Gene LmjF32.1460 (L.major)

LmjF32.1460

Species: L.major
Alias: LmajK173, LmjF32.1460
External Links:
Annotation:

Classification

Group: PKL
Family: PIKK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
LmjF32.1460.AA Protein None 3207 None Fasta, JSON
LmjF32.1460.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of LmjF32.1460.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT LmjF32.1460.AA FAT 2269-2283 73 0.037398 7.44 Pfam 1-15 (408) Show / Hide 
Range on Protein: 2269-2283
Range on HMM: 1-15/408
Sequence Identity: 73% (11 aa)

QAYANEAAWRLGQWD
. .| ||||||||||
APLAAEAAWRLGQWD
FAT LmjF32.1460.AA FAT 2441-2480 14 2.089118 1.59 Pfam 159-208 (408) Show / Hide 
Range on Protein: 2441-2480
Range on HMM: 159-208/408
Sequence Identity: 14% (7 aa)

EPLLALHRLIYREL----------DMPQKVAETWLKQSELLRNGGLGEAA
...|.......  .          . |.  ...|.| ..| |  |. . .
QRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANLCRKHGRMQLC
FAT LmjF32.1460.AA FAT 2541-2666 10 1.1e-05 19.31 Pfam 304-408 (408) Show / Hide 
Range on Protein: 2541-2666
Range on HMM: 304-408/408
Sequence Identity: 10% (14 aa)

LLTNWLIET--------GSERPEHIFAEYEKARELDRKSEL-VHHQMALFYDHLHTLASNASEGAAAQLTAAATSPTSSSTANVSAAVMYNAALQHQKEM
..  |...         . |... |   | .| ..|....   .|..||... . ..  ..... ..                                 
KQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN--------------------------------

V-DSIQRCATRAIVHFGEALLRGVE-KASVSLPRMLT
. . |.. .. |. .| ...  . . ..  ...|.|.
YTHMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Kinase LmjF32.1460.AA PIKK 2862-3127 30 2.3e-80 273.29 In-house 1-290 (290) Show / Hide 
Range on Protein: 2862-3127
Range on HMM: 1-290/290
Sequence Identity: 30% (89 aa)

CFDHFDDRVVVMRSLQKPKRIWVHTNDGREMSFLCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEWLNDTTPLAKVAM
    .|..| || ..||||.|     ||.|  .||| ... |.| |.|..  |||  .  |||  ......|.||....|. | .|||......|     
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

ECYA----LDRSG-------------------VHISSVKKWMTLVDEKKMSKMELFTKYILPEAPPVMHQWLDRTFASNQSWYEARTLFTQSTALWSIAG
. ..    . . .                    .    .. | . ..  . | |.| .   . .|.. . |. |.| . ..|.|.|. .| |.|.....|
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

HIVGLGDRHAENLMIDMERGELMHVDFACMFD-KGEKLEVPEQVRFRLTQNLTDVMGVLGAHGPFQATCEVALRCEMKNKSAVMSIIETL
 | |||||| ||.||||. ||. |.||.| |  ... |.||| | ||||.|... ||. |  |.| ..||....|  ...  .|.. |..
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase LmjF32.1460.AA ATR 2862-3127 36 1.4e-77 263.83 In-house 2-267 (267) Show / Hide 
Range on Protein: 2862-3127
Range on HMM: 2-267/267
Sequence Identity: 36% (96 aa)

CFDHFDDRVVVMRSLQKPKRIWVHTNDGREMSFLCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEWLNDTTPLAKVAM
    ||| | .. ||||||.| ..  ||.    .|| ||. ||| | |..  |.|   . | | .|. . .| |..  | |.|..||| |.|  |  .  
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

ECYALDRSGVHISSVKKWMTLVDEKKMSKMELFTKYILPEAPPVMHQWLDRTFASNQSWYEARTLFTQSTALWSIAGHIVGLGDRHAENLMIDMERGELM
. .   .       ... |     ..  |.  | ...||  ||. |.|  |.|   |.|| .|  .  |.| |.. | |.||||||..|..||   ||..
KLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECV

HVDFACMFDKGEKLEVPEQVRFRLTQNLTDVMGVLGAHGPFQATCEVALRCEMKNKSAVMSIIETL
|||..|.| .||..|||| | ||||.|.   || ....| |   ||| ..|  ...  .||.... 
HVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase LmjF32.1460.AA PI3Kc 2893-3196 24 2.3e-61 211.07 SMART 1-336 (336) Show / Hide 
Range on Protein: 2893-3196
Range on HMM: 1-336/336
Sequence Identity: 24% (85 aa)

SFLCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEWLNDTTPLAKVAMECYA-------------LDRSGV--------
....|..|  |.| |||..  |||    .| |. |  . .|.|.. .....| .||| .....|... .. .              .|.  |        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY

----HISSVKKWMTLVDEKKMSKMELFTKYILPEAPPVMHQWLDRTFASNQ-SWYEARTLFTQSTALWSIAGHIVGLGDRHAENLMIDMERGELMHVDFA
    | .  .. |   ....| . ..|.. . |. |||...|. ..| .   .|.|||. ||.|.| ......| |.|||| .|.|.||. |...|.|| 
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

CMFDKGEKLEVP-----EQVRFRLTQNLTDVMG----VLGAHGPFQATCEVALRCEMKNKSAVMSIIETLLHEPL-IEWRRQSSRSHSSNGPKQLMERVA
..|..|.|....     | | ||||... .|||    . |  | |. .|. |.|  .|.. ..|...|.... |. ..|| .        . .  ..| .
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM--------EKDIKYLRQR

RRLDGFLDLYSVPAKRD-----TLSLNVESQVAKLIHHSSDLNNL
 |||.  |  . .   .      .. ..||.  ...    .....
FRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase LmjF32.1460.AA PI3_PI4_kinase 2891-3137 24 6.9e-57 200.11 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2891-3137
Range on HMM: 1-300/300
Sequence Identity: 24% (72 aa)

EMSFLCKAKDEPR--KDIRMMEVA-----------------------ALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEWLNDTTPLAKVAMECY-
...|..| .|  |  .| |||.                          ||| .  .| .  |...... |.. .....| .|||....|.....  ... 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

---ALDRSGVHISSVKKWMTLVDEKKMSKMELFTKYILPEAPPVMHQWLDRTFASN-QSWYEARTLFTQSTALWSIAGHIVGLGDRHAENLMI--DMERG
   . ..   |. ..|.|    . ..| | |.|.. | .. .|...||. ... .    | |||. |. | | ......| |.||||..|.|.  |...|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

ELMHVDFACMFD--KGEKLEVPEQVRFRLTQ------NLTDVM------GVLGAHGPFQATCEVALRCEMKNKSAVMSII-------ETLLHEPLIEWRR
.|.|.|| ..|.  |.. ...|| | ||.|.      .. ..|      ...|  | |. .|..|.|   ... ..|. .       |...| .|..||.
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase LmjF32.1460.AA ATM 3020-3135 40 1.6e-30 94.39 In-house 133-248 (304) Show / Hide 
Range on Protein: 3020-3135
Range on HMM: 133-248/304
Sequence Identity: 40% (47 aa)

WYEARTLFTQSTALWSIAGHIVGLGDRHAENLMIDMERGELMHVDFACMFDKGEKLEVPEQVRFRLTQNLTDVMGVLGAHGPFQATCEVALRCEMKNKSA
|.| |  .| | |  || | |.||||||  |..|     ||.|.|    |..|  |  || | ||||  . | ||. |  | |   ||  .      .  
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQET

VMSIIETLLHEPLIEW
.. |.| || .|| .|
LLTIVEVLLYDPLFDW
Kinase LmjF32.1460.AA FRAP 3020-3137 38 1.7e-26 94.34 In-house 133-251 (251) Show / Hide 
Range on Protein: 3020-3137
Range on HMM: 133-251/251
Sequence Identity: 38% (46 aa)

WYEARTLFTQSTALWSIAGHIVGLGDRHAENLMIDMERGELMHVDFACMFDKGEKLE-VPEQVRFRLTQNLTDVMGVLGAHGPFQATCEVALRCEMKNKS
|.| || .| | |  |.|| | ||||||  |.|..   | ..|.||   |.   . |  || . ||||  |.  | . |  | .  |||. ..    .| 
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

AVMSIIETLLHEPLIEWRR
 || ..|     ||. || 
SVMAVLEAFVYDPLFYWRL
Kinase LmjF32.1460.AA SMG1 3020-3079 48 2.9e-19 60.36 In-house 183-242 (242) Show / Hide 
Range on Protein: 3020-3079
Range on HMM: 183-242/242
Sequence Identity: 48% (29 aa)

WYEARTLFTQSTALWSIAGHIVGLGDRHAENLMIDMERGELMHVDFACMFDKGEKLEVPE
|.     .  |||  |. | |.|||||| .| .|||  || .|.|.   |.|| || |||
WWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase LmjF32.1460.AA FATC 3175-3207 48 2.2e-15 52.34 Pfam 1-33 (33) Show / Hide 
Range on Protein: 3175-3207
Range on HMM: 1-33/33
Sequence Identity: 48% (16 aa)

LSLNVESQVAKLIHHSSDLNNLSQMYIWWMAWI
..|.|| || .||.  .| .||.||||.|..| 
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase LmjF32.1460.AA DNAPK 3036-3137 27 6.4e-14 46.88 In-house 199-301 (301) Show / Hide 
Range on Protein: 3036-3137
Range on HMM: 199-301/301
Sequence Identity: 27% (28 aa)

IAGHIVGLGDRHAENLMIDMERGELMHVDFACMFD-KGEKLEVPEQVRFRLTQNLTDVMGVLGAHGPFQATCEVALRCEMKNKSAVMSIIETLLHEPLIE
| . | | |||| .| |. || |.   .||   |   .  | |||   ||||   .  |  ..  | .      ...   | .   .  ..    .|.. 
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD

WRR
| .
WKN
Kinase LmjF32.1460.AA DNAPK 2863-2956 36 1.3e-12 42.07 In-house 4-97 (301) Show / Hide 
Range on Protein: 2863-2956
Range on HMM: 4-97/301
Sequence Identity: 36% (34 aa)

FDHFDDRVVVMRSLQKPKRIWVHTNDGREMSFLCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEWLNDTTPL
   ||.|| || || .|||| .   | ||  |. |     | | |       ||  |  ||    .   || |.|  .      |||.. |  |
IAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVL
Kinase LmjF32.1460.AA FRAP 2891-2949 37 5.2e-10 33.09 In-house 1-59 (251) Show / Hide 
Range on Protein: 2891-2949
Range on HMM: 1-59/251
Sequence Identity: 37% (22 aa)

EMSFLCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEW
|  || | ..  | | | |   .|.|     .||...|  |..||||  || .   | |
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGW
Kinase LmjF32.1460.AA SMG1 2870-2956 27 2.5e-07 20.16 In-house 1-87 (242) Show / Hide 
Range on Protein: 2870-2956
Range on HMM: 1-87/242
Sequence Identity: 27% (24 aa)

VVVMRSLQKPKRIWVHTNDGREMSFLCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEWLNDTTPL
. ..    |||..     ||.   .| |  ..   | |.|   ...|  |         ||  | ||.| |     .| |    |||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL
Kinase LmjF32.1460.AA ATM 2895-2959 26 0.000437 8.5 In-house 3-69 (304) Show / Hide 
Range on Protein: 2895-2959
Range on HMM: 3-69/304
Sequence Identity: 26% (18 aa)

LCKAKDEPRKDIRMMEVAALMNSFFLSDPEAKRKRFSLRRYSITALSDDCAVIEWLNDTTPLAK--V
| | .|. |.|  |  |  . |       | ....  .  | .  ||    |.||   | |  |  .
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLI
Kinase LmjF32.1460.AA FATC 3073-3082 50 27.964008 0.69 Pfam 1-10 (33) Show / Hide 
Range on Protein: 3073-3082
Range on HMM: 1-10/33
Sequence Identity: 50% (5 aa)

EKLEVPEQVR
|.| |..||.
EPLSVEQQVD