Gene LmjF24.0670 (L.major)
LmjF24.0670
Species: L.major
Alias: LmajK065, LmjF24.0670
External Links:
Annotation:
Group:
CMGC
Family:
CMGC-Unique
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| LmjF24.0670.AA | Protein | None | 1163 | None | Fasta, JSON |
| LmjF24.0670.kin_dom | Protein Kinase Domain | None | 289 | None | Fasta, JSON |
Protein domains of LmjF24.0670.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | LmjF24.0670.AA | CMGC | 178-289 | 19 | 5.1e-28 | 88.39 | In-house | 288-513 (513) | Show / Hide |
Range on Protein: 178-289 Range on HMM: 288-513/513 Sequence Identity: 19% (45 aa) TLHYRSPEQLMGKR-----SVVSENFAAVDLWGLGCTLYEMVTG--------TRPFPGSSE-----------LQVLMSILDALG---------------- |..||.|| |.| . . . ..| |..|| ..||.|| |||.|| . | | . || TRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFC --SD----------------------------------IQS---FPVATKH--ATLFDKIP---------------------------------ASPAFV .. ||| || .. || ..| ..| .. KHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAI DLLQRLLCLDPTRRCTAKEALHHSFL |||...|..||..| ||..|| | .. DLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | LmjF24.0670.AA | CDK | 178-289 | 32 | 5.2e-26 | 80.06 | In-house | 182-284 (284) | Show / Hide |
Range on Protein: 178-289 Range on HMM: 182-284/284 Sequence Identity: 32% (39 aa) TLHYRSPEQLMGKRSVVSENF---AAVDLWGLGCTLYEMVT---GTRPFPGSSELQVLMSILDALGS-DIQSFPVATKHATLFDKIPASPAFVDLLQRLL || ||.|| |.| |.. ..|.|..|| ..||.| . |||.||. | | . .|. . .. | || |||...| TLWYRAPELLLG-----SKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------DLLNKML CLDPTRRCTAKEALHHSFL |.||..|..|..||.| .. CYDPKKRISAEQALQHPYF |
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| Kinase | LmjF24.0670.AA | Pkinase | 177-289 | 27 | 1.9e-22 | 80.48 | Pfam | 173-293 (293) | Show / Hide |
Range on Protein: 177-289 Range on HMM: 173-293/293 Sequence Identity: 27% (36 aa) GTLHYRSPEQLMGKRSVVSENFAAVDLWGLGCTLYEMVTGTRPFPGS------SELQVLMSILD-ALGSDIQSF----------PVATKHATLFDKIPAS ||..|..|| .. .. .|| |..||.||||..| ||||. ...|.. |.. | .|.. . .. | |. ... | GTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-HF-HWTF-HNW--S PAFVDLLQRLLCLDPTRRCTAKEALHHSFL ... |.. ..||.||..|.||...|.| .. EECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| S_TKc | LmjF24.0670.AA | S_TKc | 1-289 | 18 | 5e-22 | 80.42 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-289
Range on HMM: 19-231/231
Sequence Identity: 18% (60 aa)
MD------------------EVSVLNYLGPHPQIVRFLGSYTTSKNTSFFTMELMDS---DVGRELREGNA----TLHEEGVCAAVAYSVLLALEQMHSH
. |...| || ||...... . . .. ||..| |. . ... . | ... ..| ...||| .|||
RHKKTGRIVAIKIIKEHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH
AVAHRDVKPGNILLKRLSEPEE-------WACIYLPRDDISARLLPKSSIVSAFDPTLCTSKEASSREVVPGIRSRDDSASYAKAALGDFSAAHSTHCAD
. |||.|| |||| . . |...
GIIHRDLKPENILLDE-----HIKICDFGLARQL------------------------------------------------------------------
DVAFFDTRGTLHYRSPEQLMGKRSVVSENFAAVDLWGLGCTLYEMVTGTRPFPGSSELQVLMSILDALGSDIQSFPVATKHATLFDKIPASPAFVDLLQR
||..|..|| | . .....| | .||.||||..| ||| ..|... .. || . |....
----TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------------------SPEAKDFIRK
LLCLDPTRRCTAKEALH-------HSFL
.|. ||..| || |||. | ..
CLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | LmjF24.0670.AA | AGC | 177-289 | 26 | 9.6e-22 | 51.59 | In-house | 267-395 (395) | Show / Hide |
Range on Protein: 177-289 Range on HMM: 267-395/395 Sequence Identity: 26% (37 aa) G--TLHYRSPEQLMGKRSVVSENFAAVDLWG--LGCTLYEMVTGTRPFPGSS----------ELQVLMSILDAL--GSDIQSFPVATKHATLFDK-IPAS | | .| .|| | |.| |. ||| .|||.|| || | . . .. .|.. .. . || . |.. | GPCTPEYMAPEIL---------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDP--QFPEDRWFS PAFVDLLQRLLCLDPTRRCT----------AKEALHHSFL | .||...||| ||..| . |.| | . PEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | LmjF24.0670.AA | STE | 1-89 | 24 | 1.6e-15 | 51.34 | In-house | 76-185 (359) | Show / Hide |
Range on Protein: 1-89 Range on HMM: 76-185/359 Sequence Identity: 24% (27 aa) MDEVSVLNYLGP-HPQIVRFLGSYTTS------KNTSFFTMELMD-SDVGRELREGNATLHE------------EGVCAAVAYSVLLA-LEQMHSHAVAH . |..... . . || ||...|.| ... . ||.|| . ... .. . | . |......| . |. ||| . | LKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIH RDVKPGNILL ||.||.|||| RDIKPANILL |
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| Kinase | LmjF24.0670.AA | Ciliate-E2 | 172-289 | 25 | 4.4e-15 | 48.21 | In-house | 244-365 (365) | Show / Hide |
Range on Protein: 172-289 Range on HMM: 244-365/365 Sequence Identity: 25% (34 aa) FFDTRGTLHYRSPEQLMGKRSVVSENF----AAVDLWGLGCTLYEMVTGTRPFPGSSELQVLMSILDALGSDIQ-SFPVATKHATLFDK-------IPAS |. . ||..| .|| |.|| ... ..|.| ||..||||..| .|| . . .|. ..| .|. |. .. | FNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWS PAFVDLLQR----LLCLDPTRRCT-AKEALHHSFL . ||... .|. || | | ....| | .. QECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | LmjF24.0670.AA | Pkinase | 3-91 | 27 | 7.2e-14 | 50.13 | Pfam | 50-143 (293) | Show / Hide |
Range on Protein: 3-91 Range on HMM: 50-143/293 Sequence Identity: 27% (27 aa) EVSVLNYLGPHPQIVRFLGSYTTSKNTSFFTMELMDS-----DVGRELR---EGNATLHEEGVCAAVAYSVLLALEQMHSHAVAHRDVKPGNILLKR |..... | || |||.......... . ||... | . .. .|. . .| .| ..| .| .|| .||. . |||.|| |||... EIQIMKRL-NHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDN |
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| Kinase | LmjF24.0670.AA | CMGC | 2-89 | 17 | 1.2e-13 | 40.33 | In-house | 70-217 (513) | Show / Hide |
Range on Protein: 2-89
Range on HMM: 70-217/513
Sequence Identity: 17% (26 aa)
DEVSVLNYLG---------------PHPQ-IVRFLGSYTTSK----------------NTSFFTMELMDSDVGRELREGN-------ATLHEEGV-----
.|.. | .| .|. ||. . ...... | .. .|.|| | . ... . .| .
REIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHP
-------CAAVA------YSVLLALE--QMHSHA--VAHRDVKPGNILL
. | .| .|. .||| . ||| || |||.
HRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILI
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| Kinase | LmjF24.0670.AA | STE | 199-289 | 23 | 3.7e-13 | 42.93 | In-house | 247-359 (359) | Show / Hide |
Range on Protein: 199-289 Range on HMM: 247-359/359 Sequence Identity: 23% (27 aa) AAVDLWGLGCTLYEMVTGTRPFPGSSELQVLMSIL--DALGS----------DIQSFPVATKHATLFDKIP-----------ASPAFVDLLQRLLCLDPT . .| | ||||. ||.|| |. . ..... |. . .. .. ..| .. . |. || | | ... | || TKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEM---ISYGGSGTTYPHKWSPEFKDFINKCLQKDPN RRCTAKEALH--HSFL | ||.. |. |.|. KRPTASQLLKSEHPFI |
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| Kinase | LmjF24.0670.AA | CDC2 | 263-289 | 48 | 7.9e-12 | 32.1 | In-house | 275-301 (301) | Show / Hide |
Range on Protein: 263-289 Range on HMM: 275-301/301 Sequence Identity: 48% (13 aa) VDLLQRLLCLDPTRRCTAKEALHHSFL .|||...|..|| .| .||||| | .. IDLLMQMLQYDPQKRISAKEALQHPYF |
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| Kinase | LmjF24.0670.AA | MSK | 176-225 | 36 | 1.1e-10 | 32.38 | In-house | 166-217 (277) | Show / Hide |
Range on Protein: 176-225 Range on HMM: 166-217/277 Sequence Identity: 36% (19 aa) RGTLHYRSPEQLMGKRSVVSENFAAVDLWGLGCTLYEMVTGTRPFP--GSSE ..|||| .|| | . . .. .|.|.|.|| .||.| || .|| .... CFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDR |
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| Kinase | LmjF24.0670.AA | DYRK | 262-289 | 35 | 6.3e-10 | 33.57 | In-house | 293-320 (320) | Show / Hide |
Range on Protein: 262-289 Range on HMM: 293-320/320 Sequence Identity: 35% (10 aa) FVDLLQRLLCLDPTRRCTAKEALHHSFL |.|.....| .||..| |...||.|... FKDFIKKCLQWDPHKRITPSQALQHPWF |
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| Kinase | LmjF24.0670.AA | CDC2 | 178-225 | 41 | 9.7e-10 | 25.56 | In-house | 168-214 (301) | Show / Hide |
Range on Protein: 178-225 Range on HMM: 168-214/301 Sequence Identity: 41% (21 aa) TLHYRSPEQLMGKRSVVSENFAAVDLWGLGCTLYEM---VTGTRPFPGSSE || ||.|| |.|.. .||.| .||...|| || .|.| || TLWYRAPEILLGCKRYS----TPVDMWSIGCIFAEMFMDVTKKPLFHGDSE |
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| Kinase | LmjF24.0670.AA | ERK7 | 258-289 | 40 | 2.1e-09 | 27.98 | In-house | 261-292 (292) | Show / Hide |
Range on Protein: 258-289 Range on HMM: 261-292/292 Sequence Identity: 40% (13 aa) ASPAFVDLLQRLLCLDPTRRCTAKEALHHSFL .... .|||.|||.. | .| ||..||.| . CCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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| Kinase | LmjF24.0670.AA | AGC | 65-89 | 55 | 2.2e-09 | 18.89 | In-house | 162-188 (395) | Show / Hide |
Range on Protein: 65-89 Range on HMM: 162-188/395 Sequence Identity: 55% (15 aa) VLLALEQMHS-HAVAHRD-VKPGNILL ..|||| .|| . . ||| .|| |||| IVLALEYLHSHMGIIHRDYLKPENILL |
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| Kinase | LmjF24.0670.AA | ERK7 | 181-237 | 37 | 2.5e-09 | 27.72 | In-house | 172-224 (292) | Show / Hide |
Range on Protein: 181-237 Range on HMM: 172-224/292 Sequence Identity: 37% (22 aa) YRSPEQLMGKRSVVSENFA-AVDLWGLGCTLYEMVTGTRPFPGSSELQVLMSILDALG ||.|| |.| |.... .||.|..|| | ||..| |||.| . . ||. .. YRAPEILLG-----SHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIP |
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| Kinase | LmjF24.0670.AA | RSK | 55-89 | 37 | 1.7e-08 | 27.56 | In-house | 103-137 (278) | Show / Hide |
Range on Protein: 55-89 Range on HMM: 103-137/278 Sequence Identity: 37% (13 aa) EGVCAAVAYSVLLALEQMHSHAVAHRDVKPGNILL | ...... . ||.| .|.. . ||| || |||. EDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILY |
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| Kinase | LmjF24.0670.AA | ERK7 | 3-89 | 31 | 5.3e-08 | 23.13 | In-house | 48-133 (292) | Show / Hide |
Range on Protein: 3-89 Range on HMM: 48-133/292 Sequence Identity: 31% (28 aa) EVSVLNYLGPHPQIVRFLGSYTTSKNTSFF-TMELMDSDVGRELREGNATLHEEGVCAAVAYSVLLALEQMHSHAVAHRDVKPGNILL |. | .. || |.| . . . .. | |..| | || . .. . | .| |. ||| | |||.|| |||| EIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGN--ILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILL |
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| Kinase | LmjF24.0670.AA | RSK | 199-235 | 35 | 1.2e-07 | 24.48 | In-house | 191-230 (278) | Show / Hide |
Range on Protein: 199-235 Range on HMM: 191-230/278 Sequence Identity: 35% (14 aa) AAVDLWGLGCTLYEMVTGTRPFPG---SSELQVLMSILDA .|.|.| ||. .||| || .|| | .. ... |. . KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKG |
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| Kinase | LmjF24.0670.AA | MSK | 54-89 | 36 | 3.5e-07 | 20.34 | In-house | 99-134 (277) | Show / Hide |
Range on Protein: 54-89 Range on HMM: 99-134/277 Sequence Identity: 36% (13 aa) EEGVCAAVAYSVLLALEQMHSHAVAHRDVKPGNILL .| |. . .. .|...||. .. ||| || |||. DESECRMIMRELVMAVDHMHQKGIIHRDLKPENILF |
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| Kinase | LmjF24.0670.AA | Ciliate-E2 | 13-101 | 21 | 4.8e-07 | 20.2 | In-house | 91-197 (365) | Show / Hide |
Range on Protein: 13-101 Range on HMM: 91-197/365 Sequence Identity: 21% (26 aa) HPQIVRFLGSYTT-SKNTSFFTMELMDSDVGRELRE-----GNATLHE--------EGVCAAVAYSVLL---------------ALEQMHSHA-VAHRDV || |... .. . ..|. .. ||. . | .|.. .|| | .. . . .| ||| .|| . ||| HPNIIKMYECFQEKDDNNIYLVMEYCQ---GGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDI KPGNILLKRLSEPEEWACI || |||. .| KPENILF---------IKI |
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| Kinase | LmjF24.0670.AA | DYRK | 200-237 | 47 | 9.2e-07 | 21.6 | In-house | 184-221 (320) | Show / Hide |
Range on Protein: 200-237 Range on HMM: 184-221/320 Sequence Identity: 47% (18 aa) AVDLWGLGCTLYEMVTGTRPFPGSSELQVLMSILDALG |.| | |||.|.|..|| |||..| | | . || AIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLG |
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| Kinase | LmjF24.0670.AA | RSK | 259-289 | 27 | 1e-06 | 20.9 | In-house | 243-278 (278) | Show / Hide |
Range on Protein: 259-289 Range on HMM: 243-278/278 Sequence Identity: 27% (10 aa) SPAFVDLLQRLLCLDPTRRCT-----AKEALHHSFL |... ||....|. || .| . |.| . |... SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | LmjF24.0670.AA | CDK | 3-89 | 26 | 6e-06 | 14.93 | In-house | 58-141 (284) | Show / Hide |
Range on Protein: 3-89 Range on HMM: 58-141/284 Sequence Identity: 26% (26 aa) EVSVLNYLGPHPQIVRFLGSYTTSK----------NTSFFTMELMDSDVGRELREGNATLHEEGVCAAVAYSVLLALEQMHSHAVAHRDVKPGNILL |.| | | || ||. . ..|.. |. .. .| || | .. . . | .|. .||. . ||| || |||. EISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILI |
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| Kinase | LmjF24.0670.AA | MSK | 258-289 | 34 | 9e-06 | 15.52 | In-house | 246-277 (277) | Show / Hide |
Range on Protein: 258-289 Range on HMM: 246-277/277 Sequence Identity: 34% (11 aa) ASPAFVDLLQRLLCLDPTRRCTAKEALHHSFL .||.. ||.|.||. || .| .. . . |. . MSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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| Kinase | LmjF24.0670.AA | CDC2 | 66-89 | 41 | 0.000496 | 7.7 | In-house | 113-136 (301) | Show / Hide |
Range on Protein: 66-89 Range on HMM: 113-136/301 Sequence Identity: 41% (10 aa) LLALEQMHSHAVAHRDVKPGNILL | ... |.. . ||| || |||. LQGVHFCHQRRIMHRDLKPQNILI |
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| Kinase | LmjF24.0670.AA | DYRK | 59-90 | 36 | 0.005086 | 7.46 | In-house | 106-138 (320) | Show / Hide |
Range on Protein: 59-90 Range on HMM: 106-138/320 Sequence Identity: 36% (12 aa) AAVAYSVLLALEQMHSH-AVAHRDVKPGNILLK . .|...|..| .|.. | | || ||.|| RKFAQQILTCLKFLHKNENIIHCDLKPENIMLK |
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