Gene 85746.m00199 (T.vaginalis)
85746.m00199
Species: T.vaginalis
Alias: TvagK0654, 85746.m00199
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 85746.m00199.AA | Protein | None | 415 | None | Fasta, JSON |
| 85746.m00199.kin_dom | Protein Kinase Domain | None | 250 | None | Fasta, JSON |
Protein domains of 85746.m00199.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 85746.m00199.AA | CMGC | 136-374 | 16 | 6.2e-51 | 165.1 | In-house | 158-513 (513) | Show / Hide |
Range on Protein: 136-374
Range on HMM: 158-513/513
Sequence Identity: 16% (63 aa)
HGLSMRK------------NKGFPLSAVRTILIQILKGLA--EMENKG--LVHGDIKPENIIFSLR----------KAGNLTSFEAYKNAISNLSFSIMR
..|| . | |.. ..| . |||.||. . .. .| |.||||| .. . .
MPLSE-HENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKS-----------------------
DEFENQDVLN----------ISLIDWSSSS-MGYN-----------------------QNAQYMQSRYYRAPEILMRSS----------YGPGVDIWSTA
. . ..|. .. . . .. .| ..|.|||||||.... |....|.|| .
---------EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVG
CVAVELFIG--------KPLFPGADE-----------LDMIRIIQQRLGIFPHSVIRKMG--------SDSIAASTD------------------EWMID
|. |.. | |||||| .| .|.. | . || .. ..|.| .. . .. .|...
CIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEF
PKNYL-----PGNFEAFICEESRRQDN---------------------------------EVLLFINLMRLMLQLNPDARASASSALSHPFI
.||. ... .. .. . ..|.|. |||..|| | .|. ||.||..
ARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
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| S_TKc | 85746.m00199.AA | S_TKc | 40-374 | 19 | 3e-39 | 137.64 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 40-374
Range on HMM: 1-231/231
Sequence Identity: 19% (68 aa)
VKILAPLGRGISGSVFAVQVVECEKQPTIVSTMLCLKIFKTNSVAISQAENEILILPLTHRNFNTGRFSVFPSYLTSFKIDGHLGFLMELGGP---SLFH
.|| ..|.| |.|. .. .. .|| | ....|| || | . . || . .|| . ||. . .||.
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFD
GLSMRKNKG----FPLSAVRTILIQILKGLAEMENKGLVHGDIKPENIIFSLRKAGNLTSFEAYKNAISNLSFSIMRDEFENQDVLNISLIDWSSSSMGY
. |. .| || .| .. ||...|. . ..| .| |.||||| .. .| ..| ..
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------------------------------HIKICDFGLARQL-
NQNAQYMQSRYYRAPEILMRSSYGP-GVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRKMGSDSIAASTDEWMIDPKNYLPGNFEA
. ...|.|||.| .||. .|.|| |. |.. |.|.|| .. |...|
---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------------------------------
FICEESRRQDNEVLLFINLMRLMLQLNPDARASASSALS-------HPFI
.....| .|| .|. | .| || ||..
------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 85746.m00199.AA | DYRK | 237-304 | 45 | 1.6e-28 | 101.06 | In-house | 163-230 (320) | Show / Hide |
Range on Protein: 237-304 Range on HMM: 163-230/320 Sequence Identity: 45% (31 aa) QYMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRK .| |||.|||||.. . |. .|.|| |. .|||.|.|||||..| |... |.. ||..|. .|.| TYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDK |
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| Kinase | 85746.m00199.AA | Pkinase | 241-374 | 23 | 2.7e-22 | 79.93 | Pfam | 174-293 (293) | Show / Hide |
Range on Protein: 241-374 Range on HMM: 174-293/293 Sequence Identity: 23% (33 aa) SRYYRAPEILM-RSSYGPGVDIWSTACVAVELFIGKPLFPGA----DELDMIRIIQQRLGIFPHSVIRKMGSDS-IAASTDEWMIDPKNYLPGNFEAFIC ...|.|||... .. ||| ||.|| |. |.. |.|.|||. . .|.. .|....| .|. . . | | .. | TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------F EESRRQDNEVLLFINLMRLMLQLNPDARASASSALSHPFI .... .| .. ... .|...| | .| .| ||.. -HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 85746.m00199.AA | RCK | 142-285 | 29 | 3e-22 | 67.14 | In-house | 96-221 (298) | Show / Hide |
Range on Protein: 142-285 Range on HMM: 96-221/298 Sequence Identity: 29% (45 aa) KNKGFPLSA--VRTILIQILKGLAEMENKGLVHGDIKPENIIFSL-----RKAGNLTSFEAYKNAISNLSFSIMRDEFENQDVLNISLIDWSSSSMGYNQ ..| .| . .. |. |||.||| | ..| | |.||||| . . || .| ..| ... ... RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFED----------------------------QDQDHIKIADFGLCREIRSK N--AQYMQSRYYRAPEILMRS-SYGPGVDIWSTACVAVELFIGKPLFPGADELD . | .|.|||||.| |. | .|||. |...|| . .|||||..|.| PPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEID |
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| Kinase | 85746.m00199.AA | DYRK2 | 238-304 | 41 | 7.4e-22 | 67.57 | In-house | 162-228 (318) | Show / Hide |
Range on Protein: 238-304 Range on HMM: 162-228/318 Sequence Identity: 41% (28 aa) YMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRK | |||.|||||. . || .|.|| |...||..|.||||| .| | . .. ||. | ... . YIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDT |
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| Kinase | 85746.m00199.AA | HIPK | 238-292 | 58 | 6.6e-19 | 55.73 | In-house | 163-217 (329) | Show / Hide |
Range on Protein: 238-292 Range on HMM: 163-217/329 Sequence Identity: 58% (32 aa) YMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQ |.||||||||||.. . .|.|| || ||| | ||.||||| | || |.| YLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQ |
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| Kinase | 85746.m00199.AA | YAK | 238-304 | 41 | 2.2e-18 | 58.69 | In-house | 165-231 (347) | Show / Hide |
Range on Protein: 238-304 Range on HMM: 165-231/347 Sequence Identity: 41% (28 aa) YMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRK | |.|.||.|||.. | .| || |. .||| | |.|||. | . | | ||..| .| . YIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQ |
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| Kinase | 85746.m00199.AA | CDKL | 242-295 | 47 | 2e-17 | 56.14 | In-house | 163-217 (286) | Show / Hide |
Range on Protein: 242-295 Range on HMM: 163-217/286 Sequence Identity: 47% (26 aa) RYYRAPEILMR-SSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLG | ||||| | .||. ||||. .|| |.. | ||.|| ..| ||. || RWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLG |
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| Kinase | 85746.m00199.AA | CDK | 242-285 | 42 | 2.2e-17 | 52.03 | In-house | 183-232 (284) | Show / Hide |
Range on Protein: 242-285 Range on HMM: 183-232/284 Sequence Identity: 42% (21 aa) RYYRAPEILM-RSSYG--PGVDIWSTACVAVELFI---GKPLFPGADELD . |||||.|. . |. ...|.|| |. .|.| .|||||| |.| LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEID |
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| Kinase | 85746.m00199.AA | MAK | 238-287 | 47 | 3.2e-17 | 50.94 | In-house | 207-257 (352) | Show / Hide |
Range on Protein: 238-287 Range on HMM: 207-257/352 Sequence Identity: 47% (24 aa) YMQSRYYRAPEILMRSS-YGPGVDIWSTACVAVELFIGKPLFPGADELDMI | | |||||.| ||. |. .|.| |...||.. .|||||. | | | YVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQI |
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| Kinase | 85746.m00199.AA | PRP4 | 236-304 | 39 | 1.5e-16 | 57.12 | In-house | 163-231 (320) | Show / Hide |
Range on Protein: 236-304 Range on HMM: 163-231/320 Sequence Identity: 39% (27 aa) AQYMQSRYYRAPEILMRSSYGPGVDIWSTACVAVELFIGKPLFPGADELDMIRIIQQRLGIFPHSVIRK . | .||.||||||.. .| ..|.||..| ||. || .||| .|.. . | .|. ||| TPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRK |
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| Kinase | 85746.m00199.AA | HIPK | 41-181 | 31 | 8.8e-13 | 36.09 | In-house | 2-133 (329) | Show / Hide |
Range on Protein: 41-181 Range on HMM: 2-133/329 Sequence Identity: 31% (44 aa) KILAPLGRGISGSVFAVQVVECEKQPTIVSTMLCLKIFKTNSVAISQAENEILILPLTHRNFNTGRFSVFPSYLTSFKIDGHLGFLMELGGPSLFHGLSM .| |||| | ||| | |. | . | .|| | . | ..|. || .. | . . .| |. | |. |. . EVLEFLGRGTFG-----QVVKCWKRGT--NEMVAIKILKNHPYYARQGQIEVSIL-HCLSQENADEYHFVRAYEC-FHHKNHTCLVFEMLEQNLYDFQKQ RKNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENII | || ..|.|| |.|. |. . . ||.| |.|||||. NKFMPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIM |
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| Kinase | 85746.m00199.AA | DYRK | 141-180 | 36 | 1.8e-10 | 35.65 | In-house | 95-135 (320) | Show / Hide |
Range on Protein: 141-180 Range on HMM: 95-135/320 Sequence Identity: 36% (15 aa) RKNKGFPLSAVRTILIQILKGLAEMENK-GLVHGDIKPENI .....|.|..||... |||..| .... ..|.|.||||| HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENI |
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| Kinase | 85746.m00199.AA | DYRK | 336-374 | 30 | 3.3e-09 | 30.82 | In-house | 283-320 (320) | Show / Hide |
Range on Protein: 336-374 Range on HMM: 283-320/320 Sequence Identity: 30% (12 aa) ESRRQDNEVLLFINLMRLMLQLNPDARASASSALSHPFI ..| | ....|... . .||..|. | ..| || ||.. DPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF |
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| Kinase | 85746.m00199.AA | MAK | 143-181 | 47 | 9.3e-09 | 23.54 | In-house | 124-163 (352) | Show / Hide |
Range on Protein: 143-181 Range on HMM: 124-163/352 Sequence Identity: 47% (19 aa) NK-GFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENII .. || ...| |. ||| ||| | | | |.|||||. DRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIM |
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| Kinase | 85746.m00199.AA | RCK | 348-374 | 48 | 1.1e-08 | 23.41 | In-house | 272-298 (298) | Show / Hide |
Range on Protein: 348-374 Range on HMM: 272-298/298 Sequence Identity: 48% (13 aa) INLMRLMLQLNPDARASASSALSHPFI |.||. ||| .|. |..|. || ||.. IELMEKMLQWDPQKRITAQQALQHPYF |
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| Kinase | 85746.m00199.AA | CDK | 349-374 | 42 | 1.3e-08 | 23.47 | In-house | 259-284 (284) | Show / Hide |
Range on Protein: 349-374 Range on HMM: 259-284/284 Sequence Identity: 42% (11 aa) NLMRLMLQLNPDARASASSALSHPFI .|. ||...|. | ||. ||.||. DLLNKMLCYDPKKRISAEQALQHPYF |
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| Kinase | 85746.m00199.AA | DYRK2 | 141-180 | 37 | 1.5e-08 | 23.54 | In-house | 94-133 (318) | Show / Hide |
Range on Protein: 141-180 Range on HMM: 94-133/318 Sequence Identity: 37% (15 aa) RKNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENI .. .|| |. || .||..| ..|.| ||||| NHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENI |
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| Kinase | 85746.m00199.AA | YAK | 346-374 | 44 | 5.4e-08 | 22.84 | In-house | 319-347 (347) | Show / Hide |
Range on Protein: 346-374 Range on HMM: 319-347/347 Sequence Identity: 44% (13 aa) LFINLMRLMLQLNPDARASASSALSHPFI .|| .. .||||| | ... | |||| CFIDFINQLLQLNPRERWKPMQAMQHPFI |
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| Kinase | 85746.m00199.AA | CDKL | 348-374 | 25 | 3e-07 | 20.82 | In-house | 260-286 (286) | Show / Hide |
Range on Protein: 348-374 Range on HMM: 260-286/286 Sequence Identity: 25% (7 aa) INLMRLMLQLNPDARASASSALSHPFI ...|. .|...|| | ... ...||. LDFMKKCLHMDPDERMTCEQLMHHPYF |
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| Kinase | 85746.m00199.AA | YAK | 144-181 | 44 | 4.5e-07 | 19.67 | In-house | 101-138 (347) | Show / Hide |
Range on Protein: 144-181 Range on HMM: 101-138/347 Sequence Identity: 44% (17 aa) KGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENII .|| . .|. ..||| |. ||| ..| | |||||. CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIM |
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| Kinase | 85746.m00199.AA | MAK | 348-374 | 37 | 7e-06 | 14.3 | In-house | 326-352 (352) | Show / Hide |
Range on Protein: 348-374 Range on HMM: 326-352/352 Sequence Identity: 37% (10 aa) INLMRLMLQLNPDARASASSALSHPFI | ||. ||| .|. |. |. .. .|. IELMKDMLQWDPNKRPTAQQCCKYPYF |
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| Kinase | 85746.m00199.AA | CDKL | 141-180 | 37 | 9e-06 | 15.73 | In-house | 90-129 (286) | Show / Hide |
Range on Protein: 141-180 Range on HMM: 90-129/286 Sequence Identity: 37% (15 aa) RKNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENI .. .| . . || .. ||||... . .| ||||||| EYPNGVDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENI |
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| Kinase | 85746.m00199.AA | HIPK | 347-374 | 28 | 1.3e-05 | 13.16 | In-house | 302-329 (329) | Show / Hide |
Range on Protein: 347-374 Range on HMM: 302-329/329 Sequence Identity: 28% (8 aa) FINLMRLMLQLNPDARASASSALSHPFI |..... |. .... | . . || |||. FVHVLKKMCTWDAHKRITPCEALNHPFV |
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| Kinase | 85746.m00199.AA | CDK | 126-180 | 20 | 6.1e-05 | 11.57 | In-house | 107-139 (284) | Show / Hide |
Range on Protein: 126-180 Range on HMM: 107-139/284 Sequence Identity: 20% (11 aa) LMELGGPSLFHGLSMRKNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENI .|. ..... |.|.||. . .. .| |.|| || YMD----------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNI |
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| Kinase | 85746.m00199.AA | PRP4 | 354-374 | 47 | 6.2e-05 | 14.08 | In-house | 300-320 (320) | Show / Hide |
Range on Protein: 354-374 Range on HMM: 300-320/320 Sequence Identity: 47% (10 aa) MLQLNPDARASASSALSHPFI .|.| | | . || |||| CLMLDPKKRITCNEALKHPFI |
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| Kinase | 85746.m00199.AA | PRP4 | 142-181 | 37 | 0.000195 | 12.25 | In-house | 99-138 (320) | Show / Hide |
Range on Protein: 142-181 Range on HMM: 99-138/320 Sequence Identity: 37% (15 aa) KNKGFPLSAVRTILIQILKGLAEMENKGLVHGDIKPENII |..|. | ||| |.. | . . . .| |||| ||. KDVGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL |
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| Kinase | 85746.m00199.AA | Pkinase | 120-183 | 28 | 0.000201 | 16.72 | Pfam | 72-142 (293) | Show / Hide |
Range on Protein: 120-183 Range on HMM: 72-142/293 Sequence Identity: 28% (20 aa) DGHLGFLMELGGP-----SLFHGLSMRKNKGF--PLSAVRTILIQILKGLAEMENKGLVHGDIKPENIIFS ..|. . ||. . .||. .| .....| . .. .. |||.||. . ..| .| |.||||| .. KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID |
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| Kinase | 85746.m00199.AA | DYRK2 | 346-374 | 34 | 0.000922 | 7.74 | In-house | 290-318 (318) | Show / Hide |
Range on Protein: 346-374 Range on HMM: 290-318/318 Sequence Identity: 34% (10 aa) LFINLMRLMLQLNPDARASASSALSHPFI .||. . .. |. | ..| || ||.| NFIDFIKRCFEWDPSERMTPSQALKHPWI |
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