Gene 88399.m00068 (T.vaginalis)

88399.m00068

Species: T.vaginalis
Alias: 88399.m00068, TvagK0660
External Links:
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
88399.m00068.AA Protein None 444 None Fasta, JSON
88399.m00068.kin_dom Protein Kinase Domain None 292 None Fasta, JSON

Protein domain

Protein domains of 88399.m00068.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88399.m00068.AA DYRK 133-424 43 7.50000000001e-139 467.59 In-house 1-320 (320) Show / Hide 
Range on Protein: 133-424
Range on HMM: 1-320/320
Sequence Identity: 43% (138 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRIEAQILARLNKN---EVKNVVKANDFFIFRSHICITFEILSKNLYEVIEASNFEPM-
.|||   | | ||||.||.|||| . |||||| | . .| |. || .|| .||..   . ...|.. |.|..| | ||.|| || ||||..   .| .  
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SPKLVRLYAVQILTALEQSHKL-GIVHCDLKPENVLLVKE-HSTSVKLIDFGSSCFVDHQMYEYIQSRYYRAPEVMLGIKYGPPMDMWSFALIIVELLTG
| .||| .| ||||.|   ||.  |.||||||||..|...     .|.||||||||.....| |||||.||||||.||..|. . ||||.  |..||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

TPLFPGQNEEEQLWMISQLIGMPPRELVVIG--KRREEFFDK--------------------SLRLLKEQTKKEYMPNSMDLAQVLKTDDMRLVDFIMKL
 |||||.|| .|| .| ...||||....  |  .|...|||.                     ... .. ......|.. ..  ....||  ..|||.|.
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKC

LTWDQRMRMTAAEALQHPWI
|.|| . |.|...||||||.
LQWDPHKRITPSQALQHPWF
Kinase 88399.m00068.AA DYRK2 133-424 45 2e-133 436.43 In-house 1-318 (318) Show / Hide 
Range on Protein: 133-424
Range on HMM: 1-318/318
Sequence Identity: 45% (144 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRIEAQILARL---NKNEVKNVVKANDFFIFRSHICITFEILSKNLYEVIEASNFEPMS
.|||   | | ||||.||||||| | ||||.| |    |.|  .| .|| ..   .|..  |.|. .|.|.|| |.||||| || |||| |   .|   |
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

PKLVRLYAVQILTALEQSHKLGIVHCDLKPENVLLVKEHSTSVKLIDFGSSCFVDH-QMYEYIQSRYYRAPEVMLGIKYGPPMDMWSFALIIVELLTGTP
..|||  | .||..|.  ||  |.||||||||.|| ..   ..|.||||||||..  ..| |||||.|||||| ||.||| . |||||  |..||.||.|
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGQNEEEQLWMISQLIGMPPRELVVIG-----KRREEFFD----------------KSLRLLKEQTKKEYMPNSMDLAQVLK-TDDMRLVDFIMKLLT
|||| || .|. ..  ..||||....        .||. ||.                .  .. |  ..| ..|.| ....||| ..|  ..|||.. ..
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WDQRMRMTAAEALQHPWI
||   |||...||.||||
WDPSERMTPSQALKHPWI
Kinase 88399.m00068.AA CMGC 133-424 20 5.3e-105 346.09 In-house 1-513 (513) Show / Hide 
Range on Protein: 133-424
Range on HMM: 1-513/513
Sequence Identity: 20% (108 aa)

FEILALFGAGAFGQVAKCYD--------------HKTMQCVAIKIIVNTEQMHEQGR-------------IEAQILARLNKNE--------------VKN
.||.   | |..|.| ||.|              |.| . ||||.| | . ..||..              | .|| .||||.               .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVKANDFFIFRS-----------------HICITFEILSKNLYEVIEASNFE-------PMSPKL------------VRLYA------VQILTALE--QS
.||  |.| ..                  |... || . ..||..|.  .|        |.|.              .. .        |||..|.    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HKLG--IVHCDLKPENVLLVKE------------------HSTSVKLIDFGSSCFVDHQ------------------------MYEYIQSRYYRAPEVML
|. .  |.|.||||||.|. ..                  ..  .|..|||.......                         ...|...|.|||||..|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GIK----------YGPPMDMWSFALIIVELLTG--------TPLFPGQNE-----------EEQLWMISQLIGMPPRELVVIGK------RREEFFDKSL
| |          |..|.||||.. |. |..||         |||||..|            .|| .| ...|.|. ..   ||      ..|| . . .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMI

RLLKEQT----------------------------KKEYMPNSMDLAQVLKT--------------------------------DDMRLVDFIMKLLTWD
 |.  ..                            .. . ..  .|   ...                                .|  ..|...|.|..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

QRMRMTAAEALQHPWI
   |.||..|||||..
PDKRITAEQALQHPYF
Kinase 88399.m00068.AA S_TKc 133-424 30 1.1e-81 278.62 SMART 1-231 (231) Show / Hide 
Range on Protein: 133-424
Range on HMM: 1-231/231
Sequence Identity: 30% (94 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRIEAQILARLNKNEVKNVVKANDFFIFRSHICITFEILSK---NLYEVIEASNFEP--
.||| . | ||||.| ||...|| . ||||||       |. | | ||| .      .|.||  |.|   .|... .| ..    .|...|.  . ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MSPKLVRLYAVQILTALEQSHKLGIVHCDLKPENVLLVKEHSTSVKLIDFGSSCFVDHQMYEYIQSRYYRAPEVMLGIKYGP-PMDMWSFALIIVELL
  ...  .| |. ||. |||  |..||.|.||||||.|| .     .|..|||.....    . .. ...|.||||.   .||. . |.||.  |. |.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TGTPLFPGQNEEEQLWMISQLIGMPPRELVVIGKRREEFFDKSLRLLKEQTKKEYMPNSMDLAQVLKTDDMRLVDFIMKLLTWDQRMRMTAAEALQ----
.| |.||      |. |. ..||                                              .  . |||.|.|..| . |.|| ||||    
CGYPPFP------QMQMMFKKIG----------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

---HPWI
   |||.
IKCHPWF
Kinase 88399.m00068.AA DYRK1 133-366 44 2.1e-81 276.76 In-house 1-239 (321) Show / Hide 
Range on Protein: 133-366
Range on HMM: 1-239/321
Sequence Identity: 44% (106 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRIEAQILARLNKNEVKN---VVKANDFFIFRSHICITFEILSKNLYEVIEASNFEPMS
.|| .| | |.||||.| |||.. . |||||| |     .| .|| ..|  .||..  .   .|.    |.|| |.|. ||.|| |||...   .|  .|
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

PKLVRLYAVQILTAL--EQSHKLGIVHCDLKPENVLLVKEHSTSVKLIDFGSSCFVDHQMYEYIQSRYYRAPEVMLGIKYGPPMDMWSFALIIVELLTGT
  |.| .| |..|||    .  | |.||||||||.||.      .|.||||||| ... .|.|||||.||.|||.|||.|   .||||   |.||. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGQNEEEQLWMISQLIGMPPRELVVIGKRREEFFDK
||| |.|| .|.  |   .||||.... .. . . .|.|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEK
Kinase 88399.m00068.AA YAK 133-364 38 5.4e-72 243.79 In-house 1-239 (347) Show / Hide 
Range on Protein: 133-364
Range on HMM: 1-239/347
Sequence Identity: 38% (92 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRIEAQILARLNKN---EVKN----VVKANDFFIFRSHICITFEILSKNLYEVIEASNF
. .|   | | ||||.||    |   .|.|.| |      |.. |.|||  ||.    . ||    ...  |||... | |. ||.|| |||| .   .|
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

EPMSPKLVRLYAVQILTALEQSHKLGIVHCDLKPENVLLVKEHSTSVKLIDFGSSCFVDHQMYEYIQSRYYRAPEVMLGIKYGPPMDMWSFALIIVELLT
  .|  |.| .  ||| ..       |.||||||||..| |  .  .|.|||||||     .| |||.|.||.||..... |    ||||   |..||  
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GTPLFPGQNEEEQLWMISQLIGMPPRELVVIGKRREEFF
| |.|||  | .|.  |    | || ...  |. .  .|
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase 88399.m00068.AA HIPK 133-366 40 7.1e-69 215.9 In-house 1-239 (329) Show / Hide 
Range on Protein: 133-366
Range on HMM: 1-239/329
Sequence Identity: 40% (96 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRIEAQILARLNKNEVK--NVVKANDFFIFRSHICITFEILSKNLYEVIEASNFEPMSP
.|.| . | | ||||.||  . |   |||||. |      ||.|| .||..| . .    ..|.| ..|  ..|.|. ||.|  |||.     .| |.  
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

KLVRLYAVQILTALEQSHKLGIVHCDLKPENVLLVKEHSTS--VKLIDFGSSCFVDHQMYE-YIQSRYYRAPEVMLGIKYGPPMDMWSFALIIVELLTGT
| .|    |.|||| .  .||..| ||||||..|| .      || |||||   | .   . |.|||||||||..||...   .||||   .| ||  | 
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW

PLFPGQNEEEQLWMISQLIGMPPRELVVIGKRREEFFDK
||.|| .| .|   |.|  . |   |.  . . . |||.
PLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDR
Kinase 88399.m00068.AA Pkinase 133-424 30 2.8e-60 211.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 133-424
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRI-----EAQILARLNKNEVKNVVKANDFFIFRSHICITFEILSK-----NLYEVIE-
..|.   |.|.||.| ||....| . ||.|||   .. ... ..     |.||..|||    .|.|.  |.|  ..||.. .| . .      |...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

--ASNFEPMSPKLVRLYAVQILTALEQSHKLGIVHCDLKPENVLLVKEHST--SVKLIDFGSSCF---VDHQMYEYIQSRYYRAPEVML-GIKYGPPMDM
    .|  .|.. .. |. ||| .||  |. ||.|.||||||.|....  .  .||..|||....    .. |. .  ...|.|||| . | .|||. ||
WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFALIIVELLTGTPLFPGQ----NEEEQLWMISQLIGMPPRELVVIGKRREEFFDKSLRLLKEQTKKEYMPNSMDLAQVLKTDDMRLVDFIMKLLTWDQ
||. .|. |.|.| |.|||.    |  .|..|| .  | |...      ..  ||  .    .             .  . .  .  . ||| ..|..| 
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-----------F-HWTF-HNWSEECKDFIKWCLCKDP

RMRMTAAEALQHPWI
  | ||...|||||.
KKRPTAEQILQHPWF
Kinase 88399.m00068.AA DyrkP 133-338 40 3.1e-49 159.93 In-house 1-211 (323) Show / Hide 
Range on Protein: 133-338
Range on HMM: 1-211/323
Sequence Identity: 40% (86 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRIEAQILARLNKN---EVKNVVKANDFFIFRSHICITFEILSKNLYEV--IEASNFEP
. |.   |. || .  .| | .| | . .||| |     .|   | ..|  .| |   . |||..  |.|  . |. |  |.|  ||||       | . 
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

MSPKLVRLYAV--QILTALEQSHKLGIVHCDLKPENVLLVKEHSTSVKLIDFGSSCFVDHQMYEYIQSRYYRAPEVMLGIKYGPPMDMWSFALIIVELLT
    . ||  .  ||| ||.  | | ..||||||||.|.       ||.||||||||.   .  |.||| ||||||..| ||   .||||   |. || |
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GTPLFPGQNEEEQ
|  ||  ||.. |
GNVLF--QNDNIQ
Kinase 88399.m00068.AA PRP4 133-372 33 1.5e-47 164.3 In-house 1-247 (320) Show / Hide 
Range on Protein: 133-372
Range on HMM: 1-247/320
Sequence Identity: 33% (83 aa)

FEILALFGAGAFGQVAKCY-DHKTMQCVAIKIIVNTEQMHEQGRIEAQILARLNKN-----EVKNVVKANDFFIFRSHICITFEILSKNLYEVI-EASNF
...    |.| |. | .|    .. . |||||| | | ||  |  |  || .|| .     . . .|.  . | .| |.|. || .| || ||. .    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

EPMSPKLVRLYAVQILTALEQSHKLGIVHCDLKPENVLLVKEHSTSVKLIDFGSSCFV-DHQMYEYIQSRYYRAPEVMLGIKYGPPMDMWSFALIIVELL
  .. | || || |.. ||    |..|.| |.|| | .|| |  .  |..||||   . .  .  | .||.|||||...|..|    |||| .  . || 
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDN-ILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGTPLFPGQNEEEQLWMISQLIGMPPRELVVIGKRREEFFDKSLRLLK
||  .|||.   . | ..  . |  |. ..  |. ....||. . ...
TGKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMY
Kinase 88399.m00068.AA CLK 133-267 32 8.1e-41 119.62 In-house 1-150 (350) Show / Hide 
Range on Protein: 133-267
Range on HMM: 1-150/350
Sequence Identity: 32% (49 aa)

FEILALFGAGAFGQVAKCYDHKT-MQCVAIKIIVNTEQMHEQGRIEAQ-ILARLNKN---EVKNV---VKANDFFIF-RSHICITFEILSKNLYEVIEAS
.||..  | |.|| | .| |||   ..||.||| | |.  |. ..| . |.  .|..   . |.    .| || | .   |||| ||.. ...|... . 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FEPMSPKLVRLYAVQILTALEQSHKLGIVHCDLKPENVLLVKE
|      ..|     .|  | |...|..  |.....| |||||| ..|..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS
Kinase 88399.m00068.AA CAMK 138-339 20 5.7e-38 119.44 In-house 1-343 (425) Show / Hide 
Range on Protein: 138-339
Range on HMM: 1-343/425
Sequence Identity: 20% (70 aa)

LFGAGAFGQVAKCYDHKTM------------QCVAIKIIVNT-----------------------------EQMHEQGRIEAQILARLNKNE----VKNV
  | |.||.| .|.. .|             | ||||||  .                             ... .. | | .|. .|....     .|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKANDFFI------------FRSH--------ICITF---EILSKN-----LYEVIEASNF-------------EPMSPKLVRLYAVQILTALEQSHKLG
.|  ...             . |.        ... .   |  |       |.. | .                  .. . .| |  ||. |..  |...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHCDLKPENVLLVKEHSTS---------------VKLIDFGSSCFVDH--------------------------QMYEYIQSRYYRA-PEVMLGIK---
|||.||||||.||.. .. |               .|.|||| ....|.                           |...  . .| | ||| .| .   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YGPPMDMWSFALIIVELLTGTPLFPGQNEEEQL
           |||. ||||   |   .|.|.| | | ...|..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEIC
Kinase 88399.m00068.AA CLK 268-349 38 1.2e-22 64.05 In-house 182-266 (350) Show / Hide 
Range on Protein: 268-349
Range on HMM: 182-266/350
Sequence Identity: 38% (33 aa)

HSTSVKLIDFGSSC---FVDHQMYEYIQSRYYRAPEVMLGIKYGPPMDMWSFALIIVELLTGTPLFPGQNEEEQLWMISQLIGMP
..| ...|||||     | .   .. ...| |||||| ||  .  | | ||.. |..|| ||  ||.. .. | | |.  . |||
KNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase 88399.m00068.AA DyrkP 390-424 51 6.1e-11 31.57 In-house 289-323 (323) Show / Hide 
Range on Protein: 390-424
Range on HMM: 289-323/323
Sequence Identity: 51% (18 aa)

LKTDDMRLVDFIMKLLTWDQRMRMTAAEALQHPWI
|.|||.  .||. ..|  |   | || |||||||.
LRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 88399.m00068.AA CAMK 399-424 46 3.9e-10 28.11 In-house 400-425 (425) Show / Hide 
Range on Protein: 399-424
Range on HMM: 400-425/425
Sequence Identity: 46% (12 aa)

DFIMKLLTWDQRMRMTAAEALQHPWI
|.| |.|. |   |||....|.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 88399.m00068.AA TyrKc 133-427 18 6e-07 -110.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 133-427
Range on HMM: 1-280/280
Sequence Identity: 18% (60 aa)

FEILALFGAGAFGQVAKCYDHKTMQCVAIKIIVNTEQMHEQGRIEAQILARL-NKNEVKNVVKANDFFIFR-------SHICITFEILSK-NLYEVIEAS
 . .   | ||||.| |.      . ||.| . .    .|  . ||.|. .|  ...  |.|.     .           ..| .|  .. .| . . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP--NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NFEPMSPKLVRLYAVQILTALEQSHKLGIVHCDLKPENVLLVKEHSTSVKLIDFGSSCFVDHQ-MY----EYI------QSR-----YYRAPEVMLGIKY
  .  ..|    ...||    |  |. ...| ||   |.|. ..|   ||  ||| | ....  .     .|.      ...        |||..   |.
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GPPMDMWSFALIIVELLT-GTPLFPG-----QNEEEQLWMISQLIGMPPREL----VVIGKRREEFFDKSLRLLKEQTKKEYMPNSMDLAQVLKTDDMRL
 .  | |||   . |..| | .  ||      . .| .  . |   ||. .                                           .    .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F-VCCPDEM

VDFIMKLLTWDQRMRMTAAEALQHPWIRSF
 . . .    |  .| | .|      .. |
YQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase 88399.m00068.AA CLK 396-424 44 2e-06 14.73 In-house 322-350 (350) Show / Hide 
Range on Protein: 396-424
Range on HMM: 322-350/350
Sequence Identity: 44% (13 aa)

RLVDFIMKLLTWDQRMRMTAAEALQHPWI
.| | | |.|  |   |.|...|||||. 
QLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 88399.m00068.AA HIPK 391-424 41 6e-06 14.15 In-house 296-329 (329) Show / Hide 
Range on Protein: 391-424
Range on HMM: 296-329/329
Sequence Identity: 41% (14 aa)

KTDDMRLVDFIMKLLTWDQRMRMTAAEALQHPWI
| |    |.   |..|||.  |.| .|||.||..
KIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase 88399.m00068.AA DYRK1 393-424 34 7.2e-05 12.48 In-house 290-321 (321) Show / Hide 
Range on Protein: 393-424
Range on HMM: 290-321/321
Sequence Identity: 34% (11 aa)

DDMRLVDFIMKLLTWDQRMRMTAAEALQHPWI
| ..  | | ..| .| . |.|  .||||...
DYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 88399.m00068.AA YAK 397-424 42 0.000151 10.93 In-house 320-347 (347) Show / Hide 
Range on Protein: 397-424
Range on HMM: 320-347/347
Sequence Identity: 42% (12 aa)

LVDFIMKLLTWDQRMRMTAAEALQHPWI
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FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase 88399.m00068.AA PRP4 399-424 46 0.000782 10.01 In-house 295-320 (320) Show / Hide 
Range on Protein: 399-424
Range on HMM: 295-320/320
Sequence Identity: 46% (12 aa)

DFIMKLLTWDQRMRMTAAEALQHPWI
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DLLDKCLMLDPKKRITCNEALKHPFI