Gene 80572.m00042 (T.vaginalis)

80572.m00042

Species: T.vaginalis
Alias: TvagK0358, 80572.m00042
External Links:
Annotation:

Classification

Group: AGC
Family: NDR
Subfamily: NDR-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
80572.m00042.AA Protein None 489 None Fasta, JSON
80572.m00042.kin_dom Protein Kinase Domain None 297 None Fasta, JSON

Protein domain

Protein domains of 80572.m00042.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 80572.m00042.AA AGC 111-407 28 1.5e-155 405.61 In-house 1-395 (395) Show / Hide 
Range on Protein: 111-407
Range on HMM: 1-395/395
Sequence Identity: 28% (116 aa)

FEKLKIIGRGSFGEVWLVRDK------EDQHIYAMKVLKKKE-LVEKN--QILNTIVE------------KDFMVQND----------NPWAVQ-LYYAF
|| ||.||.||||.|.|||.|        ...|||||||||.  |.|.  .. .|..|            .. ... .          .|. |. |.|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDSRC--LYFVMEFLP--------GGDLMTLLINRN-----ILTETETRFLIAE-------TILAVNCVHK-QGFIHRD-IKPDNLLLTKNGHVRLTDFG
|| .   ||||||..|        ||.....|....     ...| ..|| .||       ..||.   |. .|.|||| .||.|.||...||..|||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSTKMDRYSDPIVQLIDEITDAFNESGNSSTPQSVINRLYYQKMHSSE----------------------RHAQVCSAVG--TTDYIAPEVLLKQPYGPS
|.... .. .. .| .. . . |..  |.   |  .      .|   .                       ...  . .|  | .|.|||.|    ||..
LCKEGMNDGEKGQQ-SQSN-MKFHW-HNKKY-Q-KS------NMD--TNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKA

VDYWS--IGAIMFEMIYGYAPFSSQT----------QRTTATKIIH----FKETLEFPSK--------PPVSTEAISLMRGLLT-DADHRLN--------
.|.||   |..|.||..|| ||....          .  .  ||..    ... ..||..        . .| || .|...||. | ..||         
CDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGD

--FEEIKSHPFF
  .||||.||.|
KGAEEIKNHPWF
Kinase 80572.m00042.AA NDR 111-407 40 5.2e-150 466.27 In-house 1-350 (350) Show / Hide 
Range on Protein: 111-407
Range on HMM: 1-350/350
Sequence Identity: 40% (142 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTIVEKDFMVQND--NPWAVQLYYAFQDSRCLYFVMEFLPGGDLMT---LLINRNI
||..||||.|.|||||||| |. .||||||...|.| ..|||. .   |.| |.. |  ||| | |||.|||. .||.|||..||||.||   ||.. .|
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LTETETRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTK--------------------------MDRYSDPIVQLIDEITDAFNE
.|| ..|| |||...|.. ||| |.|||||||||.|. | ||. ||||||.|                             .|.  . ..  . . ....
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

SGNSSTPQSVINRLYYQK-----MHSSERHAQVC-----SAVGTTDYIAPEVLLK-QPYGPSVDYWSIGAIMFEMIYGYAPFSSQTQRTTATKIIHFKET
| ...   . ....  |      ..  ..  |       |.||| ||.||||... . |....|.|| |.||.||. ||.|| | | ..|  ||...|.|
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

L-----EFPSKPPVSTEAISLMRGLLT-DADHRLN-----FEEIKSHPFF
.     .||.  ..| ||  | | |.. |.||||      ..||||||||
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase 80572.m00042.AA MAST 111-407 34 3.3e-101 309.98 In-house 1-337 (337) Show / Hide 
Range on Protein: 111-407
Range on HMM: 1-337/337
Sequence Identity: 34% (116 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTIVEKDFMVQNDNPWAVQLYYAFQD--SRCLYFVMEFLPGGDLMTLLINRN-ILT
|| .|.|..| .| |.||. |.   ..||||...  .  |||. . .||..  .. .||. | ..|.||    . |..|||.. |||  .|| . .  . 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ETETRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTK--MD----RYSD---------------PIVQLIDEITDAFNESGNSSTP
| .... ||||.|..   |..| .|||.||||.|...|||. ||||||| .  ||     |..               .| .   .  ..|.  || .. 
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

QSVINRLYYQ-------KMHSSERHAQVCSAVGTTDYIAPEVLLKQP-YGPSVDYWSIGAIMFEMIYGYAPFSSQTQRT-TATKIIHFKETLEFPSK---
|.. . .  |       . |  ..  |.|   || |||||||.|.|. ||..||.|| | ||.| . |. ||   |.   .  .||. .. .|.|..   
QIQQQQEQPQCQQQNEMRPHNIHQNKQCC---GTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDP

---PPVSTEAISLMRGLLT-DADHRLNFE---EIKSHPFF
    ..| ||. |.. ||. .   || .    |||.||||
NDDDCMSPEAQDLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase 80572.m00042.AA S_TKc 111-407 27 9.3e-95 322.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 111-407
Range on HMM: 1-231/231
Sequence Identity: 27% (87 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTIVEKDFMVQNDNPWAVQLYYAFQDSRCLYFVMEFLPG--GDLMTLLINRNI---
.|.|..||.|.||.|...|.|....|.|.|..|           ... | . . . . |. |.||..|||  .||.|||...|  |||.... .|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTETETRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTKMDRYSDPIVQLIDEITDAFNESGNSSTPQSVINRLYYQKMHSSE
   ..| ..||.......|..  |..|.||||.||.|.||..  |. ..||||....                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

RHAQVCSAVGTTDYIAPEVLLKQPYGP-SVDYWSIGAIMFEMIYGYAPFSSQTQRTTATKIIHFKETLEFPSKPPVSTEAISLMRGLLT-DADHRLNFEE
      . .|| .|.|||||   .||. ..| ||.| |..||..|| ||.   |  .  |.|              | ||....|..|. | ..|.   |
-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-E

IKS-------HPFF
.         ||.|
ALQDEWDIKCHPWF
Kinase 80572.m00042.AA MAST 111-407 33 2.6e-92 297.86 In-house 1-334 (334) Show / Hide 
Range on Protein: 111-407
Range on HMM: 1-334/334
Sequence Identity: 33% (112 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTIVEKDFMVQNDNPWAVQLYYAFQDSRCLYFVMEFLPGGDLMTLLINRNILTETE
||  |.|..| .| |.||. |.   ..||||.|| ..  ||.. . .||..   . .||. | ..|.||  . |..|||.. |||. .|| . . . |  
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

TRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTK--MD----RYSD---------------PIVQLIDEITDAFNESGNSSTPQSV
... ||||.|..   |..| .|||.||||.|...|||. ||||||| .  ||    .|..               .. | . ...  |.  || .. |..
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

INRLYYQKMHS---SERHAQVCSAVGTTDYIAPEVLLKQP-YGPSVDYWSIGAIMFEMIYGYAPFSSQTQRTTATKIIHFK-ETLEFPSK------PPVS
 . .  |.       .   |. . .|| |||||||.|.|. .|..||.|| | ||.| . |. ||   |.  .  .|.. .    |.| .         |
QQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMS

TEAISLMRGLLTD-ADHRLNFE----EIKSHPFF
 ||. |.. ||.     || .     |.|.||||
PEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase 80572.m00042.AA DMPK 111-261 48 1.1e-87 216.55 In-house 1-152 (270) Show / Hide 
Range on Protein: 111-261
Range on HMM: 1-152/270
Sequence Identity: 48% (73 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTIVEKDFMVQNDNPWAVQLYYAFQDSRCLYFVMEFLPGGDLMTLLINRN-ILTET
|| ||.|||| |||| .|| |. . .||||...|.|.. . .      |.| ||  . .| .||.||||| . ||.|||. ||||| ||. .    . | 
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

ETRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTKMDR
 .|| .|| .||.. .|. |..|||||||| || ..||..| |||   ||.|
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNR
Kinase 80572.m00042.AA AktR 111-407 33 7e-86 291.62 In-house 1-268 (268) Show / Hide 
Range on Protein: 111-407
Range on HMM: 1-268/268
Sequence Identity: 33% (103 aa)

FEKLKIIGRGSFGEVWLVRDK-EDQHIYAMKVLKKKELVEKNQILNTIVEKDFMV-QNDNPWAVQLYYAFQDSRCLYFVMEFLPGGDLMTLLINRNILTE
|. .|..|.| ||.| ||..| ..| .||||..|||...|.||.  || |.. |  ....|  |.|.|.||. ..|.|.||. |||.| . | ... ..|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

TETRFLIAETILAVNCVHKQ-GFIHRDIKPDNLLLTKNGHVRLTDFGLSTKMDRYSDPIVQLIDEITDAFNESGNSSTPQSVINRLYYQKMHSSERHAQV
 ..|| .|. .||.   |..   | ||.||.|.|| ..|||..||||||                                       |.| . . .|. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK-------------------------------------LQFMMHYDEKAY-

CSAVGTTDYIAPEVLLK-QPYGPSVDYWSIGAIMFEMIYGYAPFSSQTQRTTATKIIHFKETLEFPSKPPVSTEAISLMRG--LLTDADHRL-----NFE
 | .||  |.|||...| .... |||.|..|.  .||..|. || .. |..   ||.     ..||  ...| .. .|  .  |  .  .||     ..|
-SFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWE

EIKSHPFF
||||||.|
EIKSHPWF
Kinase 80572.m00042.AA RSK 114-407 31 5.4e-81 275.38 In-house 1-278 (278) Show / Hide 
Range on Protein: 114-407
Range on HMM: 1-278/278
Sequence Identity: 31% (99 aa)

LKIIGRGSFGEVWLVRDK---EDQHIYAMKVLKKKELVEKNQ-ILNTIVEKDFMVQND-NPWAVQLYYAFQDSRCLYFVMEFLPGGDLMTLLINRNI---
||  |.|..|.| |.| .     ..|||||||||...| ..  .  |  | . .      |  |.|.||||.   || .||...||.| | | .. .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LTETETRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTK---NGHVRLTDFGLSTKMDRYSDPIVQLIDEITDAFNESGNSSTPQSVINRLYYQKMHSSE
..|.| .| .|| .||| . |.||.||||.||.| |..    .||..|||||.. ..                                        . .
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF----------------------------------------RCD

RHAQVCSAVGTTDYIAPEVLL---KQP-YGPSVDYWSIGAIMFEMIYGYAPFSS---QTQRTTATKIIHFKETLEFPSKPPVSTEAISLMRGLLT-DADH
   .  . ..| .|.|||.|    .|  .. ..|.|| |..|.||  |. || .   ...  . ..| . | .|..|  . .|.|| .| |..|. |   
HNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHK

RLN-----FEEIKSHPFF
||.      ||||.||.|
RLGCGPQDAEEIKQHPWF
Kinase 80572.m00042.AA Pkinase 111-407 25 6.6e-70 243.35 Pfam 1-293 (293) Show / Hide 
Range on Protein: 111-407
Range on HMM: 1-293/293
Sequence Identity: 25% (85 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTI-VEKDFMVQNDNPWAVQLYYAFQDSRCLYFVMEFLPGG----DLMTLLI--NR
......||.||||.|.. ..| ...|.|.|..||..  .. .. ..   |   |   . |  |.||..|.|.. .|.|||...||    ||....   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NIL--TETETRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTKNGHV----RLTDFGLSTKMDRYSDPIVQLIDEITDAFNESGNSSTPQSVINRLYYQK
. .  .| | .| . ... ...  |..|.||||.||.|.|. .|||.    ...||||. ..|                                     
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------------------------

MHSSERHAQVCSAVGTTDYIAPEVLL-KQPYGPSVDYWSIGAIMFEMIYGYAPFSSQ------TQRTTATKIIHFKETLEFPSKPPVS------------
     .     . .|| .|.||||..  |.|||.|| ||.| |..||. |. ||...      .|.    .| . .   ..| . ..|            
---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWT

-----TEAISLMRGLLT-DADHRLNFEEIKSHPFF
      |........|. |   |...|.|. ||.|
FHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 80572.m00042.AA Akt 111-256 44 1.5e-66 211.71 In-house 1-148 (264) Show / Hide 
Range on Protein: 111-256
Range on HMM: 1-148/264
Sequence Identity: 44% (66 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIY-AMKVLKKKELVEKNQILNTIVEKDFMVQNDNPWAVQLYYAFQDSRCLYFVMEFLPGGDLMTLLINRNILTET
|. ||..|.|||| | ||..| .| .| |||||||. ...|||. .|. |.   .  ..|  |.|.|.||..  |||||.. .||.| ..|  ... .| 
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

ETRFLIAETILAVNCVHKQGFIHRD-IKPDNLLLTKNGHVRLTDFGLS
..|| .|| |||  . |... | ||  || |.|. |.||..||||||.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase 80572.m00042.AA ROCK 111-261 48 3.6e-57 193.18 In-house 1-150 (263) Show / Hide 
Range on Protein: 111-261
Range on HMM: 1-150/263
Sequence Identity: 48% (73 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTIVEKDFMVQNDNPWAVQLYYAFQDSRCLYFVMEFLPGGDLMTLLINRNILTETE
|. .|.|||| |||| |||.|. ...||||.| | |.. .        |.| |     .| |||.||||| | || ||...|||||. |. | ..  |  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEKW

TRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTKMDR
.||  .| .||.. .|  ||||||.||||.|| | ||..| |||   ||..
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNK
Kinase 80572.m00042.AA DMPK 309-407 45 1.7e-53 130.09 In-house 160-270 (270) Show / Hide 
Range on Protein: 309-407
Range on HMM: 160-270/270
Sequence Identity: 45% (50 aa)

SAVGTTDYIAPEVL------LKQPYGPSVDYWSIGAIMFEMIYGYAPFSSQTQRTTATKIIHF-KETLEFPSKPP--VSTEAISLMRGLLTDADHRLN--
.|||| |||.||||      .|  |||..|.|| | .|.||.||  ||.  .   | .|| .. |. |.||..|.  ||.|| .| . ||.|...||   
VAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRN

-FEEIKSHPFF
 .|..| ||||
GYEDFKCHPFF
Kinase 80572.m00042.AA CRIK 111-261 45 4.9e-53 167.25 In-house 1-152 (272) Show / Hide 
Range on Protein: 111-261
Range on HMM: 1-152/272
Sequence Identity: 45% (69 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTIVEKDFMVQNDNPWAVQLYYAFQDSRCLYFVMEFLPGGDLMTLLINRN-ILTET
||   .||.| ||.| .|| |    ||||||..||..  . |.     |.| |     ||  || |||||   || .||. |||||  |.      . | 
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

ETRFLIAETILAVNCVHKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTKMDR
  ||  || |.||  .|. |..||||||.| |.   ||. | |||   ||.|
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNR
Kinase 80572.m00042.AA CRIK 311-407 37 6.3e-35 108.53 In-house 162-272 (272) Show / Hide 
Range on Protein: 311-407
Range on HMM: 162-272/272
Sequence Identity: 37% (42 aa)

VGTTDYIAPEVL--------LKQPYGPSVDYWSIGAIMFEMIYGYAPFSSQTQRTTATKIIH------FKETLEFPSKPPVSTEAISLMRGLLTDADHRL
||| ||.|||||         |  || . |.||.| | .||..|  ||.  .   |  .|.       |.. | ||  |.|| .. .|.. ||..   ||
VGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAYEMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL

NFEEIKSHPFF
 .| .. ||||
KYEQLCCHPFF
Kinase 80572.m00042.AA ROCK 310-407 40 8.8e-28 91.46 In-house 159-263 (263) Show / Hide 
Range on Protein: 310-407
Range on HMM: 159-263/263
Sequence Identity: 40% (43 aa)

AVGTTDYIAPEVLLKQP----YGPSVDYWSIGAIMFEMIYGYAPFSSQTQRTTATKIIHFKETLEFPSKPPVSTEAISLMRGLLTDADHRL---NFEEIK
|||| |||.||||  |     ||  .|.||.|  ..||. |  ||  ..   | .||.  |. |.||  . .|..|  |..  |||...||     ..||
AVGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIK

SHPFF
 |.||
QHKFF
Kinase 80572.m00042.AA Akt 312-407 37 3.5e-23 70.89 In-house 164-264 (264) Show / Hide 
Range on Protein: 312-407
Range on HMM: 164-264/264
Sequence Identity: 37% (39 aa)

GTTDYIAPEVLLKQPYGPSVDYWS-IGAIMFEMIYGYAPFSSQTQRTTATKIIHFKETLEFPSKPPVSTEAISLMRGLLT-DADHRL----N-FEEIKSH
||  |.|||.|... .. .|| |. .|..|.||..|  || .| . .   ||  . . ..|| |. .| |. .| .|||. | ..||    |  .|||.|
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKI--KNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRH

PFF
|.|
PWF
Kinase 80572.m00042.AA TyrKc 111-407 21 4.7e-11 -43.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 111-407
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

FEKLKIIGRGSFGEVWLVRDKEDQHIYAMKVLKKKELVEKNQILNTIVEKDFMVQN--DNPWAVQLYYAFQDS-------RCLYFVMEFLPGGDLMTLLI
 ...|..|.| ||||.. . |       ..|  |.   ..  .   . |   | .   ..|  |.|| .  ..         |. |||. |.|||   | 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NRNILTETETRFLIAETI-LAVNCVHKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTKMDRY---SDPIVQLIDEITDAFNESGNSSTPQSVINRLYYQK
..     ...   ..  |    .  |....||||.   | |...|..|. .||||| . . .                               .  || |
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--------------------------ESKDYYRK

M-HSSERHAQVCSAVGTTDYIAPEVLLKQPYGPSVDYWSIGAIMFEMI-YGYAPFSSQTQ-RTTATKIIHFKETLEFPSKPPV---------STEAISLM
. |....      ..      |||.. .  . .  | || |  |.|.  ||  | . ..|   ... .|.. .. . . .||          ..|  ..|
KEHKGGK------TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM

RGLLTD-ADHRLNFEEIKSHPFF
.      .. | .|.||  | .|
KQCWHEDPEDRPTFSEI--HECF
Kinase 80572.m00042.AA S_TK_X 408-471 24 3e-07 31.35 SMART 1-79 (79) Show / Hide 
Range on Protein: 408-471
Range on HMM: 1-79/79
Sequence Identity: 24% (20 aa)

SSVDWDNLFN----SVSPCIPTLE----SDLDTSHFD-VFEPLPEEEARPKSPHDKEVEDLANIA----------FMGFSYNK
...|||.|.|       | .|..     |. ||| ||  |.  .       .|.|. . . ..            | ||.|. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM----LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase 80572.m00042.AA Pkinase_C 425-473 24 5.6e-05 20.85 Pfam 1-46 (46) Show / Hide 
Range on Protein: 425-473
Range on HMM: 1-46/46
Sequence Identity: 24% (12 aa)

TLESDLDTSHFDVFEPLPEEEARPKS-PHDKEVEDLANIAFMGFSYNKKA
...|..|||.||...   ..|. . . | .      .. .| ||.|    
QVKSPTDTSNFDPEF---TDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase 80572.m00042.AA Pkinase_Tyr 226-264 38 0.000468 14.36 Pfam 128-164 (270) Show / Hide 
Range on Protein: 226-264
Range on HMM: 128-164/270
Sequence Identity: 38% (15 aa)

HKQGFIHRDIKPDNLLLTKNGHVRLTDFGLSTKMDRYSD
. ...||||.   | |.|.|..|. .||||.  .  |.|
ESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YND
Kinase 80572.m00042.AA Pkinase_Tyr 111-127 41 0.003207 11.53 Pfam 1-17 (270) Show / Hide 
Range on Protein: 111-127
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

FEKLKIIGRGSFGEVWL
 ...| .|.|.||||..
ITFGKKLGEGAFGEVYK
Kinase 80572.m00042.AA Pkinase_Tyr 172-196 39 1.7868 2.23 Pfam 67-94 (270) Show / Hide 
Range on Protein: 172-196
Range on HMM: 67-94/270
Sequence Identity: 39% (11 aa)

VQLYYAFQ-DSRC--LYFVMEFLPGGDL
|.|| .   ...   .| |||. |.|||
VRLYGVCTDQGEPNQIYIVMEYMPHGDL