Gene 94173.m00214 (T.vaginalis)

94173.m00214

Species: T.vaginalis
Alias: 94173.m00214, TvagK0608
External Links:
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
94173.m00214.AA Protein None 126 None Fasta, JSON
94173.m00214.kin_dom Protein Kinase Domain None 118 None Fasta, JSON

Protein domain

Protein domains of 94173.m00214.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 94173.m00214.AA RCK 4-122 39 1.4e-40 126.32 In-house 1-127 (298) Show / Hide 
Range on Protein: 4-122
Range on HMM: 1-127/298
Sequence Identity: 39% (50 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEECLQLKEVKSLRKIK-YDNVVRLMQVFRENE--YLYLVFECLGESLLKTLQN---RTGPF
   || .||| .| |.| .. .||.|||||||||||.. ||| .|.|.|||||..  .|.. |  |.|.|.   ||.|||.. . | . ...   |. ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

TDAE--VRYVMHEVLSGLAIVHRRRIF
.  .  ..  |  .| |||  |.  .|
PENQRSIKNIMYQILQGLAHMHKHGFF
Kinase 94173.m00214.AA MAK 4-118 34 6.2e-39 121.28 In-house 1-149 (352) Show / Hide 
Range on Protein: 4-118
Range on HMM: 1-149/352
Sequence Identity: 34% (51 aa)

FEEIKVIGDGGFGIVTKCRD------------------------------NDTGQIVAIKKMKQKFATFEECLQLKEVKSLRKIK-YDNVVRLMQVFR--
.  || .||| .| |.. ..                              .||| .||||.||.|| ..|||..| |||||.|..  .|.|.|  |.|  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

ENEYLYLVFECLGESLLKTLQNRTG-PFTDAEVRYVMHEVLSGLAIVHR
||. ||.|||.. | |   .  |.   |   ..| .|  .| ||| .|.
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHK
Kinase 94173.m00214.AA CMGC 4-122 22 1.6e-36 116.91 In-house 1-206 (513) Show / Hide 
Range on Protein: 4-122
Range on HMM: 1-206/513
Sequence Identity: 22% (46 aa)

FEEIKVIGDGGFGIVTKCRD--------------NDTGQIVAIKKMKQKFATFEECL-----------QLKEVKSLRKIK----------------YDN-
.| ||.|| | .|.| ||||              ..|..||||||.|..|   |...            | |.| |....                 .| 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVRLMQVFRENE-----------------YLYLVFECLGESLLKTLQNRTG--------PFTDAE------------VRYVM------HEVLSGLA--IV
.|.|  .|. ..                 .||||||... .|.. ..|  .        |... .            ..| |      . .| ||.    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HRRR--IF
|...  |.
HSHWGNII
Kinase 94173.m00214.AA Pkinase 4-121 27 1.2e-24 88.24 Pfam 1-129 (293) Show / Hide 
Range on Protein: 4-121
Range on HMM: 1-129/293
Sequence Identity: 27% (35 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEECLQLK---EVKSLRKIKYDNVVRLMQVFRENEYLYLVFECLGE-----SLLKTLQ-NRT
.. ...|| |.|| | ||.. .||.|||.|..| . .  ... ..    |.. ..... .|.|||  .|... ..|.|.|...      .|   ..  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPF--TDAEVRYVMHEVLSGLAIVHRRRI
|.|  .. |.. .| ..|.||.  |...|
GCFYFSEWECKFYMYQILRGLEYCHSMGI
Kinase 94173.m00214.AA CDC2 4-122 31 5.3e-24 70.19 In-house 1-125 (301) Show / Hide 
Range on Protein: 4-122
Range on HMM: 1-125/301
Sequence Identity: 31% (40 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEEC-----LQLKEVKSLRKIK-YDNVVRLMQVFRENEYLYLVFECLGESLLKTLQNRTG--
.. |. || | .|.|.||.|..|.||||.|| . .  ...|        ..|   | ..|  .|.|.|  |. .   ||.|||.|   | | . .  .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLE--QEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKN

-PFTDAEVRYVMHEVLSGLAIVHRRRIF
 ... . |.  |.  |.|..  |.|||.
KHMPPQLVKSYMYQILQGVHFCHQRRIM
Kinase 94173.m00214.AA CDK 4-121 26 2.9e-20 61.38 In-house 1-129 (284) Show / Hide 
Range on Protein: 4-121
Range on HMM: 1-129/284
Sequence Identity: 26% (37 aa)

FEEIKVIGDGGFGIVTKCRDNDTG-----QIVAIKKMKQKF---ATFEECLQ---LKEVKSLRKIKYDNVVRLMQVFREN-----------EYLYLVFEC
.| .. || | .|.| |.|| .||     ||||.|| .         .| .    . |.. |...  .|.|.|. |.  .             ||.||| 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

LGESLLKTLQNRTGPFTDAEVRYVMHEVLSGLAIVHRRRI
.   | | .           ..  |.  |.||.  |...|
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWI
Kinase 94173.m00214.AA Ciliate-E2-Unclassified 4-121 18 4.6e-20 66.29 In-house 1-165 (352) Show / Hide 
Range on Protein: 4-121
Range on HMM: 1-165/352
Sequence Identity: 18% (30 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEECLQ------------LKEVK-------------SLRKIKYDNVVRLMQVFRENEYLYLV
.. ||.|| ||||.| ||......  ....|.. |.  .  ...            ... |             .|. ..  ..|... .|.  ...|.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

FECL-GESLLKTLQNRTG----------------PFTDAEVR-----YVMHEVLSGLAIVHRR-RI
 | . | .|.. ...| .                 ||. ...     . . ..|.||   |.   |
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNI
Kinase 94173.m00214.AA STE 4-121 20 1.8e-19 65.53 In-house 1-173 (359) Show / Hide 
Range on Protein: 4-121
Range on HMM: 1-173/359
Sequence Identity: 20% (35 aa)

FEEIKVIGDGGFGIVTKCRDND---------------TGQIVAIKKMKQKFAT----------------FEECLQLKEVKSLRKIK--YDNVVRLMQVFR
.| |..|| |.|| | |.....               ||.|.|||.|. .  .                 |.   |||.| ..| .   .|.|.    . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EN-------EYLYLVFECLG-ESLLKTLQN--RT-----------GPFTDAEVRYVMHEVLSG-LAIVHRRRI
 .       ..|... | ..  || . ...   .           ..|   ...|. ...| | |.  |. .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHI
Kinase 94173.m00214.AA Ciliate-E2 4-122 20 2.7e-19 62.87 In-house 1-183 (365) Show / Hide 
Range on Protein: 4-122
Range on HMM: 1-183/365
Sequence Identity: 20% (37 aa)

FEEIKVIGDGGFGIVTKCRDNDTG-----------------------QIVAIKKM--KQKFATFEECLQLKEVK----------SLRKIKYDNVVRLMQV
.. ||.|| |.||.| ||..  ..                       .|.|.| |  .|..... |  ...|..           |.... .|....  .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FR--ENEYLYLVFE-CLGESLLKTLQNRT----------GPFTDAEVRYVMHEVLS---------------GLAIVHRRR-IF
|    ....|||.| | | .|.. ..|.           ..||. |..|.| ..|.               .|   | .  |.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNII
Kinase 94173.m00214.AA CDKL 4-121 33 2.2e-18 59.49 In-house 1-119 (286) Show / Hide 
Range on Protein: 4-121
Range on HMM: 1-119/286
Sequence Identity: 33% (40 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQ-KFATFEECLQLKEVKSLRKIKYDNVVRLMQVFRENEYLYLVFECLGESLLKTLQNRTGPFTDAEV
.| . ..| |  | | |||. .||||||||| |  .    .    . |.| |.  |  | | |  ||| .  |.||||    ..| .|. .     .  |
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEHVV

RYVMHEVLSGLAIVHRRRI
| .|  .|....  |   .
RKYMWQILKAINFCHKHNC
Kinase 94173.m00214.AA STE20 4-114 26 4.9e-17 59.05 In-house 1-131 (288) Show / Hide 
Range on Protein: 4-114
Range on HMM: 1-131/288
Sequence Identity: 26% (35 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQI----VAIKKMKQKFAT---FEECLQLKEVKSLRKIKYDNVVRLMQVFREN----EYLYLVFECLGE-SLLKTLQ
.| ...|| |..| | |.....||..    ||||||. . .     |. . .||.  ... |  |.|.    .  .    . |..| | .|  ||.  ..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

N--RTG------PFTDAEVRYVMHEVLSGLA
.  ..|      |.. ... |...||| ||.
HCMKCGKNHKGHPMNEEQIAYICREVLQGLD
Kinase 94173.m00214.AA S_TKc 4-126 15 3.2e-08 -56.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-126
Range on HMM: 1-231/231
Sequence Identity: 15% (38 aa)

FEEIKVIGDGGFGIVTKCRDNDTGQIVAIKKMKQKFATFEECLQLKEVKSLRKIKYDNVVRLMQVFRENEYLYLVFECLGE---SLLKTLQNRTGP----
.| ...|| |.|| | |||...||.|||||..|        .  ..|.. |.| . .|.|.|  ||.. ..||.|.|...    .|.. ...| ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FTDAEVRYVMHEVLSGLAIVHRRRI---------------------------------------------F----------------------------
 |.  ..|..|......|.  |...|                                             .                            
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMM

--------------------------------------PSRY
                                          
FKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 94173.m00214.AA Pkinase_Tyr 4-80 28 1e-06 22.97 Pfam 1-87 (270) Show / Hide 
Range on Protein: 4-80
Range on HMM: 1-87/270
Sequence Identity: 28% (25 aa)

FEEIKVIGDGGFGIVTKCRDN----DTGQIVAIKKMKQKFATFEE---CLQLKEVKSLRKI-KYDNVVRLMQVFR-ENEY--LYLVFE
 . .|..| | || | |.. .    .|.. ||.|..|.  |. |.      ..|.| .... . .|.|||. |   . |   .|.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVME