Gene LmjF34.3940 (L.major)
LmjF34.3940
Species: L.major
Alias: LmajK175, LmjF34.3940
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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LmjF34.3940.AA | Protein | None | 2628 | None | Fasta, JSON |
LmjF34.3940.kin_dom | Protein Kinase Domain | None | 274 | None | Fasta, JSON |
Protein domains of LmjF34.3940.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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FATC | LmjF34.3940.AA | FATC | 831-844 | 42 | 15.524274 | 1.51 | Pfam | 1-14 (33) | Show / Hide |
Range on Protein: 831-844 Range on HMM: 1-14/33 Sequence Identity: 42% (6 aa) LALDPKQQVDTLVA . |.. |||| |.. EPLSVEQQVDRLIQ |
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PDZ | LmjF34.3940.AA | PDZ | 1355-1423 | 14 | 1e-05 | 26.2 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 1355-1423 Range on HMM: 1-80/80 Sequence Identity: 14% (12 aa) QKFGINYDQDPERGVIVTKLAPNGVGARAG------VPIGAQLLAIND-IPVR--AVSDIRGLIEGL------THIELLLSYEV . .|.. |...... |.|. ..|| . .| ..|..|. .||. .. .. . ....|.. .. GGLGFSIVG----GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG |
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PDZ | LmjF34.3940.AA | PDZ | 1345-1420 | 17 | 0.000154 | 18.1 | Pfam | 1-86 (86) | Show / Hide |
Range on Protein: 1345-1420 Range on HMM: 1-86/86 Sequence Identity: 17% (15 aa) VVSVDRESTSQKFGINYDQDPER----GVIVTKLAPN-GVGARAG-VPIGAQLLAINDIPVR--AVSDIRGLIEGLT--HIELLLS |.. .. . ...|.. . .. |...... |. | .|.| .| |...||. ..| .. .. .| | . |.. QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ |
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FAT | LmjF34.3940.AA | FAT | 1642-1914 | 18 | 4.3e-08 | 27.33 | Pfam | 67-408 (408) | Show / Hide |
Range on Protein: 1642-1914 Range on HMM: 67-408/408 Sequence Identity: 18% (65 aa) D--ELLRYTDKVRESMLESFAD-SLNENYNRAYEGMTRLQHLRHFEELVSFTTAC-----------EERQALLKRVWHRRLVQM-SSRPDDLMTVLSINS | | || ||.|. ... . .| |||.| | |.| | .||. . . | .|.|. ... | .|| . . .. |. . DTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQ LVLE--------------PEDDLHSYVYVIRCLCKSQWFSHAEHLLQRLLR---ENASLEVLCECDPELIHTYIKYVYLAKDKHGAYVELKNILS-AVEV .|.. | .|.. . |. .. .| | .|.. .. . . .|. .. | || . ..... |. .|. .| . HVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHP--RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQH D-----------------------PEDPRAEMWG-QCWLLLGEWTMYL--------FPECGEEAIKELMCATELGPNSAA-AFHSLGILHCDLARDPSTQ | .| ... . | ...|.| | .|. .|... | ||.. |... | |... . . .| DLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQ GE--------VQNNHLICCINSLFKSIQLCNDVPGSLVMQDVLRILS . . .|.. . |.|| |.. | . || ||.|. PQREEQNYTHMIIQHVVPAVKCFFHSIALSQG---SNSRQDTLRLLW |
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Rapamycin_bind | LmjF34.3940.AA | Rapamycin_bind | 2023-2111 | 30 | 3.2e-38 | 122.45 | Pfam | 1-100 (100) | Show / Hide |
Range on Protein: 2023-2111 Range on HMM: 1-100/100 Sequence Identity: 30% (30 aa) EMVRIAILWTEKWHAAIQQAAY---KPNNTAAIFSMLQPLYAELDR-ASTPNELSFRCNFGQTLRRAKVALE-------EAKTDEAWGFLRQVYAQLRRG |..|.||||.|.|| ....|.. ...| ..|..|.||...|.. .|..| || . ||..|..|. ... |. ..|| .. ||. ..|. ELIRVAILWHEMWHEGLEEASRQYFGDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRKQ |
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Kinase | LmjF34.3940.AA | PIKK | 2148-2421 | 37 | 2.4e-104 | 352.99 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 2148-2421 Range on HMM: 1-290/290 Sequence Identity: 37% (108 aa) TIRKFHSRVYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLE || . .| ||..||||..| . .||| |..|.||||| |||.||||...|. |..| |.. . |.|. |.|||.... |...||.|. |. . RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK TYRQAHEVSVYEEVNL---------------IMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVG ..|. . . |. .| ... .| .| .........|.||| . .. .|| ..|.|.. |. | ..| |.||| QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG YVLGLGDRHLNNLML-QGNGTVVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSENLLSILEAF |.|||||||..|.|. . .| .||||||.|||.|| | | ||||||| .| |.|..||.|..| .|| .|. . .| | |....|.| YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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Kinase | LmjF34.3940.AA | FRAP | 2177-2431 | 44 | 7.1e-99 | 334.78 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 2177-2431 Range on HMM: 1-251/251 Sequence Identity: 44% (115 aa) KYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLETYRQAHEVSVYEEVNLIMKKGGLDTIEDY | ||||||||.|||||||| || .. . . . .||| |..||| | | .|||.. |. .. ||..... | |.. .. ..|| EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRM-----CNDY HRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQ-GNGTVVHIDFGDCFEVAMHRALYAEAV .|| .. . |.|.|| ..|. . | | |. | | || |||.||.|||||||. |.||| | .||||||||||||| | . | . DHLPLMNKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKI PFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSENLLSILEAFIYDPIINWRL ||||||.|| |. ..|..| || |||| || . | | .. .||||.|||...||| PFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL |
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Kinase | LmjF34.3940.AA | PI3Kc | 2179-2492 | 22 | 1.1e-69 | 238.7 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2179-2492 Range on HMM: 1-336/336 Sequence Identity: 22% (78 aa) RFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKML-ETYRQAH------------------EVSVYE ....|...|.|||.|.||..||...| |.| ... | . .|..||. .. |...|| |.||. ... . . ... . . AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM EVNLIMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTC-EQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQ-GNGTVVHID ..| .. . . . .| .. . ..... | ..... |.. ||.|. . | | . | .. . .|...||.|.||.||||..|.|| .| ..||| Y-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHID FGDCFEVAMHRALYA----EAVPFRLTRLLVCALG----ITGVDGLYRMTCELAMKNLHRHSENLLSILEAFIYDPI-INWRLNTVNDVTEKSGSKSAQQ ||..|. .. . .. |.||||||. .| . | ..|..|..|..|. |.. . .||. .....|...|||| ..|| . .. .. FGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--------EKDIKYLR ESNNGG--TAALAGETAAA-ACLGIDNAAQAEAKPVAMQLSKSVSKP .. . . .| . ... | .... .. . .... . .. QRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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Kinase | LmjF34.3940.AA | PI3_PI4_kinase | 2177-2431 | 25 | 2.3e-69 | 241.56 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2177-2431 Range on HMM: 1-300/300 Sequence Identity: 25% (80 aa) KYRFLLKGHEDMR--QDERVMQFI-----------------------RLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLETYR- |.|..||..|.| ||.|.||.| ||.... ..|.. ... | .||. .. |...||.|..|. . . ||. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV --------QAHEVSVYEEVNLIMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTC-EQWLSYRQTYGQTLAAMSMVGYVLGLGDRH . | ... . . .... . |.. . .... .|||. |.. ||.|| .. | |...|... .| |..|.|.||.|||| KCKHKHFNKEHKMWMKMWPDWWHLM-------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRH LNNLML---QGNGTVVHIDFGDCFE-VAMHRALYAEAVPFRLTR------LLVCAL------GITGVDGLYRMTCELAMKNLHRHSENLLSIL------- ..|.|. ..| ..|||||.||. ..|.. |.||||.|. .| |. . .| .|..| .|. |. | ||.. ... | NDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRG EAFIYDPIINWRL |....|....|| ECMVHDGLPMWRS |
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Kinase | LmjF34.3940.AA | ATR | 2148-2421 | 30 | 2.4e-49 | 166.12 | In-house | 2-267 (267) | Show / Hide |
Range on Protein: 2148-2421 Range on HMM: 2-267/267 Sequence Identity: 30% (84 aa) TIRKFHSRVYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLE | | | .. | |||..| | |||| | . | ..|.|.| | |.| ||. . . | . .. |||||| |. ... ||.|| |. .|. YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD T-YRQAHEVSVYEEVNLIMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLM .. . . .. . | | . | . |.. .. . | . | .|| | |. | . |...||||..|||||| .|.. KLWKEKKQYMQFYQLRQCMDKKSREEWE--------KQKVFREFLLPRHP-PIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNIL LQG-NGTVVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSENLLSILEAF .. || .||.|. | | ||||||. .| ..| . .||.| || |. . | ....|....| IDKINGECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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Kinase | LmjF34.3940.AA | ATM | 2314-2432 | 43 | 2.1e-31 | 97.31 | In-house | 133-251 (304) | Show / Hide |
Range on Protein: 2314-2432 Range on HMM: 133-251/304 Sequence Identity: 43% (52 aa) WLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQGNGT-VVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSE | | | | |.|||.||||||| |... .|||| | || | ||||||| .| .|||||.| .| || | . | WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE NLLSILEAFIYDPIINWRLN || | | .|||. | .| TLLTIVEVLLYDPLFDWTMN |
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Kinase | LmjF34.3940.AA | SMG1 | 2285-2363 | 47 | 2.2e-19 | 60.73 | In-house | 154-233 (242) | Show / Hide |
Range on Protein: 2285-2363 Range on HMM: 154-233/242 Sequence Identity: 47% (38 aa) KALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQ-GNGTVVHIDFGDCFE || | || || | | | | . | | | | ||||||..||||||| | .. | |||||. ||| KAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE |
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Kinase | LmjF34.3940.AA | DNAPK | 2147-2246 | 35 | 5.4e-19 | 65.61 | In-house | 2-101 (301) | Show / Hide |
Range on Protein: 2147-2246 Range on HMM: 2-101/301 Sequence Identity: 35% (35 aa) ITIRKFHSRVYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKML . | | || || | .|.|| . | . |. || ||.||| |. | || | . . | | .||.| | . ||.|| . .| VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL |
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Kinase | LmjF34.3940.AA | SMG1 | 2156-2237 | 36 | 1.4e-17 | 54.68 | In-house | 1-82 (242) | Show / Hide |
Range on Protein: 2156-2237 Range on HMM: 1-82/242 Sequence Identity: 36% (30 aa) VYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVE . ..| | ||... |||| | .| || ||. |||.|||. ...|.| | |.| || |.. ||. ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVD |
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Kinase | LmjF34.3940.AA | DNAPK | 2310-2431 | 31 | 1e-16 | 57.23 | In-house | 179-301 (301) | Show / Hide |
Range on Protein: 2310-2431 Range on HMM: 179-301/301 Sequence Identity: 31% (39 aa) TCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQ-GNGTVVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLH ||| .| | . . | ...|| ||||||| | || .. |||| | | | |||||| . . .. |... .|. . TCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFR RHSENLLSILEAFIYDPIINWRL . |. . || || . | KDRNILTNFCDVFINDPSFDWKN |
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Kinase | LmjF34.3940.AA | ATM | 2179-2235 | 35 | 1.1e-08 | 23.4 | In-house | 1-57 (304) | Show / Hide |
Range on Protein: 2179-2235 Range on HMM: 1-57/304 Sequence Identity: 35% (20 aa) RFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGW | | || .|.||| . | . |. | | | | |.|| ||. | RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
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FATC | LmjF34.3940.AA | FATC | 2595-2628 | 55 | 3.5e-16 | 54.89 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2595-2628 Range on HMM: 1-33/33 Sequence Identity: 55% (19 aa) ESLDVPHQVDRLIQEATSLDNLSDAFLTGWAPFW |.|.|. ||||||||||. .||. .. ||.|.| EPLSVEQQVDRLIQEATDPENLCQMYI-GWCPWW |