Gene LmjF20.1340 (L.major)
LmjF20.1340
Species: L.major
Alias: LmajK135, LmjF20.1340
External Links:
Annotation:
Group:
Other
Family:
Other-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| LmjF20.1340.AA | Protein | None | 377 | None | Fasta, JSON |
| LmjF20.1340.kin_dom | Protein Kinase Domain | None | 263 | None | Fasta, JSON |
Protein domains of LmjF20.1340.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | LmjF20.1340.AA | Pkinase | 45-279 | 21 | 5.8e-27 | 96.42 | Pfam | 1-222 (293) | Show / Hide |
Range on Protein: 45-279 Range on HMM: 1-222/293 Sequence Identity: 21% (56 aa) IWTPQRLGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAGVSPHVVPMYKPWFDCREGVIALPMDAGDFSLEQYAV . . ...|.||||.| ..... . |||.|..|.| . . .|... .| . .|..| .| . | .. | . |. . |. . YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLN-HPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMD HC-------GFRF--PPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVN---VFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGV-EEVEQELKR . . .| .. . ... | .|.....|..|..|||.||.|. .. . |. .|.| |||||. . . . .. LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------------CVKICDFGLAKQFDY-NNS-MTT CVGTPHYMAPETFSHLC-DCDVPAACDVWSLGVTLFRLATGVFPVFDQ------D .|||.||||| . . . . ..|.||.|..|. ...| .| .. | FCGTPWYMAPEV---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHD |
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| Kinase | LmjF20.1340.AA | S_TKc | 46-359 | 18 | 1.2e-25 | 92.41 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 46-359 Range on HMM: 1-231/231 Sequence Identity: 18% (64 aa) WTPQR-LGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAGVSPHVVPMYKPWFDCREGVIALPMDAGDF---SLEQ .. | .| |.||.| ... .. |. |.|.|. . . ||...... |..| .| . | . . . |. | .| . YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFD YAVHCGFR-----FPPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQELKRCVGTP | ...| . ||. ....| ..|....|..|..|||.||.| .. . | |||||. . . ..||| YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL-------TTFCGTP HYMAPETFSHLCDCDVPA-ACDVWSLGVTLFRLATGVFPVFDQDVTASWPPASASSARLGVPACDHRGRALSSGAPRRGDCGRIDACRESTPPPNYGKRS .||||| . .||.||.|..|. ...| | |. . | WYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------------------------------------S TAAA-------GHRRDSRAGAAERLV---P---HPPN | . | .| | | || PEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | LmjF20.1340.AA | CAMK | 165-274 | 23 | 3.7e-25 | 77.41 | In-house | 191-333 (425) | Show / Hide |
Range on Protein: 165-274 Range on HMM: 191-333/425 Sequence Identity: 23% (37 aa) AVAHLHRRGVVHRDVKPDNFVVN-------------VFDTVGGAGAGGDGDCGEARPPF-VRILDFGLACGVEEVE-----------------------Q ||...| ...|||| ||.| .. .|| . . | |||.|. ... | | AVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD----------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ ELKRCVGTPHYMA-PETFSHLC-----------DCDVPAACDVWSLGVTLFRLATGVFP .| ..|||.||| || .. .. .||.||.|| |. . .| .| KMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP |
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| Kinase | LmjF20.1340.AA | AGC | 158-279 | 17 | 9.7e-25 | 59.51 | In-house | 151-309 (395) | Show / Hide |
Range on Protein: 158-279
Range on HMM: 151-309/395
Sequence Identity: 17% (33 aa)
MCAQ-------CARAVAHLHR-RGVVHRD-VKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVE-------------------------
..|. . |. .||. .|..||| .||.| . . ... ||||.. .
YAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-------------------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKS
-------------------------EVEQELKRCVG--TPHYMAPETFSHLCDCDVPAACDVWS--LGVTLFRLATGVFPVFDQD
. .. . .| ||.||||| . ||| || ||. .. . || | ....
NMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-------YGKACDWWSFGLGCLMYEMLTGYPPFYGDN
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| Kinase | LmjF20.1340.AA | CAMK-Unique | 159-274 | 26 | 5e-22 | 69.32 | In-house | 163-292 (363) | Show / Hide |
Range on Protein: 159-274 Range on HMM: 163-292/363 Sequence Identity: 26% (36 aa) CAQCARAVAHLHRRGVVHRDVKPDNFVVNVF--DTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQE--LKRCVGTPHYMAP------------- ... . |||..| ..|||| |..| .|. | .| . . . .. ..||||.| ..... . .. .||| |||| MQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN----HHRDFPYDWSN-WHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTR -ETFS-HLCDCDVPAACDVWSLGVTLFRLATGVFP |. . |. . | | |||||... ...| | DEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPP |
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| Kinase | LmjF20.1340.AA | CAMKL | 165-274 | 29 | 2.5e-20 | 61.44 | In-house | 139-235 (297) | Show / Hide |
Range on Protein: 165-274 Range on HMM: 139-235/297 Sequence Identity: 29% (34 aa) AVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEV----EQELKRCVGTPHYMAPETFSHLCDCDVPAACDVWS ||...|..|.|||| ||.| . . . | |||.. ... .| || . |.|.||||| |. . . |.|| AVNYCHSHGIVHRDIKPENILLDENGNN-----------------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWS LGVTLFRLATGVFP .||.|. . .| .| CGVILYAMVCGYLP |
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| Kinase | LmjF20.1340.AA | Ciliate-E2 | 165-274 | 22 | 1e-18 | 60.89 | In-house | 172-295 (365) | Show / Hide |
Range on Protein: 165-274 Range on HMM: 172-295/365 Sequence Identity: 22% (33 aa) AVAHLHRRG-VVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQE-------------------------------LKRC |. .|| .. ..||| ||.| .. . | ||||. . . .|. ... ALEYLHSKNNIIHRDIKPENILF------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTI VGTPHYMAPETFSHLC------DCDVPAACDVWSLGVTLFRLATGVFP .|||.||||| .. . .||.|||||.|... .| .| CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP |
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| Kinase | LmjF20.1340.AA | STE | 158-287 | 24 | 2.2e-18 | 61.6 | In-house | 156-281 (359) | Show / Hide |
Range on Protein: 158-287 Range on HMM: 156-281/359 Sequence Identity: 24% (37 aa) MCAQCARA-VAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEE----------------VEQELKRCVGTPHYMA .| |. .. ..||. ...|||.||.| . | . |||.. ... |. . .|||| .|| ICRQILKGLLYYLHSHHIIHRDIKPANILL------------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMA PETFSH-----LCDCDVPAACDVWSLGVTLFRLATGVFPVFD-QDVTASWPPA || . ..|. ||.|||| |. .||| | .| .. | .. . PEVIQQNGQGRDKGYDT--KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIP |
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| Kinase | LmjF20.1340.AA | TKL | 155-279 | 18 | 6.4e-16 | 53.81 | In-house | 134-293 (364) | Show / Hide |
Range on Protein: 155-279
Range on HMM: 134-293/364
Sequence Identity: 18% (32 aa)
LLSMCAQCARAVAHLHR--------RGVVHRDVKPDNFVVNVFDT------VGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQ-------------
..... ..||....|| ....||| |..| |. | . .. . .. | ||||. ... ..
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY-----------NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE
------ELKRCVGTPHYMAPETFSHLCD-------------CDVPAACDVWSLGVTLFRLATGVFPVFDQD
. ...||| .|||| . . . .|||.| |. |. ..|. | .|..
HQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
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| Kinase | LmjF20.1340.AA | CAMKK | 215-271 | 28 | 4.1e-15 | 43.98 | In-house | 242-322 (396) | Show / Hide |
Range on Protein: 215-271 Range on HMM: 242-322/396 Sequence Identity: 28% (23 aa) DFGLACGVEEVEQELKR-----------CVGTPHYMAPETFSHLCD--------------CDVPAACDVWSLGVTLFRLATG ||| .. .|. .|.|.. ..|||..|||| .| . .. . |.|.|.|||||. . .| DFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGK-AADIWALGVTLYCFVFG |
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| Kinase | LmjF20.1340.AA | CAMKK-Unclassified | 213-274 | 26 | 5.2e-15 | 45.05 | In-house | 245-332 (392) | Show / Hide |
Range on Protein: 213-274 Range on HMM: 245-332/392 Sequence Identity: 26% (23 aa) ILDFGLACGVEEVEQE-LKRCVGTPHYMAPETFSHLCDCDVPAA-------------------------CDVWSLGVTLFRLATGVFP | |||.. .| .|. || . ||...|||| .| . . . .|.||||||.. .... | IADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLP |
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| Kinase | LmjF20.1340.AA | RSK | 211-274 | 32 | 1.7e-09 | 31.24 | In-house | 146-211 (278) | Show / Hide |
Range on Protein: 211-274 Range on HMM: 146-211/278 Sequence Identity: 32% (22 aa) VRILDFGLACG-VEEVEQELKRCVGTPHYMAPETFS---HLCDCDVPAACDVWSLGVTLFRLATGVFP ... |||... . . .| .. ..| .||||| . . | .|||.||||| .. . || | IKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD--KACDWWSLGVLMYEMLTGCPP |
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| Kinase | LmjF20.1340.AA | TyrKc | 45-376 | 15 | 1.1e-07 | -98.46 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 45-376
Range on HMM: 1-280/280
Sequence Identity: 15% (60 aa)
IWTPQRLGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAG-VSPHVVPMYKPWFDCREGVIALP------------
| . || | ||.| .. .. ||| . . .| . || . .. | |..| .| ||. .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFM---REARIMCKLGGHHPNIVRLY--------GVCTQQGRNFMYIEPLMI
----MDAGDFS--LEQYAVHCGFRFPPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEV
|. || | . . ... |||.| | |. ..||.....||| | |. |.| ||||. ...
VMEYMPHGDLKDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------------TVKISDFGLSRDIYDD
-----EQELKRC---VGTP-----HYMAPETFSHLCDCDVPAACDVWSLGVTLFRLATGVFPVFDQDVTASWPPASASSARLGVPACDHRGRALS----S
... .| |. ||||.. . . . . |||| ||... . | . .. . |.. .. | . . . . . |
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTT--KSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMS
GAPRRGDCGRIDACRESTPPPNYGKRSTAAAGHRRDSRAGAAERLVPHPPNACVSPGCDGCCVR-----------RSAY
.. | . . |. . ..
---------------------------------------------FVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
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| Kinase | LmjF20.1340.AA | RSK | 160-183 | 54 | 3.7e-07 | 22.61 | In-house | 111-134 (278) | Show / Hide |
Range on Protein: 160-183 Range on HMM: 111-134/278 Sequence Identity: 54% (13 aa) AQCARAVAHLHRRGVVHRDVKPDN |. . || ||| .|..||| ||.| AEIVLAVEHLHQQGIIHRDLKPEN |
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| Kinase | LmjF20.1340.AA | CAMKK-Unclassified | 161-183 | 20 | 0.000119 | 10.73 | In-house | 186-229 (392) | Show / Hide |
Range on Protein: 161-183 Range on HMM: 186-229/392 Sequence Identity: 20% (9 aa) QCARAVAHLHRRG---------------------VVHRDVKPDN ||. .. .| .. ..||| ||.| QCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQN |
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| Kinase | LmjF20.1340.AA | Pkinase_Tyr | 149-179 | 32 | 0.000172 | 15.83 | Pfam | 107-137 (270) | Show / Hide |
Range on Protein: 149-179 Range on HMM: 107-137/270 Sequence Identity: 32% (10 aa) RFPPLALLSMCAQCARAVAHLHRRGVVHRDV .... ||.||.| |.. ..|.... .|||. PLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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| Kinase | LmjF20.1340.AA | CAMKK | 169-183 | 22 | 0.001072 | 7.11 | In-house | 192-226 (396) | Show / Hide |
Range on Protein: 169-183 Range on HMM: 192-226/396 Sequence Identity: 22% (8 aa) LH-RRG-------------------VVHRDVKPDN || .. ..||| ||.| LHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQN |
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| Kinase | LmjF20.1340.AA | STE | 46-83 | 25 | 0.003599 | 7.19 | In-house | 1-51 (359) | Show / Hide |
Range on Protein: 46-83 Range on HMM: 1-51/359 Sequence Identity: 25% (13 aa) WTP-QRLGAGSFGTVTLAYRH------EGDAV------WRKTAVKRISLRK |. ...| |.|||| .|..| . . | . |.|...|.. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLEN |
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| Kinase | LmjF20.1340.AA | CAMK | 50-64 | 53 | 0.019475 | 2.86 | In-house | 1-15 (425) | Show / Hide |
Range on Protein: 50-64 Range on HMM: 1-15/425 Sequence Identity: 53% (8 aa) RLGAGSFGTVTLAYR || ||||.| |... TLGRGSFGKVKLCIH |
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| Kinase | LmjF20.1340.AA | CAMKL | 44-62 | 52 | 0.108542 | 1.0 | In-house | 1-18 (297) | Show / Hide |
Range on Protein: 44-62 Range on HMM: 1-18/297 Sequence Identity: 52% (10 aa) YIWTPQRLGAGSFGTVTLA |. . || ||||.| || YRIGK-TLGKGSFGKVKLA |
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| Kinase | LmjF20.1340.AA | TKL | 51-80 | 27 | 0.144895 | 1.42 | In-house | 1-35 (364) | Show / Hide |
Range on Protein: 51-80 Range on HMM: 1-35/364 Sequence Identity: 27% (10 aa) LGAGSFGTVTLA-YRHEGDAVW-----RKTAVKRIS .| |.||.| . .| .| . . |||... IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFK |
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| Kinase | LmjF20.1340.AA | Pkinase_Tyr | 255-266 | 50 | 5.992044 | 0.45 | Pfam | 194-205 (270) | Show / Hide |
Range on Protein: 255-266 Range on HMM: 194-205/270 Sequence Identity: 50% (6 aa) ACDVWSLGVTLF . |||| ||... KSDVWSFGVLMW |
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