Gene 85781.m00199 (T.vaginalis)

85781.m00199

Species: T.vaginalis
Alias: 85781.m00199, TvagK0289
External Links:
Annotation:

Classification

Group: TKL
Family: TKL-Tvag1

Sequence

Name Sequence Type Origin Length Description Download
85781.m00199.AA Protein None 681 None Fasta, JSON
85781.m00199.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of 85781.m00199.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 85781.m00199.AA TKL 28-274 23 1.9e-77 263.58 In-house 1-364 (364) Show / Hide 
Range on Protein: 28-274
Range on HMM: 1-364/364
Sequence Identity: 23% (89 aa)

LGSGGFGEVYYGVHEP--------SGYRCAIKRLFFKELKGDDL-------------------------LLFKREIEVLIRCTNPFCLPIVG------W-
.||||||||| |..          .|.  |.|..  .. . ...                           ...|| ...|.  |  ....|      . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-TAYYP------YSIITQYIPNGSLYQKLYKSKHNNKLTPTEKSIIMYGIAVGMEHIHSLG--------IIHRDLKSMNILLDDRNF-------------
   . |      . |...|.|.|||.  |          .  .  ....|| ||.. || .        |||||||| |||.|. .              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-PMICDFGLSRVLPEEHE-------------------LMTLEIGTTNWMAPELFEKS----------------EYTEKIDVYAFSMIIVEMLTETMPF--
 . ||||||||.. .. .                       ..||..|||||.....                ||.||.|||.| ... |.||   |.  
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

IKYK--------DAEIAKMVLAGKRPKLP------------DDTPRKIKHLVTRCWSQNPSERPTFSDIVKEL
..|         ...... .. |.|| .|            .|.|. .| | ..||...|..||.|..|.|.|
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 85781.m00199.AA TKL-Unique 24-274 29 1.3e-69 237.59 In-house 1-290 (290) Show / Hide 
Range on Protein: 24-274
Range on HMM: 1-290/290
Sequence Identity: 29% (86 aa)

IGKKLGSGGFGEVYYGVHEPSGYRCAIKRLFFKELKGDDLLL-FKREIEVLIRCT-NPFCLPIVGWTA----YYP-YSIITQYIPNGSLYQKLY----KS
...|.|.||.|.|| |..   ||  |||.....|..  ...  |..|. .. .    |. . ..|...    | | ..|.. |.| ||||  |      .
FWNKIGEGGYGQVYKGKWR--GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

---KHNNKLTPTEKSIIMYGIAVGMEHIHSLG--IIHRDLKSMNILLDDR-----NFPMICDFGLSRVLP--EEHELM-------TLEIGTTNWMAPELF
   . |.||..  .  .   || ||...|...  |||||||| |.|.| .     .   |||||||...    .  .        . ..|...|||||..
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

EK--SEYTEKIDVYAFSMIIVEMLTETM------PFIKYKDAEIAKMVLA---GKRPKLPDDTPRKIKHLVTRCWSQNPSERPTFSDIVKEL
.   . |.||.|||.|...  |..| .       |. .. . ....||     ..||..|.. |  ...| ..|| ..||.||.|..|...|
RMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 85781.m00199.AA HH498 22-274 32 2.7e-55 173.56 In-house 1-284 (284) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-284/284
Sequence Identity: 32% (94 aa)

FDIGKKLGSGGFGEVYYGVHEPSGYRCAIKRLFFKEL--KGD------DLLLFKREIEVLIRCTNPFCLPIVGWTAYYP--YSIITQYIPNGSLYQKL--
.   .| ||| ||.|| |     .   |.||   .    |.|      | .   ||. .. |  .|     |. .   |    |.|||. ||||.  |  
IEFHEKIGSGSFGKVYKGEWR--NKIVAVKRYRAMAFCCKSDSYQWIVDMFC--REVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNT

--------YKSKHNNK-----LTPTEKSIIMYGIAVGMEHIHS---LGIIHRDLKSMNILLDDRNFPMICDFGLSRVLPEEHE-LMTLEIGTTNWMAPEL
            ||.|     . .  | .|   .| ||.  |.     |||||| | |||..      . ||| || . . |.  ||  .|   ||||| 
IPIGGAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEV

FE-KSEYTEKIDVYAFSMIIVEMLTETMPFIKYKD-AEIAKMVLAGKRPKLPDD----TPRKIKHLVTRCWSQNPSERPTFSDIVKEL
|     |..|.||. . |.| ||.|  .||  ||  |  |.|  .  || .|       |...  |. .||...|..||.|..||  |
FSQCQKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
Kinase 85781.m00199.AA MLK 22-274 30 4.6e-55 189.25 In-house 1-291 (291) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-291/291
Sequence Identity: 30% (88 aa)

FDIGKKLGSGGFGEVYYGVHEPSGYR-----CAIKRLFF----KELKGDDLLLFKREIEVLIRCTNPF----CLPIVGWTAYYPYS--IITQYIPNGSLY
... ...|||.||.|. |.    . .      |.|| ..    |  ..     |..|.. | .   |       ...|  . .|.   |...|...||||
IQFHEWIGSGSFGKVWKGRWR--NKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLY

QKLYKSK-------HNNK----LTPTEKSIIMYGIAVGMEHIHSLG---IIHRDLKSMNILLDD-----RNFPM-ICDFGLSRVLPEEHELMTLEIGTTN
  |.  .       ||.|     ..  .  ... .| ||.  ||.    |||||||| |||.|.     ..  . |||||.|| . . .. |.  .||  
NVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYA

WMAPELF---EKSEYTEKIDVYAFSMIIVEMLTETMPFI-KYK-DAEIAKMVLAGKRPKLPDDTPRKIKHLVTRCWSQNPSERPTFSDIVKEL
||||| .   . . |.|| ||. . ... ||||  .|.   |.  | ...... |.|| .| . |. .| | ..||.|.|..||.|. ||..|
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
S_TKc 85781.m00199.AA S_TKc 22-279 27 8e-55 189.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-279
Range on HMM: 1-231/231
Sequence Identity: 27% (73 aa)

FDIGKKLGSGGFGEVYYGVHEPSGYRCAIKRLFFKELKGDDLLLFKREIEVLIRCTNPFCLPIVGWTAYYPYSIITQYIPN--GSLYQKLYKSKHNNK--
..|..|.|.|.||.|| ..|  .| ..|||..            ..|||..| .   |.   . ..     . ... |...  |.|.. . | ... .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTPTEKSIIMYGIAVGMEHIHSLGIIHRDLKSMNILLDDRNFPMICDFGLSRVLPEEHELMTLEIGTTNWMAPELFEKSEYTE-KIDVYAFSMIIVEML
 ... .   .|| |. ..|..||.||||||||  |||||.    .||||||.|.|       |  .|| ..||||..    |.  |.|....  |. |||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TETMPFIKYKDAEIAKMVLAGKRPKLPDDTPRKIKHLVTRCWSQNPSERPTFSDIVK----ELKHGDV
.   ||    .... |...           ..  |... .|.  .|..|||  .. .      .|  .
CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 85781.m00199.AA Dicty5 129-278 42 2.8e-54 185.24 In-house 112-260 (260) Show / Hide 
Range on Protein: 129-278
Range on HMM: 112-260/260
Sequence Identity: 42% (64 aa)

GIAVGMEHIHSLGIIHRDLKSMNILLDDRNFPMICDFGLSR-VLPEEHELMTLEIGTTNWMAPELFEKSEYTEKIDVYAFSMIIVEMLTETMPFIKYKDA
.|| .|.|.|| .||||||||||.|.  .    | ||| || |  .    ||...|| .|||.|||    |..| |||.|  .  ||.|   |.      
DIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFV--DNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYDNINNW

EIAKMVLAGKRPKLPDDTPRKIKHLVTRCWSQNPSERPTFSDIVKELKHGD
.|. ||  | || .| | |  |  |.  || | |. ||.|  |.| ..   
NIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase 85781.m00199.AA Pkinase 22-274 26 9.8e-51 179.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

FDIGKKLGSGGFGEVYYGVHEPSGYRCAIKRLFFKELKGDDLLLFKR--EIEVLIRCTNPFCLPIVGWTA--YYPYSIITQYIPNG----SLYQKLY--K
. ||.|.|||.||.|| ..|  .| . |.|..  .. | . .    |  ||... |.  |. . . .|     ..| ... | ..|    .|.  .   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWR

SKHNNKLTPTEKSIIMYGIAVGMEHIHSLGIIHRDLKSMNILLDDRNFP----MICDFGLSRVL-PEEHELMTLEIGTTNWMAPELFE-KSEYTEKIDVY
..    ... |   .|| |. |.|..|| ||||||||. |||.|... .     ||||||....     . ||   || ..||||.    ..|. |.|..
HGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

AFSMIIVEMLTETMPFIKY----KDAEIAKMVLAGKRPKLPDDTP-----------------------RKIKHLVTRCWSQNPSERPTFSDIVKE--L
..  |. |||.   ||       . ..  .|.   ..|.|. | |                       .  |.....|. ..|..|||. .|..   .
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 85781.m00199.AA TK 22-274 15 5.9e-47 154.99 In-house 1-486 (486) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-486/486
Sequence Identity: 15% (77 aa)

FDIGKKLGSGGFG---EVYYGVHEPSG-------------------------YRCAIKRLFFK-ELKGDDLLL--------------FKREIEVLI--RC
  .|||||.| ||   ||| |  .. .                          ..|.| |  . .   .. ..              . .|....    .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

TNPFCLPIVGWTAYY-------------PYSIITQYIPNGS----LYQKLYKSKH---------------------------------------------
  |  . ..|                  |. |.. | |.|.    | . | |...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------NNKLTPTEKSIIMYGIAVGMEHIHSL------GIIHRDLKSMNILLDDRNF-----------PMICDFG---
                            ...||. ..  ... || |||..||.      ...||||   |.|....|              |.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRVLPEEHELMTLEIGTTN--------------------------WMAPELFEKSE---------YTEKIDVYAFSMIIVEMLTET-MPFIKYK
     |.| ......  . . ..|.                          ||||| ... .         .|.| ||..|   . |..|   .|.  . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

D----------AEIAKMVLAG--------------KRPKLPDDTP--------------RKIKHLVTRCWSQNPSERPTFSDIVKEL
.          .|. ... .|               |.. |.. |                .  | ..||. .|..|||||.....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase 85781.m00199.AA LRRK 92-276 33 2.1e-46 160.48 In-house 129-351 (351) Show / Hide 
Range on Protein: 92-276
Range on HMM: 129-351/351
Sequence Identity: 33% (75 aa)

PYSIITQYIPNGSLYQKLYKSKHNN------KLTPTEKSIIMYGIAVGMEHIHSLG--IIHRDLKSMNILL--DDRNF-------PM---ICDFGLSR--
|. ... |.|.|.||. | ..|..       ..... |  |.. || |||. ||    |||||||| ||||   . |.       ..   |.|||.||  
PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMF

-VLPEEHE-LMTLEIGTTNWMAPELFEK---SEYTEKIDVYAFSMIIVEMLTET-MPFIKYK-------DAEIAKMVLAGKRPKLPDD-TPR-----KIK
 ...  .. ..... |.  |||||   .   .|||||.|.|.| ||. | || .  ||  ..         .| . .. | ||..| .  |.       .
QCFH--MGVAKGCV-GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQ

HLVTRCWSQNPSERPTFSDIVKELKH
 | . ||...| .||.||.||| |. 
DLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 85781.m00199.AA Pkinase_Tyr 22-274 30 2.2e-46 157.73 Pfam 1-270 (270) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-270/270
Sequence Identity: 30% (83 aa)

FDIGKKLGSGGFGEVYYGVHE----PSGYRCAIKRLFFKELKGDD---LLLFKREIEVLIRC-TNPFCLPIVGWTA--YYP--YSIITQYIPNGSLYQKL
  .|||||.| ||||| |.        .. .|.| |  ||   ..   .  | ||....     .|  .  .|       |  . |.. | |.|.|.  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

YKS-KHNNKLTPTEKSIIMYGIAVGMEHIHSLGIIHRDLKSMNILLDDRNFPMICDFGLSRVL-PEEHE-LMTL-EIGTTNWMAPELFEKSEYTEKIDVY
 |    ...||. ..  . . || |||. .| ..|||||   |.|... |.  ||||||.| . ...    ..        ||||| .  ...|.| ||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

AFSMIIVEMLT-ETMP-FIKYKDAEIAKMV-LAGKRPKLPDDTPRKIKHLVTRCWSQNPSERPTFSDIVKEL
.|   . |..|   .| .   ...|. ...   | | . |...| .| .| ..|| ..|..|||||.|. .|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 85781.m00199.AA TyrKc 22-274 27 8.2e-46 159.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-274
Range on HMM: 1-280/280
Sequence Identity: 27% (79 aa)

FDIGKKLGSGGFGEVYYGVHEPSGYRCAIKRLFFKELKGDDLLLFKREIEVLIRC--TNPFCLPIVGWTAY--------YPYSIITQYIPNGSLYQKLYK
   |||||.| ||||| |.     . .|.| |  || .   .  | ||.... .    .|  . ..|             |. |.. | |.|.| . | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKML--KEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SKHNNKLTPTEKSIIMYGIAVGMEHIHSLGIIHRDLKSMNILLDDRNFPMICDFGLSRVLPEE------HELMT-----LEI--GTTNWMAPELFEKSEY
....  |.. ..  ... || |||..|| ..|||||   |.|.....   |.|||||| . ..      ..  .      .       ||||| . ....
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TEKIDVYAFSMIIVEMLTETMPFIKY------KDAEIAKMVLAGKRPKLPDD--------TPRKIKHLVTRCWSQNPSERPTFSDIVKEL
|.| ||..|   . |..|  ..          ...|. . | .|.|.. |..         | ..  . ..||  .|..|||||.|....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 85781.m00199.AA RAF 22-276 27 1.6e-44 142.1 In-house 1-282 (282) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-282/282
Sequence Identity: 27% (78 aa)

FDIGKKLGSGGFGEVYYGVHEPSGYRCAIKRLFFKELKGDDLLL---FKREIEVLIRCTNPFCLPIVGWTAYYP---YSIITQYIPNGSLYQKLYKSKHN
...... ||| || || |    .    |.|.|  ...  ...     || |. |. .      |   |..       | |.||.    |||...  ..  
VMVMTRIGSGSFGTVYRGHWHGD---VAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETR

NKLTPTEKSIIMYGIAVGMEHIHSLGIIHRDLKSMNILLDDRNFPMICDFGLSRVLPEEH--ELMTLEI--GTTNWMAPELFE--------------KSE
 |.   .   |   .. ||.  |.  |||||||| ||.|.. .   | |||| .|   .      ..|.  .   |||||                 .  
EKFDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENP

YTEKIDVYAFSMIIVEMLTETMPF---IKYKDAEIAKMV----LAGKRPKLPDDTPRKIKHLVTRCWSQNPSERPTFSDIVKELKH
|. . |||.| ... |..|. ||.   |. .|  |..|.    |   . |.  |.|.... |.. ||. .. ||| |  |.|... 
YSFQSDVYSFGIVMYELMTRHMPYGCHIWNRD-QIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase 85781.m00199.AA Dicty4 130-276 37 1.4e-42 139.89 In-house 121-277 (277) Show / Hide 
Range on Protein: 130-276
Range on HMM: 121-277/277
Sequence Identity: 37% (59 aa)

IAVGMEHIHS--LGIIHRDLKSMNILLDDRNFPMICDFGLSR----VLPEEHELMTLEIGTTNWMAPELFEKSEYTEKIDVYAFSMIIVEMLTETMPFI-
.| || . |.    |||||||| |.| |. .   .||||||.    .      .||  .||. |||||   . .|.|| ||| |...  |.||   |.  
AARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-CGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQK

KYKD-AEIAKMVLA-GKRPKLPDDTPRKIKHLVTRCWSQNPSERPTFSDIVKE--LKH
 ...  ...  |   . ||..||..| ..|||...||. .|. ||.|. |...  | |
HHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 85781.m00199.AA STE 22-269 20 1.5e-39 137.32 In-house 1-350 (359) Show / Hide 
Range on Protein: 22-269
Range on HMM: 1-350/359
Sequence Identity: 20% (72 aa)

FDIGKKLGSGGFGEVYYGVHE-PS--------------GYRCAIKRLFFKELK---------------GDDLLLFKREIEVLIRCT--NPFCLPIVGWTA
... .|.|.|.||.||....  ..              | ..|||.. ... .                ...  ...||... .|    |.     |   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YYP--------YSIITQYIPNGSLYQKLY-KSKHNNKLTPT--------EKSI--IMYGIAVG-MEHIHSLGIIHRDLKSMNILLDDRNFPMICDFGLSR
.            |.  |...||| . .  | .... |.          |. |  | . |  | ....||..|||||.|. ||||       .||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLPEE----------------HELMTLEIGTTNWMAPELFEK------SEYTEKIDVYAFSMIIVEMLTETMPFIKYKDAEIAKMVLAG-----------
 | ..                 .  .  .||  |||||  ..      ..|..| |.. .   |.||.|   |. .... .   | . .           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----KRPKLPDDTP-------------------RKIKHLVTRCWSQNPSERPTFSD
    . |.|||..                     . |. . .|   .|..||| |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase 85781.m00199.AA LRRK 22-37 47 9.9e-05 12.65 In-house 1-17 (351) Show / Hide 
Range on Protein: 22-37
Range on HMM: 1-17/351
Sequence Identity: 47% (8 aa)

FDIGKKLGSGGFG-EVY
. |....|.|||| .||
LKIEEQIGRGGFGTFVY
Kinase 85781.m00199.AA Dicty4 22-39 50 0.000832 8.77 In-house 1-18 (277) Show / Hide 
Range on Protein: 22-39
Range on HMM: 1-18/277
Sequence Identity: 50% (9 aa)

FDIGKKLGSGGFGEVYYG
 .|....|.|.||||| |
INIEQRIGKGSFGEVYKG