Gene LmjF34.4530 (L.major)

LmjF34.4530

Species: L.major
Alias: LmjF34.4530, LmajK176
External Links:
Annotation:

Classification

Group: PKL
Family: PIKK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
LmjF34.4530.AA Protein None 2438 None Fasta, JSON
LmjF34.4530.kin_dom Protein Kinase Domain None 324 None Fasta, JSON

Protein domain

Protein domains of LmjF34.4530.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF3385 LmjF34.4530.AA DUF3385 733-889 18 9.7e-40 141.57 Pfam 1-181 (181) Show / Hide 
Range on Protein: 733-889
Range on HMM: 1-181/181
Sequence Identity: 18% (33 aa)

GASPYVLYPRLFQQLCTLLHRTEESVDIRLEALRCIGVIGALDSHVFQ--SFNLNEKEKACEMSAVVVDRVTHVKCCRIVLGAVAALL-DPESKRSAGAR
. .||  ||.|...|. .|.  ... .||.|...|.|..||||.....  . .....  . .    ....... .|. |.| . .    .......... 
VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALDPYKHKMNEIERHSDKHHIKF-RDDQHQNQNNPCTDIMLMMQGYSPLSNDEYYPTVVI

EGLLR--------------TGVQTM----LNIF----EHIPCSKSEIGLVIGPLARVIRQLPGGRLFATVLFEFCNIIRYAG
 .|.|              ..||..    ..||    ....|. ...  .| |. .|.|..| ..|  ......| .... .
NSLMRLILKDPSLSSHHTVMVVQAITWWEMYIFSLKTMGLKCQVPFLPQIIPPFLQVMRTCPPCSLREFYFQQLCTLVSIVK
FAT LmjF34.4530.AA FAT 1472-1663 22 3.8e-27 91.13 Pfam 1-235 (408) Show / Hide 
Range on Protein: 1472-1663
Range on HMM: 1-235/408
Sequence Identity: 22% (53 aa)

SQYAADASIRLQSWDT--LEHVLDWLP------------PDMV-----LYHVSKAALEV--VRGNYD--AALVSVTNGRKVLLEDLTS-LLHESYARAYE
. .|| |. ||..||   ... .. ..             |.        ....| | .   ....|   |   . ..|. |.. .|. | .||| |.| 
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

GLVVAQQLTEMEEVIIAKQTQKAL------SSAAHIPHLCHIWEQRIRMM-HATVPTWKQVLGIRGLLIS--------------PHEDVKTRIQFTKLCR
 .|  |.|.|.||.|  |.           .|.. . |.   |..| ... .  |  | . |  | . .|              |||| .. |.| .|||
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCR

QEKAGQLEKFTLAELLGFANPTLEQLTSRNVNPRVVM
     || . ||..|...  .. ...   .  | ...
KHGRMQLCEKTLKMLYTYDPSEEDWHP--RAPPQWTY
FAT LmjF34.4530.AA FAT 1722-1787 30 2.7e-13 44.75 Pfam 330-408 (408) Show / Hide 
Range on Protein: 1722-1787
Range on HMM: 330-408/408
Sequence Identity: 30% (24 aa)

QCFKTAIMYDPQWFL-AWRKWAEANAQLLQTDK-------------GEETCRNAIEGFIRSIQLGTSDSTLIQDVLKLLT
||..||. .||||   ||  || .| ...| ..               .  ..|...|..|| |. ... . || |.||.
QCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQGSNSR-QDTLRLLW
Rapamycin_bind LmjF34.4530.AA Rapamycin_bind 1894-1993 37 4e-52 166.39 Pfam 1-100 (100) Show / Hide 
Range on Protein: 1894-1993
Range on HMM: 1-100/100
Sequence Identity: 37% (37 aa)

ELIRVSALIYEQWYDKLEAAATAFFGRRSTDEMIRTLLPIHETLTRVPETVVESEFLSKYSKRLTEARDWLRSYSSTRYTGDIQSAWKLYHSVYCNIDKQ
|||||. | .|.|.. || |....||..  ..| ..|.| || |.. ||| .|..|  .....|.||..|...| .|.  .. ..||..|..|.. |.||
ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ
Kinase LmjF34.4530.AA FRAP 2063-2317 52 2.2e-125 422.82 In-house 3-251 (251) Show / Hide 
Range on Protein: 2063-2317
Range on HMM: 3-251/251
Sequence Identity: 52% (135 aa)

KFLLKGREDLRLDERVMQLFSLVNILMQSDSRASKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEVVKHFRERKSIPVELEMRMLDQIITFDNSKAYD
 |||||.||.| |||||||| |.| |.. .  . |  .  |||||. ||  | |.||||  |||||  .. .|... |    | ...|. .       ||
HFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKK-NLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMC-----NDYD

YLTIMSKVEVLEFLSDHTSGQDIRKAMWSTSPNCEVWYDRRRMYTTSLANMSIVGYILGLGDRHPNNIMLQRASGLVVHIDFGDCFEVAMTRDKFPEKVP
 |..| |||. ..  . | |.|..| .|  ||| |.|..||  || ||| ||..||||||||||| |||||| .| .|||||||||||||.|.|||||.|
HLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIP

FRLTRMLRSALDVSGVDGAFRACSETAMCVLREGSHSVLALLEAFIQDPLISWRL
|||||||  |... |..| .|  .|. | |.||   ||.| ||||. |||. |||
FRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase LmjF34.4530.AA PIKK 2032-2307 40 6.30000000001e-106 358.22 In-house 1-290 (290) Show / Hide 
Range on Protein: 2032-2307
Range on HMM: 1-290/290
Sequence Identity: 40% (117 aa)

KVNRFQKDIIVIASKQRPKRIGIITAEGKLQKFLLKGREDLRLDERVMQLFSLVNILMQSDSRASKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEVV
 .  . . ..|.|.||.||.| |    ||   .|.||.||||.|.||||||.|.| . | |.. .|   ..|..|||.|. .. |.|.|||.|.||.|  
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKR-HLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIY

KHFRERKSIPVELEMRM-------------LD--QIITFDNSKAYDYLTIMSKVEVLEFLSDHTSGQDIRKAMWSTSPNCEVWYDRRRMYTTSLANMSIV
|  ...| |  | |  |             ..    .    .  |. .. . ||||.. ... | . . .|. |...|..| |..|| .|| |.| |..|
KQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMV

GYILGLGDRHPNNIMLQRASGLVVHIDFGDCFEVAMTRDKFPEKVPFRLTRMLRSALDVSGVDGAFRACSETAMCVLREGSHSVLALLEAF
|||||||||||.|||... .| .||||||.|||.||.| ..||||||||||..  |. . ||.| ||.| |..| ..|..  ......|.|
GYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase LmjF34.4530.AA PI3_PI4_kinase 2061-2317 28 1.5e-78 272.07 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2061-2317
Range on HMM: 1-300/300
Sequence Identity: 28% (89 aa)

LQKFLLKGREDLR--LDERVMQLF-----------------------SLVNILMQSDSRASK-NLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEVVKHF
 ..|..|| .|||   |.|.||..                       .|.| . ..|.   . |  .|.| |.. |. .. |.|.||. |.|.||. . .
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRN--MQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTY

RERKSIPV---ELEMRMLDQIITFDNSKAYDYLTIMSKVEVLEFLSDHTSGQDIRKAMWSTSPNC-EVWYDRRRMYTTSLANMSIVGYILGLGDRHPNNI
.......    |. |.|.... . ..        .| |||| |  .  | . ....  |...|.. | | ..|. ...|.| |..|.||||.||||..||
MVKCKHKHFNKEHKMWMKMWPDWWHLM-------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNI

ML--QRASGLVVHIDFGDCFE-VAMTRDKFPEKVPFRLTR------MLRSAL------DVSGVDGAFRACSETAMCVLREGSHSVLALL-------EAFI
|.   . .| ..|||||.||. ..| ....||.||||.|.      .. .|.      |.|| .| || . ..|. .||. ......||       |...
MVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMV

QDPLISWRL
.|.|..|| 
HDGLPMWRS
Kinase LmjF34.4530.AA PI3Kc 2063-2373 25 2.3e-70 240.99 SMART 1-336 (336) Show / Hide 
Range on Protein: 2063-2373
Range on HMM: 1-336/336
Sequence Identity: 25% (88 aa)

KFLLKGREDLRLDERVMQLFSLVNILMQSDSRASKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEVVKHFRERKSIPVELE-MRMLDQIIT-------
 ...|...||| |.|.||.|.|.| . |.|. .. .. .....|.. |. .. |.|.||  |.|||.. | ... |..|  ..  .|.|   .       
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDK-ECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNM

---------FDNSKAYDYLTIMSKVEVLEFLSDHTSGQDIRKAMWSTSPNC-EVWYDRRRMYTTSLANMSIVGYILGLGDRHPNNIMLQRASGLVVHIDF
          .  . |. .|.| .... |.  . . . .... .|...|.  |.|...|. .| |.| ...|.||||.||||..|||| . .| ..||||
YMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDF

GDCFEVAMTRDKFP----EKVPFRLTRMLRSALD----VSGVDGAFRACSETAMCVLREGSHSVLALLEAFIQDPL-ISWRLINRHGQEPESSNDHKTIE
|..|. .... .|.    |.||||||...  .      .||..| || | ..|....|. |.....|.|... ||. ..||       |    . .....
GHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-----EKDIKYLRQRFR

EQ-VNIANMRNATSA----AEAESMCDSFGQRDSGPFSVAKHL
.. ..  . ..   .    .  |....|.  |    |   ...
LDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase LmjF34.4530.AA ATM 2198-2315 45 7.7e-35 108.46 In-house 132-248 (304) Show / Hide 
Range on Protein: 2198-2315
Range on HMM: 132-248/304
Sequence Identity: 45% (54 aa)

VWYDRRRMYTTSLANMSIVGYILGLGDRHPNNIMLQRASGLVVHIDFGDCFEVAMTRDKFPEKVPFRLTRMLRSALDVSGVDGAFRACSETAMCVLREGS
.|...|  || | |  |||||||||||||  ||..   |  .|||| |  ||        || ||||||| .   . . ||.| || | |  | |.|   
IWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ

HSVLALLEAFIQDPLISW
  .| . |  . |||  |
ETLLTIVEVLLYDPLFDW
Kinase LmjF34.4530.AA ATR 2194-2307 34 2.3e-28 93.42 In-house 155-267 (267) Show / Hide 
Range on Protein: 2194-2307
Range on HMM: 155-267/267
Sequence Identity: 34% (39 aa)

PNCEVWYDRRRMYTTSLANMSIVGYILGLGDRHPNNIMLQRASGLVVHIDFGDCFEVAMTRDKFPEKVPFRLTRMLRSALDVSGVDGAFRACSETAMCVL
|  . ||  |  |  | | ...||||.|||||| .||....  | .||.|.   |    . .  || ||||||. .  ..   . .| ||   |  | ..
PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCM

REGSHSVLALLEAF
|.    .......|
RDHRDDIMSVWDCF
Kinase LmjF34.4530.AA SMG1 2040-2137 38 7e-20 62.41 In-house 1-97 (242) Show / Hide 
Range on Protein: 2040-2137
Range on HMM: 1-97/242
Sequence Identity: 38% (38 aa)

IIVIASKQRPKRIGIITAEGKLQKFLLKGREDLRLDERVMQLFSLVNILMQSDSRASKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEVVKHFRER
| ..  | .||..  . ..||   .| || ||| ||||.||  |.|| .     |      |    ||||||    |.| ||||   |  . | .  |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPR-FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQR
Kinase LmjF34.4530.AA DNAPK 2031-2130 33 4.3e-16 54.9 In-house 2-100 (301) Show / Hide 
Range on Protein: 2031-2130
Range on HMM: 2-100/301
Sequence Identity: 33% (34 aa)

AKVNRFQKDIIVIASKQRPKRIGIITAEGKLQKFLLKGREDLRLDERVMQLFSLVNILMQSDSR-ASKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHE
 ..  |   . |.||  ||||| |   . .   |. || ||||.| |. |||   |  .  |.   .. |  |   |.. |.    | | |||   .| .
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQREL--QLRTYNIIPMTNRLGLIEWVDNTVVLKD

V
.
I
Kinase LmjF34.4530.AA ATR 2031-2138 31 5.9e-16 50.45 In-house 1-108 (267) Show / Hide 
Range on Protein: 2031-2138
Range on HMM: 1-108/267
Sequence Identity: 31% (34 aa)

AKVNRFQKDIIVIASKQRPKRIGIITAEGKLQKFLLKGREDLRLDERVMQLFSLVNILMQSDSRASKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEV
| .  |.  . ..|| |.||.| .  ..||.   . | ..||| | | |.  .|.| . . | .  .   .... |.| || |. .|| ||.   ||. .
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRF-YHMRTYAVIPLNDQCCIIEWVNNTATLRPI

V-KHFRERK
. | ..|.|
LDKLWKEKK
Kinase LmjF34.4530.AA DNAPK 2215-2317 33 9.9e-16 53.56 In-house 199-301 (301) Show / Hide 
Range on Protein: 2215-2317
Range on HMM: 199-301/301
Sequence Identity: 33% (34 aa)

IVGYILGLGDRHPNNIMLQRASGLVVHIDFGDCFEVAMTRDKFPEKVPFRLTRMLRSALDVSGVDGAFRACSETAMCVLREGSHSVLALLEAFIQDPLIS
| ..||| |||| || |     | .. ||||  |  |      ||  ||||||     .   .. | ..     .|  .|      .   . ||.||.. 
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD

WRL
|  
WKN
Kinase LmjF34.4530.AA SMG1 2172-2249 43 1e-15 48.42 In-house 156-233 (242) Show / Hide 
Range on Protein: 2172-2249
Range on HMM: 156-233/242
Sequence Identity: 43% (34 aa)

VLEFLSDHTSGQDIRKAMWSTSPNCEVWYDRRRMYTTSLANMSIVGYILGLGDRHPNNIMLQRASGLVVHIDFGDCFE
||| | . |    . | .||     . |.     |  | | ||.||||.||||||  |...    | |||||.  |||
VLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
Kinase LmjF34.4530.AA ATM 2063-2123 36 7.8e-08 20.68 In-house 1-60 (304) Show / Hide 
Range on Protein: 2063-2123
Range on HMM: 1-60/304
Sequence Identity: 36% (22 aa)

KFLLKGREDLRLDERVMQLFSLVNILMQSDSRASKNLGFQIQRYSVTPLKDNVGIIGWVDG
. | |||.||| |  . | | . | |.|      |     |  | | ||    |.. |  |
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRK-LTICTYKVVPLSQRSGVLEWCTG
FATC LmjF34.4530.AA FATC 2406-2438 48 2.6e-14 48.89 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2406-2438
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

ELLDPRTQVGQLIEEATDVTNVAQSWSGWYPFW
| |..  || .||.||||. | .| ..|| |.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW