Gene LmjF28.3000 (L.major)
LmjF28.3000
Species: L.major
Alias: LmajK116, LmjF28.3000
External Links:
Annotation:
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| LmjF28.3000.AA | Protein | None | 387 | None | Fasta, JSON |
| LmjF28.3000.kin_dom | Protein Kinase Domain | None | 258 | None | Fasta, JSON |
Protein domains of LmjF28.3000.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | LmjF28.3000.AA | S_TKc | 13-270 | 24 | 3.4e-59 | 203.89 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-270 Range on HMM: 1-231/231 Sequence Identity: 24% (68 aa) LRFVGFLGCGAFGDAYVVRDAS-DTCFVVKRSKSLVKQSGFLEEYLGMMNLCSLNVVTSHDAWIDHESRVCILMDYCDA--GDLGDYLKKGYP------L ... .| |||| | .|. . . . .|. | .. | ... |.|. .|.. | ..... |.||| ||| ||.|| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVAKLGDFGSVKRLSRCGARVVSRVGTPLYLAPEIISGYAYTS-KADIWSMGLV || .. ....|....|...|... .|||.|||||.|.. . |..|||. ..| . .||| |.|||.. |. |.|.|| | . PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI VYRLMVNNSPFRVTSVDTHTRCVLRLSPPHPSTLSGYSRALGDCVMAMLSRNWKRRPNAEALLR-------CDLF .| ... ||. . . ... |. . | .. .| .. ..|| | .|. | LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Pkinase | LmjF28.3000.AA | Pkinase | 13-270 | 24 | 3.4e-49 | 174.57 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 13-270 Range on HMM: 1-293/293 Sequence Identity: 24% (75 aa) LRFVGFLGCGAFGDAYVVRDASDTC-FVVKRSKSLVKQSGFLE------EYLGMMNLCSLNVVTSHDAWIDHESRVCILMDYCDAG----DLGDYLK--K ..... .| |.|| | .. .. . ..||. | . |.... | | .|.. |.|. .|.. | ...... |.||. | || ||.. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR GYPL--PEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVA----KLGDFGSVKRL-SRCGARVVSRVGTPLYLAPEIIS-GYAYT . .. .|.|. ... |.| ||...|... .|||.|||||.... .. |..|||. | . . ...||| |.|||.| | |. HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN-------GHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG SKADIWSMGLVVYRLMVNNSPFRVT------SVDTHTRCVLR--LSPPHPSTLSGY----------------SRALGDCVMAMLSRNWKRRPNAEALLRC .|.|.||.|...| .. . ||. . . . ... |. . | . |.. |... | . .| .. |.||.|| .| PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH DLF . | PWF |
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| Kinase | LmjF28.3000.AA | NEK | 66-207 | 34 | 3.7e-44 | 153.02 | In-house | 65-218 (286) | Show / Hide |
Range on Protein: 66-207 Range on HMM: 65-218/286 Sequence Identity: 34% (54 aa) NVVTSHDAWIDHES-RVCILMDYCD-AGDLGDY---LKKGY----PLPEEEVLSIVAQLLLGLDHIHKR-----NRVHRDIKPENIFLSSARTGGGRWPV |.|. .|..|.... . || |.||. ||| . .||. ...||... . .|..|.|...|.| . .|||||| ||||.. ... .. NIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDY---HN AKLGDFGSVKRLSRCGARVVS-RVGTPLYLAPEIISGYAYTSKADIWSMGLVVYRLM .|.|||| | |.. . |||| |..||.... |..|.|||| | |.| .. VKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMC |
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| Kinase | LmjF28.3000.AA | Ciliate-E2 | 66-270 | 20 | 1.5e-43 | 147.4 | In-house | 93-365 (365) | Show / Hide |
Range on Protein: 66-270 Range on HMM: 93-365/365 Sequence Identity: 20% (61 aa) NVVTSHDAWID-HESRVCILMDYCDAGDLGDYLK------------KGYPLPEEEVLSIVAQLLL---------------GLDHIHKRN-RVHRDIKPEN |.. ...... .. . . |.||. ||| ||.| . .. |.|.. | .|.| .| ..|..| .|||||||| NIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN IFLSSARTGGGRWPVAKLGDFGSVKRL----------SRCGARVVSR----------------------VGTPLYLAPEIIS---------GYAYTSKAD |.. |. ||| |.. ..|. . .||| |.||||.. . |. |.| ILF------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD IWSMGLVVYRLMVNNSPFRVTSVDTHTRCVLRLSPPHPS-----------TLSGYSRALGDCVMA----MLSRNWKRRPN-AEALLRCDLF |||.| . |... .. || . . | .....|.. | | || .. . |.. .| .| | IWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | LmjF28.3000.AA | STE | 13-270 | 20 | 5.4e-42 | 145.84 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 13-270
Range on HMM: 1-359/359
Sequence Identity: 20% (75 aa)
LRFVGFLGCGAFGDAYVVRDA----------------SDTCFVVKRSK----------------SLV---KQSGFLEEYLGMMNLC--SLNVVTSHDAWI
.......| |||| | .. . . . .|. . . . .. .|.| |... . |.|. ... .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
DH------ESRVCILMDYCDAGDLGDYLKKGY--------------PLPEEEVLSIVAQLLLG-LDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVAKL
. .. ..| | |.|.| | | .|. | ..||... |. |.| | |...|. ...|||||| ||.| .||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------------VKL
GDFGSVKRLSRCGA----------------RVVSRVGTPLYLAPEIISG------YAYTSKADIWSMGLVV------YRLMVNNSPFRV-TSVDTHTRCV
||| ..|. .| . . |||| . |||.|.. |. |.|||| |... . . .|.|. . ....
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ
L---------RLSPPHPSTLS----------------GYSRALGDCVMAMLSRNWKRRPNAEALLR--CDLF
.|| |..|| .| . | . | .. . ||.|. ||. .
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | LmjF28.3000.AA | CAMK | 18-270 | 16 | 1.8e-39 | 124.37 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 18-270
Range on HMM: 1-425/425
Sequence Identity: 16% (69 aa)
FLGCGAFGDAYVVRDASDTC-------------FVVKR-SKS-----------------------------LVKQSGFLEEYLGMMN-------LCSLNV
|| |.|| . ... ..|. . .| .|. ... .. |. |.. | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VTSHDAWIDH------------------ESRVCILM---DYCDAG----DLGDYLKKG---------------YPLPEEEVLSIVAQLLLGLDHIHKRNR
. .... |. ...... | .||. | || ||... ..|.|. .. |.. .....|..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
VHRDIKPENIFLSSARTGGGRWP-----------VAKLGDFGSVKRLSR-----------------------CGARVVSRVGTPLYLA-PEIISG-----
||||.||||| |.. .. . . |. ||| ... . | ..||| | | ||...|
VHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
---------YAYTSKADIWSMGLVVYRLMVNNSPFRVTSVD-----------------THTRCVLRLSPPHPSTLS-----------------GYSRALG
|. |.|.||.| . | . . .||. . . ... . ||. |..| |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DCVMAMLSRNWKRRPNAEALLRCDLF
| . || .. ..|...| |. .
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | LmjF28.3000.AA | NEK1 | 83-207 | 38 | 1.7e-34 | 117.15 | In-house | 77-215 (276) | Show / Hide |
Range on Protein: 83-207
Range on HMM: 77-215/276
Sequence Identity: 38% (54 aa)
ILMDYCDAGDLGDYLK----KGYPLPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTG----------GGRWPVAKLGDFGSVKRLSRCGA
| |.|||.||| . || . .| . .. |. |.| |||.|. |||||. ||||.. . | |..||||||. . |. .
IVMEYCDGGDLMQKINRQKRKGKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTME
RVVSRVGTPLYLAPEIISGYAYTSKADIWSMGLVVYRLM
.||| || |||. |. | |||| | | | |.
YACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELC
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| Kinase | LmjF28.3000.AA | ULK | 85-214 | 31 | 2.9e-34 | 117.05 | In-house | 99-257 (329) | Show / Hide |
Range on Protein: 85-214
Range on HMM: 99-257/329
Sequence Identity: 31% (51 aa)
MDYCDAGDLGDYLKKGYP----------LPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSS-----ARTGGGRW----PVAKLGDFGSVKRLSR
|.||. ||| .|.|| . |.|.|.... |.| |. ..||.| .||||||.|| .. .. .|.|..||| | ..
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK----KVHPNGVLKIADFGFAKHVDN
C---GARVVSRV------GTPLYLAPEIIS----GYAYT-SKADIWSMGLVVYRLMVNNSPFR
. .. | ||||| ||.|.. . |. .|.||||.| . | . .. ||.
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY
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| Kinase | LmjF28.3000.AA | CAMKL | 75-270 | 26 | 2.4e-33 | 103.69 | In-house | 84-297 (297) | Show / Hide |
Range on Protein: 75-270 Range on HMM: 84-297/297 Sequence Identity: 26% (59 aa) IDHESR------VCILMDYCDAGD--LGDYLK-KGY---PLPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVAKLGDFGSVKR |. .. ... | ||. |. | ||.. .|. ..||.| . |.. .....|... |||||||||| |.. ..|. ||| IETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-----NIKIIDFGFSNM LSRC----GARVVSRVGTPLYLAPEIISG--YAYT-SKADIWSMGLVVYRLMVNNSPFRVTSVD---------THTRCVLRLSPPHPSTLSGYSRALGDC .| | . |.| | ||||..| | |.||||.| . | ... . ||. .. . .. ||... .| | | YRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDL--- VMAMLSRNWKRRPNAEALLRCDLF || .| ..||... ... . IRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | LmjF28.3000.AA | ULK | 85-204 | 31 | 3.3e-33 | 115.2 | In-house | 96-243 (324) | Show / Hide |
Range on Protein: 85-204 Range on HMM: 96-243/324 Sequence Identity: 31% (48 aa) MDYCDAGDLGDYLKKGYP---------LPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSS-----ARTGGGRW----PVAKLGDFGSVKRLSRC |.||. ||| .|.|| . |.|.|.... |.. |. ..||.| .||||||.|| .. .. .|.|..||| | . MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK----KVHPNGVLKIADFGFAKHVDNN G---ARVVSRV------GTPLYLAPEIIS----GYAYT-SKADIWSMGLVVY . . | ||||| ||.|.. . |. .|.||||.| . | NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFY |
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| Kinase | LmjF28.3000.AA | Ciliate-E2-Unclassified | 85-213 | 28 | 1.6e-32 | 110.17 | In-house | 100-270 (352) | Show / Hide |
Range on Protein: 85-213 Range on HMM: 100-270/352 Sequence Identity: 28% (49 aa) MDYCDAGDLGDYLKK-----------------GYPLPEEEVL-----SIVAQLLLGLDHIHKRN-RVHRDIKPENIFLSSARTGGGRWPVAKLGDFGSVK |.||. ||| .|.|| . ..|.... . ||.|.||...|. | .|||||||||.... |. |||. | MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK----NYYIKIIDFGISK RLSRC---------------GARVVSRVGTPLYL----APEIISGYAYT----SKADIWSMGLVVYRLMVNNSPF .. . . ...||| |. |||.. | | |.||||.| . | .. .. || KYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF |
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| Kinase | LmjF28.3000.AA | STE7-Unclassified | 66-202 | 31 | 5.5e-26 | 88.58 | In-house | 66-214 (301) | Show / Hide |
Range on Protein: 66-202 Range on HMM: 66-214/301 Sequence Identity: 31% (49 aa) NVVTSHDAWIDHES--RVCILMDYCDAGDLG---DYLKKGY--------PLPEEEVLSIVAQLLLGLDHIHKRN-RVHRDIKPENIFLSSARTGGGRWPV ..|. ..| .. .. . |.| | | |.| | .||.| ..|| . .|. |.. ||...|.. .||||||.|| ..| | YIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKIDIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNS--KG-----Q AKLGDFGSVKRLSRCGARVVSRVGTPLYLAPEIISGY-----AYTSKADIWSMGLV .|. ||| ..| ... ||. | .||.|.| .|. | |||| ||. VKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRPSYSVKSDIWSLGLT |
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| Kinase | LmjF28.3000.AA | TyrKc | 13-270 | 20 | 7.6e-13 | -14.96 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-270 Range on HMM: 1-280/280 Sequence Identity: 20% (60 aa) LRFVGFLGCGAFGD---AYVVRDASDTCFV-VKRSKSLVKQSGFLEEYLGMMNL--CSLNVVTSHDAWIDHE------SRVCILMDYCDAGDLGDYLKKG ... ||.|||| . | || |. . |..| |..| |.| . . .... ..|.| |.. ||| |||.| ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH YP-LPEEEVLSIVAQLLLGLDHIHKRNRVHRDIKPENIFLSSARTGGGRWPVAKLGDFGSVKRLSRC------GARVVSRV--GTP--L---YLAPEIIS | |. .. ||. | | ...|..| .|||. |. ... . ..| .||| . . . ... |. | .||| | RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN GYAYTSKADIWSMGLVVYRLMVNNSPFR-------VTSVDTHTRCVLRLSPPHPST----LSGYSRALGDCVMAMLS---RNWKRRPNAEALLRCDLF . .|.| |.|| | . . .. . . .. . . . . .| | . .. . . |.. .. . ||. ... ...| YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | LmjF28.3000.AA | Pkinase_Tyr | 76-132 | 31 | 2e-06 | 22.38 | Pfam | 75-137 (270) | Show / Hide |
Range on Protein: 76-132 Range on HMM: 75-137/270 Sequence Identity: 31% (20 aa) DHESR--VCILMDYCDAGDLGDYLKK----GYPLPEEEVLSIVAQLLLGLDHIHKRNRVHRDI |.. ..| | |. ||| |||.| . ||. .. |.. .| |... . .| .|||. DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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| Kinase | LmjF28.3000.AA | Pkinase_Tyr | 180-198 | 47 | 0.085558 | 6.7 | Pfam | 181-199 (270) | Show / Hide |
Range on Protein: 180-198 Range on HMM: 181-199/270 Sequence Identity: 47% (9 aa) LAPEIISGYAYTSKADIWS .||| |. . .|.| |.|| MAPECINYGKFTTKSDVWS |
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| Kinase | LmjF28.3000.AA | STE7-Unclassified | 13-31 | 26 | 0.20425 | 0.88 | In-house | 1-19 (301) | Show / Hide |
Range on Protein: 13-31 Range on HMM: 1-19/301 Sequence Identity: 26% (5 aa) LRFVGFLGCGAFGDAYVVR |.... || |..| .. .. LERLKYLGHGMHGTVVKCL |
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| Kinase | LmjF28.3000.AA | NEK1 | 237-270 | 29 | 0.28914 | 0.35 | In-house | 243-276 (276) | Show / Hide |
Range on Protein: 237-270 Range on HMM: 243-276/276 Sequence Identity: 29% (10 aa) SGYSRALGDCVMAMLSRNWKRRPNAEALLRCDLF . ||. | | |..|| . || . ..| PHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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