Gene MLKz_h (S.moellendorffii)

MLKz_h

Species: S.moellendorffii
Alias: MLKz_h
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLKz

Sequence

Name Sequence Type Origin Length Description Download
MLKz_h.AA Protein None 371 None Fasta, JSON
MLKz_h.NA RNA None 1116 None Fasta, JSON
MLKz_h.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of MLKz_h.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MLKz_h.AA TKL 66-326 24 2.2e-77 263.37 In-house 1-364 (364) Show / Hide 
Range on Protein: 66-326
Range on HMM: 1-364/364
Sequence Identity: 24% (91 aa)

IGLGAIGKVHRGTYNN----------EEVAIKLLDCSKPGLAGDGISD------------------WRRVCLMRELRIWRKLDHPNIVKLIG---ASPG-
|| |. |.|..|....          ..||.| .      .  . . .                  | | .. .|... ..|.|||||...|   ..|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VADKN-AFSNVCCLVSEYMSTGSLREYLMSQHKRLSYKLVIQLGIDIARGLEYLHSRK--------IIHRDVKTKNILLDSALR--------------A
 |  ..   .. .|.| ||.. |||..||          . ... .|||||..||||..        ||||| |.||||.|. ..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFDSARILMEADQ-------------------AMSGEIGTFGYMAPEVMDGR----------------AYDCKSDVFSFGICLLEIYSCDMAYG-LV
||.||  .| . .  .                   . . ..||...|||||..|                  |. |.||.||||.| ||...   |  . 
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

CLSLA------DITKGLVYRNLRPKIP------------RSCPGELAYVMKRCWKKNPDKRPRMSEVVRML
. .        .. .. ....||| ||             .|| ...  |..||. .|.||| ..|..  |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLKz_h.AA TKL-Unique 62-326 29 4.7e-67 229.08 In-house 1-290 (290) Show / Hide 
Range on Protein: 62-326
Range on HMM: 1-290/290
Sequence Identity: 29% (87 aa)

IREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLD-HPNIVKLIGASPGVADKNAFSNVCCLVSEYMSTGSLREYL
. ..|| |. |.| .|... ..|||| .   . ..  . . .     . .|.... ||. |||||...|..   .|.    . .|.|.||.. |||...|
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQE-----FENEVNWMKKLHYHPNIVHYMGYC---MDHQVYPPNMCIVMEYCPGGSLYDVL

M---------SQHKRLSYKLVIQLGIDIARGLEYLHSRK--IIHRDVKTKNILLDSA-----LRAKIGDFDSARILMEADQAMSGEI---------GTFG
          .... |........ ||||.|..|||...  ||||| |..|.|.|..     ...|| ||  ....   ..  ..|.         |.| 
HQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFR

YMAPEVMDG--RAYDCKSDVFSFGICLLEIYSCDM--AYGLVCLSLADI-TKGLVYR---NLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRML
.|||||. .    |..||||.||||.| ||.. .    |     .....  . .|     |.||.|| .|| |.   ...||. .|..||  .|..  |
WMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLKz_h.AA TK 60-326 17 2.8e-61 203.88 In-house 1-486 (486) Show / Hide 
Range on Protein: 60-326
Range on HMM: 1-486/486
Sequence Identity: 17% (83 aa)

LVIREVIGLGAIG---KVHRGTYNN---------------------------EEVAIKLLDCSKPGLAGDGIS-DWRRVC--------LMRELRIWR--K
... ...| |. |   .|..|....                           ..||.| |    .  . . .  ....          ...|. . .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-RDGGEDFLEEAEEMKMMCHSL

LDHPNIVKLIGASPGVADKNAFS-----NVCCLVSEYMSTGS----LREYLMSQHKR-------------------------------------------
..|||||.|.|..  .. |  |.       ...| |||. |.    ||.|| . ...                                           
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

------------LSYKLVIQ-------------------LGIDIARGLEYLHSR------KIIHRDVKTKNILLDSALR-----------AKIGDFD---
            |. |  .|                      .||.|.|||||.      ...|||. . |.|... ..           .||.||    
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----SARILMEADQAMSGEIGTFGY--------------------------MAPEVMDGRA---------YDCKSDVFSFGICLLEIYS-CDMAYGLVC
      || . . |   . . .. |                           ||||....|          .  ||||.|||... ||.. ... |.   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

LS------------LADITKG---------LVYRNLRPKIPRSCPG-------------ELAYV-MKRCWKKNPDKRPRMSEVVRML
 .            .  ...|          | . .|.. |  ||              |. |  |..||...|..||..|.....|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
S_TKc MLKz_h.AA S_TKc 60-329 26 9.9e-60 205.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 60-329
Range on HMM: 1-231/231
Sequence Identity: 26% (77 aa)

LVIREVIGLGAIGKVHRGTYNN--EEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGVADKNAFSNVCCLVSEYMST--GS
  | ..|| || |||.... ..  ..|||| ..                  ..||..| .| .|||||||...           .  ..| ||...  |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGD

LREYLMSQHKR-----LSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDFDSARILMEADQAMSGEIGTFGYMAPEVMDGRAYDC-
|..|. .. ..     ..   .  .   |...|||.||..|||||.|  |||||.  . ||.|| .||.|       .  .||  ||||||.    |.. 
LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKC

KSDVFSFGICLLEIYSCDMAYGLVCLSLADITKGLVYRNLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVR------MLEAI
|.|. |.|..| | ..    .      .. . | ..            . |.   ...|..|.|.|||   |. .      . . .
KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLKz_h.AA MLK 60-326 29 1.4e-58 200.98 In-house 1-291 (291) Show / Hide 
Range on Protein: 60-326
Range on HMM: 1-291/291
Sequence Identity: 29% (88 aa)

LVIREVIGLGAIGKVHRGTYNNEE-----VAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPN----IVKLIGASPGVADKNAFSNVCCLVSEY
. . |.|| |. |||..|.. |..     ||.|  . ..   ..|  ..  .  . .| |. |.|.|||    |... |..      .   .  |.|.||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSD--TYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVC------LQPPCHFCIVMEY

MSTGSLREYLMSQHK-------------RLSYKLVIQLGIDIARGLEYLHSRK---IIHRDVKTKNILLDS------ALRAKIGDFDSARILMEADQAMS
.. ||| ..| .. .             . .  ....   ..|||..|||| .   ||||| | .|||.|        . .|| ||. .| . . .. | 
CEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM

GEIGTFGYMAPEVM---DGRAYDCKSDVFSFGICLLEIYSCDMAYGLVCLSLADITKGLVYRNLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRM
. .||. .|||||     .  |. |.||.|.|..| |. .. . |    .. . |  . .| .||| || .||  ..  ||.||. .| ||| ....|  
SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK-QHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQH

L
|
L
Kinase MLKz_h.AA TyrKc 60-326 29 9.9e-57 195.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 60-326
Range on HMM: 1-280/280
Sequence Identity: 29% (88 aa)

LVIREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKL--DHPNIVKLIGASPGVADKNAF--SNVCCLVSEYMSTGS
..  ...| || |.|..||.. ..||.| |  ..            |  .|||.|| .||  .|||||.|.|.      .  |  .   ..| |||. |.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGD

LREYLMSQHKRLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDFDSARILMEA-------DQAMS----GEI--GTFGYMAPEVM
|..|| . ...|. |  ..  ..||.| |||||...||||  . |.|... ...||.||  .| . .        |  ..    |.        ||||..
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

DGRAYDCKSDVFSFGICLLEIYS-CDMAYGLVC---LSLADITKGLVYRNLRPKIPR-------SCPGELAYVMKRCWKKNPDKRPRMSEVVRML
. . .  ||||.|||.|. ||.. ... |  .    .| ... . .  .. .|. |         || |.  .||.||. .|..||..||... .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLKz_h.AA Pkinase 60-326 25 2.1e-50 178.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 60-326
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

LVIREVIGLGAIGKVHRGTYNNEE--VAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGAS-PGVADKNAFSNVCCLVSEYMSTG--
..| ..|| |. |.| ...  ...  ||.| .. ..     | .  ..     .|..| ..|.|||||.|...           .. ...| ||.  |  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLY

--SLREYLM-SQHKRL--SYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRA----KIGDFDSARIL-MEADQAMSGEIGTFGYMAPEVMD-
  .| .|.. ..|...  |.. ..     |.|||||.||..|||||.|  |||.|.        ||.|| .|. .    .. |..  || .||||||   
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

GRAYDCKSDVFSFGICLLEIYSCDMAYGLVCLSLAD------ITKGLVYRNLRPKIPRSCP-----------------------GELAYVMKRCWKKNPD
|. |. |.|..|.|. | | ..     |    .  .        . ...|...|......|                        |.  ..|.|..|.| 
GQYYGPKVDMWSCGCILYEMLC-----GRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

KRPRMSEVVRM--L
|||   ...    .
KRPTAEQILQHPWF
Kinase MLKz_h.AA Dicty5 120-330 33 6e-50 170.09 In-house 56-260 (260) Show / Hide 
Range on Protein: 120-330
Range on HMM: 56-260/260
Sequence Identity: 33% (73 aa)

DHPNIVKLIGASPGVADKNA-FSNVCCLVSEYMSTGSLREYLMSQHK----RLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDF
||||...  ||  .  ...  |      |.|| . |||..||  | |     ..| . . . ||||.....|||  |||||.|  |.|.   . .|| ||
DHPNFIRCYGA--HQYNDKYPF-----HVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDF

DSARILMEADQAMSGEIGTFGYMAPEVMDGRAYDCKSDVFSFGICLLEIYSCDMAYGLVCLSLADITKG-LVYRNLRPKIPRSCPGELAYVMKRCWKKNP
   |   ..   |  ..||  .||.|.  |. |. | ||.|||| | |.   . .|      .. .    .|    || ||  || | . . | ||   |
GTSRF-VDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEPYD----NINNWNIPVMVMKGERPTIPKDCPTEISNLIKKCWQQKP

DKRPRMSEVVRMLEAIA
 .||   |.. ..| | 
HNRPSFKEICKYFESII
Kinase MLKz_h.AA Dicty4 60-263 33 1.7e-49 163.31 In-house 1-210 (277) Show / Hide 
Range on Protein: 60-263
Range on HMM: 1-210/277
Sequence Identity: 33% (73 aa)

LVIREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGVADKNA---FSNVCCLVSEYMSTGSL
..| . || |. |.|..||    |||.|.|   . ..  . ... |     .|  |  |. ||||... ||.      .|    .  .| |.|||. |.|
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFR-----KEVHIMCKIRHPNICLFMGAC------TAPRSHPGKMCIVTEYMPKGNL

REYLMS------QHKRLSYKLVIQ---LGIDIARGLEYLHSRK--IIHRDVKTKNILLDSALRAKIGDFDSARILMEAD--QA-MSGEIGTFGYMAPEVM
 . | .      | . |.. |...   ...|.|||. .||..   ||||| |. |.| |  .|.|..||  ...  .    .. ... .|| ..||||||
YSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM

DGRAYDCKSDVFSFGICLLEI
 ...|. |.||.|||| | ||
MHQPYNEKADVYSFGIVLWEI
Kinase MLKz_h.AA LRRK 111-328 29 2e-49 170.52 In-house 106-351 (351) Show / Hide 
Range on Protein: 111-328
Range on HMM: 106-351/351
Sequence Identity: 29% (75 aa)

RELRIWRKLDHPNIVKLIGASPGVADKNAFSNVCCLVSEYMSTGSLREYLMSQHK--------RLSYKLVIQLGIDIARGLEYLHSRK--IIHRDVKTKN
.|. | ..|.|||||.|.| .          . .|.| ||.. |.| ..| . ..        ..|  |.... ..||.|.|||||..  ||||| |. |
HEVWIMSHLNHPNIVSLKGFC---------IHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPN

ILL---D---------SALRAKIGDFDSARILMEADQA--MSGEIGTFGYMAPEVMDGR---AYDCKSDVFSFGICLLEIYSCD-MAYGLVC----LSLA
|||   .          .  |||.||   | .  ...    .|  |..|.||||.| .     |. |.|..|||. | |... .  ...       ... 
ILLWSSPQNHSPNYPNAHVCAKIADFGISR-MFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWM

DITKGLVYRNLRPKIPRS-CPG-----ELAYVMKRCWKKNPDKRPRMSEVVRMLEA
 . . .. . |||.|| . ||.     ..   .. ||. .|.||| .|..|  |. 
EQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLKz_h.AA Dicty4-Unclassified 60-326 31 1.5e-46 157.42 In-house 1-263 (263) Show / Hide 
Range on Protein: 60-326
Range on HMM: 1-263/263
Sequence Identity: 31% (85 aa)

LVIREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGV-ADKNAFSNVCCLVSEYMSTGSLRE
. |   || |.. |||.|     .||.| .   |     . | |       .|  |   . ||| ||. |..    . |  .    | | | |  | | |
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDF-----KKEVEILGSIQHPNLVKCYGYCINPRSHKSTM----CIVMEFMHKGNLFE

YLM----SQHKRLSYKL--VIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDFDSARILMEADQAMSGEIGTFGYMAPEVMDGRAYDCKSD
        | . ..     .|   .|||.|. .||.| .||||.|  |||.|    .||.||  .|   .  . |    ||    .||.. . .|  |||
VIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRV-IDFNFNMTTIAGTPKWESPECLMHESYNQKSD

VFSFGICLLEIYSCDMAYGLVCLSLADITKGLVYRNLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRML
|.|... | |    |  | .   |  ..      . |||||| .|.  .    | ||   | ||| | ...  |
VYSYAMMLYELATGDEPY-QEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase MLKz_h.AA LISK 65-263 30 6.1e-43 137.24 In-house 1-232 (296) Show / Hide 
Range on Protein: 65-263
Range on HMM: 1-232/296
Sequence Identity: 30% (74 aa)

VIGLGAIGKVHRGTYN--NEEVAIKLLDC--SKPGLAGDGISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGVA-DKNAFSNVCCLVSEYMSTGSLREY
.|| |. ||| .||..  ....||| .     .|      . .  .  . ||. . ..|.|||||. .|..  .  |.  .     .| ||.. | |..|
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDP------NDPEYQKFMLREVQMMKNLRHPNIVQFMGVC--YHNDGQLH-----IVTEYINGGDLHQY

LMSQHK---RLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLD----SALRAKIGDFDSARILMEAD----------------------------
| .  |    |. .. . .  |||.|..||||..||||| | ||.|..    .  |.|..||  ||.. . .                            
LKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPK

-------QAMSGEIGTFGYMAPEVMDGRAYDCKSDVFSFGICLLEI
       . |.   ||   ||||.. |. || ..||||||| |.||
KCMNQRKRRMT-ICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEI
Kinase MLKz_h.AA Pkinase_Tyr 60-214 31 7.5e-36 122.04 Pfam 1-155 (270) Show / Hide 
Range on Protein: 60-214
Range on HMM: 1-155/270
Sequence Identity: 31% (53 aa)

LVIREVIGLGAIGKVHRGTYN------NEEVAIKLL--DCSKPGLAGDGISDWRRVCLMRELRIWRKL-DHPNIVKLIGASPGVADKNAFSNVCCLVSEY
... ...| || |.|..||..      . .||.| |  ..... .         |  .|||..| ..| .|||||.|.|.     . |      ..| ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--------CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN----QIYIVMEY

MSTGSLREYLMSQ---HKRLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSALRAKIGDF
|  |.|..|| ..    ..|. |  .|  ..||.|.|||.|...||||. ..|.|... . .||.||
MPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDF
Kinase MLKz_h.AA TK-Unique 60-263 28 1.5e-34 116.56 In-house 1-232 (294) Show / Hide 
Range on Protein: 60-263
Range on HMM: 1-232/294
Sequence Identity: 28% (70 aa)

LVIREVIGLGAIGKVHRGTYNN--------EEVAIKLLDCSKPGLAGDGISDWRRVCLMRELRIWRKLD-HPNIVKLIGASPGVADKNAFSNVCCLVSEY
|.. .||| || | |.||.. .          ||.|.|         |. .| ..  ...|... ..|. |||||...|..     |.   .  ... ||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK--------DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCT----KSD--EPWMIIMEY

MSTGSLREYLMSQHKR-------------------------LSYKLVIQLGIDIARGLEYLHS--RKIIHRDVKTKNILLDSALRAKIGDFDSARILM-E
.. |.|. || .  .                          .|.|.... ...||.|.|||.|  .||.|||. ..|.|| . ...||.||  || .. .
CPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTN

ADQAMSGEIGTFG--YMAPEVMD--GRAY-DCKSDVFSFGICLLEI
 ...|... |.    .||||..   .. |  .|||| |||. . ||
GVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEI
Kinase MLKz_h.AA Pkinase_Tyr 237-326 32 1.2e-23 80.68 Pfam 181-270 (270) Show / Hide 
Range on Protein: 237-326
Range on HMM: 181-270/270
Sequence Identity: 32% (30 aa)

MAPEVMDGRAYDCKSDVFSFGICLLEIYS-CDMA-YGLVCLSLADITKGLVYRNLRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRML
||||..  . .  |||| |||... ||.. ...  |  .  | ... . .  .. | ..|. || |.  .||.||...|..||..||....|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM--SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLKz_h.AA Dicty4 289-328 35 3.2e-13 40.61 In-house 236-277 (277) Show / Hide 
Range on Protein: 289-328
Range on HMM: 236-277/277
Sequence Identity: 35% (15 aa)

LRPKIPRSCPGELAYVMKRCWKKNPDKRPRMSEVVRM--LEA
|||.|| .||  ..  ...|| ..| .|| ..|..    ||.
LRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLKz_h.AA TK-Unique 290-326 31 1.6e-10 32.63 In-house 257-294 (294) Show / Hide 
Range on Protein: 290-326
Range on HMM: 257-294/294
Sequence Identity: 31% (12 aa)

RPKIPRSC-PGELAYVMKRCWKKNPDKRPRMSEVVRML
|.. | .| . |. ..||.||...|..||  .... .|
RMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase MLKz_h.AA LRRK 60-90 21 3.1e-07 21.65 In-house 1-60 (351) Show / Hide 
Range on Protein: 60-90
Range on HMM: 1-60/351
Sequence Identity: 21% (13 aa)

LVIREVIGLGAIG-KVHRGTYNN----------------------------EEVAIKLLD
|.| | || |. | .|.|.....                            ..|||| ..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWN
Kinase MLKz_h.AA LISK 286-326 30 5.4e-05 11.95 In-house 255-296 (296) Show / Hide 
Range on Protein: 286-326
Range on HMM: 255-296/296
Sequence Identity: 30% (13 aa)

YRNLRPKIPRS-CPGELAYVMKRCWKKNPDKRPRMSEVVRML
|. ...||. . || ..  .. .| | .|..||  .|.|. |
YEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase MLKz_h.AA Dicty5 60-89 36 6.6e-05 12.81 In-house 1-30 (260) Show / Hide 
Range on Protein: 60-89
Range on HMM: 1-30/260
Sequence Identity: 36% (11 aa)

LVIREVIGLGAIGKVHRGTYNNEEVAIKLL
  . ..|  || |.|  | |.   |||| .
VSFHDWIASGASGRVYNGIYKGMDVAIKVY