Gene 86498.m00531 (T.vaginalis)

86498.m00531

Species: T.vaginalis
Alias: TvagK0657, 86498.m00531
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
86498.m00531.AA Protein None 482 None Fasta, JSON
86498.m00531.kin_dom Protein Kinase Domain None 296 None Fasta, JSON

Protein domain

Protein domains of 86498.m00531.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 86498.m00531.AA DYRK2 154-449 44 2.4e-140 459.32 In-house 1-318 (318) Show / Hide 
Range on Protein: 154-449
Range on HMM: 1-318/318
Sequence Identity: 44% (140 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRLNDLDPDRTSDIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRFQPMT
.||  | ||| ||||..|.|||||| ||||.. |    |.|  .|. |....   |.| |...|. .| |. | |. . || |.|||||| .   ||  .
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LHQIHAIAKHILTGLAFCHKNKIVHCDMKPENVLLTQNSTMNCRIIDFGSSCFIGH-QKYEYIQSRFYRAPEVILGIKYGPPMDIWSFACIIIEMMIGRP
|  . . |. ||..| | |||.|.|||.||||.|| |    .  .||||||||    . | |||||||||||||||.||| . |.||| ||. |. .| |
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

IFPGENEHEQLEMIMEILGVPPLSIINQA-----KRKNEFFS---------------HDGKPLLRNRRKKLRMPGQSNLRAATK-FHDPVFIDFLQKCLE
.|||||| .|. ..||.|| || ......     .|.. ||                 . ...  ||..| |.|| ... .. |   |. ||||...|.|
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WDHDKRITAEQALNHQWF
|| ..|.|..|||.| |.
WDPSERMTPSQALKHPWI
Kinase 86498.m00531.AA DYRK 154-449 44 1.5e-133 449.95 In-house 1-320 (320) Show / Hide 
Range on Protein: 154-449
Range on HMM: 1-320/320
Sequence Identity: 44% (141 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRLNDLDPDRTSDIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRFQPM-
.||  . ||| |||| .|.||||.. ||||.. | . .|.|..||. |...||. ||| ....|. .| |..|.|  . || | |||||. .  .||.  
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

TLHQIHAIAKHILTGLAFCHKN-KIVHCDMKPENVLLTQN-STMNCRIIDFGSSCFIGHQKYEYIQSRFYRAPEVILGIKYGPPMDIWSFACIIIEMMIG
.|  .  .|. |||.| | ||| .|.|||.||||..| |  .  .  .||||||||.... | |||||||||||||||..|. . |.||. ||. |. .|
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

RPIFPGENEHEQLEMIMEILGVPPLSIINQA--KRKNEFFSH-------------------DGKPLLRNRRKKLRMPGQSNLRAATKFHDPVFIDFLQKC
 |.|||||| .|| .|||.|| ||  .|...  .||..||                     .. .. ...|.. |.||..|. .. . .|  |.||..||
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKC

LEWDHDKRITAEQALNHQWF
|.|| .||||..|||.| ||
LQWDPHKRITPSQALQHPWF
Kinase 86498.m00531.AA CMGC 154-449 21 2e-111 367.56 In-house 1-513 (513) Show / Hide 
Range on Protein: 154-449
Range on HMM: 1-513/513
Sequence Identity: 21% (113 aa)

FEIRAVFGKGAFGQVLRCFD--------------HKTKQQVAIKLVINTEQMHKQGK-------------IEVAIIQRLN----------DLDPDRTSD-
.||  . |.|..|.| .|.|              |.|...|||| . | . .. |.|              |. | ..||          | |||   . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-IVRTFDAFIWRQ-----------------HIAVSFEILGMNLYEYSRSIRF-------QPMTLHQ------------IHAIA------KHILTGLA--F
 ||. .| |  ..                 |.   || ....||.| .. .|       .|..  .            |  .       . ||.||.  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

CHKNK--IVHCDMKPENVLLTQN------------------STMNCRIIDFGSSCFIGHQ------------------------KYEYIQSRFYRAPEVI
||...  |.|.|.||||.|...|                  . .. .|.|||.......                          ..|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGIK----------YGPPMDIWSFACIIIEMMIG--------RPIFPGENE-----------HEQLEMIMEILGVPPLSIINQAK-------RKNEFFSH
|| |          |..|.|.||..||. ||. |        .|.|||..|            .||..|...|| |. ..|...|       ...|....
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

DG--------------------KPLLRNRRKK---LRMPGQSNLRAATKFHD-----------------------------------PVFIDFLQKCLEW
 .                    ..  || ...   . ..   ...   ..|.                                   | .||.|.|.|..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DHDKRITAEQALNHQWF
|.||||||||||.| .|
DPDKRITAEQALQHPYF
Kinase 86498.m00531.AA DYRK1 154-402 39 6.1e-79 268.56 In-house 1-251 (321) Show / Hide 
Range on Protein: 154-402
Range on HMM: 1-251/321
Sequence Identity: 39% (99 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRLNDLDPDRTSDIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRFQPMT
.|| .  |||.|||| . .||.....||||.. |      | .||. ..  .|  |..    ||.    |..| |. . ||.|  |||.  |   |. . 
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LHQIHAIAKHILTGLAFCHKN--KIVHCDMKPENVLLTQNSTMNCRIIDFGSSCFIGHQKYEYIQSRFYRAPEVILGIKYGPPMDIWSFACIIIEMMIGR
|  .. .|. ..| | |      .|.|||.||||.||        .||||||||  |.  |.||||||||.|||.|||.|   .|.||  ||..|| .| 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PIFPGENEHEQLEMIMEILGVPPLSIINQAKRKNEFFSHDGKPLLRNRRKK
|.| | || .|.. |.|.||.||  .|.|| .   .| .| .     ....
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTR
Kinase 86498.m00531.AA S_TKc 154-449 25 1.4e-77 264.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 154-449
Range on HMM: 1-231/231
Sequence Identity: 25% (80 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRLNDLDPDRTSDIVRTFDAFIWRQHIAVSFEILGM---NLYEYSRSIRFQ
.||  . ||||||.| .| ..||...|||| .       .. . |..| ..       .   ||. .|.|   .|. . .| ..    .|..| .. . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P----MTLHQIHAIAKHILTGLAFCHKNKIVHCDMKPENVLLTQNSTMNCRIIDFGSSCFIGHQKYEYIQSRFYRAPEVILGIKYGP-PMDIWSFACIII
.    ..  ..  ... |. .|..||...|.|.| ||||.||..    .  |.|||.....    . .. ...|.||||.   .||. . |.||. ||..
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMMIGRPIFPGENEHEQLEMIMEILGVPPLSIINQAKRKNEFFSHDGKPLLRNRRKKLRMPGQSNLRAATKFHDPVFIDFLQKCLEWDHDKRITAEQALN
||. |.| ||      |..|.....|                                               .| ..||..|||..| .||.|| .||.
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ

-------HQWF
       |.||
DEWDIKCHPWF
Kinase 86498.m00531.AA Pkinase 154-449 28 6e-69 240.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 154-449
Range on HMM: 1-293/293
Sequence Identity: 28% (93 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKI-----EVAIIQRLNDLDPDRTSDIVRTFDAFIWRQHIAVSFEILGM-----NLYEY
..|  . |.|.||.| .| ...| ..||.| .   .. ... ..     |..| .|||         |||..|.|  ..|| . .| ...      |..|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

SR---SIRFQPMTLHQIHAIAKHILTGLAFCHKNKIVHCDMKPENVLLTQNSTMNC----RIIDFGSSCFI---GHQKYEYIQSRFYRAPEVIL-GIKYG
 .   . .|  .. ...  ... || ||..||...|.|.|.||||.|.   .....    .|.|||.....   ..  . .  ...|.|||||. | .||
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYG

PPMDIWSFACIIIEMMIGRPIFPGE----NEHEQLEMIMEILGVPPLSIINQA--KRKNEFFSHDGKPLLRNRRKKLRMPGQSNLRAATKFHDPVFIDFL
|. |.||. ||..||. |||.|||.    | |.|..|| .|.| |. . . .   ..  . |.|   .                ..   .  .. ..||.
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------F-HWTF-HNWSEECKDFI

QKCLEWDHDKRITAEQALNHQWF
 .||..|  ||.||||.|.| ||
KWCLCKDPKKRPTAEQILQHPWF
Kinase 86498.m00531.AA YAK 154-388 37 5.6e-65 219.57 In-house 1-239 (347) Show / Hide 
Range on Protein: 154-388
Range on HMM: 1-239/347
Sequence Identity: 37% (90 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRLND-LDPDRTS---DIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRF
. .  . |.| ||||  |    |.  .|.| . |      |.| |. | . ||.  ||.       |.|  | |... |  . ||.| .|||||    .|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QPMTLHQIHAIAKHILTGLAFCHKNKIVHCDMKPENVLLTQNSTMNCRIIDFGSSCFIGHQKYEYIQSRFYRAPEVILGIKYGPPMDIWSFACIIIEMMI
  .    |    | || |.      .|.||| ||||..| .      .||||||||      | |||.|.||.||.|... |    | ||  ||. |   
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GRPIFPGENEHEQLEMIMEILGVPPLSIINQAKRKNEFF
| |||||  | .|.  | ..|| ||  .|.| . || .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase 86498.m00531.AA HIPK 154-391 34 1e-63 199.33 In-house 1-240 (329) Show / Hide 
Range on Protein: 154-391
Range on HMM: 1-240/329
Sequence Identity: 34% (84 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRLNDLDPDRTSDIVRTFDAFIWRQHIAVSFEILGMNLYEYSRSIRFQPMT
.|.  . |.| |||| .|  . |.  ||||.  |     .||.||| |...| ....|   ..|| .. |  ..|.   ||.|  |||.. .  .| |. 
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEY-HFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LHQIHAIAKHILTGLAFCHKNKIVHCDMKPENVLLTQNSTMNCR--IIDFGSSCFIGHQ-KYEYIQSRFYRAPEVILGIKYGPPMDIWSFACIIIEMMIG
|. | .| . .|| |.   .  ..| |.||||..|   .    |  .|||||   . .  .  |.|||.|||||.|||...   .|.||  |.| | . |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

RPIFPGENEHEQLEMIMEILGVPPLSIINQAKRKNEFFSHD
.| .|| .| .|   | .  . |  .....| .|. || .|
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRD
Kinase 86498.m00531.AA CDK 260-449 29 3.3e-49 155.51 In-house 113-284 (284) Show / Hide 
Range on Protein: 260-449
Range on HMM: 113-284/284
Sequence Identity: 29% (61 aa)

IAKHILTGLAFCHKNKIVHCDMKPENVLLTQNSTMNCR----IIDFGSSCFIG--------HQKYE-YIQSRFYRAPEVIL-GIKYG--PPMDIWSFACI
. . .| ||..||.|.|.| |.|| | |.. | .   .    | ||| ..  |         ..|   .  . |||||. |   .|.  .| |.||. ||
YMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCI

IIEMMI---GRPIFPGENEHEQLEMIMEILGVPPLSIINQAKRKNEFFSHDGKPLLRNRRKKLRMPGQSNLRAATKFHDPVFIDFLQKCLEWDHDKRITA
..||.    ..|.|||..|..||..| .|.| |  ..    .   ..                                    |.|.|.|  | .|||.|
FAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------------------DLLNKMLCYDPKKRISA

EQALNHQWF
||||.|..|
EQALQHPYF
Kinase 86498.m00531.AA DyrkP 154-388 32 4.9e-44 142.52 In-house 1-239 (323) Show / Hide 
Range on Protein: 154-388
Range on HMM: 1-239/323
Sequence Identity: 32% (78 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRLNDLDPDRTSDIVRTFDAFIWRQHIAVSFEILGMNLYE---YSRSIRFQ
. |    |  || . . | | .| | . .|.. |      |   |. ... .|         ..| .| |  . |. .  |.|  ||||   . |    |
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

P-MTLHQIHAIAKHILTGLAFCHKNKIVHCDMKPENVLLTQNSTMNCRIIDFGSSCFIGHQKYEYIQSRFYRAPEVILGIKYGPPMDIWSFACIIIEMMI
.  |.  .  | . || .| . |  ...|||.||||.|.   .  . .||||||||||      |.||| |||||||.| ||   .|.||  ||. |.  
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GRPIFPGENEHEQLEMIMEILGVPPLSIINQAKRKNEFF
|  .|  .|    |  .. |.|  |  ..   .  . ||
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFF
Kinase 86498.m00531.AA CLK 154-290 28 2.4e-40 118.21 In-house 1-149 (350) Show / Hide 
Range on Protein: 154-290
Range on HMM: 1-149/350
Sequence Identity: 28% (43 aa)

FEIRAVFGKGAFGQVLRCFDHKT-KQQVAIKLVINTEQMHKQGKIEVA-IIQRLNDL-DPDRTSD--IVRTFDAFIW-RQHIAVSFEILGMNLYEYSRSI
.|| .. | |.|| |..| |||  |..||.| . | |.   . ..|.  |.. .|   ||. ..   ... .| |     ||. .||..| ..|.  .| 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

R------FQPMTLHQIHAIAKHILTGLAFCHKNKIVHCDMKPENVLLTQ
.      ..|  ...| ..|. ... . | |..|..| | |||| ....
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVD
Kinase 86498.m00531.AA CLK 297-392 35 1.2e-26 76.34 In-house 187-289 (350) Show / Hide 
Range on Protein: 297-392
Range on HMM: 187-289/350
Sequence Identity: 35% (37 aa)

RIIDFGSSC---FIGHQKYEYIQSRFYRAPEVILGIKYGPPMDIWSFACIIIEMMIGRPIFPGENEHEQLEMIMEILG-VPPLSIINQAKR----KNEFF
..|||||     |    ... ...| |||||||||  .  | |.||..||..|  .|   |.. ...| |.|. .|.|   | . | |. |    | ..|
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMI-QRTRRFKVKQKYF

SHDG
 |..
YHNR
Kinase 86498.m00531.AA PRP4 273-388 35 2e-21 75.19 In-house 124-239 (320) Show / Hide 
Range on Protein: 273-388
Range on HMM: 124-239/320
Sequence Identity: 35% (41 aa)

KNKIVHCDMKPENVLLTQNSTMNCRIIDFGSSCFIGHQK-YEYIQSRFYRAPEVILGIKYGPPMDIWSFACIIIEMMIGRPIFPGENEHEQLEMIMEILG
|..|.| |.|| |.|   . .    ..||||   |  .    | .||||||||.|.|..|    |.|| .| . |.  |  .|||    . | ..|.. |
KCNILHADIKPDNILVNESKNT-LKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFMDYKG

VPPLSIINQAKRKNEFF
  |  .|   . | ..|
KMPNKMIRKGQFKDNHF
Kinase 86498.m00531.AA PRP4 154-242 39 4.7e-20 70.13 In-house 1-92 (320) Show / Hide 
Range on Protein: 154-242
Range on HMM: 1-92/320
Sequence Identity: 39% (36 aa)

FEIRAVFGKGAFGQVLRCF-DHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRLNDL--DPDRTSDIVRTFDAFIWRQHIAVSFEILGMNLYE
...    |.| |. | ||    .....|||| . | | ||| |  |. |.|.|||   |..  . .|| |. | .|||.   || . ||| |
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLRE
Kinase 86498.m00531.AA DyrkP 406-449 50 5.4e-13 38.46 In-house 280-323 (323) Show / Hide 
Range on Protein: 406-449
Range on HMM: 280-323/323
Sequence Identity: 50% (22 aa)

PGQSNLRAATKFHDPVFIDFLQKCLEWDHDKRITAEQALNHQWF
| .|||||  .  | .|||| ..||  |  .| ||  ||.| ||
PKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 86498.m00531.AA CLK 422-449 46 4.4e-11 28.74 In-house 323-350 (350) Show / Hide 
Range on Protein: 422-449
Range on HMM: 323-350/350
Sequence Identity: 46% (13 aa)

FIDFLQKCLEWDHDKRITAEQALNHQWF
..| ..|.|| |  ||||. .|| | .|
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 86498.m00531.AA TyrKc 154-449 17 2.7e-07 -104.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 154-449
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)

FEIRAVFGKGAFGQVLRCFDHKTKQQVAIKLVINTEQMHKQGKIEVAIIQRL--NDLDPDRTSDIVRTFDAFIWR-------QHIAVSFEILGM-NLYEY
 .   . | ||||.| ..      .|||.| . .    ..    |  |  .|  .         ||| . . .         . . . .|     .| .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

SRSIRFQPMTLHQIHAIAKHILTGLAFCHKNKIVHCDMKPENVLLTQNSTMNCRIIDFGSSCFIGHQ-------KYEYI----QSR-----FYRAPEVIL
 |. | .  .. . . ..  |  | .. |.....| |    |.|.. |    ..| ||| | .|..        .|       ...        |||.| 
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GIKYGPPMDIWSFACIIIEMM-IGRPIFPGE----NEHEQLEMIMEILGVPPLSII----NQAKRKNEFFSHDGKPLLRNRRKKLRMPGQSNLRAATKFH
  |. .  |.|||   . |..  | .  ||.     . ...    .  . .|                                      .        .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------F-----VCCP

DPVFIDFLQKCLEWDHDKRITAEQALNHQWF
| ..    ..| . | ..| | ..   |. |
DEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase 86498.m00531.AA CDK 154-183 31 9.8e-07 17.4 In-house 1-35 (284) Show / Hide 
Range on Protein: 154-183
Range on HMM: 1-35/284
Sequence Identity: 31% (11 aa)

FEIRAVFGKGAFGQVLRCFDHKTK-----QQVAIK
.|. .  | |..|.| .. |..|.     | ||.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALK
Kinase 86498.m00531.AA PRP4 424-449 50 1e-06 20.66 In-house 295-320 (320) Show / Hide 
Range on Protein: 424-449
Range on HMM: 295-320/320
Sequence Identity: 50% (13 aa)

DFLQKCLEWDHDKRITAEQALNHQWF
|.| |||  |  |||| ..|| |  .
DLLDKCLMLDPKKRITCNEALKHPFI
Kinase 86498.m00531.AA HIPK 422-449 46 5e-06 14.55 In-house 302-329 (329) Show / Hide 
Range on Protein: 422-449
Range on HMM: 302-329/329
Sequence Identity: 46% (13 aa)

FIDFLQKCLEWDHDKRITAEQALNHQWF
|.. | | . || .||||  .||||.. 
FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 86498.m00531.AA DYRK1 422-449 39 0.000147 11.37 In-house 294-321 (321) Show / Hide 
Range on Protein: 422-449
Range on HMM: 294-321/321
Sequence Identity: 39% (11 aa)

FIDFLQKCLEWDHDKRITAEQALNHQWF
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FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 86498.m00531.AA YAK 421-449 31 0.001784 7.23 In-house 319-347 (347) Show / Hide 
Range on Protein: 421-449
Range on HMM: 319-347/347
Sequence Identity: 31% (9 aa)

VFIDFLQKCLEWDHDKRITAEQALNHQWF
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CFIDFINQLLQLNPRERWKPMQAMQHPFI