Gene MLKz_d-1 (S.moellendorffii)

MLKz_d-1

Species: S.moellendorffii
Alias: MLKz_d-1
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKz

Sequence

Name Sequence Type Origin Length Description Download
MLKz_d-1.AA Protein None 409 None Fasta, JSON
MLKz_d-1.NA RNA None 1230 None Fasta, JSON
MLKz_d-1.kin_dom Protein Kinase Domain None 246 None Fasta, JSON

Protein domain

Protein domains of MLKz_d-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKz_d-1.AA MLK 127-381 33 2.4e-95 323.09 In-house 1-291 (291) Show / Hide 
Range on Protein: 127-381
Range on HMM: 1-291/291
Sequence Identity: 33% (98 aa)

LAMGHAFAQGASGRLYRGTYDGED-----VAVKILE-RPKNNAERAQVMEQQFTQEVRMLAALKHQN----VVRFIGACRKPLV-WCIVTEYAKGGSVRS
.   .    |..|  ..|.. ..|     ||||. . |.   . ..    ..| .|.| |. |.|.|    ...| |.| .|    |||.||. |||  .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

FLSKRKS------------RPVPLKLAVKQALDIAQGMQYLHNLGF---IHRDLKSDNLLIA------TDKSIKIADFGVARIEVQT-EGMTPETGTYRW
.|  ..|            | ... .|.. ||..|.||.|||..     ||||||| |.||.       ..  ||.|||..|   |. . |.   |||.|
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

MAPEMI---QHRLYTHKVDVYSFGIVLWELITGLLPFQ-NMTAVQAAFAVVNRGYRPGIPADCPPALAEIMSRCWDANPDSRPGFAQVVKML
||||.|   ..  |. |.||.|.|.||||..|. .|..  . . ..|. |.. | || || .||. ... |..||...| .|| |.|.|. |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLKz_d-1.AA TKL 133-381 27 2e-92 313.39 In-house 1-364 (364) Show / Hide 
Range on Protein: 133-381
Range on HMM: 1-364/364
Sequence Identity: 27% (101 aa)

FAQGASGRLYRGTYDG----------EDVAVKILERPKN---------------------NAERAQVMEQQFTQEVRMLAALKHQNVVRFIGACRKPLV-
  .|..|  |.|.. |          .|||||.. .  .                     |.. |. ..... .|..|.  |.|.|.|.|.|.|  |   
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------WCIVTEYAKGGSVRSFLSKRKSRPVPLKLAVKQALDIAQGMQYLHNLG--------FIHRDLKSDNLLIATDKS--------------
             |||.||..||| ...|         . . .. |||||.||.|||. .         |||||||.|.|.  .                
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

IKIADFGVARIEVQTEGMTP--------------------ETGTYRWMAPEMIQ----------------HRLYTHKVDVYSFGIVLWELITGLLPFQNM
.||.||| .|   |...|.                     . ||.||||||...                .. |. |.|||||||||||..|. .|....
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

TAVQAA---------FAVVNRGYRPGIP------------ADCPPALAEIMSRCWDANPDSRPGFAQVVKML
   .             |...|.|| ||             |||| ....| .|||..|..|| | ...| |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKz_d-1.AA TKL-Unique 129-381 33 2.1e-86 293.35 In-house 1-290 (290) Show / Hide 
Range on Protein: 129-381
Range on HMM: 1-290/290
Sequence Identity: 33% (99 aa)

MGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAERAQVMEQQFTQEVRMLAALK-HQNVVRFIGACR----KPLVWCIVTEYAKGGSVRSFLSK----
 .    .|..|. |.|.. |..||.|...  . |..    |.| |  ||. .  |. | |.|...|.|     .|  .|||.||  ||| .. |.     
FWNKIGEGGYGQVYKGKWRGYPVAIKQFH--P-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

----RKSRPVPLKLAVKQALDIAQGMQYLHNLG--FIHRDLKSDNLLIATD-----KSIKIADFGVARIEVQTEGMTPE----------TGTYRWMAPEM
    ... . .... || |.|||||| |||...   ||||||| |.|.  .      .|||.||| ...  .   ||             |..||||||.
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEV

IQH--RLYTHKVDVYSFGIVLWELITGLL------PFQNMTAVQAAFAVVN--RGYRPGIPADCPPALAEIMSRCWDANPDSRPGFAQVVKML
.     .|. |.|||||||||||..|. .      |.|.|.  | . .|    ..||| || .||. . ... .||. .|. || | .... |
LRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKz_d-1.AA Dicty4 127-383 36 1.2e-84 282.21 In-house 1-277 (277) Show / Hide 
Range on Protein: 127-383
Range on HMM: 1-277/277
Sequence Identity: 36% (101 aa)

LAMGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAERAQVMEQQFTQEVRMLAALKHQNVVRFIGACR----KPLVWCIVTEYAKGGSVRSFLSK---
.. .    .|. |  |.||  | .||||.|   . |.. .   |  | .||  .. . | |.. | |||     .|   ||||||   |.. | | .   
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNE--FRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

----RKSRPVPLKLA-VKQALDIAQGMQYLHN--LGFIHRDLKSDNLLIATDKSIKIADFGVAR----IEVQTEGMTPETGTYRWMAPEMIQHRLYTHKV
    ... . || ..  . |.|.|.||..||.    .|||||||.|||.  .. .|..||| ..    .| .. ...   ||  |||||. .|. |. |.
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGIVLWELITGLLPFQ--NMTAVQAAFAVVNRGYRPGIPADCPPALAEIMSRCWDANPDSRPGFAQVVKM--LEE
|||||||||||. |.  |.|   |  .|...||.| . || ||..||| ... . .||| .| .|| |.....   ||.
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKz_d-1.AA TyrKc 127-381 29 7.7e-82 279.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 127-381
Range on HMM: 1-280/280
Sequence Identity: 29% (86 aa)

LAMGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAERAQVMEQQFTQEVRMLAAL--KHQNVVRFIGACRKP-------LVWCIVTEYAKGGSVRSFL
. .|.    || |. |.||.. ..|||| |   .         .. | .| |..  |  .|.|.||..|.|...          .||.||...|. ...|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

SKRKSRPVPLKLAVKQALDIAQGMQYLHNLGFIHRDLKSDNLLIATDKSIKIADFGVARIEVQT-------EGMTP-----ET--GTYRWMAPEMIQHRL
 |.. . ...|  .. ...||.||.|||  ..|||||   | |.. .. .||.||| .|            .  ..     .     .|||||| |... 
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YTHKVDVYSFGIVLWELIT-GLLPFQNM----TAVQAAFAVVNRGYRPGIPAD--------CPPALAEIMSRCWDANPDSRPGFAQVVKML
.|.| ||.|||...||. | |  |  .|       | ... | .|||. .|..        ||... .||..||...|..|| |..... .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKz_d-1.AA Pkinase_Tyr 127-381 31 2.5e-81 276.06 Pfam 1-270 (270) Show / Hide 
Range on Protein: 127-381
Range on HMM: 1-270/270
Sequence Identity: 31% (89 aa)

LAMGHAFAQGASGRLYRGTYD------GEDVAVKILERPKNNAERAQVMEQQFTQEVRMLAAL-KHQNVVRFIGACR-----KPLVWCIVTEYAKGGSVR
. .|.   .|| |. |.||..      . .||||.|   |..|   | . . | .|....  | .|.|.||..|.|      .   ..||.||...|. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML---KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLL

SFLSKR--KSRPVPLKLAVKQALDIAQGMQYLHNLGFIHRDLKSDNLLIATDKSIKIADFGVAR-I-------EVQTEGMTPETGTYRWMAPEMIQHRLY
..| |.    .|...|  .. ...||.||.||.. ..|||||   | |.. .. .||.||| || |        ....|. |     .||||| |... .
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLP----IKWMAPECINYGKF

THKVDVYSFGIVLWELIT-GLLP-FQNMTAVQAAFAVVNRGYRPGIPADCPPALAEIMSRCWDANPDSRPGFAQVVKML
|.| ||.|||...||..| |  | ...|.  .   ..  .|||  .| .||. . ..| .||...|. || |.... .|
TTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKz_d-1.AA LRRK 135-383 28 5.5e-74 252.11 In-house 9-351 (351) Show / Hide 
Range on Protein: 135-383
Range on HMM: 9-351/351
Sequence Identity: 28% (97 aa)

QGASG-RLYRGTYDG----------------------------EDVAVKILERP---------KNNA-----------------ERAQVME--QQFTQEV
.|..| . ||... |                            ..||.|...|.          .|.                 . .  ..  . | .||
RGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRHEV

RMLAALKHQNVVRFIGACRKPLVWCIVTEYAKGGSVRSFLSKRKSRP------V-PLKLAVKQALDIAQGMQYLHNLG--FIHRDLKSDNLLIATDK---
 ..  |.| |.|  .| | .||  |.|.|||  |.  .||...|. .      . .  |  | ||.|| ||.|||.    .|||||||.| |. . .   
WIMSHLNHPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNH

---------SIKIADFGVAR--IEVQTE-GMTPETGTYRWMAPEMIQHR---LYTHKVDVYSFGIVLWELITGL-LPFQNMTAV-----QAAFAV-VNRG
          .||||||  |    ....  .. . |. .||||| ..      || |||.||||..||||.|.. .||.... .     .  .   ...|
SPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCV-GNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEG

YRPGIPAD-CPP-----ALAEIMSRCWDANPDSRPGFAQVVKMLEE
 || || . |||      . . .  ||...|..|| | |.|| |..
LRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKz_d-1.AA TK 127-381 18 1.1e-72 242.78 In-house 1-486 (486) Show / Hide 
Range on Protein: 127-381
Range on HMM: 1-486/486
Sequence Identity: 18% (89 aa)

LAMGHAFAQGASG---RLYRGTYDG---------------------------EDVAVKILERPKNNAERAQVM-EQQ----------FTQEVRMLA--AL
. .|.   .|. |   . |.|.. |                           ..||||.|    ....... . | .          . .|  |.   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHQNVVRFIGACRKP------------LVWCIVTEYAKGGS----VRSFLSKRK----------------------------------------------
.|.|.||..|.| ..              |.||.||...|.     |..| |..                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----SRPVPLKLAVKQALD-----------------------IAQGMQYLHNL------GFIHRDLKSDNLLIATDKS-----------IKIADFG----
    ....|. |  |. |.                       ||.||.||| .      .|.||||   | |.. ..            .||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----VARIEVQTEGMTPETGTYR---------------------------WMAPEMIQHRL---------YTHKVDVYSFGIVLWELIT-G-LLPFQNMT
     ||   . .  .  .. ..                           ||||| ...|          .|.| ||.|||...||. | |   .  .|.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

A--------VQAAFAVVNRG--------------YRPGIPADCP--------------PALAEIMSRCWDANPDSRPGFAQVVKML
         .|  .  . ||              .|.  |..||              ......| .||...|. || |.|....|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLKz_d-1.AA Dicty5 127-385 37 1.5e-71 244.06 In-house 1-260 (260) Show / Hide 
Range on Protein: 127-385
Range on HMM: 1-260/260
Sequence Identity: 37% (99 aa)

LAMGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAER-AQVMEQQFTQEVRMLAALK--HQNVVRFIGACRKPLVW-CIVTEYAKGGSVRSFLS-KRK
 ...   | ||||| | | | | |||.| .       |       . |  || .. . .  | |..|. || ..      .|||| . ||... |  .||
VSFHDWIASGASGRVYNGIYKGMDVAIKVY-----SQENCMCFDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRK

--SRPVPLKLAVKQALDIAQGMQYLHNLGFIHRDLKSDNLLIATDKSIKIADFGVAR-IEVQTEGMTPETGTYRWMAPEMIQHRLYTHKVDVYSFGIVLW
    |.   . .  |.||||.|..||  . ||||||| | ||  .  ||| |||. | .. .  .|| . ||  |||.|. . . |. |.||||||||||
TTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRY-HMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLW

ELITGLLPFQNMTAVQAAFAVVNRGYRPGIPADCPPALAEIMSRCWDANPDSRPGFAQVVKMLEEAR
|..|   |. |..    .   |  | || ||.|||   . .   ||   |  || |  ..|..|   
EMFTRKEPYDNINNWNIPV-MVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase MLKz_d-1.AA Dicty4-Unclassified 127-381 34 4.7e-65 221.73 In-house 1-263 (263) Show / Hide 
Range on Protein: 127-381
Range on HMM: 1-263/263
Sequence Identity: 34% (92 aa)

LAMGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAERAQ-VMEQQFTQEVRMLAALKHQNVVRFIGACRKP----LVWCIVTEYAKGGSVRSFLS---
.       .|.  . ..|   | |||||..     |  ..   | | |  || .|  . | | |.  |.|  |       |||.|    |          
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFN---ENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKP

KRKSRPVPLKL--AVKQALDIAQGMQYLHNLGFIHRDLKSDNLLIATDKSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRLYTHKVDVYSFGIV
  . .|. |     .| |.|||||||.||   |||||.|| |.|.  .  |||||||..|    .  ||   || .| .||   |  |. | ||||....
SEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMM

LWELITGLLPFQNMT-AVQAAFAVVNRGYRPGIPADCPPALAEIMSRCWDANPDSRPGFAQVVKML
|.||.||  |.|     . ||  |  .. || ||  |.. .      ||   |  || . |... |
LYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKz_d-1.AA DRK 127-383 35 2.1e-64 217.03 In-house 1-258 (258) Show / Hide 
Range on Protein: 127-383
Range on HMM: 1-258/258
Sequence Identity: 35% (94 aa)

LAMGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAERAQVMEQQFTQEVRMLAALKHQNVVRFIGACRKPLVWCIVTEYAKGGSVRSFLSKRKSRPVP
 . |     |  |  .|||  |  |||| |  .  | .    . . | .|. ..  | | |.. |.|.|  |   ||..||   ||  . |   .     
IKIGNRIGRGNYGEVFRGTWRGTQVAVKML--FNHNINDENFL-NEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIE-MD

LKLAVKQALDIAQGMQYLHNLG--FIHRDLKSDNLLIATDKSIKIADFGVAR----IEVQTEGMTPETGTYRWMAPEMIQHRLYTHKVDVYSFGIVLWEL
  |  . ..|.| || |||.     |||||||.|||.     .|.|||| .     .. ..  ||.  ||  | |||      || | |||||.|||||.
WPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTM-CGTPCWTAPEVLRNQRYTEKADVYSFAIVLWEC

ITGLLPFQNMTAVQAAFAVVNRGYRPGIPADCPPALAEIMSRCWDANPDSRPGFAQVVKMLEE
.| . |.. |   |  |.|   | || .|. |||  .  | .||. .|  || . .... || 
VTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLKz_d-1.AA Pkinase 135-381 24 3.7e-64 224.26 Pfam 9-293 (293) Show / Hide 
Range on Protein: 135-381
Range on HMM: 9-293/293
Sequence Identity: 24% (71 aa)

QGASGRLYRGTYDGED--VAVKILERPKNNAERAQV---MEQQFTQEVRMLAALKHQNVVRFIGACRKPLVWCIVTEYAKGG----SVRSFLSKRKSRPV
.|..|. |...  |.   |||||....... .  |          .|..... |.| |.||...... .   ..|.||. ||    .  ...| ......
SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF

--PLKLAVKQALDIAQGMQYLHNLGFIHRDLKSDNLLIATDKSI----KIADFGVARI--EVQTEGMTPETGTYRWMAPEMIQ-HRLYTHKVDVYSFGIV
  . . . . .. |..|..|.|. |.||||||..|.||  .  |    ||.|||.|.   .   . ||  .||...|||| |. .. |..|||..|.|..
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCI

LWELITGLLPFQNM------TAVQAAFAVVNRGYRPGIPADCP-------------------PALAEIMSRCWDANPDSRPGFAQVVKM--L
|.|...| .||..       .  |  . .  . ..  .| .|.                   ... .....|.. .| .||...|...   .
LYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase MLKz_d-1.AA S_TKc 127-381 24 4.3e-61 210.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 127-381
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

LAMGHAFAQGASGRLYRGTY--DGEDVAVKILERPKNNAERAQVMEQQFTQEVRMLAALKHQNVVRFIGACRKPLVWCIVTEYAKG--GSVRSFLSKRKS
  ..    .|| |. |...   .|. ||.||.              ... .|...|   .| |.|.......     ..|.||. |  |...... ||..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

RP----VPLKLAVKQALDIAQGMQYLHNLGFIHRDLKSDNLLIATDKSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRLYTH-KVDVYSFGIVL
..     |   | . .  |.....|.|..|.|||||| .|.|. .   |||.|||.||.       |   ||  .||||..    |.. |.|..|.|..|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

WELITGLLPFQNMTAVQAAFAVVNRGYRPGIPADCPPALAEIMSRCWDANPDSRPGFAQVVK---------ML
.|...|  ||.    .|. | ..            .| . .....|.. .|. ||.  .. .          .
YEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKz_d-1.AA MLK 264-381 38 1.7e-38 124.74 In-house 164-280 (280) Show / Hide 
Range on Protein: 264-381
Range on HMM: 164-280/280
Sequence Identity: 38% (45 aa)

DKSIKIADFGVARIEVQTEGMTPETGTYRWMAPEMIQHRLYTHKVDVYSFGIVLWELITGLLPFQNMTAVQAAFAVVNRGYRPGIPADCPPALAEIMSRC
.|  || |||.||   .|  |    ||| ||||| |.  ..    || |.|..||||.||  |.. . ..  |. | ...    ||  ||   | .|  |
NKQLKITDFGLAREWHKTTRMS-AAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDC

WDANPDSRPGFAQVVKML
|. .| .||.|..... |
WNQDPHKRPKFSEILQQL
Kinase MLKz_d-1.AA MLK 127-261 35 7e-35 112.56 In-house 1-136 (280) Show / Hide 
Range on Protein: 127-261
Range on HMM: 1-136/280
Sequence Identity: 35% (50 aa)

LAMGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAERAQVM---EQQFTQEVRMLAALKHQNVVRFIGACRKPLVWCIVTEYAKGGSVRSFLSKRKSR
| .      |  |. ||....|| ||||.  .  .  . .|..     |  || |....|||.|...  |.| ..   |.| ||..||| .  .. .   
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQ--DPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK---

PVPLKLAVKQALDIAQGMQYLHNLG---FIHRDLKSDNLLI
 .|..  |  |  ||.||.|||| .    |||||||.| ||
RIPPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI