Gene LmjF20.1330 (L.major)

LmjF20.1330

Species: L.major
Alias: LmajK134, LmjF20.1330
External Links:
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
LmjF20.1330.AA Protein None 384 None Fasta, JSON
LmjF20.1330.kin_dom Protein Kinase Domain None 293 None Fasta, JSON

Protein domain

Protein domains of LmjF20.1330.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LmjF20.1330.AA S_TKc 60-360 21 4.7e-38 133.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 60-360
Range on HMM: 1-231/231
Sequence Identity: 21% (66 aa)

WTPQR-LGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAGVSPHVVPMYKPWFDCREGVIALPMDAGDF---SLEQ
..  | .| |.||.| ... ..     |. |.|.|.              . . ||......    |..| .|  . |   . . . |.  |    .| .
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFD

YAVHCGFR-----FPPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQELKRCVGTP
| ...| .     ||.    ....| ..|....|..|..|||.||.|  ..                       . | |||||. .       . ..|||
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL-------TTFCGTP

HYMAPETFSHLCDCDVPA-ACDVWSLGVTLFRLATGVFPVFEVDKTWQQPPFTELHSGKLWLPSRNLFHEPLSAESLAVLSVAASMLVLDPRCRPTADAA
.||||| .           .||.||.|..|. ...|  |           ... ..  .                |  ...    .|. ||. ||||  |
WYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EA

LL--QLQGFQEAF
|   ..    . |
LQDEWDIKCHPWF
Kinase LmjF20.1330.AA Pkinase 59-353 20 4.1e-31 111.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 59-353
Range on HMM: 1-293/293
Sequence Identity: 20% (67 aa)

IWTPQRLGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAGVSPHVVPMYKPWFDCREGVIALPMDAGDFSLEQYAV
. . ...|.||||.| .....       . |||.|..|.|     .    .   .|... .| . .|..| .|  . |  .. | . |.  .  |.  . 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRLN-HPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMD

HC-------GFRF--PPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVN---VFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGV-EEVEQELKR
 .       . .|  ..  . ... | .|.....|..|..|||.||.|. ..   . |.                  .|.| |||||. . .   . .. 
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------------CVKICDFGLAKQFDY-NNS-MTT

CVGTPHYMAPETFSHLC-DCDVPAACDVWSLGVTLFRLATGVFPVFEV---DKTWQQPPFTELHSGKLWLPSRNLFHEPL-------------SAESLAV
 .|||.|||||    .  . . . ..|.||.|..|. ...| .|  .    |.   |    ..  |. .  ..   ...               . | . 
FCGTPWYMAPEV---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

LSVAASMLVLDPRCRPTADAALLQ--L
...  ..| .|| .||||. .|    .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase LmjF20.1330.AA CAMK 179-288 23 3.7e-25 77.41 In-house 191-333 (425) Show / Hide 
Range on Protein: 179-288
Range on HMM: 191-333/425
Sequence Identity: 23% (37 aa)

AVAHLHRRGVVHRDVKPDNFVVN-------------VFDTVGGAGAGGDGDCGEARPPF-VRILDFGLACGVEEVE-----------------------Q
||...| ...|||| ||.|  ..             .||                   . . | |||.|. ... |                       |
AVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD----------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ

ELKRCVGTPHYMA-PETFSHLC-----------DCDVPAACDVWSLGVTLFRLATGVFP
 .| ..|||.||| || ..                 .. .||.||.|| |. . .| .|
KMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP
Kinase LmjF20.1330.AA AGC 172-288 18 3.7e-24 57.98 In-house 151-304 (395) Show / Hide 
Range on Protein: 172-288
Range on HMM: 151-304/395
Sequence Identity: 18% (33 aa)

MCAQ-------CARAVAHLHR-RGVVHRD-VKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVE-------------------------
..|.        . |. .||. .|..||| .||.| . .                       ... ||||.. .                          
YAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED-------------------GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKS

-------------------------EVEQELKRCVG--TPHYMAPETFSHLCDCDVPAACDVWS--LGVTLFRLATGVFP
                         . ..  .  .|  ||.||||| .          ||| ||  ||. .. . ||  |
NMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-------YGKACDWWSFGLGCLMYEMLTGYPP
Kinase LmjF20.1330.AA CAMK-Unique 173-288 26 5e-22 69.32 In-house 163-292 (363) Show / Hide 
Range on Protein: 173-288
Range on HMM: 163-292/363
Sequence Identity: 26% (36 aa)

CAQCARAVAHLHRRGVVHRDVKPDNFVVNVF--DTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQE--LKRCVGTPHYMAP-------------
... . |||..|  ..|||| |..| .|.    |        .| .  . .  .. ..||||.| ..... .  ..  .||| ||||             
MQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN----HHRDFPYDWSN-WHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTR

-ETFS-HLCDCDVPAACDVWSLGVTLFRLATGVFP
 |.   .  |. .  | | |||||... ...|  |
DEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPP
Kinase LmjF20.1330.AA CAMKL 179-288 29 2.5e-20 61.44 In-house 139-235 (297) Show / Hide 
Range on Protein: 179-288
Range on HMM: 139-235/297
Sequence Identity: 29% (34 aa)

AVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEV----EQELKRCVGTPHYMAPETFSHLCDCDVPAACDVWS
||...|..|.|||| ||.|  .   .                    . | |||..   ...    .| || . |.|.||||| |.   .     . |.||
AVNYCHSHGIVHRDIKPENILLDENGNN-----------------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWS

LGVTLFRLATGVFP
.||.|. . .| .|
CGVILYAMVCGYLP
Kinase LmjF20.1330.AA Ciliate-E2 179-288 22 1e-18 60.89 In-house 172-295 (365) Show / Hide 
Range on Protein: 179-288
Range on HMM: 172-295/365
Sequence Identity: 22% (33 aa)

AVAHLHRRG-VVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQE-------------------------------LKRC
|. .|| .. ..||| ||.| ..                        . | ||||.  . . .|.                                ...
ALEYLHSKNNIIHRDIKPENILF------------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTI

VGTPHYMAPETFSHLC------DCDVPAACDVWSLGVTLFRLATGVFP
.|||.||||| ..           .   .||.|||||.|... .| .|
CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
Kinase LmjF20.1330.AA STE 172-291 24 5.5e-18 60.2 In-house 156-270 (359) Show / Hide 
Range on Protein: 172-291
Range on HMM: 156-270/359
Sequence Identity: 24% (35 aa)

MCAQCARA-VAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEE----------------VEQELKRCVGTPHYMA
.| |. ..  ..||. ...|||.||.|  .                        | . |||..  ...                  |. . .|||| .||
ICRQILKGLLYYLHSHHIIHRDIKPANILL------------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMA

PETFSH-----LCDCDVPAACDVWSLGVTLFRLATGVFPVFE
||  .        ..|.   ||.|||| |.  .|||  | ..
PEVIQQNGQGRDKGYDT--KCDIWSLGCTIIEMATGKPPWHD
Kinase LmjF20.1330.AA TKL 169-293 18 1.3e-15 52.66 In-house 134-293 (364) Show / Hide 
Range on Protein: 169-293
Range on HMM: 134-293/364
Sequence Identity: 18% (31 aa)

LLSMCAQCARAVAHLHR--------RGVVHRDVKPDNFVVNVFDT------VGGAGAGGDGDCGEARPPFVRILDFGLACGVEEVEQ-------------
..... ..||....||         ....||| |..|  |.   |      .            .. . .. | ||||.  ... ..             
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMY-----------NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAE

------ELKRCVGTPHYMAPETFSHLCD-------------CDVPAACDVWSLGVTLFRLATGVFPVFEVD
       . ...||| .|||| .    .              .   .|||.| |. |. ..|.  | .. .
HQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
Kinase LmjF20.1330.AA CAMKK 229-285 28 4.1e-15 43.98 In-house 242-322 (396) Show / Hide 
Range on Protein: 229-285
Range on HMM: 242-322/396
Sequence Identity: 28% (23 aa)

DFGLACGVEEVEQELKR-----------CVGTPHYMAPETFSHLCD--------------CDVPAACDVWSLGVTLFRLATG
||| .. .|. .|.|..           ..|||..|||| .|   .              .. . |.|.|.|||||. . .|
DFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRFIYCGK-AADIWALGVTLYCFVFG
Kinase LmjF20.1330.AA CAMKK-Unclassified 227-288 26 5.2e-15 45.05 In-house 245-332 (392) Show / Hide 
Range on Protein: 227-288
Range on HMM: 245-332/392
Sequence Identity: 26% (23 aa)

ILDFGLACGVEEVEQE-LKRCVGTPHYMAPETFSHLCDCDVPAA-------------------------CDVWSLGVTLFRLATGVFP
| |||..  .|  .|. || . ||...|||| .|   .   . .                         .|.||||||.. ....  |
IADFGISVIMEHEQQKKLKNNAGTYCFMAPEFWSKENFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLP
Kinase LmjF20.1330.AA TyrKc 59-353 18 5.5e-10 -61.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 59-353
Range on HMM: 1-280/280
Sequence Identity: 18% (62 aa)

IWTPQRLGAGSFGTVTLAYRHEGDAVWRKTAVKRISLRKETRLSAVLEKVRCTGREVALCRRAG-VSPHVVPMYKPWFDCREGVIALP------------
|   . || | ||.| ..         .. ||| .   .       .|  .   ||  . .. |   |..| .|        ||.  .            
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFM---REARIMCKLGGHHPNIVRLY--------GVCTQQGRNFMYIEPLMI

----MDAGDFS--LEQYAVHCGFRFPPLALLSMCAQCARAVAHLHRRGVVHRDVKPDNFVVNVFDTVGGAGAGGDGDCGEARPPFVRILDFGLACGVEEV
    |. ||    |  .  .    ...  |||.| | |.  ..||.....|||    |  |.                       |.| ||||.  ... 
VMEYMPHGDLKDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------------TVKISDFGLSRDIYDD

-----EQELKRC---VGTP-----HYMAPETFSHLCDCDVPAACDVWSLGVTLFRLATGVFPVFEVD----KTWQQPPFTELHSGKLWLPSRNLFHEPL-
     ... .|     |.        ||||.. . . .    . |||| ||... . |   .  . .    ...|.      . . .  |  ..  . . 
DQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-FTT--KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS

---SAESLAVLSVAASMLVLDPRCRPTADAALLQL
     . .    .  .    || .|||  .   ..
FVCCPDEMYQ--IMKQCWHEDPEDRPTFSEIHECF
Kinase LmjF20.1330.AA RSK 225-288 32 1.7e-09 31.24 In-house 146-211 (278) Show / Hide 
Range on Protein: 225-288
Range on HMM: 146-211/278
Sequence Identity: 32% (22 aa)

VRILDFGLACG-VEEVEQELKRCVGTPHYMAPETFS---HLCDCDVPAACDVWSLGVTLFRLATGVFP
... |||...  . . .| ..  ..| .|||||      . .  |  .|||.||||| .. . ||  |
IKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD--KACDWWSLGVLMYEMLTGCPP
Kinase LmjF20.1330.AA RSK 174-197 54 3.7e-07 22.61 In-house 111-134 (278) Show / Hide 
Range on Protein: 174-197
Range on HMM: 111-134/278
Sequence Identity: 54% (13 aa)

AQCARAVAHLHRRGVVHRDVKPDN
|. . || ||| .|..||| ||.|
AEIVLAVEHLHQQGIIHRDLKPEN
Kinase LmjF20.1330.AA CAMKK-Unclassified 175-197 20 0.000119 10.73 In-house 186-229 (392) Show / Hide 
Range on Protein: 175-197
Range on HMM: 186-229/392
Sequence Identity: 20% (9 aa)

QCARAVAHLHRRG---------------------VVHRDVKPDN
||. ..  .| ..                     ..||| ||.|
QCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQN
Kinase LmjF20.1330.AA Pkinase_Tyr 163-193 32 0.000172 15.83 Pfam 107-137 (270) Show / Hide 
Range on Protein: 163-193
Range on HMM: 107-137/270
Sequence Identity: 32% (10 aa)

RFPPLALLSMCAQCARAVAHLHRRGVVHRDV
....  ||.||.| |.. ..|.... .|||.
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase LmjF20.1330.AA CAMKK 183-197 22 0.001072 7.11 In-house 192-226 (396) Show / Hide 
Range on Protein: 183-197
Range on HMM: 192-226/396
Sequence Identity: 22% (8 aa)

LH-RRG-------------------VVHRDVKPDN
||  ..                   ..||| ||.|
LHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQN
Kinase LmjF20.1330.AA STE 60-97 25 0.003599 7.19 In-house 1-51 (359) Show / Hide 
Range on Protein: 60-97
Range on HMM: 1-51/359
Sequence Identity: 25% (13 aa)

WTP-QRLGAGSFGTVTLAYRH------EGDAV------WRKTAVKRISLRK
|.  ...| |.|||| .|..|      . . |       .  |.|...|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLEN
Kinase LmjF20.1330.AA CAMK 64-78 53 0.019475 2.86 In-house 1-15 (425) Show / Hide 
Range on Protein: 64-78
Range on HMM: 1-15/425
Sequence Identity: 53% (8 aa)

RLGAGSFGTVTLAYR
 || ||||.| |...
TLGRGSFGKVKLCIH
Kinase LmjF20.1330.AA CAMKL 58-76 52 0.108542 1.0 In-house 1-18 (297) Show / Hide 
Range on Protein: 58-76
Range on HMM: 1-18/297
Sequence Identity: 52% (10 aa)

YIWTPQRLGAGSFGTVTLA
|.  .  || ||||.| ||
YRIGK-TLGKGSFGKVKLA
Kinase LmjF20.1330.AA TKL 65-94 27 0.144895 1.42 In-house 1-35 (364) Show / Hide 
Range on Protein: 65-94
Range on HMM: 1-35/364
Sequence Identity: 27% (10 aa)

LGAGSFGTVTLA-YRHEGDAVW-----RKTAVKRIS
.| |.||.|  . .| .|  .      .  |||...
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFK
Kinase LmjF20.1330.AA Pkinase_Tyr 269-280 50 5.992044 0.45 Pfam 194-205 (270) Show / Hide 
Range on Protein: 269-280
Range on HMM: 194-205/270
Sequence Identity: 50% (6 aa)

ACDVWSLGVTLF
. |||| ||...
KSDVWSFGVLMW