLK
 ||||. ..|||. .||||||||.||. | |   . .||||||| ||||    |||||| |  .|||| ||||||   |  ||||||.|||||| .|  .
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

GELPWMDEKSEDVNVKFAKVLKKKQSTKIEDLCKGLPIEFTRYFEMIKSLQFHQEPEYDQY
| |||   |      |. ..  || ||||..||||.| ||..|..  ..|.| . |.|   
GSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 94962.m00228.AA CK1 13-273 29 2.2e-94 319.87 In-house 1-339 (339) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-339/339
Sequence Identity: 29% (99 aa)

FSLGEKIGAGGFG-QIYEA-----EDTRQH-----IKVALKIEPNDVKNSP--LEIESKMYGVFTNNN--------------------YVPKMYFYGSDS
. ...||| |||| |||..     .|.  .      ..|.|.||.. . ..  |..|..||  .....                    ........| . 
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

DKN-LLAIDLLDKSLEKHLA---DCKRKMSLKTVLMLIDQMITCVQYIHSCDFIHRDIKPENFMTGC-------------GEFSKRIYIIDFGLCK-RYR
|..  . ..|| ..||. ..    |.||.|.||.||. .||.  ..|.|.| ||||||||.||. |              .. ....|.||||... .||
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NQ-----------YNHQHIPYTE---GNSLTG-TPRYASINALAGGKQSRRDDMESLGYVWIYLLKGE--LPWMDEKSEDV-------NVKFAKVLKKKQ
.             ..||.|. |     ...| |.||.|||.  |  |.||||..|..|. |..|||.  |||.. |.|.          | ..  .|| 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

STKIEDLCKG-----LPIEFTRYFEMIKSLQFHQEPEYDQY
||... ||..     .| ||  ....|.||... .|.|.  
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 94962.m00228.AA CK1-A 13-273 46 2.2e-93 316.56 In-house 1-261 (261) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-261/261
Sequence Identity: 46% (121 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIKVALKIEPNDVKNSPLEIESKMYGVFTNNNYVPKMYFYGSDSDKNLLAIDLLDKSLEKHLADCKRKMSLKTVLML
. |  |||.| || || .  ...   ||.|.| |...   |  |.|.| .      .|.| .||.. | | . .|||  |||     |||. ..||||||
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

IDQMITCVQYIHSCDFIHRDIKPENFMTGCGEFSKRIYIIDFGLCKRYRNQYNHQHIPYTEGNSLTGTPRYASINALAGGKQSRRDDMESLGYVWIYLLK
 ||||. . |.|   ||||||||.||. | |    ....||||| |.|| .  .||||| |   |||| |||||||  |  |||||||||.||| .|  .
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

GELPWMDEKSEDVNVKFAKVLKKKQSTKIEDLCKGLPIEFTRYFEMIKSLQFHQEPEYDQY
|.|||   |      |. |.. || || || |||| | ||. |.. ...|.|...|.|   
GKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 94962.m00228.AA CK1-G 13-273 39 1.3e-84 286.72 In-house 1-266 (266) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-266/266
Sequence Identity: 39% (106 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIKVALKIEPNDVKNSPLEIESKMYGVFTNNN-YVPKMYFYGSDSDKNLLAIDLLDKSLEKHLADCKRKMSLKTVLM
.  | ||| | || ..| .   .   || |.||   .   |  | ..| .       .|. |..|     | . .|||  |||     | || |.|||.|
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVCM

LIDQMITCVQYIHSCDFIHRDIKPENFMTG--CGEFSKRIYIIDFGLCKRYRNQYNHQHIPYTEGNSLTGTPRYASINALAGGKQSRRDDMESLGYVWIY
.  |||. ..|.|| . | ||.||.||. |    .  . |.|||||. | |.     ||||| |  ||||| || |||   |  ||||||||.|| . .|
VAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFMY

LLKGELPWMDEKSEDVNVKFAKVLKKKQSTKIEDLCKG--LPIEFTRYFEMIKSLQFHQEPEYDQY
 | |.|||   | .    .. |. ..|..| |||||..  .|..| .| . . .|.|  .| ||  
FLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 94962.m00228.AA TTBKL 13-277 25 3e-50 167.87 In-house 1-288 (288) Show / Hide 
Range on Protein: 13-277
Range on HMM: 1-288/288
Sequence Identity: 25% (75 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIK-VALKIEPNDVKNSP--LEIESKMYGVFTNN--NYVPKMYFYGSDSDKNLLAIDLLDKSLEKHLADCKRK--MS
.   ..|| |||||.|...|.  . .  |.|.|.|   . .  ...| ..     .|   ..||....|   | | ..  |. ..| .. .. ..|  .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LKTVLMLIDQMITCVQYIHSCDFIHRDIKPENFMTGCGEF----SKRIYIIDFGLCKRYRNQYNHQ----------HIPYTE---GNSLTGTPRYASINA
  |.. .  | . .....|.| |||||.|| |...|. .     ....|.||||....|..  . .          . .  .     .. ||.||.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

LAGGKQSRRDDMESLGYVWIYLLKGELPWMDEKSEDVNVKFAKVLKKKQSTKIEDLCKG------LPIEFTRYFEMIKSLQFHQEPEYDQYRQMF
 ..  |.| ||. |. |. |.|..| ||| ......      .. ..|...| |||.|.      .| ||.  .....||.....| |.  .. |
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKM------EIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 94962.m00228.AA Worm6 91-273 28 8.2e-34 118.65 In-house 87-279 (279) Show / Hide 
Range on Protein: 91-273
Range on HMM: 87-279/279
Sequence Identity: 28% (55 aa)

KSLEKHLADC-KRKMSLKTVLMLIDQMITCVQYIHSCDFIHRDIKPENFMTGC-----GEFSKRIYIIDFGLCK--RYRNQYNHQHIPY-TEGNSLTGTP
|.|.   ... .||.|. | | .  |..  ..  |.| |||||.|| ||  |       . ...||..|||.|.  .|.|. |  . |  |.     ||.
KNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACG-FRGTV

RYASINALAGGKQSRRDDMESLGYVWIYLLKGELPWM-DEKSEDVNVKFAKVLKKKQSTKIEDLCKGLPI-EFTRYFEMIKSLQFHQEPEYDQY
|||....  |  |.|.||.||  |. . ...|.|||.  ... .|.. . .  ......  ... .. |  ||.. ...| ..... .|.|.. 
RYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 94962.m00228.AA TTBK 13-273 32 1.7e-33 115.74 In-house 1-257 (257) Show / Hide 
Range on Protein: 13-273
Range on HMM: 1-257/257
Sequence Identity: 32% (87 aa)

FSLGEKIGAGGFGQIYEAEDTRQH-IKVALKIEPNDVKNSPLEIESKMYGVFTNNNYVPKMYFYGSDSDKNLLAIDLLDKSL-EKHLADCKRKMSLKTVL
     ||| |||| ||||.|   |  .||.|.|  . .   | .|          ..| . .  | . . | .  .|. |.| .   .  . . || | |
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

MLIDQMITCVQYIHSCDFIHRDIKPENFMTG-CGEFSKRIYIIDFGLCKRYRNQYNHQHIPYTEGNSLTGTPRYASINALAGGKQSRRDDMESLGYVWIY
 |  |..  .. |||  | |||||| ||  |   .  ...|..||||  .| |       |  |     || |||||||       |.||. || |. . 
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPR-EVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LLKGELPWMDEKSEDVNVKFAKVLKKKQSTKIEDLCKGLPIEFTRYFEMIKSLQFHQEPEYDQY
 ..| |||   |  |      .| . |.     .| | .| ||  . . ||||..   |.|   
FVQGQLPWRKIKDKD------QVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 94962.m00228.AA Pkinase 13-264 19 3.8e-32 114.75 Pfam 1-258 (293) Show / Hide 
Range on Protein: 13-264
Range on HMM: 1-258/293
Sequence Identity: 19% (53 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIKVALKIEPNDVKNSPLEI------ESKMYGVFTNNNYVPKMYFYGSDSDKNLLAIDLLDK-----SLEKHLA-DC
. .|.|||.|.||. |.. .    ..||.|| . . ..|  ..      | ..   .   | |   ... . .|.  .  .....     .|  ..  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

KRKM--SLKTVLMLIDQMITCVQYIHSCDFIHRDIKPENFMTG-CGEFSKRIYIIDFGLCKRYRNQYNHQHIPYTEGNSLTGTPRYASINALA-GGKQSR
....  | ... . . |..  ..|.||. .||||.||||..    |. . .. |.||||.| ..      . ...  ....|||.|..   .  | . ..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

RDDMESLGYVWIYLLKGELPWMDE----KSEDVNVKFAKVLKKKQSTKIEDLCKGLPIEFTRYFEMIKSLQF
. || |.| . ...| |..|. ..    .  | ........... .  .. .| . . . .|. .  . ...
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWT
Kinase 94962.m00228.AA VRK 86-231 32 6.5e-18 54.37 In-house 108-256 (284) Show / Hide 
Range on Protein: 86-231
Range on HMM: 108-256/284
Sequence Identity: 32% (49 aa)

IDLLDKSLEKHLA-DCKRKMSLKTVLMLIDQMITCVQYIHSCDFIHRDIKPENFMTGCGEFSKRIYIIDFGLCKRYRNQYNHQHIPYTEGNSLT--GTPR
.. .. .|.| .   .. . | |||| |  .|.   .|.|. .  | ||| .| . |  .   . | .|.||  || .  .|   .| |.      ||. 
MPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHR--QYKEDPRRCHNGTCE

YASINALAGGKQSRRDDMESLGYVWIYLLKGELPWMDEKS--EDVNVKFAK
. |. |  |   ||| | |.|||  .. | |.||||| .     . |  ||
FTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAK
Kinase 94962.m00228.AA S_TKc 13-264 20 3.7e-16 59.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-264
Range on HMM: 1-231/231
Sequence Identity: 20% (55 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIKVALKIEPNDVKNSPLEIESKMYGVFTNNNYVPKMYFYGSDSDKNLLAIDLLDK---SLEKHLADCKRK-----M
. ...||| |.||. | . ... . .||.|| .   ..   ||.  .     .  .. |.| .  | |.  .  ...|    .| ... ...|.     .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLKTVLMLIDQMITCVQYIHSCDFIHRDIKPENFMTGCGEFSKRIYIIDFGLCKRYRNQYNHQHIPYTEGNSLTGTPRYASINALAGGKQSR-RDDMESL
.  ..  .. |..  ..|.||  .||||.|||| .        .| |.||||....              ... ||| | .   |   . .. . |. |.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GYVWIYLLKGELPWMDEKSEDVNVKFAKVLKKKQSTKIEDLCKGLPIEFTR----YFEMIK-------SLQF
| . . .| |. |.      .... | |..    |    |. ...     .      |  .          |
GCILYEMLCGYPPFP-----QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 94962.m00228.AA VRK 13-53 39 3.7e-08 22.7 In-house 1-45 (284) Show / Hide 
Range on Protein: 13-53
Range on HMM: 1-45/284
Sequence Identity: 39% (18 aa)

FSLGEKIGAGGFGQIYEA-----EDTRQHIKVALKIEPNDVKNSPL
. || .|| |||| ||.|     . .    .   |||| . .| ||
WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEP-PHENGPL
Kinase 94962.m00228.AA Worm6 13-44 38 2e-06 19.73 In-house 1-34 (279) Show / Hide 
Range on Protein: 13-44
Range on HMM: 1-34/279
Sequence Identity: 38% (13 aa)

FSLGEKIGAGGFGQIYEAEDTRQHI--KVALKIE
.....||| |||| .|..||.      ..|.| |
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCE
Kinase 94962.m00228.AA TyrKc 13-215 15 3e-06 -122.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-215
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

FSLGEKIGAGGFGQIYEAEDTRQHIKVALKIEPNDVKNSPLEIESKMYGVF-TNNNYVPKMYFYGSDS-------DKNLLAIDLLDK-SLEKHLADCKRK
 .||.|.| | ||..|... .   |.|| |   .|     .  | ..   .  ..  . ..| . ...       .  ..   . .. .| ..| ....|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

MSLKTVLMLIDQMITCVQ------YIHSCDFIHRDIKPENFMTGCGEFSKRIYIIDFGLCKRYRNQ--------YN------HQH--IPY--------TE
      | . |    |.|      |.||  .||||.   | . | .    .. | ||||..   .         |       . .  .|.         .
------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

G------------------NSLTGTPRYA-------SINALAGGKQSRRDDMESLGY-----------------VWIY---------LLKGEL
|                   .. ..| .         . ...  || .| .    .|                  | .          .. ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF