Gene LmjF36.6320 (L.major)

LmjF36.6320

Species: L.major
Alias: LmjF36.6320, LmajK177
External Links:
Annotation:

Classification

Group: PKL
Family: PIKK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
LmjF36.6320.AA Protein None 2613 None Fasta, JSON
LmjF36.6320.kin_dom Protein Kinase Domain None 249 None Fasta, JSON

Protein domain

Protein domains of LmjF36.6320.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF3385 LmjF36.6320.AA DUF3385 814-975 26 3.2e-55 194.55 Pfam 1-181 (181) Show / Hide 
Range on Protein: 814-975
Range on HMM: 1-181/181
Sequence Identity: 26% (48 aa)

DVDVYETNPELLRVLLSALHGGFKETWPVRLDVLKLMGIIGAVDPVRAK--EITRHLR-------DGG-LSSSGAAAPAALQLSSS---RGEEAIAQNVV
..|.|.. |.||.||...|...|.. ||.|....|.|||.||.||...|  ||.||..       |..  .... . ...| . ..   ...| ... |.
VIDPYYDYPQLLGVLFNILKTEFQN-WPIRRETIKCMGILGALDPYKHKMNEIERHSDKHHIKFRDDQHQNQNNPCTDIMLMMQGYSPLSNDEYYPTVVI

KNVLG-VLQLPCLSDDQCLCAVQVI----ANTLSLKEAASGCLTPMYRDILHTVIQQI-TLQA-KIRENLFGLMTHIVYLYG
..... .|..|.||.......||.|     . .|||.  ..|..|.. .|.....|.. |...  .|| .|  ....|....
NSLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRTCPPCSLREFYFQQLCTLVSIVK
FAT LmjF36.6320.AA FAT 1538-1871 21 6.1e-63 210.98 Pfam 1-408 (408) Show / Hide 
Range on Protein: 1538-1871
Range on HMM: 1-408/408
Sequence Identity: 21% (88 aa)

APYGAHAAWLLRCWDD--MEKITAYMT------------DDGY--VGTTAVFYRAVLAT--HKLKFH--DAVPVIQNCRKRLDSTLSA-LVAESYDRAYG
||..|.||| |  ||.  |.. .. |             .| .  ..    |..|.|.   |. .|   .|   | ..|..||  ..| |. ||| |.|.
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

LFVGIQQLSELEEFA----FVADN--------PQGLNHWQELWEKRL--A-AMAYEGWPGTLANHTLVIP--------------LAQELEMWLRFVSLSR
. | .|.|.||||..      ..|        |. ..|. . |.|||     . .| |   |.....|..               .. ..||..|..| |
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCR

VHGRDRTSRDILFELLGKQ-TIAAALEQPQLPQPPIALAACQHFYDINERERAVELLETYLK-KMDPAAPSLLS------------------IGGGQANL
 |||   . . |..|.. . .    ..    ..|..  | ...... .... | . |.  .. .|   ...  .                  .. ..  |
KHGRMQLCEKTLKMLYTYDPSEEDWHP---RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLL

A-MCHAKLASWLFTVAKKKRQNVDARYREYIRHHLEKATSLDSTNGT-IWHTWARFNHDLVTHRSRGAASEVR---RDEHVKHIVAAMDGYVRSVSCSQE
|  |..|.. |.      ...| .    . | ..  .|| .| .     ||.||..|  ...|   .  .| .   . .   |.| |.... .|.. ||.
AMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTH-MIIQHVVPAVKCFFHSIALSQG

---LEDMLGFLS
   ..|.| .|.
SNSRQDTLRLLW
Rapamycin_bind LmjF36.6320.AA Rapamycin_bind 1993-2091 37 2.5e-49 157.57 Pfam 1-100 (100) Show / Hide 
Range on Protein: 1993-2091
Range on HMM: 1-100/100
Sequence Identity: 37% (37 aa)

ELVRCAVLWTELWFDELERAWFQWGRDKNAHNVFLVLQPLLEQLSH-PNTLAESHFVTEFGELLGGACEYVEKAASTGNNVYMEDAWNRFKTAVKRMDEQ
||.|.|.||.|.|...||.|..|. .|.|....| .|.||.|.|.. | |..|..|| .||. |  |.|...|  .||...... ||. ...  .|...|
ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase LmjF36.6320.AA FRAP 2160-2408 54 7.4e-125 421.1 In-house 2-251 (251) Show / Hide 
Range on Protein: 2160-2408
Range on HMM: 2-251/251
Sequence Identity: 54% (135 aa)

YKFLLKGHEDLRLDERVMQLLAFANTLLEKHSTIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQLIKDYRVHSK-YLSIEMNLMLSFNVDLDRLQVI
| ||||||||.| ||||||| .  |.||.   . |...  || .|. ||| |.||.||| .||||| ||.|||   .  . || |.|..   | |.|  .
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPLM

QHVEPFEFALEQTEGTDLANSFWMRAPSAESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSGRVVHIDFGDCFDVAQNRSAFPEKVPFRLTR
. || |..... | | ||.   |.. |. | |..||| |  |||||||.| |||||||||||.|.  ..|..|||||||||.||  |  ||||.||||||
NKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTR

MLVKAMEMGGIDGLFRHGCITVMGVLREEGSSILALLEAFVHDPLVSWWR
||| |||  ||.| .|  | .|| |.||.  |..| ||||| |||  |  
MLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase LmjF36.6320.AA PIKK 2130-2398 39 1.1e-109 370.67 In-house 1-290 (290) Show / Hide 
Range on Protein: 2130-2398
Range on HMM: 1-290/290
Sequence Identity: 39% (114 aa)

RIASFQSTLRVMNSKQHPRRLYMTGTDGVLYKFLLKGHEDLRLDERVMQLLAFANTLLEKHSTIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQLIK
||...   . || .|| |...|. | ||  | .|.|||||||.|.|||||. . ||.|.| .. |.|.  |...||.|.| . ||..|||||.||. ..|
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DYRV--HSKYLSI-EM------------------NLMLSFNVDLDRLQVIQHVEPFEFALEQTEGTDLANSFWMRAPSAESWLDRRTTYVCSLATMSMVG
...   | ..  .  |                  ..|..  .... .   . || |. ... | . .... || ..|..|.|..||. |  |.|.|.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

HILGLGDRHPSNLMIHSFSGRVVHIDFGDCFDVAQNRSAFPEKVPFRLTRMLVKAMEMGGIDGLFRHGCITVMGVLREEGSSILALLEAF
 |||||||||.|.|| . .| .||||||.|| .|  | ..||||||||||..| ||.  |..|.||  |..|| ..|.   ......|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase LmjF36.6320.AA PI3_PI4_kinase 2159-2408 30 1.2e-87 302.29 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2159-2408
Range on HMM: 1-300/300
Sequence Identity: 30% (91 aa)

LYKFLLKGHEDLR--LDERVMQLL-----------------------AFANTLLEKHSTIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQLIKDYRV
 |.|..||..|||   |.|.||..                        . |... |.. . ||.. .| ... |.... |...||.||.|.|.... |.|
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

HSK--YLSIEMNLMLSFNVDLDRLQVIQHVEPFEFALEQTEGTDLANSFWMRAPSA-ESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMI--HSFSG
  |  .. .| . ..  . | . |  .| || || .. .| . .| . ||.  |.| | |...|...|.|.| |..|..|||.||||..|.|.  . ..|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

RVVHIDFGDCFD-VAQNRSAFPEKVPFRLTR------MLVKAM------EMGGIDGLFRHGCITVMGVLREEGSSILALL-------EAFVHDPLVSWWR
 ..|||||.||. .....  .||.||||.|.      ..|.||      .  | .|.||. | ... .||. . ....||       |..|||.|..|..
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase LmjF36.6320.AA PI3Kc 2161-2461 25 4.8e-69 236.62 SMART 1-336 (336) Show / Hide 
Range on Protein: 2161-2461
Range on HMM: 1-336/336
Sequence Identity: 25% (88 aa)

KFLLKGHEDLRLDERVMQLLAFANTLLEKHSTIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQLI-KDYRVHSKYLSIE---MNLMLSF--------
 ...|...||| |.|.||..   |... | . ..|||. .. ... |.... |...|| ||.||||.  | .   .......   |  ||          
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

-----------NVDLDRLQVIQHVEPFEFALEQTEGTDLANSFWMRAPSA-ESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSGRVVHIDFG
           . . ...  ..... ||.|. .. . .|.. || . |.. |.| ..|.... |.| ..||..|||.||||..|.|..  .| ..|||||
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

DCFDVAQNRSAFP----EKVPFRLTRMLVKAME----MGGIDGLFRHGCITVMGVLREEGSSILALLEAFVHDPLVSWWRDESEDGATASAAAASAALS-
..|. .. .  |.    |.||||||...| .|.      | .|.||  | ... ..|..  .|..|.|..|.||.  .|| .   . .     ..  |. 
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM---EKDIKYLRQRFRLDH

SSMPSAGADA------ALGHYSQRAAYAAIGESFHKSRTA
 |   |   .      .| . |  . . .. ..||. . .
LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase LmjF36.6320.AA ATR 2130-2398 30 4.8e-47 158.14 In-house 2-267 (267) Show / Hide 
Range on Protein: 2130-2398
Range on HMM: 2-267/267
Sequence Identity: 30% (81 aa)

RIASFQSTLRVMNSKQHPRRLYMTGTDGVLYKFLLKGHEDLRLDERVMQLLAFANTLLEKHSTIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQLIK
 || |.  . .. | |.|... . |.|| .|  . | ..||| | | |.     | .. |    .||   .. ..| || ...... ||.|  ||. ...
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

DYRVHSKYLSIEMNLMLSFNVDLDRLQVIQHVEPF-EFALEQTEGTDLANSFWMRAPSAESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSG
      |  .   .| .        .   | |  | || | .       . |  | | ...|   |  |. | | ..||| |.||||||  |..| .  |
KLWKEKKQYMQFYQLRQCMDKKSREEWEKQKV--FREFLLPRHPPI-FHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKING

RVVHIDFGDCFDVAQNRSAFPEKVPFRLTRMLVKAMEMGGIDGLFRHGCITVMGVLREEGSSILALLEAF
 .||.|.   |   . .   || ||||||. .| .|   . .||||. |. .| ..|..   |......|
ECVHVDYNCIFNSGE-QFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase LmjF36.6320.AA ATM 2290-2406 43 3.8e-32 99.7 In-house 133-248 (304) Show / Hide 
Range on Protein: 2290-2406
Range on HMM: 133-248/304
Sequence Identity: 43% (51 aa)

WLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSGRVVHIDFGDCFDVAQNRSAFPEKVPFRLTRMLVKAMEMGGIDGLFRHGCITVMGVLREEGS
| ..|  |  | || |.|| ||||||||  |..|   |  .|||| |  |.  .     || ||||||| .|  | . |..| ||  |   | |.|    
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

SILALLEAFVHDPLVSW
 .| . |  . |||  |
TLLTIVEVLLYDPLFDW
Kinase LmjF36.6320.AA DNAPK 2284-2408 30 4.4e-20 69.65 In-house 177-301 (301) Show / Hide 
Range on Protein: 2284-2408
Range on HMM: 177-301/301
Sequence Identity: 30% (38 aa)

APSAESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSGRVVHIDFGDCFDVAQNRSAFPEKVPFRLTRMLVKAMEMGGIDGLFRHGCITVMGV
. . | .|  |  .. . |     . ||| ||||  | |.    | .. ||||  |  |    . ||  ||||||  .  |   .| |...   |  |  
STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA

LREEGSSILALLEAFVHDPLVSWWR
.| .    .   . |. ||.. | .
FRKDRNILTNFCDVFINDPSFDWKN
Kinase LmjF36.6320.AA SMG1 2138-2229 40 1.9e-18 57.57 In-house 1-92 (242) Show / Hide 
Range on Protein: 2138-2229
Range on HMM: 1-92/242
Sequence Identity: 40% (38 aa)

LRVMNSKQHPRRLYMTGTDGVLYKFLLKGHEDLRLDERVMQLLAFANTLLEKHSTIQRRDC---MIQVFSVTPLSENAGLVGWVDNCDTLHQLIK
. ..  |  |..|   | ||  | .| || ||| ||||.|| |.  ||.     || | .        .|||||   .||. |||    |  | |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMF---ATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK
Kinase LmjF36.6320.AA DNAPK 2130-2227 34 3.8e-18 62.49 In-house 3-100 (301) Show / Hide 
Range on Protein: 2130-2227
Range on HMM: 3-100/301
Sequence Identity: 34% (34 aa)

RIASFQSTLRVMNSKQHPRRLYMTGTDGVLYKFLLKGHEDLRLDERVMQLLAFANTLLEKHSTIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQL
||| |     || |   |.|. . | |     |. || ||||.| |. ||    |  .|  .  | |.     ... |.    ||. ||||  .|  .
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI
Kinase LmjF36.6320.AA SMG1 2276-2350 41 3.6e-13 39.83 In-house 169-242 (242) Show / Hide 
Range on Protein: 2276-2350
Range on HMM: 169-242/242
Sequence Identity: 41% (31 aa)

LANSFWMRAPSAESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSGRVVHIDFGDCFDVAQNRSAFPE
||   |      . |      |  | | ||||| |.||||||  | .|    | |||||.  ||.  .   . ||
LAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNV-PE
Kinase LmjF36.6320.AA ATM 2161-2217 35 1.2e-08 23.33 In-house 1-57 (304) Show / Hide 
Range on Protein: 2161-2217
Range on HMM: 1-57/304
Sequence Identity: 35% (20 aa)

KFLLKGHEDLRLDERVMQLLAFANTLLEKHSTIQRRDCMIQVFSVTPLSENAGLVGW
. | || .||| |  . |     |||| .     .|   |  . | |||  .| . |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW
FATC LmjF36.6320.AA FATC 2581-2613 60 4e-21 70.72 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2581-2613
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

DGLSVQAQVSRLISEATSNENLCVHFQGWCPFW
 .|||..||.|||.|||..||||....||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW