Gene LmjF29.1450 (L.major)

LmjF29.1450

Species: L.major
Alias: LmajK169, LmjF29.1450
External Links:
Annotation:

Classification

Group: PKL
Family: PIK
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
LmjF29.1450.AA Protein None 2662 None Fasta, JSON
LmjF29.1450.kin_dom Protein Kinase Domain None 344 None Fasta, JSON

Protein domain

Protein domains of LmjF29.1450.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3Ka LmjF29.1450.AA PI3Ka 2158-2238 25 8.8e-05 18.0 Pfam 88-181 (211) Show / Hide 
Range on Protein: 2158-2238
Range on HMM: 88-181/211
Sequence Identity: 25% (24 aa)

IIQALRLLDPRYAA-YKAVNSYAICSLLS-QRSENLIFYLPQLLQLLATD------ESGSIEAFLVRMSAKST-MFAHQLLWSLQTES----EG
. .|| |||. ..     | .||. .| | .  . | .||.|| | |  .        .  . ||.. . ..   ..|.. | . .|.    ||
PCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEG
PI3Ka LmjF29.1450.AA PI3Ka 2093-2258 14 0.000934 -57.03 SMART 1-232 (232) Show / Hide 
Range on Protein: 2093-2258
Range on HMM: 1-232/232
Sequence Identity: 14% (33 aa)

HHNPAV-VVSMVYRFSSIPA-----VRLAASQRVVAHPER--YS-NVAEAVD-----LYL--TEDVLRAGAPRLFLFCSCT------IIQALRLLDPRYA
... .. . .  ..     .       | . ..      |  |. |. .|        .|  ..   .  . ...    .       . .|| ||||...
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP

AY--KAVNSYAICSLLSQRSENLIFYLPQLLQLLATD----------------------------ESGSIEAFLVRMSAKSTMFAHQLLWSLQTES----
 |   .| .||. .| ..  . | .||.|| | |  .                            . .    ||.. . ..  ..|.. | |..|.    
DYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNPRIGHFFYWYLKSEMYDHC

--EGSG-------ALAKKCQQV-ERRVKAVFT
  . .         |   |..  ..... .| 
QLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK
PI3Kc LmjF29.1450.AA PI3Kc 2388-2659 26 2.4e-72 247.57 SMART 1-336 (336) Show / Hide 
Range on Protein: 2388-2659
Range on HMM: 1-336/336
Sequence Identity: 26% (95 aa)

ACIFKMGDDCRQDQISLQLIGLMQRILNSI----GVPSFLYPYRVITTGKSSGVIECVPRSRSRNEIG--------------------------------
| ||| |||.|||.  .|...||..|. .     ...  ..||..| ||. .|.||.|| . .. .|                                 
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

-----------------------KLVESNVA--------EFFVQTFGHPESAGFRRARENFVRSTAAYSVVSFILNIKDRHNGNIMID-ADGNLVHIDFG
                       |. | ...        ..|...|. |.   .. ||.||.||.|.|..|..||.|.||||.|||.|  .|...|||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN-EDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

FLFDTSPGGDINF-----ESSPFKLTTEMVQLIGMDVSGESTLQSKTLARALVDEENYIYFKTLVNRCYLAVRQYAREICVMVELMLRSGL-PCFKPK-K
..|. .|.  . |     |  ||.||..|| ..|                  .. ... ||.|.. | |.|.|... .|  ..|.|..... ||.. . |
HIFGHGPKK-PGFKHHHRERVPFRLTHDMVYVMGGG---------------GKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEK

TIADLAQRLAVD-KNEIEAADYMRR-----LIHESRQNFRTVLYDYYQKVAEG
.|. | ||. .| ... ||| |. .     ||..|.. . | .|.  ...|..
DIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
PI3_PI4_kinase LmjF29.1450.AA PI3_PI4_kinase 2385-2554 25 7.6e-43 153.45 Pfam 1-254 (300) Show / Hide 
Range on Protein: 2385-2554
Range on HMM: 1-254/300
Sequence Identity: 25% (66 aa)

VVKACIFKMGDDCR--QDQISLQLI-----------------------GLMQRILNSIGVPSF----LYPYRVITTGKSSGVIECVPRSRSRNEIGKLV-
 . . ||| |||.|  ||.  .|.|                       .|| ... . |.       . |||.| ||. .|.||.||.. . .|| .   
WY-PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYM

------------------------------------------ESNVAEFFVQTFGHP-ESAGFRRARENFVRSTAAYSVVSFILNIKDRHNGNIMI---D
                                               ..|. ... . |  .   ||.||||| | ..||..||.. ||||.|||.   .
VKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWE--ARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDK

ADGNLVHIDFGFLFD-TSPGGDINFESSPFKLTT------EMVQLIGM----DVSGE
 .|.|.|||||. |. .   .....|  ||..|       .|| ..|     |.||.
TTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGD
Kinase LmjF29.1450.AA ATR 2460-2548 35 2.3e-16 51.88 In-house 148-234 (267) Show / Hide 
Range on Protein: 2460-2548
Range on HMM: 148-234/267
Sequence Identity: 35% (32 aa)

EFFVQTFGHPESAGFRRARENFVRSTAAYSVVSFILNIKDRHNGNIMIDA-DGNLVHIDFGFLFDTSPGGDINF-ESSPFKLTTEMVQLIG
..| ..|  |..  .  .|||..||.|....| .|. . |||  ||.||   | .||.|.  .|    |  ..  |  ||.||  ||  .|
DWFNRRF--PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNS--GEQFEVPEIVPFRLTHNMVFGMG
Kinase LmjF29.1450.AA PIKK 2459-2522 43 7.4e-14 47.16 In-house 169-231 (290) Show / Hide 
Range on Protein: 2459-2522
Range on HMM: 169-231/290
Sequence Identity: 43% (28 aa)

AEFFVQTFGHPESAGFRRARENFVRSTAAYSVVSFILNIKDRHNGNIMIDAD-GNLVHIDFGFLF
...|...|  | .. . ..|||. ||.|  ..| .|| . |||  |||||.. | .||||||..|
KKWFWRKF--PDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCF
Kinase LmjF29.1450.AA FRAP 2478-2519 48 3.5e-09 30.02 In-house 137-179 (251) Show / Hide 
Range on Protein: 2478-2519
Range on HMM: 137-179/251
Sequence Identity: 48% (21 aa)

RENFVRSTAAYSVVSFILNIKDRHNGNIMID-ADGNLVHIDFG
| |. || |  |.. .|| . |||  |||..   | .||||||
RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG
Kinase LmjF29.1450.AA ATM 2478-2549 40 7e-08 20.83 In-house 137-208 (304) Show / Hide 
Range on Protein: 2478-2549
Range on HMM: 137-208/304
Sequence Identity: 40% (30 aa)

RENFVRSTAAYSVVSFILNIKDRHNGNIMIDADG-NLVHIDFGFLFDTSPGGDI--NFESSPFKLTTEMVQLIGM
|  . || |  |.| .|| . |||  ||.|      ||||| |  |.    | |    |  ||.|| ..|  .|.
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ---GKILPTPETVPFRLTRDIVDGMGI
Kinase LmjF29.1450.AA SMG1 2476-2518 43 3e-06 16.6 In-house 185-228 (242) Show / Hide 
Range on Protein: 2476-2518
Range on HMM: 185-228/242
Sequence Identity: 43% (19 aa)

RARENFVRSTAAYSVVSFILNIKDRHNGNIMID-ADGNLVHIDF
|    . ||||  |.| .|. . |||  |..||   |  ||||.
RVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY
Kinase LmjF29.1450.AA PI3_PI4_kinase 2575-2610 20 0.480697 5.56 Pfam 258-300 (300) Show / Hide 
Range on Protein: 2575-2610
Range on HMM: 258-300/300
Sequence Identity: 20% (9 aa)

FKTLVNRCYLAVRQYAREICVMV-------ELMLRSGLPCFKP
|...  . |.|.|.... .  .        |.|...|||... 
FRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS