Gene 96903.m00101 (T.vaginalis)

96903.m00101

Species: T.vaginalis
Alias: TvagK0693, 96903.m00101
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
96903.m00101.AA Protein None 383 None Fasta, JSON
96903.m00101.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 96903.m00101.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96903.m00101.AA NEK 4-257 36 2.9e-104 352.67 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-286/286
Sequence Identity: 36% (104 aa)

FKLVKEIGRGGYGRALLVRSQVNGEL-----KVIKEINWSLSSKEEKEAAL-SELKILKTVNCDNIIKVCSAAETKG--KLLILMEYAD-DGDLEKKIQS
....|.||.| .|.. .||.. .|        |.|.|| .  | .||..|. .| .|||  ...||.|   . . ..  .| | |||..  |||..||.|
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

-SNGR----LFCEEVIIDFFTQTCLAVKYLHDR-----KLIHRDIKPANIFLCS-GG---IVKLGDFGLARTLDTTMDHAVT-QVGTALYAAPEVLKGLP
  ...    .| ||.| |.|.| |||.||.|||     | .||||||.|||| . .    .||.||||... |..|.|.| | ||||  |..|||... |
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YSFSADCWGLGCVLYHLMAQ--RPPFLGE--TVAKVAKNVISQ-KVK-IPSR--YSDELREICQGLLEKDPKNRLTVSDVLNRPIL
|.. .| | ||||||.....  ..|| ..       .....   . . |||.  ||..|... . .| |||..| .....|..|..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 96903.m00101.AA S_TKc 4-257 29 5.6e-84 286.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-231/231
Sequence Identity: 29% (80 aa)

FKLVKEIGRGGYGRALLVRSQVNGELKVIKEINWSLSSKEEKEAALSELKILKTVNCDNIIKVCSAAETKGKLLILMEYADD--GDLEKKIQSSNGRL--
......||.|..|.  ..|    |..  ||.|.         | ...|..|||  ...||.|   . .. ..| . |||.|   ||| . |.. ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FCEEVIIDFFTQTCLAVKYLHDRKLIHRDIKPANIFLCSGGIVKLGDFGLARTLDTTMDHAVTQVGTALYAAPEVLKGLPYSF-SADCWGLGCVLYHL
  | | ..  .. |.|.|..|.|... ||||.||.||.|..   .|..|||||| |        |..||  | |||||   .|.. ..| | .||.|| .
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

MAQRPPFLGETVAKVAKNVISQKVKIPSRYSDELREICQGLLEKDPKNRLTVSDVLN-------RPIL
.. .|||   ..... |..           |.|.... ...|.|||..|.|. ..|.        | .
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 96903.m00101.AA NEK1 4-257 38 3.6e-82 279.3 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-276/276
Sequence Identity: 38% (106 aa)

FKLVKEIGRGGYGRALLVRSQVNGELKVIKEINWSLSSKEEKEAALSELKILKTVNCDNIIKVCSAAETKGK--LLILMEYADDGDLEKKIQSS--NGRL
.   | || | .|.|.||..   | . |||||| . ....|.|... | .||.     ||.|  .. |  |.  | | |||.| ||| .||.     | |
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FCEEVIIDFFTQTCLAVKYLHDRKLIHRDIKPANIFLC--SGG---------------IVKLGDFGLARTLDTTMDHAVTQVGTALYAAPEVLKGLPYSF
| |  | ..|.| |||... |||| .|||||. ||||   ..|               .||||||| ||.|  ||..| | .||  |  ||    .||  
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

SADCWGLGCVLYHLMAQRPPFLGETVAK-VAKNVISQKVKIPSRYSDELREICQGLLEKDPKNRLTVSDVLNRPIL
  | | |||||| |..   || .      | | . .   .||..|| ||..    .. ..|..|  | ..| ||..
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 96903.m00101.AA Pkinase 4-257 25 1.7e-75 261.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-293/293
Sequence Identity: 25% (74 aa)

FKLVKEIGRGGYGRALLVRSQVNGELKVIKEINWSLSSKEEKEAALS--ELKILKTVNCDNIIKVCSAAETKGKLLILMEYADDG----DLEKKIQ-SSN
..... ||.|..|.  . . . .|.. ..|.|. .  .........   |..|.| .|..||..   . |.|... . |||.. |    ||   |. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL-FCEEVIIDFFTQTCLAVKYLHDRKLIHRDIKPANIFLCSGGIV----KLGDFGLARTL-DTTMDHAVTQVGTALYAAPEVLK-GLPYSFSADCWGL
|.. | |........|.. ...|.|... ||||.||.||.. . | .    |..|||||. .       . | .||  |.||||.. | .|. ..| |..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVLYHLMAQRPPFLGE------TVAKVAKNVISQKVKIPSRYS---------------------DELREICQGLLEKDPKNRLTVSDVLNRPIL
||.|| ..  |||| |.      .  .. ... . ... .. ..                     .|..... ..|.|||| |.|  ..|. | .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 96903.m00101.AA AGC 4-257 21 8.6e-74 189.29 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-395/395
Sequence Identity: 21% (86 aa)

FKLVKEIGRGGYGRALLVRSQ------VNGEL---KVIKEIN-WSLSSKEEKEAALSE------------LKILKTVN----------CDNIIK-VCSAA
|...| ||.|..|.  |||         .|..   ||.|      .  | . | ...|             .||...|          ...|.|   .. 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKGK--LLILMEYAD--------DGDLEKKIQSS---NGRLFCEEVIIDFFTQ-------TCLAVKYLHD-RKLIHRD-IKPANIFLCSGGIVKLGDFG
..| .  | ..|||.          |..|  ..     . . | ||..  .. .       ..||. |||. .. |||| .|| || | . | .|| |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LARTLDTTM------------------------------------------------DHAVTQ--VG--TALYAAPEVLKGLPYSFSADCWG--LGCVLY
|.  . . .                                                ... |.  .|  |. | |||.|    |....| |.  |||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

HLMAQRPPFLGETVA----------KVAKNVI------SQKVKIP----------SRYSDELREICQGLLEKDPKNRLT----------VSDVLNRPIL
 ... .||| |...           .. ....      ..|||.|          .  |.|.. ....||.|||..||.          .... | |  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 96903.m00101.AA Ciliate-E2 4-257 20 1e-67 231.32 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-365/365
Sequence Identity: 20% (79 aa)

FKLVKEIGRGGYG-----RALLVRS------------------QVNGELKVIKEINWS-LSSKEEKEAAL----------SELKILKTVNCDNIIKVCSA
.|..| ||.|..|     .  .|.                   .|.. .. .| .. . . ... ..  .           |..||...|..||||   .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

AE--TKGKLLILMEYADDGDLEKKIQSSNG-RLFC--------EEVIIDFFTQTCL---------------AVKYLHDRK-LIHRDIKPANIFLCSGGIV
 .  .. .. . |||.. |||.. |....  |...        |. |.....| .                |..||| ..  ||||||| ||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGLARTLDTTMD-------------------------------HAVTQVGTALYAAPEVLKGLP---------YSFSADCWGLGCVLYHLMAQRPP
|. ||||.. .|. ..                                . |..||. | |||.|.| .         |....| | ||..|| ..  .||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FLGETVAKVAKNVISQKVKIP------------------SRYSDELREICQG----LLEKDPKNRLT-VSDVLNRPIL
|         .. . .|...|                     |.|   ...     .|.|||..|.|  ...|| |..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 96903.m00101.AA Ciliate-E2-Unclassified 4-257 21 1.3e-65 224.34 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-352/352
Sequence Identity: 21% (75 aa)

FKLVKEIGRGGYGRALLVRSQVNG------ELKVIKEINWSLSSKE----EKEAALSELK-------------ILKTVNCDNIIKVCSAAETKGKLLILM
.|..| ||.||.|   ...   ..      ..|.|....  .  ..     .. .. ..|             ||.  .. .|.| . . ..| .. | |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYADDGDLEKKIQSSNG---------------RLFCEEVII-----DFFTQTCLAVKYLHDRK-LIHRDIKPANIFLCSGG---IVKLGDFGLARTLDTT
||...|||.. |.....               . | |. ..     ..| | ... .|||  .  ||||||| ||.. ..|    .|. |||... ... 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------MDHAVTQVGTALYA----APEVLKGLPYS----FSADCWGLGCVLYHLMAQRPPFLGETVAK----------------VAKNVIS
                ... |..||  |     |||||.|  |.    ...|.|.||..|| .. ...|| ...  .                . .| . 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

QKVKIPS--------RYSDELREICQ----GLLEKDPKNRLTVSDVLNRPIL
.....|.        . |.|  ....     .|.|.|..|.| ...|| |..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 96903.m00101.AA CAMK 9-257 19 1.2e-63 203.62 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-257
Range on HMM: 1-425/425
Sequence Identity: 19% (83 aa)

EIGRGGYGRALLVRSQVNG------------ELKVIKEINWS-LSSKE-------------------------EKEAALSELKILKT-------VNCDNI
..|||..|   |..   ..            .   || |. . |..|.                          ..  ..|..|.|.       ..  ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKVCSAAE------------TKGK--------LLILM---EYADDG----DLEKKIQSSNG-------------RLFCEEVIIDFFTQTCLAVKYLHDRK
||   . |            |  |        . . |   ||.. |    ||  .|..  .             . |.|.    .| | | ||.|.|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LIHRDIKPANIFLCSG-----------------GIVKLGDFGLARTLDT-----------------------TMDHAVTQVGTALYAA-PEVLKG-----
 .|||.|| || |..                  . .|. |||.|. .|                        . .   |..||  |.| ||||.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------LPYSFSADCWGLGCVLYHLMAQRPPFLGE-------------TVAKVAKNVISQKVK-IPSR---------------YSDE--------LR
          .|....|.| .|..|| .   .||| |.             .  .  ..... |   .|.                 |||         .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

EICQGLLEKDPKNRLTVSDVLNRPIL
   ...|..||..|.|....|| | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 96903.m00101.AA ULK 4-257 25 7.8e-60 205.09 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-329/329
Sequence Identity: 25% (85 aa)

FKLVKEIGRGGYGRALLVRSQVN----GELKVIKEINWSLSSKEEKE--------AALSELKILKTVN----CDN----IIKVCSAAETK--GKLLILME
. | ...| | .|.    | . .    .|. ..| |  .  .....|           .| ||.|. .    . |    |.|     ||.    . | ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YADDGDLEKKIQSS--------NGRLFCEEVIIDFFTQTCLAVKYLHDRKLIHRDIKPANIFLCSG------------GIVKLGDFGLARTLDTT-M--D
| ..||||. |.          ... . |. .| || | . . |.||... |||||||.|| .  |            |..|..|||.|...|   |  .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

HAVTQV------GTALYAAPEVLKGL----PYS-FSADCWGLGCVLYHLMAQRPPFLGETVAKVA-----KN----------VISQKVKIP-----SRYS
 ..|.|      || || ||..|.|.    ||. . .| | |||..| .   .||| .    .       |.          . .|. ..|        |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DELREICQGLLEKDPKNRLTVSDVLNRPIL
.|.... ...|..|.| | .  ...| |..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 96903.m00101.AA ULK 4-257 25 1.5e-57 197.47 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-324/324
Sequence Identity: 25% (84 aa)

FKLVKEIGRGGYG-RALLVRSQVN---GELKVIKEINWSLSSKEEKE--------AALSELKILKTVN---CDN--IIKVCSAAETK--GKLLILMEYAD
. | ...| | .|      | . .   ...  .| |. .  .| ..|           .| .|.|. .   . |  |.|     ||.    . | ||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

DGDLEKKIQSS-------NGRLFCEEVIIDFFTQTCLAVKYLHDRKLIHRDIKPANIFLCSG------------GIVKLGDFGLARTLDTTM---DHAVT
.||||. |.         ... . |. .| || | | . |.||... |||||||.|| .  |            |..|..|||.|...|  .   .   |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

QV------GTALYAAPEVLKGL----PYS-FSADCWGLGCVLYHLMAQRPP----FLGET--VAKVAKN-------VISQKVKIP-----SRYSDELREI
.|      || || ||..|.|.    ||. . .| | |||..| .   ..|    |  .   ..|  .|       .  |....|        |.|....
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

CQGLLEKDPKNRLTVSDVLNRPIL
 ...|..|.| | .  ...| |..
IRRMLQYDEKDRISWEEIFNHPWF
Kinase 96903.m00101.AA NEK8 10-194 35 6.3e-57 161.01 In-house 7-213 (278) Show / Hide 
Range on Protein: 10-194
Range on HMM: 7-213/278
Sequence Identity: 35% (73 aa)

IGRGGYGRALLVRSQVNG--ELKVIKEINWSLSSKEEKEAALSELKILKTVNCDNIIKVCSAAETKGKLLILMEYADDGDLEKKIQSSNGRLFCEE----
.|||  | . | |    .   | ..|.|| .  |..|  .|..|  .|. .. .|||      .  . |.| ||||| | |. .||.  . || ||    
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLK

-------------VIIDFFTQTCLAVKYLHDRKLIHRDIKPANIFLCSG-GIVKLGDFGLARTLDTT--MDHAVTQVGTALYAAPEVLKGLPYSFSADCW
              |...|.|.|.|| ..|.    |||.|..|||.    ..||.||||..  . |   |  . | ||| .|  ||  .| || .  | |
QVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMW

GLGCVLY
 ||||||
ALGCVLY
Kinase 96903.m00101.AA STE 4-257 23 1.3e-56 194.36 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-359/359
Sequence Identity: 23% (87 aa)

FKLVKEIGRGGYG---RALLV------RSQVN------GELKVIKEIN---------------WSLSSKEEKEAALSELKILKTVN--CDNIIKVCSAAE
......||.|..|   .|. .      ... .      ||.  ||..|                . . .||..  | |.||.|  |  ..||.|   . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TKG-------KLLILMEYADDGDLEKKIQ---SSNGRL---------FCEEVIIDFFTQTCLA-VKYLHDRKLIHRDIKPANIFLCSGGIVKLGDFGLAR
 .|       .| | ||| | | |.. |.   . ...|         | |..|. .  |.. .  .|||. . ||||||||||.|     ||| |||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

TLDT---------------TMD-HAVTQVGTALYAAPEVLKG------LPYSFSADCWGLGCVLYHLMAQRPPFLGETVAKVAKNVI-------------
 |.                ||. .  | |||  . ||||...       .|....| | |||.. ..   .||.  ..  ..  . .             
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---SQKVKIPS-------------------RYSDELREICQGLLEKDPKNRLTVSDVLN--RPIL
    .  ..|.                   ..|.|...  .  |.|||..| |.|. |.   | .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 96903.m00101.AA Pkinase_Tyr 40-194 23 3.5e-22 75.73 Pfam 40-205 (270) Show / Hide 
Range on Protein: 40-194
Range on HMM: 40-205/270
Sequence Identity: 23% (40 aa)

SSKEE--KEAALSELKILKTV-NCDNIIKVCSAAE-TKGK--LLILMEYADDGDLEKKIQSS--NGRLFCEEVIIDFFTQTCLAVKYLHDRKLIHRDIKP
...|.  .|. ..|.||.|.  ...||..   .    ..   ..| |||.  ||| .  ..   ... .. . .... .| . .  ||.....||||.  
AMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAA

ANIFLCSGGIVKLGDFGLARTLDTTMDHA-VTQVGTAL---YAAPEVLKGLPYSFSADCWGLGCVLY
 |. . ....|| .||||||.. .  |   ... |. |     |||...   ..   | |  | ...
RNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMW
Kinase 96903.m00101.AA TyrKc 4-259 19 1.5e-15 28.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FKLVKEIGRGGYG---RALLVRSQVNGELKV-IKEINWSLSSKEEKEAALSELKILKTV--NCDNIIKVCSAAETK-------GKLLILMEYADDGDLEK
 .| |..|.| .|   .. .        ..| .| .. .      .|. ..|..|.. .  . .||..   .. ..       . |.|.|||.. ||| .
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

KIQSSNGRLFCEEVIIDFFTQTCLAVKYLHDRKLIHRDIKPANIFLCSGGIVKLGDFGLARTLDTT--------MDHA-----VTQVGTALYAAPEVLKG
 .... .. .| .  ..| .| .    |||....||||.   |. . ....|| .||||.| ..          . ..        .      |||... 
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

LPYSFSADCWGLGCVLYHLMAQ-RPPFLG-----ETVAKVAKNVISQ-KVKIPSR--------YSDELREICQGLLEKDPKNRLTVSDVLNRPILRL
  ...  | |  | ... ..    .|  |      . . | ..| .    ..|           .||. .| .   . ||..| | |..    . ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase 96903.m00101.AA NEK8 222-257 30 3.7e-10 25.07 In-house 243-278 (278) Show / Hide 
Range on Protein: 222-257
Range on HMM: 243-278/278
Sequence Identity: 30% (11 aa)

IPSRYSDELREICQGLLEKDPKNRLTVSDVLNRPIL
|...|| |.|     .| .|| .| ..| .. .| .
ISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC