Gene LmjF20.1120 (L.major)
LmjF20.1120
Species: L.major
Alias: LmjF20.1120, LmajK174
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| LmjF20.1120.AA | Protein | None | 3279 | None | Fasta, JSON |
| LmjF20.1120.kin_dom | Protein Kinase Domain | None | 314 | None | Fasta, JSON |
Protein domains of LmjF20.1120.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FAT | LmjF20.1120.AA | FAT | 2266-2626 | 16 | 2.1e-15 | 51.81 | Pfam | 1-408 (408) | Show / Hide |
Range on Protein: 2266-2626
Range on HMM: 1-408/408
Sequence Identity: 16% (76 aa)
ARCGATAAWLLGRWDD--VQHLAERLS--------------MSEQHTTALRLFFLNGVAL---KSAITEHSSAAYENLRHMITQSKLVIDESLRT-LLPL
|. .| ||| || ||. .. . . .. . .| | || .| .. .. . .|.. | . |. .. | .
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDE-PTWDRSFFQAILCLYKHHNQFDTY-EAHR-----YIDKARQLLDTEWTACLPGE
SYTHAYESLTMLQHFTEMEEMIDYC-HCRST---------KGRQQIYERWNNRFRSLNPDSLQPSLLSLMLHSLVLS--------------TGEMADMIL
|| .| . .| .|.|| | |. | .. . .. . |..| . . . |.....|.| . | ..|..
SYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWI
HFCE-TRQASHPQLAEWAMSWLR---------HGSFSGRSSNLCSPSVASPASPGPVEGITVTTLSSADKNPKVAVGFITHLWSQGKRQAAVESMEMFLR
| . | . ..||.| ... |. |. | . . ..|..|..| | . .. |.
KFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHP----------------------------------RAPPQWTYAYLKYMWATGQQQEAFQHLREFTS
-DCGRD-----------------------LEENNATCYG-DAQLRLGTWKQEL---HADSFWERGFRDEELGHFHKAIRAVPSSYE-AWHSWGLMNYRIQ
| ||. .. .. . ...| | ..| .. |... || |.....|. |..|. |||.|.|.| ..
CHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVF
QRDHNLSP-------EDQRTFVEAAHQGFVGAICRCKDSSEALPAVMRLLQ
| . . . ... ..| | ..| .| .. |... |||.
QHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALSQG-SNSRQDTLRLLW
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| Kinase | LmjF20.1120.AA | FRAP | 2927-3180 | 42 | 1.7e-89 | 303.59 | In-house | 2-251 (251) | Show / Hide |
Range on Protein: 2927-3180 Range on HMM: 2-251/251 Sequence Identity: 42% (109 aa) YTYCLKGNEDIRMDERVMQLLGMVNVLLSHTRISS--SAYIHRFPVIPISSNVGLLGWVENANTINNTICNYRSNISNVRTHQESSVLRAYVGSFGNWDK | . ||| |||| ||||||| |..| || . | |. .||.| | ||.|||.. |. | .|| ..| | . . .. ..|. YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKY-HIRYNIE---YNIMDRMCNDYDH LSLIQRTEILDFVMQSEHCEAVDVSRAMWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETI | |... || ..|. | | . .| . | |..||| .| |||||||.||.|||||||. ||.. .|||||||||| |.| | .|| | LPLMNKVEIFRYIMNNTKGE--DLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKI PFRLTRMLTNAMEVFGVDGVFR-ASATRTQTTLHKNRDSIMALLSAFVHDPIVQYKG ||||||||.||||. |..| .| .... . . ...|.|| | ||| ||. .. PFRLTRMLVNAMEACGIEGNYRNTCELVMK-VIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | LmjF20.1120.AA | PIKK | 3050-3170 | 44 | 5.7e-57 | 195.58 | In-house | 170-290 (290) | Show / Hide |
Range on Protein: 3050-3170 Range on HMM: 170-290/290 Sequence Identity: 44% (54 aa) RAMWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASA .. |... ..|.|..||...| |.|.|.||||.|||||||. ||.| |..|.|||||||..| .. | ||..||||||...|||...||.||||.. KWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCC TRTQTTLHKNRDSIMALLSAF . . ..|...|... .| EHVMMCMRQHRETLMTVCEVF |
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| Kinase | LmjF20.1120.AA | PI3_PI4_kinase | 2926-3180 | 21 | 2.5e-51 | 181.63 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2926-3180
Range on HMM: 1-300/300
Sequence Identity: 21% (68 aa)
LYTYCLKGNEDIR--MDERVMQLL-----------------------GMVNVLLSHTRISSS--AYIHRFPVIPISSNVGLLGWVENANTINNTICNYR-
| . .||..| | |.|.||.. ...| ... . . .. . .|| ... |...||.|. |... ...|.
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
---------SNISNVRTHQESSVLRAYVGSFGNWDKLSLIQRTEILDFVMQSEHCEAVDVSRAMWHRANTA-EQWLDRRTAFTVSLATMSMVGYVLGLGD
... ... ... | ..|..|. | |.. .. . | .| | |...|. |. |.| |..|.|.||.||
KCKHKHFNKEHKMWMKMWPDWWHLM-------------RMQKVEV--FEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGD
RHLGNILI--SMSSGKIVHIDFGDSFD-VGRLRHVLPETIPFRLTR------MLTNAM------EVFGVDGVFRASATRTQTTLHKNRDSIMALL-----
||..||.. ...|...|||||..|. . . ||..|||.|. .. .|| ...| .| || . .. | .. ...|.||
RHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVM
--SAFVHDPIVQYKG
...|||... .
RGECMVHDGLPMWRS
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| Kinase | LmjF20.1120.AA | PI3Kc | 2928-3231 | 17 | 1.6e-49 | 171.72 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2928-3231
Range on HMM: 1-336/336
Sequence Identity: 17% (67 aa)
TYCLKGNEDIRMDERVMQLLGMVNVLLSHT----RISSSAYIHRFPVIPISSNVGLLGWVENANTINNTICNYRSNIS----------------------
.|...| | |.|.||.....| ... | . .. .. .||.... |...|| |. |. . ..|. . .
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRR--DLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNM
------------------------------NVRTHQESSVLRAYVGSFGNWDKLSLIQRTEILDFVMQSEHCEAVDVSRAMWHRANTAEQWLDRRTAFTV
.. ... . . . |.. . | | ..|. ||
YMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN------------------------------------EDWWEARDNFTR
SLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLP----ETIPFRLTRMLTNAME----VFGVDGVFRASATRTQTTLHKNRDSI
|.| ..||.|.||.||||..||.. | .|...|||||. |. |..... . |. |||||... ..|. . |..| || . |. . . |....|
SCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLI
MALLSAFVHDPI-VQYKGK--MKNIMEKSRSPQ-DIAERIRNKLRGT-EMAIDHSK-VNIFNTTQDSCRRPDLL
|.|....|.||| . ... ... ... .. | .... | . ..... ....... . .
MNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| Kinase | LmjF20.1120.AA | ATR | 3059-3170 | 37 | 5.7e-33 | 109.39 | In-house | 157-267 (267) | Show / Hide |
Range on Protein: 3059-3170 Range on HMM: 157-267/267 Sequence Identity: 37% (42 aa) AEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASATRTQTTLHK ..|| | .. | | ..||||..|||||| |||| | .||.|. | |. | ||..|||||. . ..| .. .|.|| . . . PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD NRDSIMALLSAF .|| ||... .| HRDDIMSVWDCF |
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| Kinase | LmjF20.1120.AA | ATM | 3062-3175 | 42 | 1.4e-32 | 101.17 | In-house | 133-245 (304) | Show / Hide |
Range on Protein: 3062-3175 Range on HMM: 133-245/304 Sequence Identity: 42% (49 aa) WLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASATRTQTTLHKNRD | ..| |.| | || |.|||.||||||| |||| | .|||| | |. |.. |||.|||||| . | . ||.|||| .| . . WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE SIMALLSAFVHDPI .. . . ||. TLLTIVEVLLYDPL |
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| Kinase | LmjF20.1120.AA | PIKK | 2897-2998 | 32 | 1.4e-28 | 101.23 | In-house | 1-104 (290) | Show / Hide |
Range on Protein: 2897-2998 Range on HMM: 1-104/290 Sequence Identity: 32% (34 aa) TIASFSSKLDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLGMVNVLLSHT-RISSSAY-IHRFPVIPISSNVGLLGWVENANTINNTIC |... . |...|..|..| . |.|| | |..|| ||.| |.|||||....| .| . .. .. | .. ||| |.. ||..||.|. |. . RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK NYRS .... QWCQ |
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| Kinase | LmjF20.1120.AA | DNAPK | 3050-3180 | 32 | 1.3e-23 | 82.65 | In-house | 171-301 (301) | Show / Hide |
Range on Protein: 3050-3180
Range on HMM: 171-301/301
Sequence Identity: 32% (42 aa)
RAMWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDFGDSFDVGRLRHVLPETIPFRLTRMLTNAMEVFGVDGVFRASA
||. . | | .| | | . | ...|| ||||| | .. |. | |. |||| || . || |||||| .| | .. |... .
RAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIM
TRTQTTLHKNRDSIMALLSAFVHDPIVQYKG
. | | . |. || . |
IHSMMAFRKDRNILTNFCDVFINDPSFDWKN
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| Kinase | LmjF20.1120.AA | SMG1 | 3052-3107 | 48 | 1.1e-16 | 51.64 | In-house | 173-228 (242) | Show / Hide |
Range on Protein: 3052-3107 Range on HMM: 173-228/242 Sequence Identity: 48% (27 aa) MWHRANTAEQWLDRRTAFTVSLATMSMVGYVLGLGDRHLGNILISMSSGKIVHIDF .| | . | .. | | ||||||..||||||| |.|| | | .||||. LWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY |
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| Kinase | LmjF20.1120.AA | SMG1 | 2905-2986 | 34 | 2.9e-14 | 43.53 | In-house | 1-84 (242) | Show / Hide |
Range on Protein: 2905-2986 Range on HMM: 1-84/242 Sequence Identity: 34% (29 aa) LDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLGMVNVLLSHTRISSSAYIH--RFPVIPISSNVGLLGWVENA . ..| | .|... |||| | | || ||. .|||.|| | .|| . | . | |. ||. ||. | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGA |
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| Kinase | LmjF20.1120.AA | DNAPK | 2897-2988 | 32 | 2.8e-12 | 40.82 | In-house | 3-96 (301) | Show / Hide |
Range on Protein: 2897-2988 Range on HMM: 3-96/301 Sequence Identity: 32% (31 aa) TIASFSSKLDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLG-MVNVLLSHTRISSSAYIHR-FPVIPISSNVGLLGWVENANT || | . |. | .||.|| . | | .| || || |.| |. || | |.. .. . | . .|| . ||. ||.| . RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVV |
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| Kinase | LmjF20.1120.AA | ATR | 2897-2989 | 28 | 4.7e-12 | 36.92 | In-house | 2-96 (267) | Show / Hide |
Range on Protein: 2897-2989 Range on HMM: 2-96/267 Sequence Identity: 28% (27 aa) TIASFSSKLDVIPSKKRPRRIQLNGSDGCLYTYCLKGNEDIRMDERVMQLLGMVNVLLSHTRISSSAYIH--RFPVIPISSNVGLLGWVENANTI || | .... | ..|..| | |||| .| | .|.| | | |. ..| .. . .| . |||. .. ... ||.| |. YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATL |
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| FATC | LmjF20.1120.AA | FATC | 3247-3279 | 45 | 7.1e-14 | 47.48 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 3247-3279 Range on HMM: 1-33/33 Sequence Identity: 45% (15 aa) LAMTPEEQVSFLIDEATRIDNYTTMYFGWGPLW . ...|.||. ||.||| ..|. || || | | EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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