Gene 87835.m00287 (T.vaginalis)
87835.m00287
Species: T.vaginalis
Alias: TvagK0906, 87835.m00287
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| 87835.m00287.AA | Protein | None | 391 | None | Fasta, JSON |
| 87835.m00287.kin_dom | Protein Kinase Domain | None | 210 | None | Fasta, JSON |
Protein domains of 87835.m00287.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 87835.m00287.AA | CAMK | 53-267 | 17 | 4.9e-45 | 142.62 | In-house | 76-425 (425) | Show / Hide |
Range on Protein: 53-267
Range on HMM: 76-425/425
Sequence Identity: 17% (61 aa)
DNLQMEFEILGS-------ISHPYIQKLIETTY----------------------NSHVLA---QIVESEEV--SLMDYYKFD---------------FP
.|.. | ||. . ..|| | ||.|. . . .. | | || . .
KNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGR
LPESVACNIFYRLVEAIYYLHSNSIVHLDIRPENVFIVDK------------------QFKLGGF-LSSRFES-----------------------EDEI
..|. |. .| ...|. |.||. |||.|. |||. ..|. . |. | .. .|.. |..
FTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQK
ITGTYGTPNFQA-PEIFTN-------------QNFDGRKADVWACGIFLLAITTGKLPYSTNGMKSSESPN-------EYIRKQVETNE-SIIPTY----
. ||| . | ||.. . .|.|.|.|.||. | . .|..|. .. .. . . . ... . . . .| |
MKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-DEWIGMNDYELFEKIMKGKYDFPPPYFSPI
-------------------LSEDLRDILQMMLNRETSKRATISQVRDHRWL
.|.. .| .. ||... .||.||.|. .| |.
SCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 87835.m00287.AA | CAMKL | 103-267 | 30 | 1.1e-41 | 130.77 | In-house | 123-297 (297) | Show / Hide |
Range on Protein: 103-267 Range on HMM: 123-297/297 Sequence Identity: 30% (54 aa) PLPESVACNIFYRLVEAIYYLHSNSIVHLDIRPENVFIVDKQ---FKLGGF-LSSRFES----EDEIITGTYGTPNFQAPEIFTN--QNFDGRKADVWAC ..||. |. .| .|.|..|.||. ||| || |||. . ... |. | .| .. ... . |.|...||||| . .||.|.|.|.| RMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSC GIFLLAITTGKLPYSTNGMK--SSESPNEYIRKQVETNESI-IPTYLSEDLRDILQMMLNRETSKRATISQVRDHRWL |. | |. .|.|| .. . .. .|. .. . . |. ..| |.||... ||.. .||.|| |.. |.|. GVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 87835.m00287.AA | Ciliate-E2-Unclassified | 104-267 | 21 | 1.5e-37 | 127.86 | In-house | 135-352 (352) | Show / Hide |
Range on Protein: 104-267 Range on HMM: 135-352/352 Sequence Identity: 21% (47 aa) LPESVAC-----NIFYRLVEAIYYLHSNS-IVHLDIRPENVFIVDK----QFKLGGFLSSRFESED----------------EIITGTYGTPNFQ----A ..| |. ..|. ..... |||.. |.| || |||... .. . |. .| .|.. .. .... . ||||.. | FTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTA PEIFTNQNFDGR---KADVWACGIFLLAITTGKLPYSTNGMKS--------------SESPNEYIRKQVETNESI---IPTYLSEDLRDILQ----MMLN ||.. .|| |.. |.|.|..|. | .. .|..|.. | .. .. .. . |... ... || .|. |... ||. PEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLK RETSKRATISQVRDHRWL .|| |..|. | |. KNPNKRITFEQILNHPWF |
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| Kinase | 87835.m00287.AA | Ciliate-E2 | 55-267 | 19 | 1.2e-36 | 123.26 | In-house | 80-365 (365) | Show / Hide |
Range on Protein: 55-267 Range on HMM: 80-365/365 Sequence Identity: 19% (59 aa) LQMEFEILGSISHPYIQKLIETTY--NSHVLAQIVE-SEEVSLMDYYK-----FDFPLP------ESVACNIFYRLVE---------------AIYYLHS . .| .|| ...||.| |..|. . . . . . | . .|.|| | ... .. | ...|.. ... |. |||| I-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS NS-IVHLDIRPENVFIVDKQFKLGGFLSSRFESED--------------------------------EIITGTYGTPNFQAPEIFTNQNFDG-------- . |.| || |||... |. | |.. ..| ... ..|||...||||. ... |. KNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD RKADVWACGIFLLAITTGKLPYSTNGMKSSESPNEYIRKQVETNESIIP------------------TYLSEDLRDILQM----MLNRETSKRAT-ISQV |.|.|..|. | .||.|. .| . .. .| ..|.. |... ||... .|| | ..|. YKCDIWSLGVILYEMLFGKPPF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI RDHRWL .| |. LNHPWF |
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| Kinase | 87835.m00287.AA | Pkinase | 57-267 | 20 | 7.5e-33 | 117.24 | Pfam | 49-293 (293) | Show / Hide |
Range on Protein: 57-267
Range on HMM: 49-293/293
Sequence Identity: 20% (52 aa)
MEFEILGSISHPYIQKLIETTYNSHVLAQIVESEEV-----SLMDYYK--FDFPL--PESVACNIFYRLVEAIYYLHSNSIVHLDIRPENVFIV-DKQF-
.| .|. ...||.| .|... ... . . | | .|.|| . . .. .| ......| ......|.||..|.| |. |||..|. . .
SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHID
---KLGGFLSSRF--ESEDEIITGTYGTPNFQAPEIFTNQNFDGRKADVWACGIFLLAITTGKLPYSTN----GMKSSESPNEYIRK-QVETNESIIPT-
|.. | .... . .. |. |||.. |||. .. .|.|.|.|.||. | .|..|.. . . . |.. ... ... .
ACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSI
---------------YLSEDLRDILQMMLNRETSKRATISQVRDHRWL
..||...|.. .|.. .|| |. |. | |.
SYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| S_TKc | 87835.m00287.AA | S_TKc | 22-267 | 23 | 2.9e-32 | 114.44 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 22-267 Range on HMM: 1-231/231 Sequence Identity: 23% (63 aa) YIIIEAI--------EKATKKRYSGRLLMRKNLFHTYYFDNLQMEFEILGSISHPYIQKLIETTYNSHVLAQIVESEEV---SLMDYYKFDFP------L | |.. | |...|. .||. | . .... | .|| . ||.| ||... .. . | . | . .|.|| | . . YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PESVACNIFYRLVEAIYYLHSNSIVHLDIRPENVFIVDKQFKLGGFLSSRFESEDEIITGTYGTPNFQAPEIFTNQNFDGRKADVWACGIFLLAITTGKL || .|. ..| ...|. |.||. |.| |. |||... . . |.. | ..|. | |||.. |||.. ....|.|.|.||. | .|. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP PYSTNGMKSSESPNEYIRKQVETNESIIPTYLSEDLRDILQMMLNRETSKRATISQVRD-------HRWL |.. ... ..| . |....|... .|... .|| |. .. | |. PFP--------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 87835.m00287.AA | QIK | 103-267 | 28 | 3.8e-28 | 99.83 | In-house | 114-272 (272) | Show / Hide |
Range on Protein: 103-267 Range on HMM: 114-272/272 Sequence Identity: 28% (48 aa) PLPESVACNIFYRLVEAIYYLHSNSIVHLDIRPENVFIVDKQF--KLGGFLSSRFESEDEIITGTYGTPNFQAPEIFTNQNFDGRKADVWACGIFLLAIT |..|..| .| .. |..|.|. ||| |. ||. . |.. |. | | . ... |.| . |||.| ...|| |.|.| |. | . PMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILL-DNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLV TGKLPYSTNGMKSSESPNEYIRKQVETNESIIPTYLSEDLRDILQMMLNRETSKRATISQVRDHRWL .|.||. ... |. | .|| ..|.|. .. || . ..| || |.. |||. CGALPFDGKTLQN-------LRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
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| Kinase | 87835.m00287.AA | MARK | 167-267 | 28 | 3.8e-26 | 82.59 | In-house | 167-262 (262) | Show / Hide |
Range on Protein: 167-267 Range on HMM: 167-262/262 Sequence Identity: 28% (29 aa) GTPNFQAPEIFTNQNFDGRKADVWACGIFLLAITTGKLPYSTNGMKSSESP--NEYIRKQVETNESIIPTYLSEDLRDILQMMLNRETSKRATISQVRDH ||| . ||||| . ||.|.|.|..|. | ....|..|. .. .. ..|.. . . ||...| ..|...| .|. ..|.||... | GTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFD-------GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKH RWL .|. PWM |
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| Kinase | 87835.m00287.AA | ULK | 104-267 | 19 | 2.8e-24 | 81.74 | In-house | 127-329 (329) | Show / Hide |
Range on Protein: 104-267 Range on HMM: 127-329/329 Sequence Identity: 19% (40 aa) LPESVACNIFYRLVEAIYYLHSNSIVHLDIRPENVFIVDKQ-------------FKLGGFLSSRFESED----EIITGTY------GTPNFQAPEIFT-- |.|. | ..|. .... .||.. |.| || |.|. | ..| .|.. | ... ..| .... . ||| . ||.|. LSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQ --NQNFDGRKADVWACGIFLLAITTGKLPYSTNGMKSSE-----SP--NEYIRKQ-VETNESIIPTY-----LSEDLRDILQMMLNRETSKRATISQVRD ..... |.|.| |. . . .|| |.... . . |.. .| .... .| . .|....|... || .. ..| .. .. . GEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFN HRWL | |. HPWF |
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| Kinase | 87835.m00287.AA | PLK1 | 26-267 | 26 | 5.2e-24 | 75.6 | In-house | 17-253 (253) | Show / Hide |
Range on Protein: 26-267 Range on HMM: 17-253/253 Sequence Identity: 26% (66 aa) EAIEKATKKRYSGRLLMRKNLFHTYYFDNLQMEFEILGSISHPYIQKLIETTYNSHVLAQIVE-SEEVSLMDYYKFDFPLPESVACNIFYRLVEAIYYLH | ..|.||... |.. .. | . | . .| .| ...|. | |. . .. . ..| . |||. | .. | . | .||.. ||| EIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLH SNSIVHLDIRPENVFIVDK-QFKLGGF-LSSRFESEDEIITGTYGTPNFQAPEIFTNQNFDGRKADVWACGIFLLAITTGKLPYSTNGMKSSESPNEYIR | |.| |.. |.|. |. | |.| | | . | . | ||||. |||. ... |.|. | . . |. |. |. .| . | | NNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGH-SFEVDIWSIGCIMYILLFGQPPFETKCLK-----ETYSR KQVETNESIIPTYLSEDLRDILQMMLNRETSKRATISQVRDHRWL . || ||...|. ..... ||. . ..| ||.|| ... --IKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | 87835.m00287.AA | TKL | 93-265 | 17 | 2.9e-22 | 76.97 | In-house | 124-364 (364) | Show / Hide |
Range on Protein: 93-265
Range on HMM: 124-364/364
Sequence Identity: 17% (42 aa)
SLMDYYKFDFPLPESVACNIFYRLVEAIYYLHSNS--------IVHLDIRPENVFIVDK-Q--------------FKLGGFLSSRFESEDEIITGT----
|| .|. .. |.. . ...||||. |.| |. ..|... .. . |.. | ||| |... . |
SLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTM
----------------YGTPNFQAPEIFTNQNFDGRKA---------------DVWACGIFLLAITTGKLPYSTNGMKSSESP---NEYIRKQVETN-ES
|||.. |||.. .|... |. ||.. || | | |...||. ... . . |.. . .. .
MESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRP
IIP------------TYLSEDLRDILQMMLNRETSKRATISQVRDHR
|| .. .......|. . . .|| . ... ..
PIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | 87835.m00287.AA | LKB | 112-207 | 34 | 2.9e-22 | 62.93 | In-house | 109-210 (265) | Show / Hide |
Range on Protein: 112-207 Range on HMM: 109-210/265 Sequence Identity: 34% (36 aa) IFYRLVEAIYYLHSNSIVHLDIRPENV-FIVDKQFKLGGF----LSSRFESEDEIITGTYGTPNFQAPEIFTN--QNFDGRKADVWACGIFLLAITTGKL .| |... |||| .|| || | | . .| |. | .. |. .|. | .|.| || ||. |.| |.|.|. |. | .|||| YFCQLCDGCEYLHSQRVVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQ-RDDCCTTSQGSPAFQPPECANGNHDTFSGFKVDIWSMGVTLYNMTTGKY PYS |.. PFE |
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| Kinase | 87835.m00287.AA | MARK | 103-138 | 50 | 1.6e-09 | 27.49 | In-house | 100-135 (262) | Show / Hide |
Range on Protein: 103-138 Range on HMM: 100-135/262 Sequence Identity: 50% (18 aa) PLPESVACNIFYRLVEAIYYLHSNSIVHLDIRPENV .|.|. | || .|.|..|.||..||| || |||. RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENI |
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| Kinase | 87835.m00287.AA | LKB | 232-267 | 26 | 1.1e-08 | 22.02 | In-house | 228-265 (265) | Show / Hide |
Range on Protein: 232-267 Range on HMM: 228-265/265 Sequence Identity: 26% (10 aa) IPT--YLSEDLRDILQMMLNRETSKRATISQVRDHRWL .|. . || . .. || . .|| .. |.. | |. MPCWYDCDKDLQNLIKGMLQYDHNKRFSCHQIMHHPWF |
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| Kinase | 87835.m00287.AA | TyrKc | 31-267 | 17 | 8e-06 | -128.34 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 31-267 Range on HMM: 1-280/280 Sequence Identity: 17% (52 aa) ATKKR----------YSGRLLMR----KNLFHTYYFDNLQMEFEILGSI--SHPYIQKLIETTYNS-------HVLAQIVES-EEVSLMDYYKFDFP-LP |... | |.. . | | . . | .|. .. .|| | .|. . . | ..| . .| || . | |. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC ESVACNIFYRLVEAIYYLHSNSIVHLDIRPENVFIVDKQ-FKLGGFLSSRFESED-------EIITGTY--GTP-----NFQAPEIFTNQNFDG---RKA . ... . . ||||. ..| |. |. . ... | . | ||. .| . .. . |. ||| . ..| | MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGKFTTKS DVWACGIFLL--AITTGKLPYST---NGMKSSESPNEYIRKQVETN-ESIIPTY--------LSEDLRDILQMMLNRETSKRATISQVRDHRWL |||. |. .. | |. ||. . .|. ....|.. .| . .... .| .. ... ..| | |.. |. . DVWSFGV-CMWEIFTYGQQPYPGMIQQ-----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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