Gene 94266.m00066 (T.vaginalis)

94266.m00066

Species: T.vaginalis
Alias: 94266.m00066, TvagK0337
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Unique

Sequence

Name Sequence Type Origin Length Description Download
94266.m00066.AA Protein None 250 None Fasta, JSON
94266.m00066.kin_dom Protein Kinase Domain None 98 None Fasta, JSON

Protein domain

Protein domains of 94266.m00066.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94266.m00066.AA Dicty4 11-20 41 0.162546 1.02 In-house 266-277 (277) Show / Hide 
Range on Protein: 11-20
Range on HMM: 266-277/277
Sequence Identity: 41% (5 aa)

FSEIIKI--LNQ
|.|||..  |. 
FEEIIQRRILEH
Kinase 94266.m00066.AA TKL 150-250 23 3e-21 73.29 In-house 1-142 (364) Show / Hide 
Range on Protein: 150-250
Range on HMM: 1-142/364
Sequence Identity: 23% (35 aa)

IGHGTSAKVYKGTYKKTH--------EDVAIKKFQFPNLN------------------------SAHFQSYQREVA-VLATAQHPTLLKLIG-TTDKPP-
|| |....||||... .         .|||.|||   | .                        . .|.   .|.. ..   .|| .....|  .. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCIITEWMSGGSLFHAIHRPGYYDMTQRTIAAIDIA
            .||..|...||||.| .|      . ||   |.|||
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIA
Kinase 94266.m00066.AA LRRK 144-227 17 1.1e-17 59.18 In-house 1-142 (351) Show / Hide 
Range on Protein: 144-227
Range on HMM: 1-142/351
Sequence Identity: 17% (25 aa)

FEQGKEIGHGTSA-KVYKGTYKK--------------------------THEDVAIKKFQFP---------------NLN-----------------SAH
.. ...|| |... .||......                            ..|||||. ..               |||                 .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FQSYQREVAVLATAQHPTLLKLIGTTDKPPFCIITEWMSGGSL
|.....||... . .|| ...|.| . . |.|...| .. |.|
FREFRHEVWIMSHLNHPNIVSLKGFCIH-PLCMVMEYAPHGDL
Pkinase 94266.m00066.AA Pkinase 144-247 24 6.6e-17 60.85 Pfam 1-113 (293) Show / Hide 
Range on Protein: 144-247
Range on HMM: 1-113/293
Sequence Identity: 24% (28 aa)

FEQGKEIGHGTSAKVYKGTYKKTHEDVAIKKFQFPNLNSAHFQSYQR--EVAVLATAQHPTLLKLIGTT-DKPPFCIITEWMSGG----SLFHAIH---R
.. |. || |....|||.. |.| . ||.|..  .. .|   |.  |  |.....  .||  ..|...  ||.  ....|.. ||    .||. |.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

PGYYDMTQRTIAAI
 ..| .. ...  .
GCFY-FSEWECKFY
Kinase 94266.m00066.AA Dicty4-Unclassified 144-234 36 9.5e-16 50.38 In-house 1-97 (263) Show / Hide 
Range on Protein: 144-234
Range on HMM: 1-97/263
Sequence Identity: 36% (36 aa)

FEQGKEIGHGTSAKVYKGTYKKTHEDVAIKKFQFPNLNSAH---FQSYQREVAVLATAQHPTLLKLIGTTDKP-----PFCIITEWMSGGSLFHAIH-RP
    ..|| |  .||.||  |    |||.|||   |  ..     | . .||..|   ||| |.|. |    |      .||..| |  | ||  || .|
IQIDQFIGKGHFSKVHKGNWK--GKDVAVKKFN-ENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKP
Kinase 94266.m00066.AA TKL-Unique 146-236 25 1.4e-15 51.54 In-house 1-105 (290) Show / Hide 
Range on Protein: 146-236
Range on HMM: 1-105/290
Sequence Identity: 25% (28 aa)

QGKEIGHGTSAKVYKGTYKKTHEDVAIKKFQFPNLNSAHFQSYQ---REVAVLATAQ-HPTLLKLIGTTD----KPP-FCIITEWMSGGSLFHAIH----
 .. || |....||||.....  .||||.| .  ... .... |   .|| .. . . || .....|..     .|| .||..| ..||||   .|    
FWNKIGEGGYGQVYKGKWRGY--PVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNN

-----RPGY
     .. .
NNNNNNNNC
Kinase 94266.m00066.AA STE 144-227 23 1e-14 48.46 In-house 1-124 (359) Show / Hide 
Range on Protein: 144-227
Range on HMM: 1-124/359
Sequence Identity: 23% (29 aa)

FEQGKEIGHGTSAKVYKGTYKK---------------THEDVAIKKFQFPNLNS---------------AHFQSYQREVAVLATAQ--HPTLLKLIGTTD
.|  ..||.|.. .|||. ..|               |.| .|||.  . | |.                 .|....|. ..   .  ||   | .|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KPP--------FCIITEWMSGGSL
|           .|. |.|.||||
KEGHNHKNDDELWICMEYMDGGSL
Kinase 94266.m00066.AA Pkinase_Tyr 144-227 28 1.2e-14 50.23 Pfam 1-94 (270) Show / Hide 
Range on Protein: 144-227
Range on HMM: 1-94/270
Sequence Identity: 28% (27 aa)

FEQGKEIGHGTSAKVYKGTYK----KTHEDVAIKKFQFPNLNSAH--FQSYQREVAVLATA-QHPTLLKLIGT-T-DKPP--FCIITEWMSGGSL
 . ||..|.|   .|||||.|    .|. .||.|.   ..  . .   ..  ||.... .  .|| ...|.|  | .. |   .|..| | .|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase 94266.m00066.AA TK 144-227 17 2e-14 44.01 In-house 1-146 (486) Show / Hide 
Range on Protein: 144-227
Range on HMM: 1-146/486
Sequence Identity: 17% (25 aa)

FEQGKEIGHGTSA---KVYKGTYK-------------------------KTHEDVAIKKFQFPNLNSAH-FQS--------------YQREVAVLAT--A
 . ||..|.|      .||||...                         .....||.|     . .|.  |.                 .| ...     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPTLLKLIG-TTDK------------PPFCIITEWMSGGS----L
.|| ...|.|  |..            .|..|..|.|..|.    |
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSL
Kinase 94266.m00066.AA RAF 144-232 30 5.2e-14 41.53 In-house 1-92 (282) Show / Hide 
Range on Protein: 144-232
Range on HMM: 1-92/282
Sequence Identity: 30% (29 aa)

FEQGKEIGHGTSAKVYKGTYKKTHEDVAIKKFQFPNLNSAHFQS---YQREVAVLATAQHPTLLKLIGTTDKPP---FCIITEWMSGGSLFHAIH
.. .. || |    ||.| .   | |||.|. .  ..  . .|    .. ||||.    |   |   | . ||    . |.|.|  . ||.| ||
VMVMTRIGSGSFGTVYRGHW---HGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIH
Kinase 94266.m00066.AA MLK 144-232 24 5.8e-14 44.94 In-house 1-102 (291) Show / Hide 
Range on Protein: 144-232
Range on HMM: 1-102/291
Sequence Identity: 24% (25 aa)

FEQGKEIGHGTSAKVYKGTYKKTH---EDVAIKKFQF----PNLNSAHFQSYQREVAVLATAQHPT----LLKLIGT-TDKPP-FCIITEWMSGGSLFHA
..  . ||.|.. ||.||.....      ||.|.. .        ..  .  ..|.  |.  .||       .. |. .. |. |||..|...||||.. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

IH
.|
LH
Kinase 94266.m00066.AA TKL-ciliate1 147-233 31 8.5e-14 43.6 In-house 4-92 (279) Show / Hide 
Range on Protein: 147-233
Range on HMM: 4-92/279
Sequence Identity: 31% (29 aa)

GKEIGHGTSAKVYKGTYKKTHEDVAIKKFQFPNLNS--AHFQSYQREV-AVLATAQHPTLLKLIGTTDK-PPFCIITEWMSGGSLFHAIHR
|..|| | . .||||  .    ||||..    |..    .   .|||. .     ||  |. |.|.  .   | ||.|   .|..|   ||
GQKIGSGHFCNVYKGRCNSY--DVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTMFDICHR
Kinase 94266.m00066.AA Dicty4 144-232 29 9.1e-14 42.47 In-house 1-94 (277) Show / Hide 
Range on Protein: 144-232
Range on HMM: 1-94/277
Sequence Identity: 29% (28 aa)

FEQGKEIGHGTSAKVYKGTYKKTHEDVAIKKFQFPNLN--SAHFQSYQREVAVLATAQHPTLLKLIGT-T----DKPPFCIITEWMSGGSLFHAIH
   ...|| |  ..||||| . .  .||.||.   | |  ..  ..  .||. ..  .|| .... |. |     .. .|| || |. |.|.  .|
INIEQRIGKGSFGEVYKGTWRGK--EVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH
Kinase 94266.m00066.AA S_TKc 144-250 12 0.000186 -111.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 144-250
Range on HMM: 1-231/231
Sequence Identity: 12% (30 aa)

FEQGKEIGHGTSAKVYKGTYKKTHEDVAIKKFQFPNLNSAHFQSYQREVAVLATAQHPTLLKLIGTTDKPPFCIITEWMSG--GSLFHAIHRPGY-----
.| ...||.|. .||||.. |||.. ||||.           .. .||...|   .|| . ||... .   .....| ..|  |.||. |.. |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

--------------------------------------------------------------------YDM----------------TQRT---------
                                                                    |.                 . ..         
PFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMF

---------------------------IAA-------IDIA
                           . .           
KKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF