Gene 87328.m00184 (T.vaginalis)

87328.m00184

Species: T.vaginalis
Alias: TvagK0394, 87328.m00184
External Links:
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
87328.m00184.AA Protein None 437 None Fasta, JSON
87328.m00184.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 87328.m00184.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH 87328.m00184.AA PH 3-96 21 1.2e-09 37.47 Pfam 1-92 (92) Show / Hide 
Range on Protein: 3-96
Range on HMM: 1-92/92
Sequence Identity: 21% (21 aa)

GQFSGILKRKGAFFGMWTACFCEVKDSEFIIYKSKENPIIERKIEICSQTVAVPIQN--HPKKFKIESPDEQALLLQAESEDNVMEWILAIKSQSI
   .| |..|| ... |  ... ....  ..||..      ...   |    ... .  .|  |.| . |.. ...|||||.   .|. ||.| . 
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
PH 87328.m00184.AA PH 3-98 19 1.2e-07 32.69 SMART 1-82 (82) Show / Hide 
Range on Protein: 3-98
Range on HMM: 1-82/82
Sequence Identity: 19% (19 aa)

GQFSGILKRKGAFFGMWTACFCEVKDSEFIIYKSKENPIIERKIEICSQTVAVPIQNHPKKFKIESPDEQALLLQAESEDNVMEWILAIKSQSIKD
 . .| |..|.  .  |. ... .... ...||.|      ...   |    ..       |.| . |.  ...|.|||.   ||. ||.. . . 
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK----KPKGSIPLSDCTVRE-P----CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
Kinase 87328.m00184.AA AGC 106-357 31 5e-153 398.9 In-house 1-395 (395) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-395/395
Sequence Identity: 31% (124 aa)

FIIYSVLGRGFYGKVMLCQKK------GGKELYAIKSIHKAR-LVKAH--KVHTAFRE------------RNVLLKIK----------HPFIVS-LSFAF
| .. |.|.| .|||.|..||      . ...||.| . |..  |.    .|. . .|            ||.| |..          |||||. | ..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSLTK--FYLGLEYVP---------GG-ELFRYLQ---KRGPLTIKEARFYAGE-------IGLALSHLHS-QGVIYRD-LKPENVLLDEEGHIKLTDFG
|. ..   |. .||.|         || ||| .||   |.| .. ..||||| |       | ||| .||| .|.|.|| |||||.||||.|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAKDTVNDS---------------------------------------------------TTNTFCG--TAEYLAPEIIRKEDYSFAIDWWS--YGCLVY
|.|  .||                                                    .|.||||  |.||.||||.    |..| ||||  .||| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMCFGQTPFYDNN----------KSRIFTRIE------VESPYFP----------PNADPVIIDFVSQFLIKDPAERKT----------FDQIKDHRFW
|| .|..|||..|          .  .| .|.       . . ||          .. .|   |.....| |||..| .          ...||.| . 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 87328.m00184.AA Akt 106-357 42 2.1e-117 376.9 In-house 1-264 (264) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-264/264
Sequence Identity: 42% (113 aa)

FIIYSVLGRGFYGKVMLCQKKGGKELY-AIKSIHKARLVKAHKVHTAFRERNVLLKIKHPFIVSLSFAFQSLTKFYLGLEYVPGGELFRYLQKRGPLTIK
| .  |||.| .|||.|..||  ...| |.|.. | ....  .|  .. |||.| ...|||||.| ..||. .| |. ..|..||||| .||...  . .
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

EARFYAGEIGLALSHLHSQGVIYRD-LKPENVLLDEEGHIKLTDFGLAKDT-VND-STTNTFCGTAEYLAPEIIRKEDYSFAIDWWS-YGCLVYEMCFGQ
.||||. || ||. ||||...|||| |||||.|.|..|||.||||||.|.  . |  .|.|||||.|||||||. . ... | |||.  ||. |||..|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFYDNNKSRIFTRIEVESPYFP--PNADPVIIDFVSQFLIKDPAERK-----TFDQIKDHRFW
 |||. .. . |  |  .   ||  .. .|   |..|. | ||| .|      . ..||.| . 
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 87328.m00184.AA AktR 106-357 40 2.7e-110 372.71 In-house 1-268 (268) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-268/268
Sequence Identity: 40% (108 aa)

FIIYSVLGRGFYGKVMLCQKK-GGKELYAIKSIHKARLVKAHKVHTAFRERNVLL-KIKHPFIVSLSFAFQSLTKFYLGLEYVPGGELFRYLQKRGPLTI
| .| .||.| .|||.|.|||   ...||.|.|.|  ...  . | . .|||..  ...||||| | ..||. .| .. .||.||||||..|.|.. .. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

KEARFYAGEIGLALSHLHSQ-GVIYRDLKPENVLLDEEGHIKLTDFGLAK---DTVNDSTTNTFCGTAEYLAPEIIRK-EDYSFAIDWWSYGCLVYEMCF
..||||. .| ||| .||..  .||||||||| ||||.||.|.|||||.|   . ..| ....|||| ||.|||.|.| . . ...|||. |...||| .
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQTPFYDNNKSRIFTRIEVES-PYFPPNADP--VIIDFVS-QFLIKDPAERKT-----FDQIKDHRFW
|..|||..|. ..| .|  .   .||.....     |..  . | |.| .| .     ...||.| . 
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 87328.m00184.AA SGK 106-357 40 3.9e-107 331.94 In-house 1-283 (283) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-283/283
Sequence Identity: 40% (115 aa)

FIIYSVLGRGFYGKVMLCQKKGG------------------KELYAIKSIHKARLV--------KAHKVHTAFRER-NVLLKIKHPFIVSLSFAFQSLTK
|.. .|.| | .|||.. ..|.                   . .||.| . |.  .        | . .|.   || ..| ..||||||.| .|||  .|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMA-ERNVILKNMKHPFIVNLHYAFQTKWK

FYLGLEYVPGGELFRYLQKRGPLTIKEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEEGHIKLTDFGLAKDTVNDS-TTNTFCGTAEYLAPEIIRK
 |. ..|| |||.| .||... .   .||||| || .|| .|||| .|||||||||.||| .||..||||||.|  . .. || ||||| ||||||..||
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

EDYSFAIDWWSYGCLVYEMCFGQTPFYDNNKSRIFTRIEVESPYFPPNADPVIIDFVSQFLIKDPAER---K-TFDQIKDHRFW
. .. . |||. ||. ||| .|  |||..||.  .  |  .   .||.  .   |   . | ||| .|   |  | .||.| | 
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 87328.m00184.AA RSK 109-357 41 1.2e-105 357.31 In-house 1-278 (278) Show / Hide 
Range on Protein: 109-357
Range on HMM: 1-278/278
Sequence Identity: 41% (116 aa)

YSVLGRGFYGKVMLCQKK---GGKELYAIKSIHKARLVKAHK-VHTAFRERNVLLKIK-HPFIVSLSFAFQSLTKFYLGLEYVPGGELFRYLQKRGP---
 .|||.| |||| ||.|.     . .|| | ..|| .|.. | . ....|||.|. .. |||||.|  |||  .|.|| .||..|||||. |||..    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LTIKEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDE---EGHIKLTDFGLAKDTVND--STTNTFCGTAEYLAPEIIR---KED-YSFAIDWWSYGC
.. .||.||. || ||..|||.||.|.|||||||.|.|.   ||||||||||..| ...|  . |.|||.|.||.|||...   ..  .. | |||| |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LVYEMCFGQTPFYD---NNKSRIFTRIEVES--PYFP--PNADPVIIDFVSQFLIKDPAERKT-----FDQIKDHRFW
| ||| .|..||.    ||.. |..||.     . .|  ..  .   |.... | .||. | .      ..||.| ..
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 87328.m00184.AA S_TKc 106-357 36 9.3e-99 335.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-231/231
Sequence Identity: 36% (98 aa)

FIIYSVLGRGFYGKVMLCQKKGGKELYAIKSIHKARLVKAHKVHTAFRERNVLLKIKHPFIVSLSFAFQSLTKFYLGLEYVPG--GELFRYLQKRGP---
. |  ..|.| .|||..|..|. ....||| |.           .. ||...| | .||.|| |  .||. ...|. .||..|  |.||.|..|||.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTIKEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEEGHIKLTDFGLAKDTVNDSTTNTFCGTAEYLAPEIIRKEDYSF-AIDWWSYGCLVYEM
   ..  .||||. .| .|| ..||.|.|.|||||||.||||  |||..|||||.        .||||| .|.|||..    |.. ..|||| ||..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CFGQTPFYDNNKSRIFTRIEVESPYFPPNADPVIIDFVSQFLIKDPAERKTFDQIKD-------HRFW
. |..||.  .  ..| .|           .|  .||... | |||..| |  ..         | . 
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 87328.m00184.AA PKA 106-357 42 6.8e-95 321.56 In-house 1-263 (263) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-263/263
Sequence Identity: 42% (113 aa)

FIIYSVLGRGFYGKVMLCQKKGGKELYAIKSIHKARLVKAHKVHTAFRERNVLLKIKHPFIV-SLSFAFQSLTKFYLGLEYVPGGELFRYLQKRGPLTIK
| |. .||.| .|.||||..|.... ||.| . |.. |.   |.    |.|.|. ||||||| .. . ||  .. |. .|||||||.| ||.|.| .. .
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

EARFYAG-EIGLALSHLHSQGVIYRDLKPENVLLDEEGHIKLTDFGLAKDTVNDSTTNTFCGTAEYLAPEIIRKE-DYSFAIDWWSYGCLVYEMCFGQTP
.|.|||  .| |||  ||||  ||||||||| |.|..||||.|||| || ...   | | ||| ||||||||  .  .  ..|||. |.|.||| .| .|
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FYDN--NKSRIFTRIEVESPYFPPNADPVI---IDFVSQFLIKDPAERK-TFDQ----IKDHRFW
|||.  ..  |. .|      ||.. |.      |.... | .|. .|  ....    ||.|.. 
FYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 87328.m00184.AA PKC 106-357 40 9.9e-93 300.9 In-house 1-262 (262) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-262/262
Sequence Identity: 40% (106 aa)

FIIYSVLGRGFYGKVMLCQKKGGKELYAIKSIHKARLVKAHKVHTAFRERNVL-LKIKHPFIVSLSFAFQSLTKFYLGLEYVPGGELFRYLQKRGPLTIK
|    |||.| .|||||  .|| .|.|||| . |   .. . |  .  |. || |  |||| ..|   ||.  . .  .||| || |    |. . .  .
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

EARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEEGHIKLTDFGLAKDTV-NDSTTNTFCGTAEYLAPEIIRKEDYSFAIDWWSYGCLVYEMCFGQTPF
 ||||| || .||  ||..|.|||||| .|||||.|||||..|||..|. . |..||.||||| .|.||||.. ..|....|||..| | |||  || ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YDNNKSRIFTRIEVESPYFPPNADPVIIDFVSQFLIKDPAER-----KT---FDQIKDHRFW
   .   .|  |  . |..|      . .  ..|. |.|..|     ..   .. |..| | 
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase 87328.m00184.AA RSK-Unclassified 106-357 38 1.7e-91 287.65 In-house 1-283 (283) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-283/283
Sequence Identity: 38% (108 aa)

FIIYSVLGRGFYGKVMLCQKKGGKELYAIKSIHKARLVKAHKVHTAFRERNVLLKIKHPFIVSLSFAFQSLTKFYLGLEYVPGGELFRYLQ--KRGPLTI
||    .|.|  ||| | .||. . .||.|  || ....  |.  .  |.|..   .||||| | ..||.  . || .|| .||..|| ||  |   .. 
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

KEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEEGHIKLTDFGLAKDT---------------------VNDST-TNTFCGTAEYLAPEIIRKEDYS
 ..|||| |. .|| .|| ...|||||||.|..|. |||..||||.| ..                      . ... || |||| ||||||.||     
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

FAIDWWSYGCLVYEMCFGQTPFYDNNKSRIFTRIEVESPYFP--PNADPVIIDFVSQFLIKDPAER---KTF--DQIKDHRFW
 |.|||  | ..||| || .|.| |||  .|. || .   ||          | .   | . || |   |    | || | | 
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 87328.m00184.AA Pkinase 106-357 32 2.8e-90 311.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-293/293
Sequence Identity: 32% (95 aa)

FIIYSVLGRGFYGKVMLCQKKGGKELYAIKSIHKARLVKAHKVHTAF-RERNVLLKIKHPFIVSLSFAFQSLTKFYLGLEYVPGG----ELFRYLQ--KR
. | ...|.| .|.| .|..||  ...|.| | | .  .  ... .  .|  ......||.|| |  .|.. .. |. .||..||    .||.|..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPL--TIKEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEEGHI----KLTDFGLAKD--TVNDSTTNTFCGTAEYLAPEIIR-KEDYSFAIDWWSY
|..  . .|..||. .|  .| ..||.|.|.|||||||.|.|..|||    |..||||||   . |.| ..||||| .|.|||.||  ..|. ..|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCLVYEMCFGQTPFYDN------NKSRIFTRIEVESPYFPPNAD---------------------PVIIDFVSQFLIKDPAERKTFDQIKDHRFW
||..|||..|..||..       ..  .. ||    . |.   .                     .  .||..  | |||..| |..||. | ..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 87328.m00184.AA p70 106-357 37 1.1e-87 297.59 In-house 1-299 (299) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-299/299
Sequence Identity: 37% (113 aa)

FIIYSVLGRGFYGKVMLCQKKGGKE---LYAIKSIHKARLVKAHK--VHTA------------------------FRERNVLLKIKHPFIVSLSFAFQSL
|    |||.| ||||..  |  |..   .|| | . ||  |   |   ||                         | |||.|  .|||||. | .|||  
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

TKFYLGLEYVPGGELFRYLQKRGPLTIKEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEEGHIKLTDFGLAKDTVNDSTT-----------NTFCG
 | || ||| .|||||  | . | .    |.||. || .|| |||..|.|||||||||..|.. ||..|||||| |  ..|..             ||||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TAEYLAPEIIRKEDYSFAIDWWSYGCLVYEMCFGQTPFYDNNKSRIFTRIEVES--PYFPPNADPVIIDFVSQFLIKDPAERKT-----FDQIKDHRFW
| || ||||...  .. |.|||| ||| | |  |. ||   |.  .   |      .  ||   .   | . ..| ..|..| .       .|. | |.
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 87328.m00184.AA RSK 106-315 39 3.3e-79 269.46 In-house 1-217 (271) Show / Hide 
Range on Protein: 106-315
Range on HMM: 1-217/271
Sequence Identity: 39% (86 aa)

FIIYSVLGRGFYGKVMLCQKK---GGKELYAIKSIHKARLVKAHKVHTAFRERNVLLKIKHPFIVSLSFAFQSLTKFYLGLEYVPGGELFRYLQKRGPLT
... ...|.| ..|| .|.|.     . .||.| | || .. . .   .  ||..|  . ||||| |  .||. .| |. ..   ||.||  |.| . ..
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

IKEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEE----GHIKLTDFGLAKDTVNDST-TNTFCGTAEYLAPEIIRKEDYSFAIDWWSYGCLVYEMC
 .|..||. || ||. .|||||...|||||||.|.|.|    ||||..|||.||    .   . |||.||.|.|||....  .. | ||||.| | ||| 
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

FGQTPFYDNNKSRIFTRI
 | |||. ... . .. |
TGCTPFQNKPRDTPMNII
Kinase 87328.m00184.AA TyrKc 106-357 24 2.8e-25 91.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 106-357
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

FIIYSVLGRGFYGKVMLCQKKGGKELYAIKSIHKARLVKAHKVHTAF-RERNVLLKI--KHPFIVSLS-FAFQSL------TKFYLGLEYVPGGELFRYL
     .||.|..|.|.... |   .  |.|....         . .| || ... |.  .|| || |   . |.          .. .||.|.| |  ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

QKRGP-LTIKEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEEGHIKLTDFGLAKDTVND------STTNTF----CGT----AEYLAPEIIRKEDY
.|..| |. |.   ..  |    ..|||...| |||   |.|..|....| .||||..|  .|      . . .     .|        .||| |..  .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SFAIDWWSYGCLVYEMC-FGQTPFYD-----NNKSRIFTRIEVE-SPYFPPN--------ADPVIIDFVSQFLIKDPAERKTFDQIKDHRFW
... | ||.| . .|.. .||.| ..      . .... ...    .  |||        . . . .  .|    ||..| || .|  |...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 87328.m00184.AA Pkinase_Tyr 106-316 27 1.2e-14 50.18 Pfam 1-230 (270) Show / Hide 
Range on Protein: 106-316
Range on HMM: 1-230/270
Sequence Identity: 27% (66 aa)

FIIYSVLGRGFYGKVMLCQKK----GGKELYAIKSIHKARLVKAHKV---HTAF-RERNVLLKI-KHPFIVSLSFAFQ-----SLTKFYLGLEYVPGGEL
 ..  .||.| .|.|...  |    ..|   |.|.. |    .|..    . .| || ... .. .|| ||.|  .       .  . |. .||.|.| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDL

FRYLQK----RGPLTIKEARFYAGEIGLALSHLHSQGVIYRDLKPENVLLDEEGHIKLTDFGLAKDTVNDSTT-NTFCGTAE---YLAPEIIRKEDYSFA
  ||.|    ..|||.|.   .. .|  ....|.|.. | |||   |.|..|....| .|||||.|  ||..   .  |.      .||| |.   .. .
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

IDWWSYGCLVYEMCF-GQTP-FYDNNKSRIFTRI-E
 | ||.| | .|..  |..| ...   .... .| |
SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYE
Kinase 87328.m00184.AA S_TK_X 358-419 28 1e-06 29.3 SMART 1-79 (79) Show / Hide 
Range on Protein: 358-419
Range on HMM: 1-79/79
Sequence Identity: 28% (23 aa)

NHLDFNALLN--KQIKPEFVPIVD----DKRIPDNFDTQFTIETPCDSLATPPNSIKSNQ--------------FYGFSFAG
 ..|...|.|  |.|.| |.| .     . .   |||. || |||    .||.... ||.              | ||..  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM---LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 87328.m00184.AA Pkinase_C 386-421 31 4e-06 25.05 Pfam 10-46 (46) Show / Hide 
Range on Protein: 386-421
Range on HMM: 10-46/46
Sequence Identity: 31% (12 aa)

NFDTQFTIETPCDSL--ATPPNSIKSNQFYGFSFAGDL
|||..|| |.| |.    .   |.. ..| ||..  . 
NFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase 87328.m00184.AA RSK 332-357 29 0.123681 1.9 In-house 241-271 (271) Show / Hide 
Range on Protein: 332-357
Range on HMM: 241-271/271
Sequence Identity: 29% (9 aa)

DFVSQFLIKDPAERKTF-----DQIKDHRFW
| ... |  ||. | .       ||| | . 
DLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF