Gene 84458.m00166 (T.vaginalis)

84458.m00166

Species: T.vaginalis
Alias: 84458.m00166, TvagK0459
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
84458.m00166.AA Protein None 347 None Fasta, JSON
84458.m00166.kin_dom Protein Kinase Domain None 188 None Fasta, JSON

Protein domain

Protein domains of 84458.m00166.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84458.m00166.AA CK1 16-270 26 6.6e-83 281.75 In-house 1-339 (339) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-339/339
Sequence Identity: 26% (91 aa)

FQVLNLIGQGGFG-NIYMV-----SEISTQ-----TNFAMKTEWLNAE--HRGIAREASILSRLQG--------------------SPMFPRIKKIGETE
..|  .||.||||  ||.|     . ....     . .|||.|  ...  |.   .|. ..  |||                    .| ....   ||..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

KFR-YFIMELLGHSLSKIKH--EYPNKRLSVQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLVRS--------------DNIYALVLIDFGLAC-SYV
..  | .|.||| .|....     .|...|.  .|...||||. .|..| .|||||||||.||..                ..   ...||||.|.  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DT-----------ESGVHLPPRT---ERAFGG-TSRYASLAALRGEDVSRKDDLISWFFSVVELATGN--LPWKRCTGKEE-------SLKQRKGVRPKD
|            . ..| |||.    . | | | ||.|... .| . .|.||| |||. ..|.  |.  |||. .. ...         |. .  ..| 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

ICNY----------LPKEMTKIYNNIIKLKFEETPDYALI
              .|.|. ||.. | .||....|||. |
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 84458.m00166.AA Worm6 16-270 31 3.4e-73 249.49 In-house 1-279 (279) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-279/279
Sequence Identity: 31% (88 aa)

FQVLNLIGQGGFGNIYMVSEISTQTN--FAMKTEW--LNAEHRGIAREASILSRL--QGSPMFPRIKKIGETEK--FRYFIMELLGHSLSKIKHEYPNKR
..|. .||.|||| .|.|.. |. ..  |||| |    |....   .|...| ..  .... |..|   | ...  |.| .|.|.| .|. .. . |...
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LSVQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLVRS------DNIYALVLIDFGLAC-SYVDTESGVHLPPR-TERAFGGTSRYASLAALRGEDVSR
.|.  .|...||.|. ||.||..||||||.||||| .        ...  . ..|||..   . . . ..  .|| |. .| || |||.||. .| . .|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

KDDLISWFFSVVELATGNLPWKRCTGKEESLKQRKGV--RP-----KDICNYLPK-EMTKIYNNIIKLKFEETPDYALI
|||. |||  .||. .|.|||. .... .  |..|    |      ..  .  || |...|   | .......|||. |
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 84458.m00166.AA TTBKL 16-274 29 2.8e-72 243.32 In-house 1-288 (288) Show / Hide 
Range on Protein: 16-274
Range on HMM: 1-288/288
Sequence Identity: 29% (86 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNFAMKTEWLNA-EHRG--IAREASILSRLQ--GSPMFPRIKKIGETEKFRYFIMELLGHSLSKIKHEYPNKR-LS
...  .||.|||| .|.|. ..... .|.. | .|  |. .  .  |. .|..||  ||| ||...  |.........|.|.| .|.....  |||. .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

VQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLVRSD---NIY--ALVLIDFGLACSYVDTESG----------VHLPPRT---ERAFGGTSRYASLAA
.. ..|.||| |... |.| .||||||.||.|. .      . .   . |||||.|  |.. ...           . .||.      | || ||.|...
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

LRGEDVSRKDDLISWFFSVVELATGNLPWKRCTGKEESLKQRKGVRPKDICNY------LPKEMTKIYNNIIKLKFEETPDYALIYDLL
 .. . .|.||| ||.....||. | |||.... |.|  .  |    .|.. .      .|.|..|.. ..  |.. ..|||  || ..
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 84458.m00166.AA TTBK 16-270 34 1.1e-54 187.99 In-house 1-257 (257) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-257/257
Sequence Identity: 34% (90 aa)

FQVLNLIGQGGFGNIYMVSEISTQ-TNFAMKTEWLNAEHRGIAREASILSRLQGSPMFPRIKKIGETEKFRYFIMELLGHSLSKIKHEYPNKRLSVQLAL
 .|.  ||.|||| ||   .. ..  . |.| |  ..       |  .| .||| .   |    |  .|| | .|.|.| .|.    . |    |.  .|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RCGIQMLKCIEQLHKHGFIHRDIKPGNFLV--RSDNIYALVLIDFGLACSYVDTESGVHLPPRTERAFGGTSRYASLAALRGEDVSRKDDLISWFFSVVE
| |.|.|. ||. |  || |||||| || .   . ..    ..|||||  |. ..  |  |||    | || ||||  | |  .  |.||| | |.  ||
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVR-PPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LATGNLPWKRCTGKEE--SLKQRKGVRPKDICNYLPKEMTKIYNNIIKLKFEETPDYALI
 . | ||| .   |..  ..|..   |  .. . .|.|.    . |  |..|..|||.||
FVQGQLPWRKIKDKDQVGEMKEKYDHR--MLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 84458.m00166.AA CK1-Unclassified 16-203 36 2.2e-53 155.92 In-house 1-199 (244) Show / Hide 
Range on Protein: 16-203
Range on HMM: 1-199/244
Sequence Identity: 36% (74 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNFAMKTEWLNAEHRGIAREASILSRLQGSP-------MFPRIKKIGETEK--FRYFIMELLGHSLSKIKHEYPNK
..|.  |||| ||.|| .  . |....|.| |  |..|. . .|| |. .||.          .|..   |  |.  . . .|.||| || ...  . |.
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-NR

RLSVQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLVR-----SDNIYALVLIDFGLACSYVDT-ESGVHLPPRTERAFGGTSRYASLAALRGEDVSRK
..|..  |  . ||.. ||.||...|||||||| |||.      ....|   .|||||.  |.|  . | | | | .. . || ||||. | .|   ||.
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVY---IIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRR

DDL
|||
DDL
Kinase 84458.m00166.AA CK1-A 16-270 33 2.9e-48 166.66 In-house 1-261 (261) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-261/261
Sequence Identity: 33% (89 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNFAMKTEWLNAEHRGIAREASILSRLQGSPMFPRIKKIGETEKFRYFIMELLGHSLSKIKHEYPNKRLSVQLALR
....  || | || ||.  .|    . |.| |  .| |  .  || .   ||| . .|...  |.   .  ..|.||| ||  .   . ..| ...  | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKTVLM

CGIQMLKCIEQLHKHGFIHRDIKPGNFLVRSD-NIYALVLIDFGLACSYVDTESGVHLPPRTERAFGGTSRYASLAALRGEDVSRKDDLISWFFSVVELA
   ||.  || .|...|||||||| |||.  .     | |||||||  | | ..  |.| |...   || ||||. |  | . ||.||. |  . ..   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

TGNLPWKRCTG-----KEESLKQRKGVRP-KDICNYLPKEMTKIYNNIIKLKFEETPDYALI
 | |||.  .      | | .  .|   | . .|   | |.. . | . .|.|||.|||  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 84458.m00166.AA CK1-D 16-270 33 1e-45 158.19 In-house 1-261 (261) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-261/261
Sequence Identity: 33% (87 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNFAMKTEWLNAEHRGIAREASILSRLQGSPMFPRIKKIGETEKFRYFIMELLGHSLSKIKHEYPNKRLSVQLALR
. .   || | ||.||.  .|.|    |.| | . ..|  .  |. .   .||    |.|. .|.   .   .|.||| ||  .   | ... |..  | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLKTVLM

CGIQMLKCIEQLHKHGFIHRDIKPGNFLVRSDNIYALV-LIDFGLACSYVDTESGVHLPPRTERAFGGTSRYASLAALRGEDVSRKDDLISWFFSVVELA
 . ||.. || .| . |||||||| |||.       .| .||||||  | |...  |.| | ..   || ||||.   .| . ||.||| |  . ..  .
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

TGNLPW---KRCTGKE--ESLKQRK-GVRPKDICNYLPKEMTKIYNNIIKLKFEETPDYALI
 | |||   |  | ..  | . ..|  .. ...|. .|.| ..  |   .|||.. |||. .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 84458.m00166.AA CK1 16-203 34 3.5e-45 153.5 In-house 1-199 (271) Show / Hide 
Range on Protein: 16-203
Range on HMM: 1-199/271
Sequence Identity: 34% (70 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNF---AMKTEWLNAEHRGIAREASILSRLQG------SPMFPRIKKIGET--EKFRYFIMELLGHSLSKIKHEYP
..|   |||| || || .  . |....   |.| |  ...|  . .|| |. .|||      .. .|...  |    ... . .|.||| || . .  . 
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLF-NFC

NKRLSVQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLV-R-SDNIYALVLIDFGLACSYVDTESGVHLPPRTERAFGGTSRYASLAALRGEDVSRKDD
|...|..  |  . ||.. || .|...|||||||| |||. |   .   . .||||||  |.| ... | | |. . . || ||||. .  |   ||.||
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

L
.
M
Kinase 84458.m00166.AA Dual 80-274 27 3.2e-30 98.75 In-house 82-282 (282) Show / Hide 
Range on Protein: 80-274
Range on HMM: 82-282/282
Sequence Identity: 27% (57 aa)

ETEKFRYFIMELLGHSLSKIKHEYPNKRLSVQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLV----RSDNIYALVLIDFGLACSYVDTESGVHLPPR
|. |  | .| . | ||  |   | .. ||.  .   .||||. |  ||  |..||.||| || .    . . .|   . ||... .|.| | ..| ..|
EQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVY---MQDFRIVRKYIDPENKKHRTAR

TERAFGGTSRYASLAALRGEDVSRKDDLISWFFSVVELA-TGN-LPWKRCTGKEESLKQR----KGVRPKDICNYLPKEMTKIYNNIIKLKFEETPDYAL
.   ..|. |||. | .   |  ||||| .|   |  |   .. ..|..     . .||      .. ...  .  |... ..   .  . .. ||||. 
KKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSH-IPRRLKPLVSYVNGYQYDSTPDYDY

IYDLL
.   |
FRNCL
Kinase 84458.m00166.AA CK1-G 16-270 28 3.1e-29 96.16 In-house 1-266 (266) Show / Hide 
Range on Protein: 16-270
Range on HMM: 1-266/266
Sequence Identity: 28% (77 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNFAMKTEWLNAEHRGIAREASILSRLQGSP-MFPRIKKIGETEKFRYFIMELLGHSLSKIKHEYPNKRLSVQLAL
..|   || | || ..    . .    | | |    .      |      | | |   |..   |   |.   .|.|||.||     .  . . ||   .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDL-FDWCDRKFSVKTVC

RCGIQMLKCIEQLHKHGFIHRDIKPGNFLV--RSDNIYALV-LIDFGLACSYVDTESGVHLPPRTERAFGGTSRYASLAALRGEDVSRKDDLISWFFSVV
   |||.. .|..|.|  | ||.|| |||.   | .   .. .||||.|  |.| | . | | |  .   || || |     |   || ||. .      
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

ELATGNLPW---KRCTGKEESLK---QRKGVRPKDICNY--LPKEMTKIYNNIIKLKFEETPDYALI
    | |||   |  . ||   |   ... . ..|.|.   .|... .    . .|.|.|.|||  .
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 84458.m00166.AA Pkinase 16-188 23 2.8e-21 76.3 Pfam 1-179 (293) Show / Hide 
Range on Protein: 16-188
Range on HMM: 1-179/293
Sequence Identity: 23% (45 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNFAMKTEWLNAEHRGIAR------EASILSRLQGSPMFPRIKKIGETEKFRYFIMELLGHSLSKIKHEY------
....  ||.|.||  |   ...|.  .|.|. ..  |. .  .      |..|. || ..|   |.. . |...  |..||.... |.     .      
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

PNKRL--SVQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLVRSDNIYA---LVLIDFGLACSYVDTESGVHLPPRTERAFGGTSRYAS
 ....  | . . ..  |.|. .| .|..|.||||.|| |.|.  .| .    . ..|||||. .       . . .    | ||..|..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA
Kinase 84458.m00166.AA S_TKc 16-313 17 5.7e-17 63.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-313
Range on HMM: 1-231/231
Sequence Identity: 17% (56 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNFAMKTEWLNAEHRGIAREASILSRLQGSPMFPRIKKIGETEKFRYFIMELLGH---SLSKIKHEYPNKR----L
...|..||.|.||  | . ...|.  .|.|        . | || .||..  . |   ... . .. .. |..||....   .| .. .... ..    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SVQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLVRSDNIYALVLIDFGLACSYVDTESGVHLPPRTERAFGGTSRYASLAALRGEDVSR-KDDLISWF
.   | .   |... .| .|.||.||||.|| | |. .     . ..|||||. .              . | ||  | .   |     .. | |  |  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

FSVVELATGNLPWKRCTGKEESLKQRKGVRPKDICNYLPKEMTKIYNNIIKLKFEETPDYALIYDLLKTSINKIAPESKNSLCVDLLGEEEIAKMSKSKL
  . |...|  |.      .. . .. |                                               || |. .   .|  .    ..  ..
CILYEMLCGYPPFP----QMQMMFKKIG----------------------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EA

EK-------MSSF
 .       .  |
LQDEWDIKCHPWF
Kinase 84458.m00166.AA Dual 16-47 36 7e-06 15.58 In-house 1-36 (282) Show / Hide 
Range on Protein: 16-47
Range on HMM: 1-36/282
Sequence Identity: 36% (13 aa)

FQVLNLIGQGGFGNIYMVSEIST----QTNFAMKTE
  | ||.| |||...| | . |     .. ...|||
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTE
Kinase 84458.m00166.AA TyrKc 16-274 20 4.2e-05 -140.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-274
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

FQVLNLIGQGGFGNIYMVSEISTQTNFAMKTEWLNAEHRGIAREASILSRL--QGSPMFPRIKK---IGETE-------KFRYFIMEL-----LGHSLSK
 . .  .| | || .|    .   .. | |.   .| .. . |||.|...|  .     | | .   .  ..       .  . .||.     | . | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGH----HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

IKHEYPNKRLSVQLALRCGIQMLKCIEQLHKHGFIHRDIKPGNFLVRSDNIYALVLI-DFGLACSYVDT----ESGVHLPPRT---ER------------
 ...     |...  |   .|  .  | ||....||||.   | || ...    | | ||||.    |     ||.    ...   ..            
HRPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

AFGGTSRYASLAALRGEDVSRKDDLISWFFSVV--ELAT-GNLPWKR-----CTGKE--ESLKQRKGVRPKDI--------CNYLPKEMTKIYNNIIKLK
 . |.   .|       ||        | | |.  |. | |  |.       .. .|  | .||..  .. .         |   |.|| .|     . .
INYGKFTTKS-------DV--------WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCC---PDEMYQIMKQCWHED

FEETPDYALIYDLL
 |. |  . |....
PEDRPTFSEIHECF
Kinase 84458.m00166.AA CK1 236-268 32 0.000144 11.87 In-house 238-271 (271) Show / Hide 
Range on Protein: 236-268
Range on HMM: 238-271/271
Sequence Identity: 32% (11 aa)

VRPKDICNY-LPKEMTKIYNNIIKLKFEETPDYA
. . . |.  .|.|..   | . .|.|||.|||.
TPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM