Gene 88420.m00071 (T.vaginalis)

88420.m00071

Species: T.vaginalis
Alias: TvagK1002, 88420.m00071
External Links:
Annotation:

Classification

Group: CK1
Family: CK1
Subfamily: CK1-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
88420.m00071.AA Protein None 302 None Fasta, JSON
88420.m00071.kin_dom Protein Kinase Domain None 167 None Fasta, JSON

Protein domain

Protein domains of 88420.m00071.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 88420.m00071.AA CK1 9-256 20 4.4e-32 109.23 In-house 1-339 (339) Show / Hide 
Range on Protein: 9-256
Range on HMM: 1-339/339
Sequence Identity: 20% (69 aa)

FDVEERVQFGAFC-AIYRV-----KDRVTG-----QILALKIEKMESS--YTILKYEYELTKQLQD--------------------IPNIVCVYDYFENK
. |..    |.|  .||.|     ||  ..     .  |.|.|. .|   .  |..||.. |.||.                    .| .. .....|..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

TDK-GFTMELLSNNLSDIRHLRRNPP-SLSMLTYIT--KECLLSLKEVHAKNVLHHDIKPSNFLIRF------ENDDY--------RVVLIDFGLSVS--
       |.||  ||.|.|  .|..   .|| | .     .| .|...| .. .| ||||.||..        ...          .|..||||.. .  
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY

LNEPES------------ISKFRY-----NLEQ-NPRYHSIDCYGNKNWTQREDLVSLIYTISDFWKDS--LPWDGRMSARL-----IYEEKVKHSLE--
..  ..            .  .|      ..    .|| ||.|  .|  . | ||.|..|.. .. | .  ||| .  .        . ..| ..  |  
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

-SL------------LPPELSFLVTDLDKGTEYLYNEAEKL
 |.            .|.|.  ... ... . |   . |..
MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 88420.m00071.AA CK1-A 9-211 26 2.5e-21 72.01 In-house 1-207 (261) Show / Hide 
Range on Protein: 9-211
Range on HMM: 1-207/261
Sequence Identity: 26% (55 aa)

FDVEERVQFGAFCAIYRVKDRVTGQILALKIEKMESSYTILKYEYELTKQLQDIPNIVCVYDYFENKTDKGFTMELLSNNLSDIRHLRRNPPSLSMLTYI
. .  ..  |.|  ||       |. .|.|.|. .  .  | ||  . ..||  . |  .  | ..|    . |.||   | |.  . .   ..     .
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLML

TKECLLSLKEVHAKNVLHHDIKPSNFLIRFENDDYRVVLIDFGLSVSLNEPESISKFRY----NLEQNPRYHSIDCYGNKNWTQREDLVSLIYTISDFWK
.   .  .  || || .| |||| |||.  .    .. ||||||.    ....     |    ||    || ||.       . |.|. |. | .  | .
ADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNR

DSLPWDG
 .||| |
GKLPWQG
Kinase 88420.m00071.AA STE 9-158 20 1.8e-19 65.48 In-house 1-199 (359) Show / Hide 
Range on Protein: 9-158
Range on HMM: 1-199/359
Sequence Identity: 20% (43 aa)

FDVEERVQFGAFCAIYRVKDRV---------------TGQILALKIEKMESS-------------------YTILKYEYELTKQLQD-IPNIVCVYDYFE
..  |..  |||   |. ...                ||.| | |. ..|..                      .. | .. |....  ||||  |....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NK-------TDKGFTMELLS-NNLSDIRH---LRRNPPS----------LSMLTYITKECLLS-LKEVHAKNVLHHDIKPSNFLIRFENDDYRVVLIDFG
..       ..    ||...   |.|| .    . .| .           | . ||....|   |.  | ... | ||||.| |.        | |.|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFG

LSVSLNE
.. .|..
VCGQLTD
Kinase 88420.m00071.AA CMGC 9-159 15 3.4e-19 58.87 In-house 1-257 (513) Show / Hide 
Range on Protein: 9-159
Range on HMM: 1-257/513
Sequence Identity: 15% (41 aa)

FDVEERVQFGAFCAIYRVKD--------------RVTGQILALKIEKMESSYTILKY--------------EYELTKQLQ----------------DIPN
... ...  |..   |. .|              . |..| |.|. | .  |.. .               | .. |.|.                . .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVCVYDYFENKT-----------------DKGFTMELLSNNLSDIRHL--------RRNPPSLSM------------LTYIT------KECLLSLK--EV
||. ||.|  |                  .  . .|.. ..| .. .         |..| |                 |..      .  | .||    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HAKN--VLHHDIKPSNFLIRFENDD-----------------YRVVLIDFGLSVSLNEP
| ..  ..| |.||.| ||  ...                  .|. ..||||. .....
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 88420.m00071.AA TTBKL 9-153 25 1.9e-17 55.5 In-house 1-156 (288) Show / Hide 
Range on Protein: 9-153
Range on HMM: 1-156/288
Sequence Identity: 25% (40 aa)

FDVEERVQFGAFCAIYRVKDRVT-GQILALKIEKME-SS-YTILKYEYELTKQLQ--DIPNIVCVYDYFENKTDKGFTMELLSNNLSDIRHLRRNP--PS
. ... .  |.| ..|.|.|... ..  |.|.||.. .    ..| | .. ..||  . | .  .... ..|    . |.|.. ||.|.|.   |.   |
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSMLTYITKECLLSLKEVHAKNVLHHDIKPSNFLIRFE---NDD-YRVVLIDFGLS
 .    |   || .||..| .  .|.|.||.|. . ..   ...  .| |||||..
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMA
Kinase 88420.m00071.AA CK1-D 9-211 26 1.7e-16 54.59 In-house 1-207 (261) Show / Hide 
Range on Protein: 9-211
Range on HMM: 1-207/261
Sequence Identity: 26% (55 aa)

FDVEERVQFGAFCAIYRVKDRVTGQILALKIEKMESSYTILKYEYELTKQLQDIPNIVCVYDYFENKTDKGFTMELLSNNLSDIRHLRRNPPSLSMLTYI
. .  ..  |.|  ||  ..  |.   |.|.| . .    |..|  . | .|    |  .  . ..       |.||   | |.    .   ||     .
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLML

TKECLLSLKEVHAKNVLHHDIKPSNFLIRFENDDYRVVLIDFGLSVSLNEPESISKFRY----NLEQNPRYHSIDCYGNKNWTQREDLVSLIYTISDFWK
.   .  .. .|..| .| |||| |||.        | .|||||.    ....     |    ||    || ||          |.|| || | .  | .
ADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNR

DSLPWDG
 |||| |
GSLPWQG
Kinase 88420.m00071.AA Ciliate-E2 9-153 17 2.8e-13 41.92 In-house 1-203 (365) Show / Hide 
Range on Protein: 9-153
Range on HMM: 1-203/365
Sequence Identity: 17% (37 aa)

FDVEERVQFGAFCAIYRVKDRVTGQILALK-------------------IEKMESSYTILKYEYELTKQLQ------------------DIPNIVCVYDY
... .   .|.|  .|..|.. ...  |.|                   ...   .   ...     ....                  . |||.  |..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--NKTDKGFTMELLSN-NLSD-IRHLRRN---------PPSLSMLTYITKECLL---------------SLKEVHAKN-VLHHDIKPSNFLIRFENDD
|.  ...   . ||...  .| | |.. . .         ....    ||.|. |                 |.. | || ..| ||||.| |.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

YRVVLIDFGLS
  . .||||||
--IKIIDFGLS
Kinase 88420.m00071.AA S_TKc 9-271 15 2e-12 5.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-231/231
Sequence Identity: 15% (47 aa)

FDVEERVQFGAFCAIYRVKDRVTGQILALKIEKMESSYTILKYEYELTKQLQDIPNIVCVYDYFENKTDKGFTMELLSN---NLSDIRHLRRNPP-----
... . .  |||   |..... ||.| |.|| |       .. | .. |.  . ||||  ||.|.. ..  . ||....   .| |. . |. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLSMLTYITKECLLSLKEVHAKNVLHHDIKPSNFLIRFENDDYRVVLIDFGLSVSLNEPESISKFRYNLEQNPRYHSIDCYGNKNWTQREDLVSLIYT-I
.  .  ..... .. |.  | ....| |.||.| |.       .. ..||||.  |          . .   | | .                    .  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----------TTFCGTPWYMAPEVL-------------GYGKCK

SDFW----------KDSLPWDGRMSARLIYEEKVKHSLESLLPPELSFLVTDLDKGTEYLYNEAEKLLQTMLR-NIK---------EE-----IKYL
.| |              |..      ....  .                            ||  ... .|. . .         .|       ..
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase 88420.m00071.AA CAMK 14-158 14 3e-12 35.03 In-house 1-248 (425) Show / Hide 
Range on Protein: 14-158
Range on HMM: 1-248/425
Sequence Identity: 14% (37 aa)

RVQFGAFCAIYRVKDRVTG------------QILALKI------------------------------EKMESSYTILKYEYELTKQLQ------DIPNI
    |.|.  ...... |.            |  | ||                              .  ...   .. |.|. |.||      | |||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VCVYDYFEN-------------------KTDKGFTM---ELLSNN------LSDIRHLRR-------------NPPSLSMLTYITKECLLSLKEVHAKNV
.  |...|.                   ...  . |   |. |.       .. |.  ..                . .   .. .  .  ..  | .|.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHHDIKPSNFLIRFENDD--------------YRVVLIDFGLSVSLNE
 | |.|| | |.   |||              . . .||||..  ...
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDP
Kinase 88420.m00071.AA Pkinase 9-153 26 1.8e-11 41.64 Pfam 1-159 (293) Show / Hide 
Range on Protein: 9-153
Range on HMM: 1-159/293
Sequence Identity: 26% (42 aa)

FDVEERVQFGAFCAIYRVKDRVTGQILALKIEKMESSYTILKY------EYELTKQLQDIPNIVCVYDYFENKTDKGFTMELLSNNL---SDIRHLR---
. .....  |.|   |. ... ||.| |.|| | ..     ..      | .. | | . ||||  ||.||.|..  . ||.. . |   .  ....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RNPP--SLSMLTYITKECLLSLKEVHAKNVLHHDIKPSNFLIRFENDDY--RVVLIDFGLS
...   |   .  . .. |  |.  |.....| |.||.|.||  .|..   .| ..||||.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLA
Kinase 88420.m00071.AA CK1-Unclassified 9-74 26 1e-10 27.84 In-house 1-73 (244) Show / Hide 
Range on Protein: 9-74
Range on HMM: 1-73/244
Sequence Identity: 26% (19 aa)

FDVEERVQFGAFCAIYRVKDRVTGQILALKIEKMESSYTILKYEYELTKQLQDIP-------NIVCVYDYFEN
. |.|..  |.|. || ...  |..  |.|.||  | .  |.||  . ..||.         .|  .| .. .
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQE
Kinase 88420.m00071.AA CK1-Unclassified 119-153 50 1.5e-10 27.41 In-house 120-155 (244) Show / Hide 
Range on Protein: 119-153
Range on HMM: 120-155/244
Sequence Identity: 50% (18 aa)

VHAKNVLHHDIKPSNFLIR-FENDDYRVVLIDFGLS
.| || .| |||| |||.   ..  ..| .||||||
LHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLS
Kinase 88420.m00071.AA CK1 119-153 50 3.2e-09 28.1 In-house 121-156 (271) Show / Hide 
Range on Protein: 119-153
Range on HMM: 121-156/271
Sequence Identity: 50% (18 aa)

VHAKNVLHHDIKPSNFLIRF-ENDDYRVVLIDFGLS
|| || .| |||| |||.   ...  .| .|||||.
VHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLA
Kinase 88420.m00071.AA CK1 9-65 27 2.7e-07 21.37 In-house 1-68 (271) Show / Hide 
Range on Protein: 9-65
Range on HMM: 1-68/271
Sequence Identity: 27% (19 aa)

FDVEERVQFGAFCAIYRVKDRVT----GQILALKIEKMESSYTILKYEYELTKQLQD---------IPNI
. |....  |.|. || ...  |    . . | |.||. |    |.||. . |.||.         ||..
YRVGRKIGQGSFGDIYLGINM-TNGEEN-HVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHM
Kinase 88420.m00071.AA TTBKL 191-230 30 0.004308 6.37 In-house 211-249 (288) Show / Hide 
Range on Protein: 191-230
Range on HMM: 211-249/288
Sequence Identity: 30% (12 aa)

DLVSLIYTISDFWKDSLPWDGRMSARLIYEEKVKHSLESL
||.|..|.|  . .  ||| . ...  |.. |.....| |
DLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDL