Gene MLKy_d (S.moellendorffii)
MLKy_d
Species: S.moellendorffii
Alias: MLKy_d
External Links:
Annotation:
Sequence
Protein domains of MLKy_d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | MLKy_d.AA | TKL | 194-394 | 24 | 5.9e-55 | 188.88 | In-house | 1-287 (364) | Show / Hide |
Range on Protein: 194-394 Range on HMM: 1-287/364 Sequence Identity: 24% (73 aa) LGRGGFSTVFAGVLQD---------GSKVAVKRLES----------------------------ARQGLKQFEAEVRTIGSIHHRNLVKLQGYGAHGQH- .|.|||..|. |... | ||||.. | |.. ...| |.. . ...| |.|.. || ... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------YYLVYEFVENLSLDKWLFSKVDDHDPDKQEHLSWKIRSRIAMDIARGLDYLHG------GCKDQVVHLDIKPQNILLDTDFG------ ...|.|.... || | | | |.|.|||||..||| . | ...| |.|..|||.| .. CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYM --------AKICDFGLARLVERS-DHEKIF--------------VNTVMRGTPGYMAPEWL-----------------HSRVTDKADVYSFGIVLLELVS .|||||||.| ...| . ... . .|||..|||| | .. . |.||||||||| |... YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT GRK ... RCR |
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Pkinase | MLKy_d.AA | Pkinase | 188-393 | 27 | 1.1e-46 | 166.18 | Pfam | 1-209 (293) | Show / Hide |
Range on Protein: 188-393 Range on HMM: 1-209/293 Sequence Identity: 27% (61 aa) GNFKTKLGRGGFSTVFAGVLQDGSK-VAVKRLESARQGLKQFEA-----EVRTIGSIHHRNLVKLQGYGAHGQHYYLVYEFVENL----SLDKWLFSKVD .. |.|.|.|..|. .. .. .| ||||... .. .. .. |.. ...| | |.| .. ..|.|.| |..|. .| .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--- DHDPDKQEHL--SWKIRSRIAMDIARGLDYLHGGCKDQVVHLDIKPQNILLDTDFGA----KICDFGLARLVERSDHEKIFVNTVMRGTPGYMAPEW-L- ... . |.. ... |.|||.|.| . ..| |.||.|||.| . ||||||||.... . . .|. |||.|||||. . ----WRHGCFYFSEWECKFYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRG HSRVTDKADVYSFGIVLLELVSGR .. . |.|..|.|..| |...|| GQYYGPKVDMWSCGCILYEMLCGR |
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Kinase | MLKy_d.AA | TKL-Unique | 190-392 | 29 | 2.4e-41 | 143.57 | In-house | 1-224 (290) | Show / Hide |
Range on Protein: 190-392 Range on HMM: 1-224/290 Sequence Identity: 29% (67 aa) FKTKLGRGGFSTVFAGVLQDGSKVAVKRLE-SARQGLK--Q-FEAEVRTIGSIH-HRNLVKLQGYGA----HGQHYYLVYEFVENLSLDKWLF-SKVDDH | |.|.||...|. |. |..||.|... . . .. | || ||... .| | |.|.. || . . ....| |... ||.. | . FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN DPDKQEHLSWKIRSRIAMDIARGLDYLHGGCKDQVVHLDIKPQNILLDTD-----FGAKICDFGLARLVERSDHEKIFVN-----TVMRGTPGYMAPEWL . |... | ..| |||.|..||| . . |.|.|..|.|.| . . .|||||||... ... ... . .. |.. .|||| | NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL HS---RVTDKADVYSFGIVLLELVSG . . |.||||||||| |.... RMNFCQYSEKSDVYSFGIVLWEIATR |
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Kinase | MLKy_d.AA | IRAK | 189-396 | 35 | 1.1e-40 | 141.51 | In-house | 2-224 (317) | Show / Hide |
Range on Protein: 189-396 Range on HMM: 2-224/317 Sequence Identity: 35% (80 aa) NFKTKLGRGGFSTVFAGVLQDGS-KVAVKRLESAR-----QGLKQFEA---EVRTIGSIHHRNLVKLQGYGAHGQHYYLVYEFVENLSLDKWLFSKVDDH . ..| ||| .|. |... .|||.| . . . ..| . |... ...| |.| | || . .| . |||.. | || | . HKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQC DPDKQEHLSWKIRSRIAMDIARGLDYLHGGC-KDQVVHLDIKPQNILLDTDFGAKICDFGLARLV-ERSDHEKIFV---NT-VMRGTPGYMAPEWLH--- | ||| .| |. .|.|. .|| . . | |||. ||||| .| .|||||||.| . |. || . | . ||| ||.|| . PP---KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ SRVTDKADVYSFGIVLLELVSGRKVV . | | |||||||||||...|...| GQLTKKTDVYSFGIVLLEVLTGCRAV |
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Kinase | MLKy_d.AA | LISK | 193-399 | 26 | 1.1e-38 | 123.24 | In-house | 1-244 (296) | Show / Hide |
Range on Protein: 193-399 Range on HMM: 1-244/296 Sequence Identity: 26% (66 aa) KLGRGGFSTVFAGVLQ-DGSKVAVKRLES------ARQGLKQFEAEVRTIGSIHHRNLVKLQGYGAH-GQHYYLVYEFVENLSLDKWLF-SKVDDHDPDK ..|.|.|. |. | . .|. .|.| ... . .| .. || .. .. |.| |. | | ....| |... | |. ... . EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDK------H QEHLSWKIRSRIAMDIARGLDYLHGGCKDQVVHLDIKPQNILLDTD----FGAKICDFGLARLVERSD----------------------HEKIFVN--T .|.|. | .|| |||.|. ||| ...| | | .|.|... . .|.||||.||... .. .|| .. KIPLPWPQRVKIALDIACGMSYLH---SMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCMN VMR------GTPGYMAPEWLHSRV-TDKADVYSFGIVLLELVSGRKVVP--LP . . ||| |||| | . ....||.||||||.|.. ..|. | .| QRKRRMTICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEIITRVKADPDYWP |
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Kinase | MLKy_d.AA | MLK | 188-393 | 27 | 1.5e-36 | 124.35 | In-house | 1-233 (291) | Show / Hide |
Range on Protein: 188-393 Range on HMM: 1-233/291 Sequence Identity: 27% (66 aa) GNFKTKLGRGGFSTVFAGVLQDGS----KVAVKRLE-------SARQGLKQFEAEVRTIGSIHHRN--LVKLQGYGA---HGQHYYLVYEFVENLSLDKW .|....| |.| |. |. . ||||| . .. ..|| |.| . |.| | ||. ...|...| |..|. || IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV L---FSKVDDHDPDKQE---HLSWKIRSRIAMDIARGLDYLHGGCKDQVVHLDIKPQNILLD------TDFGAKICDFGLARLVERSDHE-KIFVNTVMR | || .| .| . ..|...|||..||| .....| |.|..|||.| . .||||||..| . ... . . . .. LHGARSKWMDAN-HNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNM----MSNA GTPGYMAPEWL----HSRVTDKADVYSFGIVLLELVSGR ||. .|||| . ..... |.||.|.|.|| |..... GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE |
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S_TKc | MLKy_d.AA | S_TKc | 188-474 | 23 | 1.8e-36 | 128.39 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 188-474 Range on HMM: 1-231/231 Sequence Identity: 23% (71 aa) GNFKTKLGRGGFSTVFAGVLQD-GSKVAVKRLESARQGLKQFEAEVRTIGSIHHRNLVKLQGYGAHGQHYYLVYEFVEN--LSLDKWLFSKVDDHDPDKQ . |.|.|.|..|. .. . | .||.|.. .... |.. . || |.||| .. . .|.|.| |.... .| . . .|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI---------KKR EH------LSWKIRSRIAMDIARGLDYLHGGCKDQVVHLDIKPQNILLDTDFGAKICDFGLARLVERSDHEKIFVNTVMRGTPGYMAPEWLHSRVTD-KA . .. ... |...|.|.| . ...| |.||.|||||. |||||||||.. | . ||| ||||| | . |. GRHGLRFPFPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL--GYGKCKC DVYSFGIVLLELVSGRKVVPLPSSAVISHGASRILKVKAFERSELLLGNMDPGLLIVPDFNLEEAKELVRVGLLCVQQEQLRRPSIGVVMK-----MLEE |..|.|..| |...|. | ...|. .|||...| | | . .||.. ... .. . DWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG----------------------SPEAKDFIR---KCLQKDPEKRPTA-EALQDEWDIKCHP AI . WF |
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Kinase | MLKy_d.AA | CAMK | 193-393 | 17 | 7.1e-34 | 106.0 | In-house | 1-331 (425) | Show / Hide |
Range on Protein: 193-393 Range on HMM: 1-331/425 Sequence Identity: 17% (59 aa) KLGRGGFSTVFAGVLQ-DG------------SKVAVKRLESA-----------------------------RQGLKQFEAEVRTIGS-------IHHRNL .||||.|..|. .. .. |||.| .. . .|... |.. . ..|.|. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKLQG--------------------YGAHGQHYYLVY---EFVENLSLDKWLFSKVDDH-----------DPDKQEHLSWKIRSRIAMDIARGLDYLHGG .|| . .|.|.| |.... | ||... .| . ... . .|. |. ...|.| IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCH-- CKDQVVHLDIKPQNILLDTDF----------------G-AKICDFGLARLVER---------SDHEKIFVNT------------VMRGTPGYMA-PEWL- .. .||.|.|| |||||... . ||.|||.|. ... ... . .. . |||.||| ||.| SHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLN --------------HSRVTDKADVYSFGIVLLELVSGR . .. |.|. | |..| ...|. GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGY |
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Kinase | MLKy_d.AA | STE | 190-393 | 20 | 1.7e-33 | 115.64 | In-house | 1-265 (359) | Show / Hide |
Range on Protein: 190-393 Range on HMM: 1-265/359 Sequence Identity: 20% (57 aa) FKT--KLGRGGFSTVFAGVLQD----------------GSKVAVKRLESARQG------------------LKQFEAEVRTIGSIH--HRNLVKLQGYGA .. |.|.|.| ||. .. . | .|.|... .. ..|.. |... . | | || |. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF HG-------QHYYLVYEFVENLSLDKWLFSKVDDHDPDK-----QEHLSWKIRSRIAMDIARG-LDYLHGGCKDQVVHLDIKPQNILLDTDFGAKICDFG .. .. ... |.... |||. . .| .|.. | ... .. ..|. .| .| |.||| ..| ||||.|||| .|.|||| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG LARLVER---SDHEKI-----------FVNTVMRGTPGYMAPEWLHSRVTD-------KADVYSFGIVLLELVSGR .. .. .. . . .. . ||| .|||| . . .. |.|..|.|....|.. |. VCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK |
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Kinase | MLKy_d.AA | RIPK | 194-395 | 27 | 4.2e-33 | 110.14 | In-house | 1-227 (290) | Show / Hide |
Range on Protein: 194-395 Range on HMM: 1-227/290 Sequence Identity: 27% (63 aa) LGRGGFSTVFAGVLQDGSKVAVKRLES--------ARQGLKQFEAEVRTIGSIHHRNLVKLQGYGAHGQH------YYLVYEFVENLSLDKWLFSKVDDH .|.|||..|| . . ...| .| .. |. .. ... |.. | . | .| |. || || . | .| . VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY- DPDKQEHLSWKIRSRIAMDIARGLDYLHGGCKD-QVVHLDIKPQNILLDTDFGAKICDFGLARLVERSDHEK--------IFVNTVMR-GTPGYMAPEWL . . |. | |. |..| ||| ... . |.| ||.|||.| .| .|| ||||| . | . | || ||.|| . ---QHHPDPWPLRCRMIHEISCGMCYLH--SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHF H----SR---VTDKADVYSFGIVLLELVSGRKV .. || | |||||.||. |. ..... RTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP |
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Kinase | MLKy_d.AA | TK | 188-391 | 16 | 7.1e-32 | 103.56 | In-house | 1-389 (486) | Show / Hide |
Range on Protein: 188-391 Range on HMM: 1-389/486 Sequence Identity: 16% (64 aa) GNFKTKLGRGGFS---TVFAGVLQDGS--------------------------KVAVKRLES-ARQGLKQFEA--------------EVRTIGSIH---- . |||.| | .|. | ..... .|||| | . . . ..|.. |.. . . ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG -HRNLVKLQG-------------YGAHGQHYYLVYEFVEN----LSLDKWLFSKVDD-------------------------------------HDPDKQ | |.|.| | . |......| |.... ||...| .. .. . |..| HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQ -------------------------------EHLSWKIRSRIAMDIARGLDYLHGGCKD----QVVHLDIKPQNILLDTDFG-----------AKICDFG ..|. . . ....||.|. ||| .. ..|| |. |.|.. . .||.||| DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH-SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG LAR-----LVERSDHEKIFVNTVMRGTPG-------------------------YMAPEWLHSRV----------TDKADVYSFGIVLLELVS |.| | . .... . . .||.. .|||| | .|| | | ||.|||... |... LSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT |
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Kinase | MLKy_d.AA | Pkinase_Tyr | 189-394 | 28 | 1.1e-29 | 101.2 | Pfam | 2-213 (270) | Show / Hide |
Range on Protein: 189-394 Range on HMM: 2-213/270 Sequence Identity: 28% (63 aa) NFKTKLGRGGFSTVFAGVLQ-----DGSKVAVKRL-ESARQG---LKQFEAEVRTIGSI-HHRNLVKLQGYGA-HGQH--YYLVYEFVENLSLDKWLFSK | |||.| | .|. |.. .. .|||| | |.| . .. | .|... .. || |.|.| | .|.. .|.| |.... .|.. | .. TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH VDDHDPDKQEHLSWKIRSRIAMDIARGLDYLHGGCKDQVVHLDIKPQNILLDTDFGAKICDFGLARLVERSDHEKIFVNTVMRGTPGYMAPE-WLHSRVT . ...|. | ....||.|..||. .| |. |.|.. .. .|||||||||... | . . . . |||| . ... | R-----EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFT DKADVYSFGIVLLELVS-GRK | ||.|||... |... |.. TKSDVWSFGVLMWEIFTYGEQ |
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Kinase | MLKy_d.AA | Dicty4 | 287-390 | 38 | 1.3e-29 | 96.06 | In-house | 106-211 (277) | Show / Hide |
Range on Protein: 287-390 Range on HMM: 106-211/277 Sequence Identity: 38% (42 aa) LSWKIRSR---IAMDIARGLDYLHGGCKDQVVHLDIKPQNILLDTDFGAKICDFGLARLVERSDHEKIFVNTVMRGTPGYMAPEWLHSRV-TDKADVYSF |.| . | .| |.|||. .||. | ..|.|.|. |.| | .. .|.|||||... . . .. . . . |||..|||| . .. . ||||||| LDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKK-HEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSF GIVLLELV |||| |.. GIVLWEIL |
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Kinase | MLKy_d.AA | TyrKc | 188-470 | 20 | 3e-17 | 56.26 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 188-470 Range on HMM: 1-280/280 Sequence Identity: 20% (64 aa) GNFKTKLGRGGFSTVFAGVLQDGSKVAVKRLESARQGLKQFEAEVRTIGSI--HHRNLVKLQGYGAHG-------QHYYLVYEFVENLSLDKWLFSKVDD .. |||.| | .|. |.. .|||| | . .. | | | .. || |.|.| |. .. . ...| |.... .|.. | .. .. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK HDPDKQEHLSWKIRSRIAMDIARGLDYLHGGCKDQVVHLDIKPQNILLDTDFGAKICDFGLARLVERSD-----HEKIFVNT--VMR--GTPGYMAPEWL |..| .. .||.| .||| ...| |. |.|.. .. .||.||||.| .. | .. . . . . |||| . --------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI -HSRVTDKADVYSFGIVLLELVSGRKVVPLP------SSAVISHGASRILKVKAFER----SELLLGNMDPGLLIVPDFNLEEAKELVRVGLLCVQQEQL ... | | ||.|||... |. . . . | . . . . . . | | . .|. .. . | . . NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------F-VCCPDEMYQIMKQCWHEDPE RRPSIGVVMKML ||. . . . DRPTFSEIHECF |
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Kinase | MLKy_d.AA | Dicty4 | 189-249 | 31 | 8.5e-07 | 18.88 | In-house | 2-66 (277) | Show / Hide |
Range on Protein: 189-249 Range on HMM: 2-66/277 Sequence Identity: 31% (21 aa) NFKTKLGRGGFSTVFAGVLQDGSKVAVKRLESARQG-----LKQFEAEVRTIGSIHHRNLVKLQGY |. ..|.|.|..|. | |..|||| | . |. |. | .|| ..| | |.... |. NIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGA |