Gene LmjF34.0940 (L.major)

LmjF34.0940

Species: L.major
Alias: LmjF34.0940, LmajK155
External Links:
Annotation:

Classification

Group: Other
Family: WEE
Subfamily: WEE-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
LmjF34.0940.AA Protein None 1001 None Fasta, JSON
LmjF34.0940.kin_dom Protein Kinase Domain None 316 None Fasta, JSON

Protein domain

Protein domains of LmjF34.0940.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc LmjF34.0940.AA S_TKc 550-865 18 9.1e-36 126.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 550-865
Range on HMM: 1-231/231
Sequence Identity: 18% (63 aa)

YNEVRLLGSGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERRYRRERSVMGMVRGLPHVVQLSAAWEEGRVPRMYLQLEYCPG--GSVASVASARQS--
|  .|..|.|.||.| . .....|..||.|. .        .. |||.... .  . |..|.|  ....    ..|. .|||.|  |.. ..   |..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

RNEPWAEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKDGAYKLSDFGCSVLLDERGRPRPETRNGYGSPVRGQRAGGVGGIPCGNPNGGPVVHT
.. |  | ... ... .  ||. .|. .| | | ||.|.|.|.    |..||| . .|                                          
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------

GAGAGGLGTSLDFNSWNEGNELSTMSIDEGDC---RYLCADMLNEKQHFK-AGDMFSLGMSLFELMSGQPLPRNGDQFLALRRRVPVEVLRRRGYSADLV
                               |    |.   .|   .. | . |. |.|  |.|...|.|. .  .... ... .          | .. 
----------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAK

ELVVALLRSDPPQRPTARQVLQ---------YL
...  .|. || .|||| ..||         ..
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LmjF34.0940.AA WEE 607-864 22 3.1e-33 108.89 In-house 65-294 (297) Show / Hide 
Range on Protein: 607-864
Range on HMM: 65-294/297
Sequence Identity: 22% (65 aa)

PHVVQLSAAWEEGRVPRMYLQLEYCPGGS--VASVASARQSRNEPWAEAEVKVFLAHMSIALDALHRA-NIAHVDFKPDNVLVDKDG-------------
||.|.   ||||..  .||.| ||| |||   .  ..   . |    |.... .| . . .|  .|   .. | | ||.|... |..             
PHIVRYYSAWEEDD--HMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNN

-------AYKLSDFGCSVLLDERGRPRPETRNGYGSPVRGQRAGGVGGIPCGNPNGGPVVHTGAGAGGLGTSLDFNSWNEGNELSTMSIDEGDCRYLCAD
        .|. ||| .. ..                                                            |. .. .. |||.||.   
NDWWFNMMCKIGDFGHVTDMNS-----------------------------------------------------------NNNNPHQEQEGDSRYMAPE

MLNE-KQHFKA--GDMFSLGMSLFELMSGQPLPRNGDQFLALR--------RRVP-VEVLRRRGYSADLVELVVALLRSDPPQRPTARQVLQY
 |.. ... ..   | ||||. ..||.....||.|||.   .|         . |  |..   ..|..| .|.   .  || ||||..| ||.
ILQGYYHYTHLYKADIFSLGITIYELACNMDLPKNGDWWHQIRQGDLSFDKNQIPFPEFD--NIISQELKQLIKWMMHPDPEQRPTCQQLLQH
Pkinase LmjF34.0940.AA Pkinase 550-720 27 7.3e-32 113.75 Pfam 1-175 (293) Show / Hide 
Range on Protein: 550-720
Range on HMM: 1-175/293
Sequence Identity: 27% (50 aa)

YNEVRLLGSGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERRYRR---ERSVMGMVRGLPHVVQLSAAWEEGRVPRMYLQLEYCPGG----SVASVASA
|  .| .||||||.| . .....|. ||||  .  .. . .....|   | ..| .. . |..|.|  ..|.   ...|. .|||.||    . ... |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

RQSRNEPW--AEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKDGAY----KLSDFGCSVLLDERGRPRPETRNGYGSP
  .|. .    | |.| ..  .  .|. .|. .| | | ||.|.|.|..|      |..|||.. ..|    . . .    |.|
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTP
Kinase LmjF34.0940.AA AGC 550-698 22 4.1e-29 71.1 In-house 1-200 (395) Show / Hide 
Range on Protein: 550-698
Range on HMM: 1-200/395
Sequence Identity: 22% (45 aa)

YNEVRLLGSGSFGTVSLFKEI------SSGEYVAVKMSPPLRTPE--------MERRYRRE------------RSVMGMVRG---------LPHVVQ-LS
.. ....| ||||.| | ..       ..|.| |.|.   |.  .        |...  .|            | .. ....          | .|. | 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKV---LKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILH

AAWEEGRVPRMYLQLEYCP--------GGSVASVASARQS-RNEPWAEAEVKVFLA-------HMSIALDALHR-ANIAHVD-FKPDNVLVDKDGAYKLS
 ...  .    |. .||.|        ||   .  . .   ..    | ... ..|       ..  ||. ||.  .| | |  ||.|.| |.||  ||.
YSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLT

DFG
|||
DFG
Kinase LmjF34.0940.AA ROCK 550-716 32 7.7e-21 67.43 In-house 1-161 (263) Show / Hide 
Range on Protein: 550-716
Range on HMM: 1-161/263
Sequence Identity: 32% (56 aa)

YNEVRLLGSGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERR-----YRRERSVMGMVRGLPHVVQLSAAWEEGRVPRMYLQLEYCPGGSVASVASARQ
.. ....| | || | | .. || .  |.||   |   || .|     .  || .|      . .|||  |. . |   .|. ..| ||| . .. |  .
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKM---LSKFEMIKRSDSAFFWEERDIMAHANS-EWIVQLHYAFQDDRY--LYMVMDYMPGGDLVNLMSNYD

SRNEPWAEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKDGAYKLSDFGCSVLLDERGRPRPETRNG
   | ||    . . . .  ||||.|     | | ||||.|.|| |  || |||  . ... |  | .|  |
V-PEKWA----RFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVG
Kinase LmjF34.0940.AA CAMK 555-705 18 6.8e-20 60.13 In-house 1-248 (425) Show / Hide 
Range on Protein: 555-705
Range on HMM: 1-248/425
Sequence Identity: 18% (46 aa)

LLGSGSFGTVSLFKEISSG------------EYVAVKM--SPPLR-------------------------TPEMERRYRRERSVMGMVRG------LPHV
 ||.||||.| | ......            . ||.|.     |.                         .|..... ||| ..| ...|       |..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLSAAWEEGRVP-----------------RMYLQL---EYCPGG----SVASVASARQSRN-----------EPWAEAEVKVFLAHMSIALDALHRANI
..|  ..| ....                 .||. .   |||.||     . .   .. ..                |.|.. .   .  |.. .|  ||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHVDFKPDNVLVDKD-----------------GAYKLSDFGCSVLLDE
.| | ||.|.|.|..                 .  |..||| .  .|.
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDP
Kinase LmjF34.0940.AA CAMKL 550-698 28 9e-18 53.16 In-house 1-174 (297) Show / Hide 
Range on Protein: 550-698
Range on HMM: 1-174/297
Sequence Identity: 28% (50 aa)

YNEVRLLGSGSFGTVSLFKEISS-GEYVAVKMSP--PLR-TPEMERR-----------YRRERSVMGMVR--GLPHVVQLSAAWEEGRV----PRMYLQL
|. .. || ||||.| | . |.  || ||.|.     ..  | |...            ||| . | |..  . |....|   .|  .       .|| .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCPGGS--VASVASARQSRNEPWAEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKDG--AYKLSDFG
|||.||.        ..  |...  | | . .   .  |.. .|. .|.| | ||.|.|.|..|    |..|||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFG
Kinase LmjF34.0940.AA RSK-Unclassified 550-700 26 4.6e-17 49.65 In-house 1-148 (283) Show / Hide 
Range on Protein: 550-700
Range on HMM: 1-148/283
Sequence Identity: 26% (42 aa)

YNEVRLLGSGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERRYRR-----ERSVMGMVRGLPHVVQLSAAWEEGRVPRMYLQLEYCPGGSVASVASARQ
.   ||.| |.|| | | ..  .    | |    |   .| |. .      |. .| .    | .|.|  .       ..|| .|||.||        | 
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKV---LHKHKMIRHNKIKYVMTEQNIMATTN-HPFIVTLYHSFQT--QDYLYLCMEYCMGGDFFRHLQTRK

SRNEPWAEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKDGAYKLSDFGCS
..    .| .|.....   .||  ||.  .   | ||||.. ...|  .|.||. |
EKC--FCEDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLS
Kinase LmjF34.0940.AA TKL 556-865 15 4.6e-15 50.68 In-house 1-364 (364) Show / Hide 
Range on Protein: 556-865
Range on HMM: 1-364/364
Sequence Identity: 15% (66 aa)

LGSGSFGTVSLFKEIS--------SGEYVAVKMSPPLR-----------------------TPEMERRYRRERSVMGMVRGL--PHVVQLSAAWEEGRV-
.|||.||.|   |           .|. ||||. .                           || ..   .|. .. | . |  |..||. ..  ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

----------PRMYLQLEYCPGGSVASVASARQSRNEPWAEAEVKVFLAH-MSIALDA------LHRAN--------IAHVDFKPDNVLVDKDGA-----
          . ...  |||||||  ..                   . . ...|||.      ||  |        |.| | |..|.|||...      
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNY

---------YKLSDFGCSVLLDERG------------RPRPETRNGYGSPVRGQRAGGVGGIPCGNPNGGPVVHTGAGAGGLGTSLDFNSWNEGNELSTM
          |..||| |  ....|            .                                                  .     |  .| 
MYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESA--------------------------------------------------E--HQ-NNRKTT

SIDEGDCRYLCADMLNEK----------------QHFKAGDMFSLGMSLFELMSGQPLPRNGD-----------QFLALRR----RVPVEVLRR------
.   |  |..   .|...                . ... |..| |. |.|......  .. .           ......     | |.    .      
MTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMC

--RGYSADLVELVVALLRSDPPQRPTARQVLQYL
       .. .|      .|| .||.. ..|..|
PCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LmjF34.0940.AA STE 550-705 18 1.9e-13 43.95 In-house 1-199 (359) Show / Hide 
Range on Protein: 550-705
Range on HMM: 1-199/359
Sequence Identity: 18% (38 aa)

YNEVRLLGSGSFGTVSLFKEIS---------------SGEYVAVKMSP----------------PLRTPEMERRYRRERSVMGMVRG-LPHVVQLSAAWE
.  .. .|.|.|||| . . .                .||..|.|  .                  . .| . .. .| ..|   .   |..|.   . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EGRVP-----RMYLQLEYCPGGSVASVASARQSRNEPWA----------EAEVKVFLAHMSIA-LDALHRANIAHVDFKPDNVLVDKDGAYKLSDFGCSV
 .  .       .. .||..|||. ..   . ....|            | ......     . |. ||. .| | | ||.|.|.      ||.|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

LLDE
 |..
QLTD
Kinase LmjF34.0940.AA Pkinase 785-865 18 1e-11 42.54 Pfam 183-293 (293) Show / Hide 
Range on Protein: 785-865
Range on HMM: 183-293/293
Sequence Identity: 18% (21 aa)

LN-EKQHFKAGDMFSLGMSLFELMSGQPLPRNG------DQFLALRRRVPVEVLRRRGYS---------------------ADLVELVVALLRSDPPQRP
..  . . .. ||.|.|  |.|...|.|. ..       ||   ..|. . .. . . ..                      .. ...  .|. || .||
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

TARQVLQY--L
||.|.||   .
TAEQILQHPWF
Kinase LmjF34.0940.AA NEK8 628-700 24 4.2e-10 24.91 In-house 79-167 (278) Show / Hide 
Range on Protein: 628-700
Range on HMM: 79-167/278
Sequence Identity: 24% (22 aa)

LEYCPGGSVASVASARQS------R---------NEPWAEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKD-GAYKLSDFGCS
.||..||  .   . .|       |         |.   | ..  ..  |..|.  .| .|| | | |. |.. ... .  |..||| |
MEYADGGTLYQMIQHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGIS
Kinase LmjF34.0940.AA NEK8 835-864 40 2.3e-08 19.87 In-house 246-275 (278) Show / Hide 
Range on Protein: 835-864
Range on HMM: 246-275/278
Sequence Identity: 40% (12 aa)

GYSADLVELVVALLRSDPPQRPTARQVLQY
.||...  || ..|  ||.|||.| |.. .
HYSNEMRMLVHNCLQQDPEQRPSASQIMAM
Kinase LmjF34.0940.AA TyrKc 550-865 13 2.8e-08 -88.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 550-865
Range on HMM: 1-280/280
Sequence Identity: 13% (48 aa)

YNEVRLLGSGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERRYRRERSVMGMV-RGLPHVVQLSAAWEEG-----RVPRMYLQLEYCPGGSVASVASAR
    . ||.| ||.| . . .   . |||||  .      ..  .|| ..| ..    |..|.| ..  ..      .. ... .||.|.|.  .   ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

QSRNEPWAEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKDGAYKLSDFGCSVLLDERGRPRPETRNGYGSPVRGQRAGGVGGIPCGNPNGGPVV
. .      ..   |    .   . ||. |. | |    |.||....                                                     
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------------------------------------------------

HTGAGAGGLGTSLDFNSWNEGNELST-------MSIDEGDC-------RYLCA-----DM------------LNEKQHFKAGDMFSLGMSLFELMSGQPL
                         |       .| | .|         |  .                   .|..    . | .| |  ..|...    
-------------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQ

PRNG-----DQFLALRRRVPVE-VLRRRGY---------SADLVELVVALLRSDPPQRPTARQVLQYL
|  |          ....|     ...  .         .... ..     . || .||| ... ...
PYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF34.0940.AA NEK 629-698 25 2.9e-08 25.6 In-house 86-168 (286) Show / Hide 
Range on Protein: 629-698
Range on HMM: 86-168/286
Sequence Identity: 25% (21 aa)

EYCP-GGSVASV---ASARQSRNEPWAEAEVKVFLAHMSIALDALHRA-----NIAHVDFKPDNVLVDKDGA----YKLSDFG
|||  ||  .        .. ....  | ..  ....|..||. .|       .| | | || |.  .|..      |. |||
EYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFG
Kinase LmjF34.0940.AA NEK 836-863 46 2.6e-05 15.09 In-house 255-282 (286) Show / Hide 
Range on Protein: 836-863
Range on HMM: 255-282/286
Sequence Identity: 46% (13 aa)

YSADLVELVVALLRSDPPQRPTARQVLQ
|| || .|.  .|. || |||...|.|.
YSQDLQNLISQMLQKDPEQRPSCNQILE
Kinase LmjF34.0940.AA NEK 550-579 28 5.3e-05 13.99 In-house 1-35 (286) Show / Hide 
Range on Protein: 550-579
Range on HMM: 1-35/286
Sequence Identity: 28% (10 aa)

YNEVRLLGSGSFGTVSLFKEISSGEY-----VAVK
| ... .|.||||.| . . .| |       .. |
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWK
Kinase LmjF34.0940.AA WEE 550-564 53 0.000193 10.89 In-house 1-15 (297) Show / Hide 
Range on Protein: 550-564
Range on HMM: 1-15/297
Sequence Identity: 53% (8 aa)

YNEVRLLGSGSFGTV
..||  .|.||||.|
FQEVQKIGEGSFGEV
Kinase LmjF34.0940.AA STE 795-865 18 0.001784 8.28 In-house 250-359 (359) Show / Hide 
Range on Protein: 795-865
Range on HMM: 250-359/359
Sequence Identity: 18% (20 aa)

DMFSLGMSLFELMSGQPL----PRNGDQFLALRRR-------------VPVEVLRR------------------RGYSADLVELVVALLRSDPPQRPTAR
|. |||  . |.  |.|     .     |....                |   |                    . .| .. . .   |. || .|||| 
DIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTAS

QVLQ----YL
| |.     .
QLLKSEHPFI
Kinase LmjF34.0940.AA NEK8 550-566 41 0.002777 5.09 In-house 1-17 (278) Show / Hide 
Range on Protein: 550-566
Range on HMM: 1-17/278
Sequence Identity: 41% (7 aa)

YNEVRLLGSGSFGTVSL
|  .| .| |.|| . |
YERIRVVGRGAFGICWL
Kinase LmjF34.0940.AA CAMK 837-863 33 0.024379 2.54 In-house 395-421 (425) Show / Hide 
Range on Protein: 837-863
Range on HMM: 395-421/425
Sequence Identity: 33% (9 aa)

SADLVELVVALLRSDPPQRPTARQVLQ
|..   |.  .|. || .|.|. |.|.
SQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase LmjF34.0940.AA CAMKL 837-863 33 0.084063 1.36 In-house 268-293 (297) Show / Hide 
Range on Protein: 837-863
Range on HMM: 268-293/297
Sequence Identity: 33% (9 aa)

SADLVELVVALLRSDPPQRPTARQVLQ
| |.  |   .|  .| .|||. |...
S-DCRDLIRKMLQVNPEKRPTIHQIMN